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The map label for this gene is pepA [H]

Identifier: 169629035

GI number: 169629035

Start: 1945756

End: 1947264

Strand: Reverse

Name: pepA [H]

Synonym: MAB_1948c

Alternate gene names: 169629035

Gene position: 1947264-1945756 (Counterclockwise)

Preceding gene: 169629038

Following gene: 169629032

Centisome position: 38.43

GC content: 68.92

Gene sequence:

>1509_bases
ATGAGCGCATACACGGCACCTTCGTTCACCCTGGCCACATCCATTCCGCAGCGCGGAGTCTCCGCCGCGGTGCTGCTGGT
GGGTGTACGCCCCAGTGACAAGGACTCCGACAAGAGCCCCAGAGTGGTCGACGCGCAACTGCTGGACAAGGCGGCCGTCA
AGTCCATCGAAGCCGCGCTCACGGCGGTCGGGGCGACGGGCTCCGCCGAGCAGCTCACCCGGGTCGTGGTCGACGGGTTG
CCGGTGGCCAGCGTGCTGGCTGTCGGGCTGGGCAAGGCCGACGACGCCGAGACGATCCGCCGCGCCGCGGCAGTGGCCGC
CCGCTCGCTCGACAATGTCGAGATCCTGGTGACCACGCTGTCCGAACGTGACGTCGACGCCACCGTGCAGGGCCTGGTGC
TGGGCGGATACCGCTTCGCCGAGTTCCGCAGCGCCAAGACCGCCCCCAAGGACGCGGGTCTGCAGAAGGTTACGTTGCTC
GTCGGCGACAAGGGCCGTGCGCAGAAAGAGGCCATGGAACGCGGTGCCGCGGTGGCGACTGCCGTCGTAACTGCCCGTGA
TTTTGTGAACACCCCGCCGAGCCACCTTTTCCCCGCCGAGTTTGCAAAGCGCGCAAAGGCTTTGGCAACCGCCGAGGGCA
TCGAGGTGGAGGTGCTCGACGAGAAGGAGCTGGCCAAGGGCGGCTACGGCGGCATCGTCGGCGTCGGCAAGGGCTCCTCG
CGTCCGCCACGGCTGGTGCGGCTGACCTATCGCGGCGCGAAGGGCAAGAAAGCCAAGTCGGTGGCGCTGGTGGGCAAGGG
CATCACCTTCGACACCGGCGGCATCTCGATCAAGCCGGCCGGCGGCATGGAGAACATGACCTCCGATATGGGCGGTGCGG
CAGCGGTTATCGCCGTCACCTTGCTGGCCGCGCGCCAGCAGCTGCCGATCGACGTGATCGCGACCGTGCCGATGGCCGAG
AACATGCCCTCATCGACGGCGCAGCGTCCCGGTGATGTGCTGACCCAGTTGGATGGCACCACCGTCGAGGTGATCAACAC
CGACGCCGAGGGCCGCCTGATCCTCGCCGACGCGATCGTGCGGGCCTGCCGGGACCAGCCGGACTACCTGATCGACACCG
CGACGCTGACCGGTGCGCAGGTTGTGGCGCTCGGCACCCGCACCCCCGGGGTGATGGGCACCGACGAGTTCCGCGACCGG
GTGTCGGCCATCTCGCAGTCGGTTGGCGAGAACGGCTGGGCCATGCCGCTGCCCGAGGAGCTGCGCGACGATCTGAAGTC
CCGGGTGGCAGACCTGGCCAATGTCACCAATCACCGCAACGGCGGCATGCTCGCCGCCGGCCAGTACCTGCGCGAGTTCG
TCGCCGACGGGGTCCAGTGGGCGCACATCGACGTCGCCGGTCCCGCGTACAACACCGGCGGGCCGTGGGGTTACACGCCC
AAGGGCGGCACCGGCGTGCCGGTGCGGACCATCTTTGGGGTGCTGGAGGACATCGCCGCCAACGGGTGA

Upstream 100 bases:

>100_bases
AGCAAGAGGTCCGTCATGGCGTTCACCCTAGCCACATGGTCTTCGCACCAGGGCCTCATCCCGGTTGGCGCCTCATCGGC
CTTCACTAGGCTGTGAACCT

Downstream 100 bases:

>100_bases
CGCCGTGAGCGCTAGGCGCCCTCGTCCATGGCCCGGCGCTTGAGGATCTTCTGTCGCGCGTCGTAATCGCGTTTGCGTTG
CGGATACCCGGTGCGGTGCA

Product: cytosol aminopeptidase (leucyl aminopeptidase)

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MSAYTAPSFTLATSIPQRGVSAAVLLVGVRPSDKDSDKSPRVVDAQLLDKAAVKSIEAALTAVGATGSAEQLTRVVVDGL
PVASVLAVGLGKADDAETIRRAAAVAARSLDNVEILVTTLSERDVDATVQGLVLGGYRFAEFRSAKTAPKDAGLQKVTLL
VGDKGRAQKEAMERGAAVATAVVTARDFVNTPPSHLFPAEFAKRAKALATAEGIEVEVLDEKELAKGGYGGIVGVGKGSS
RPPRLVRLTYRGAKGKKAKSVALVGKGITFDTGGISIKPAGGMENMTSDMGGAAAVIAVTLLAARQQLPIDVIATVPMAE
NMPSSTAQRPGDVLTQLDGTTVEVINTDAEGRLILADAIVRACRDQPDYLIDTATLTGAQVVALGTRTPGVMGTDEFRDR
VSAISQSVGENGWAMPLPEELRDDLKSRVADLANVTNHRNGGMLAAGQYLREFVADGVQWAHIDVAGPAYNTGGPWGYTP
KGGTGVPVRTIFGVLEDIAANG

Sequences:

>Translated_502_residues
MSAYTAPSFTLATSIPQRGVSAAVLLVGVRPSDKDSDKSPRVVDAQLLDKAAVKSIEAALTAVGATGSAEQLTRVVVDGL
PVASVLAVGLGKADDAETIRRAAAVAARSLDNVEILVTTLSERDVDATVQGLVLGGYRFAEFRSAKTAPKDAGLQKVTLL
VGDKGRAQKEAMERGAAVATAVVTARDFVNTPPSHLFPAEFAKRAKALATAEGIEVEVLDEKELAKGGYGGIVGVGKGSS
RPPRLVRLTYRGAKGKKAKSVALVGKGITFDTGGISIKPAGGMENMTSDMGGAAAVIAVTLLAARQQLPIDVIATVPMAE
NMPSSTAQRPGDVLTQLDGTTVEVINTDAEGRLILADAIVRACRDQPDYLIDTATLTGAQVVALGTRTPGVMGTDEFRDR
VSAISQSVGENGWAMPLPEELRDDLKSRVADLANVTNHRNGGMLAAGQYLREFVADGVQWAHIDVAGPAYNTGGPWGYTP
KGGTGVPVRTIFGVLEDIAANG
>Mature_501_residues
SAYTAPSFTLATSIPQRGVSAAVLLVGVRPSDKDSDKSPRVVDAQLLDKAAVKSIEAALTAVGATGSAEQLTRVVVDGLP
VASVLAVGLGKADDAETIRRAAAVAARSLDNVEILVTTLSERDVDATVQGLVLGGYRFAEFRSAKTAPKDAGLQKVTLLV
GDKGRAQKEAMERGAAVATAVVTARDFVNTPPSHLFPAEFAKRAKALATAEGIEVEVLDEKELAKGGYGGIVGVGKGSSR
PPRLVRLTYRGAKGKKAKSVALVGKGITFDTGGISIKPAGGMENMTSDMGGAAAVIAVTLLAARQQLPIDVIATVPMAEN
MPSSTAQRPGDVLTQLDGTTVEVINTDAEGRLILADAIVRACRDQPDYLIDTATLTGAQVVALGTRTPGVMGTDEFRDRV
SAISQSVGENGWAMPLPEELRDDLKSRVADLANVTNHRNGGMLAAGQYLREFVADGVQWAHIDVAGPAYNTGGPWGYTPK
GGTGVPVRTIFGVLEDIAANG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=488, Percent_Identity=33.4016393442623, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI47155554, Length=322, Percent_Identity=35.0931677018634, Blast_Score=153, Evalue=5e-37,
Organism=Escherichia coli, GI1790710, Length=357, Percent_Identity=39.4957983193277, Blast_Score=238, Evalue=9e-64,
Organism=Escherichia coli, GI87082123, Length=418, Percent_Identity=36.1244019138756, Blast_Score=186, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=293, Percent_Identity=35.1535836177474, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17565172, Length=217, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21355725, Length=442, Percent_Identity=30.5429864253394, Blast_Score=176, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24661038, Length=443, Percent_Identity=29.3453724604966, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24662227, Length=414, Percent_Identity=29.2270531400966, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI20129969, Length=415, Percent_Identity=29.8795180722892, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI21357381, Length=306, Percent_Identity=35.9477124183007, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI221379063, Length=306, Percent_Identity=35.9477124183007, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI221379062, Length=306, Percent_Identity=35.9477124183007, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI21355645, Length=486, Percent_Identity=27.3662551440329, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24662223, Length=486, Percent_Identity=27.3662551440329, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI161077148, Length=418, Percent_Identity=27.511961722488, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI20130057, Length=418, Percent_Identity=27.511961722488, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI19922386, Length=434, Percent_Identity=26.7281105990783, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI20129963, Length=436, Percent_Identity=27.7522935779816, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646701, Length=272, Percent_Identity=30.1470588235294, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646703, Length=272, Percent_Identity=30.1470588235294, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21358201, Length=272, Percent_Identity=30.1470588235294, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 52033; Mature: 51902

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAYTAPSFTLATSIPQRGVSAAVLLVGVRPSDKDSDKSPRVVDAQLLDKAAVKSIEAAL
CCCCCCCCEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHH
TAVGATGSAEQLTRVVVDGLPVASVLAVGLGKADDAETIRRAAAVAARSLDNVEILVTTL
HHHCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEC
SERDVDATVQGLVLGGYRFAEFRSAKTAPKDAGLQKVTLLVGDKGRAQKEAMERGAAVAT
CCCCCCHHHHEEEECCCHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHHCCHHHHH
AVVTARDFVNTPPSHLFPAEFAKRAKALATAEGIEVEVLDEKELAKGGYGGIVGVGKGSS
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCHHHCCCCCCCEEEECCCCC
RPPRLVRLTYRGAKGKKAKSVALVGKGITFDTGGISIKPAGGMENMTSDMGGAAAVIAVT
CCCEEEEEEECCCCCCCCCEEEEEECCEEEECCCEEEECCCCCHHHHHHCCCHHHHHHHH
LLAARQQLPIDVIATVPMAENMPSSTAQRPGDVLTQLDGTTVEVINTDAEGRLILADAIV
HHHHHHCCCEEEEEECCCCCCCCCCHHCCCCHHHHHCCCCEEEEEECCCCCCEEHHHHHH
RACRDQPDYLIDTATLTGAQVVALGTRTPGVMGTDEFRDRVSAISQSVGENGWAMPLPEE
HHHCCCCCEEEEEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHH
LRDDLKSRVADLANVTNHRNGGMLAAGQYLREFVADGVQWAHIDVAGPAYNTGGPWGYTP
HHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCC
KGGTGVPVRTIFGVLEDIAANG
CCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAYTAPSFTLATSIPQRGVSAAVLLVGVRPSDKDSDKSPRVVDAQLLDKAAVKSIEAAL
CCCCCCCEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHH
TAVGATGSAEQLTRVVVDGLPVASVLAVGLGKADDAETIRRAAAVAARSLDNVEILVTTL
HHHCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEC
SERDVDATVQGLVLGGYRFAEFRSAKTAPKDAGLQKVTLLVGDKGRAQKEAMERGAAVAT
CCCCCCHHHHEEEECCCHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHHCCHHHHH
AVVTARDFVNTPPSHLFPAEFAKRAKALATAEGIEVEVLDEKELAKGGYGGIVGVGKGSS
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCHHHCCCCCCCEEEECCCCC
RPPRLVRLTYRGAKGKKAKSVALVGKGITFDTGGISIKPAGGMENMTSDMGGAAAVIAVT
CCCEEEEEEECCCCCCCCCEEEEEECCEEEECCCEEEECCCCCHHHHHHCCCHHHHHHHH
LLAARQQLPIDVIATVPMAENMPSSTAQRPGDVLTQLDGTTVEVINTDAEGRLILADAIV
HHHHHHCCCEEEEEECCCCCCCCCCHHCCCCHHHHHCCCCEEEEEECCCCCCEEHHHHHH
RACRDQPDYLIDTATLTGAQVVALGTRTPGVMGTDEFRDRVSAISQSVGENGWAMPLPEE
HHHCCCCCEEEEEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHH
LRDDLKSRVADLANVTNHRNGGMLAAGQYLREFVADGVQWAHIDVAGPAYNTGGPWGYTP
HHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCC
KGGTGVPVRTIFGVLEDIAANG
CCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA