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The map label for this gene is adhC [C]

Identifier: 169628957

GI number: 169628957

Start: 1868400

End: 1869440

Strand: Reverse

Name: adhC [C]

Synonym: MAB_1869c

Alternate gene names: 169628957

Gene position: 1869440-1868400 (Counterclockwise)

Preceding gene: 169628960

Following gene: 169628956

Centisome position: 36.89

GC content: 66.28

Gene sequence:

>1041_bases
GTGGAGCTGGTGGACATCGTGATCCCTGATCCGGGCCCCGGTGAGGTCGTGGTGAAGGTGCAGGCCTGCGGGGTATGCCA
CACCGATCTGACCTACCGCGAGGGCGGGATCAACGACGAGTTCCCGTTCCTGCTCGGCCATGAGGCGGCGGGGATTGTGG
AGACCGTCGGCGAAGGCGTAACCACCGTCGAGCCGGGCGATTTCGTGATCCTGAACTGGCGCGCGGTGTGTGGGGTGTGC
CGGGCCTGCAAGCGCGGGCGGCCGCAGTACTGCTTCGACACCTTCAACGCCGCTCAGAAGATGACACTCACCGACGGCAC
CGAGCTGACCCCCGCCCTGGGCATCGGCGCATTCATCGAGAAGACGCTGGTACATGCCGGGCAATGCACCAAGGTCGATC
CGACCGCGGATCCGGCCGTGGTGGGCCTGCTGGGCTGCGGCGTGATGGCCGGACTCGGCGCGGCGGTGAACACCGGCAAT
GTGGGCCGCGACGACACCGTCGCGGTCATCGGCTGTGGTGGGGTCGGCGATGCGGCGATCGCCGGGGCCCGGTTGGCGGG
GGCGCGCAAGATCATCGCCATCGACACCGATGACACCAAGCTGGCCTGGGCCAAGGACTTCGGGGCCACCGACACCATCA
ATGCCCGCAAGGTCGACGACGTGGTCACCGCGATCCAGGAACTGACCGACGAATTCGGCGCCGACGTGGTGATCGACGCG
GTAGGCCGCCCCGAAACCTGGAAACAGGCCTTCTACGCACGCGATCTGGCCGGCACGGTGGTGTTGGTCGGCGTCCCCAC
ACCGGATATGACGCTCGAGATGCCCTTGATCGACTTCTTCTCACGCGGCGGCTCGTTGAAGTCCTCCTGGTATGGCGACT
GCCTGCCCGAGCGCGACTTCCCCACCCTGGTATCGCTCTACCAACAGGGCCGACTGCCCCTGGACCGATTCGTCTCCGAG
CGCATCGGCATCGAAAGCATCGAAGCCGCGTTCGAAAAGATGCACCATGGCGAGGTCCTGCGCTCCGTAGTGGTGCTCTA
G

Upstream 100 bases:

>100_bases
AGTCGGCGACAAGGTCGAGAGCACCCATGCCTGGGACTGTAGCGTCATGCGCATGTCTCAAACTGTGCGCGGTGTGATCG
CTCGGTCGGTAAAAGCTCCT

Downstream 100 bases:

>100_bases
CCGCACTCCGATGTCGATCAATCGGAGGCAGTTCGTGGTCGGCGGAGCCGCCGCTACCGCTGCCACCACGGGACTGGCGG
CACTGGCCGGGTGCGGCCAC

Product: zinc-dependent alcohol dehydrogenase AdhE2

Products: NA

Alternate protein names: NAD/mycothiol-dependent formaldehyde dehydrogenase; MD-FALDH [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MELVDIVIPDPGPGEVVVKVQACGVCHTDLTYREGGINDEFPFLLGHEAAGIVETVGEGVTTVEPGDFVILNWRAVCGVC
RACKRGRPQYCFDTFNAAQKMTLTDGTELTPALGIGAFIEKTLVHAGQCTKVDPTADPAVVGLLGCGVMAGLGAAVNTGN
VGRDDTVAVIGCGGVGDAAIAGARLAGARKIIAIDTDDTKLAWAKDFGATDTINARKVDDVVTAIQELTDEFGADVVIDA
VGRPETWKQAFYARDLAGTVVLVGVPTPDMTLEMPLIDFFSRGGSLKSSWYGDCLPERDFPTLVSLYQQGRLPLDRFVSE
RIGIESIEAAFEKMHHGEVLRSVVVL

Sequences:

>Translated_346_residues
MELVDIVIPDPGPGEVVVKVQACGVCHTDLTYREGGINDEFPFLLGHEAAGIVETVGEGVTTVEPGDFVILNWRAVCGVC
RACKRGRPQYCFDTFNAAQKMTLTDGTELTPALGIGAFIEKTLVHAGQCTKVDPTADPAVVGLLGCGVMAGLGAAVNTGN
VGRDDTVAVIGCGGVGDAAIAGARLAGARKIIAIDTDDTKLAWAKDFGATDTINARKVDDVVTAIQELTDEFGADVVIDA
VGRPETWKQAFYARDLAGTVVLVGVPTPDMTLEMPLIDFFSRGGSLKSSWYGDCLPERDFPTLVSLYQQGRLPLDRFVSE
RIGIESIEAAFEKMHHGEVLRSVVVL
>Mature_346_residues
MELVDIVIPDPGPGEVVVKVQACGVCHTDLTYREGGINDEFPFLLGHEAAGIVETVGEGVTTVEPGDFVILNWRAVCGVC
RACKRGRPQYCFDTFNAAQKMTLTDGTELTPALGIGAFIEKTLVHAGQCTKVDPTADPAVVGLLGCGVMAGLGAAVNTGN
VGRDDTVAVIGCGGVGDAAIAGARLAGARKIIAIDTDDTKLAWAKDFGATDTINARKVDDVVTAIQELTDEFGADVVIDA
VGRPETWKQAFYARDLAGTVVLVGVPTPDMTLEMPLIDFFSRGGSLKSSWYGDCLPERDFPTLVSLYQQGRLPLDRFVSE
RIGIESIEAAFEKMHHGEVLRSVVVL

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=355, Percent_Identity=36.056338028169, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI4501929, Length=355, Percent_Identity=35.7746478873239, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI4501933, Length=355, Percent_Identity=33.8028169014084, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI71565154, Length=365, Percent_Identity=35.8904109589041, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI156523966, Length=356, Percent_Identity=33.1460674157303, Blast_Score=175, Evalue=5e-44,
Organism=Homo sapiens, GI71743840, Length=355, Percent_Identity=33.5211267605634, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI262073058, Length=355, Percent_Identity=33.5211267605634, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI4501939, Length=348, Percent_Identity=33.3333333333333, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI71565152, Length=359, Percent_Identity=32.033426183844, Blast_Score=165, Evalue=4e-41,
Organism=Homo sapiens, GI156627571, Length=364, Percent_Identity=26.9230769230769, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI1786552, Length=355, Percent_Identity=35.4929577464789, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI1788073, Length=349, Percent_Identity=27.2206303724928, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1790045, Length=346, Percent_Identity=25.4335260115607, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI87081918, Length=276, Percent_Identity=31.5217391304348, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1788407, Length=340, Percent_Identity=26.1764705882353, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787863, Length=340, Percent_Identity=26.1764705882353, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87082125, Length=273, Percent_Identity=28.9377289377289, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1786518, Length=349, Percent_Identity=26.647564469914, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788075, Length=338, Percent_Identity=26.0355029585799, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1786825, Length=251, Percent_Identity=28.2868525896414, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI226510992, Length=362, Percent_Identity=24.0331491712707, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1790718, Length=312, Percent_Identity=24.3589743589744, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25146526, Length=361, Percent_Identity=34.9030470914127, Blast_Score=177, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI71997431, Length=370, Percent_Identity=34.5945945945946, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17565904, Length=333, Percent_Identity=35.7357357357357, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17562876, Length=352, Percent_Identity=28.4090909090909, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17562878, Length=346, Percent_Identity=25.7225433526012, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17562582, Length=352, Percent_Identity=25.2840909090909, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71988145, Length=352, Percent_Identity=26.1363636363636, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562584, Length=352, Percent_Identity=25.8522727272727, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320033, Length=360, Percent_Identity=35.8333333333333, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6319621, Length=351, Percent_Identity=29.0598290598291, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6323729, Length=349, Percent_Identity=26.0744985673352, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6322619, Length=355, Percent_Identity=29.5774647887324, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323961, Length=349, Percent_Identity=25.7879656160458, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=355, Percent_Identity=29.2957746478873, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=352, Percent_Identity=25.8522727272727, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319257, Length=354, Percent_Identity=24.5762711864407, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6319258, Length=290, Percent_Identity=24.4827586206897, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17737895, Length=361, Percent_Identity=36.01108033241, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI17737897, Length=342, Percent_Identity=27.4853801169591, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17137530, Length=349, Percent_Identity=26.3610315186246, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45550770, Length=339, Percent_Identity=23.598820058997, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45551930, Length=339, Percent_Identity=23.598820058997, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221457811, Length=339, Percent_Identity=23.598820058997, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR017816
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.306 [H]

Molecular weight: Translated: 36671; Mature: 36671

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELVDIVIPDPGPGEVVVKVQACGVCHTDLTYREGGINDEFPFLLGHEAAGIVETVGEGV
CCEEEEEECCCCCCCEEEEEEECCEEECCCEECCCCCCCCCCEEECCCHHHHHHHHCCCC
TTVEPGDFVILNWRAVCGVCRACKRGRPQYCFDTFNAAQKMTLTDGTELTPALGIGAFIE
EEECCCCEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEECCCCCCCHHHHHHHHHH
KTLVHAGQCTKVDPTADPAVVGLLGCGVMAGLGAAVNTGNVGRDDTVAVIGCGGVGDAAI
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHH
AGARLAGARKIIAIDTDDTKLAWAKDFGATDTINARKVDDVVTAIQELTDEFGADVVIDA
HHHHHCCCEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEC
VGRPETWKQAFYARDLAGTVVLVGVPTPDMTLEMPLIDFFSRGGSLKSSWYGDCLPERDF
CCCCHHHHHHHHHHCCCCEEEEEEECCCCCEEECHHHHHHHCCCCCCCCCCCCCCCCCCC
PTLVSLYQQGRLPLDRFVSERIGIESIEAAFEKMHHGEVLRSVVVL
HHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MELVDIVIPDPGPGEVVVKVQACGVCHTDLTYREGGINDEFPFLLGHEAAGIVETVGEGV
CCEEEEEECCCCCCCEEEEEEECCEEECCCEECCCCCCCCCCEEECCCHHHHHHHHCCCC
TTVEPGDFVILNWRAVCGVCRACKRGRPQYCFDTFNAAQKMTLTDGTELTPALGIGAFIE
EEECCCCEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEECCCCCCCHHHHHHHHHH
KTLVHAGQCTKVDPTADPAVVGLLGCGVMAGLGAAVNTGNVGRDDTVAVIGCGGVGDAAI
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHH
AGARLAGARKIIAIDTDDTKLAWAKDFGATDTINARKVDDVVTAIQELTDEFGADVVIDA
HHHHHCCCEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEC
VGRPETWKQAFYARDLAGTVVLVGVPTPDMTLEMPLIDFFSRGGSLKSSWYGDCLPERDF
CCCCHHHHHHHHHHCCCCEEEEEEECCCCCEEECHHHHHHHCCCCCCCCCCCCCCCCCCC
PTLVSLYQQGRLPLDRFVSERIGIESIEAAFEKMHHGEVLRSVVVL
HHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9346279; 1597190; 9202149 [H]