BacMap

Definition	Mycobacterium abscessus ATCC 19977 chromosome chromosome 1, complete sequence.
Accession	NC_010397
Length	5,067,172

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The map label for this gene is yusZ [H]

Identifier: 169628398

GI number: 169628398

Start: 1306852

End: 1307658

Strand: Direct

Name: yusZ [H]

Synonym: MAB_1305

Alternate gene names: 169628398

Gene position: 1306852-1307658 (Clockwise)

Preceding gene: 169628397

Following gene: 169628399

Centisome position: 25.79

GC content: 63.44

Gene sequence:

>807_bases
ATGTCTGAACATTGGACCGTCCTGGTCACCGGCGCTTCCAGCGGGATCGGCGCGAGTGCGGCCCGAATCTTCGCAGAACG
GGGACACCGCGTATTCGGAACCAGTCGCAATCCCGACACCATCACCGATCGCGTCCCCGGGGTGCAGTACCTGCGGCTCG
ATCAAACCGATAAGGCCAGCATCGCTGAATGCGTTGCCCAGGCCGGTGAGGTGGACATCCTCGTCAACAATGCCGGTGAG
AGTCAGATCGGTGCGCTGGAAGACGTTTCGATGGATGACTTCGAGAAGCTCTACATGACCAATGTCTTTGGGCCCGTTGC
TCTCACCAAGGCGGTGCTGCCCGGTATGCGGGAGCGGCGCCGGGGCGCCGTCGTCATGGTGGGGTCCATGGCGGGCACCT
TGCATGTCCCGTTCCGATCGACCTATAGCTCCGCGAAATCGGCATTGCACACCGTGGCCGACTGTCTGCGCTATGAGGTG
GCGCCGTTCGGGATCACCGTGAGCACCGTGGAGCCCGGCGTGATCGCCACCGGAATCGAGACGCGACGCAACCGCATCGT
CCCCGATGGATCCCCCTACCGGGACGCATTCCGGACGGTCGATGCGGCCATGGCCGCGCGGGAAGAACACGGCACGGCCA
CCGATGAACTGGGGCGCCTGGTTGTCGATGTGGCGCTGAGTCCGAGCCCGAAACCTTTGTACGCCAAGGGGAGTAATGCT
CCGATCATCATGACCGCACAGCGTCTGCTGCCCGCCCGGTTGTTCCTCAAGTTCCTGGCACGCATGCACGGGCTGAAGGT
GCGTTAG

Upstream 100 bases:

>100_bases
TGGGCCGGACTGGTGGACATCGTGGCGGCCATAGCAACGCTGACCTGGATGGCGGTGGTGGGCCGGCGAAGCGGCCACCT
TGGTCGGCTACCGTGGCGCC

Downstream 100 bases:

>100_bases
GTCATGTTCCCTCAAGGTATGCATCCCACCGGATCGTCAGATGCCTTCCATTCCAAGGACATCGGCAGGCTCCTGCTGCA
GTGCCCCGATCGGATCGGCG

Product: short-chain dehydrogenase/reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: ORFA [H]

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MSEHWTVLVTGASSGIGASAARIFAERGHRVFGTSRNPDTITDRVPGVQYLRLDQTDKASIAECVAQAGEVDILVNNAGE
SQIGALEDVSMDDFEKLYMTNVFGPVALTKAVLPGMRERRRGAVVMVGSMAGTLHVPFRSTYSSAKSALHTVADCLRYEV
APFGITVSTVEPGVIATGIETRRNRIVPDGSPYRDAFRTVDAAMAAREEHGTATDELGRLVVDVALSPSPKPLYAKGSNA
PIIMTAQRLLPARLFLKFLARMHGLKVR

Sequences:

>Translated_268_residues
MSEHWTVLVTGASSGIGASAARIFAERGHRVFGTSRNPDTITDRVPGVQYLRLDQTDKASIAECVAQAGEVDILVNNAGE
SQIGALEDVSMDDFEKLYMTNVFGPVALTKAVLPGMRERRRGAVVMVGSMAGTLHVPFRSTYSSAKSALHTVADCLRYEV
APFGITVSTVEPGVIATGIETRRNRIVPDGSPYRDAFRTVDAAMAAREEHGTATDELGRLVVDVALSPSPKPLYAKGSNA
PIIMTAQRLLPARLFLKFLARMHGLKVR
>Mature_267_residues
SEHWTVLVTGASSGIGASAARIFAERGHRVFGTSRNPDTITDRVPGVQYLRLDQTDKASIAECVAQAGEVDILVNNAGES
QIGALEDVSMDDFEKLYMTNVFGPVALTKAVLPGMRERRRGAVVMVGSMAGTLHVPFRSTYSSAKSALHTVADCLRYEVA
PFGITVSTVEPGVIATGIETRRNRIVPDGSPYRDAFRTVDAAMAAREEHGTATDELGRLVVDVALSPSPKPLYAKGSNAP
IIMTAQRLLPARLFLKFLARMHGLKVR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI20149619, Length=204, Percent_Identity=39.2156862745098, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI7657478, Length=189, Percent_Identity=36.5079365079365, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI157739938, Length=185, Percent_Identity=33.5135135135135, Blast_Score=107, Evalue=9e-24,
Organism=Homo sapiens, GI7706318, Length=190, Percent_Identity=36.8421052631579, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI44680136, Length=183, Percent_Identity=34.9726775956284, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI44680133, Length=183, Percent_Identity=34.9726775956284, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI17738292, Length=183, Percent_Identity=34.9726775956284, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI223718074, Length=189, Percent_Identity=33.8624338624339, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI4503817, Length=182, Percent_Identity=31.3186813186813, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI119392083, Length=191, Percent_Identity=32.4607329842932, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI32483357, Length=182, Percent_Identity=34.0659340659341, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI7705855, Length=218, Percent_Identity=31.1926605504587, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI150247226, Length=278, Percent_Identity=29.136690647482, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI7705925, Length=177, Percent_Identity=29.9435028248588, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI50726952, Length=274, Percent_Identity=30.2919708029197, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI40548397, Length=286, Percent_Identity=26.9230769230769, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI214010158, Length=286, Percent_Identity=26.9230769230769, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI214010156, Length=286, Percent_Identity=26.9230769230769, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI22758144, Length=286, Percent_Identity=26.9230769230769, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI5031737, Length=182, Percent_Identity=33.5164835164835, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI19743808, Length=275, Percent_Identity=27.6363636363636, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI33667109, Length=182, Percent_Identity=33.5164835164835, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI126723191, Length=176, Percent_Identity=32.9545454545455, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4504503, Length=288, Percent_Identity=25.3472222222222, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI109715829, Length=197, Percent_Identity=29.9492385786802, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI210032110, Length=264, Percent_Identity=26.1363636363636, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI59889578, Length=176, Percent_Identity=26.7045454545455, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI22507405, Length=195, Percent_Identity=32.8205128205128, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI40254992, Length=177, Percent_Identity=29.3785310734463, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=183, Percent_Identity=37.7049180327869, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1787820, Length=179, Percent_Identity=33.5195530726257, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1786701, Length=265, Percent_Identity=31.3207547169811, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI87082100, Length=183, Percent_Identity=34.9726775956284, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI2367365, Length=199, Percent_Identity=30.1507537688442, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786812, Length=190, Percent_Identity=32.1052631578947, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI87082160, Length=191, Percent_Identity=27.7486910994764, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787905, Length=194, Percent_Identity=30.4123711340206, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788459, Length=199, Percent_Identity=25.6281407035176, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17570069, Length=189, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71997402, Length=189, Percent_Identity=32.8042328042328, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71994600, Length=187, Percent_Identity=32.620320855615, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17557780, Length=299, Percent_Identity=28.0936454849498, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994604, Length=187, Percent_Identity=31.0160427807487, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562908, Length=194, Percent_Identity=32.4742268041237, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=192, Percent_Identity=31.7708333333333, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=195, Percent_Identity=31.2820512820513, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=190, Percent_Identity=31.5789473684211, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25152911, Length=216, Percent_Identity=30.0925925925926, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17559552, Length=219, Percent_Identity=27.8538812785388, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI212646214, Length=221, Percent_Identity=26.2443438914027, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17538486, Length=193, Percent_Identity=27.979274611399, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=190, Percent_Identity=31.0526315789474, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560176, Length=217, Percent_Identity=27.1889400921659, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=190, Percent_Identity=32.1052631578947, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=195, Percent_Identity=30.7692307692308, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=193, Percent_Identity=29.0155440414508, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=193, Percent_Identity=29.5336787564767, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI32563809, Length=195, Percent_Identity=27.6923076923077, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17507613, Length=195, Percent_Identity=27.6923076923077, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=192, Percent_Identity=27.0833333333333, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=192, Percent_Identity=28.6458333333333, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=239, Percent_Identity=28.0334728033473, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=193, Percent_Identity=29.0155440414508, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=194, Percent_Identity=29.8969072164948, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=192, Percent_Identity=29.1666666666667, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322067, Length=276, Percent_Identity=28.2608695652174, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6323882, Length=198, Percent_Identity=30.8080808080808, Blast_Score=79, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6322861, Length=184, Percent_Identity=26.6304347826087, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21358495, Length=268, Percent_Identity=33.955223880597, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI28571526, Length=188, Percent_Identity=34.5744680851064, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI23397609, Length=184, Percent_Identity=35.8695652173913, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357041, Length=188, Percent_Identity=31.3829787234043, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24643142, Length=183, Percent_Identity=30.6010928961749, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24644339, Length=256, Percent_Identity=26.5625, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI116007236, Length=202, Percent_Identity=30.1980198019802, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI116007238, Length=214, Percent_Identity=28.5046728971963, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI161076933, Length=214, Percent_Identity=31.3084112149533, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24584748, Length=214, Percent_Identity=31.3084112149533, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24641232, Length=221, Percent_Identity=30.7692307692308, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28571387, Length=204, Percent_Identity=30.3921568627451, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640442, Length=221, Percent_Identity=28.9592760180996, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI21355319, Length=182, Percent_Identity=28.021978021978, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28574402, Length=208, Percent_Identity=30.7692307692308, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24584744, Length=208, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21356301, Length=182, Percent_Identity=29.6703296703297, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24580925, Length=190, Percent_Identity=31.0526315789474, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639444, Length=194, Percent_Identity=27.8350515463918, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 28868; Mature: 28737

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHWTVLVTGASSGIGASAARIFAERGHRVFGTSRNPDTITDRVPGVQYLRLDQTDKAS
CCCCEEEEEECCCCCCCHHHHHHHHHCCCEEECCCCCCCCHHHCCCCCEEEEECCCCHHH
IAECVAQAGEVDILVNNAGESQIGALEDVSMDDFEKLYMTNVFGPVALTKAVLPGMRERR
HHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCHHHHC
RGAVVMVGSMAGTLHVPFRSTYSSAKSALHTVADCLRYEVAPFGITVSTVEPGVIATGIE
CCCEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEECCH
TRRNRIVPDGSPYRDAFRTVDAAMAAREEHGTATDELGRLVVDVALSPSPKPLYAKGSNA
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHEEEEEEECCCCCCEEECCCCC
PIIMTAQRLLPARLFLKFLARMHGLKVR
CEEEEHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SEHWTVLVTGASSGIGASAARIFAERGHRVFGTSRNPDTITDRVPGVQYLRLDQTDKAS
CCCEEEEEECCCCCCCHHHHHHHHHCCCEEECCCCCCCCHHHCCCCCEEEEECCCCHHH
IAECVAQAGEVDILVNNAGESQIGALEDVSMDDFEKLYMTNVFGPVALTKAVLPGMRERR
HHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCHHHHC
RGAVVMVGSMAGTLHVPFRSTYSSAKSALHTVADCLRYEVAPFGITVSTVEPGVIATGIE
CCCEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEECCH
TRRNRIVPDGSPYRDAFRTVDAAMAAREEHGTATDELGRLVVDVALSPSPKPLYAKGSNA
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHEEEEEEECCCCCCEEECCCCC
PIIMTAQRLLPARLFLKFLARMHGLKVR
CEEEEHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377; 8396117 [H]