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The map label for this gene is prs [H]

Identifier: 169628240

GI number: 169628240

Start: 1162044

End: 1163030

Strand: Reverse

Name: prs [H]

Synonym: MAB_1147c

Alternate gene names: 169628240

Gene position: 1163030-1162044 (Counterclockwise)

Preceding gene: 169628241

Following gene: 169628238

Centisome position: 22.95

GC content: 65.75

Gene sequence:

>987_bases
GTGAGCACCGACTGGACGGACAACCGCAAGAATCTGATGCTGTTCTCGGGTCGTGCACACCCCGAGTTGGCCGAACAGGT
CGCCAAGGAACTCGACGTGCAGGTGACCGCGCAAACCGCTCGCGATTTCGCCAACGGCGAGATCTTCGTGCGGTTCGAGG
AATCGGTGCGCGGCTGCGACGCGTTCGTCCTGCAATCGCACCCGGCGCCGCTGAACACCTGGCTGATGGAACAGCTCATC
ATGATCGACGCCCTCAAGCGGGGCAGCGCCAAGCGCATCACCGCGATCCTGCCGTTCTACCCCTATGCCCGCCAGGACAA
GAAGCACCGCGGTCGCGAGCCCATCTCGGCCCGCCTGGTGGCCGACCTGTACAAGACCGCCGGCGCCGACCGCATCGTCA
CCGTCGACCTGCACACCGACCAGATCCAGGGCTTCTTCGACGGACCGGTGGACCACATGCGCGCCCAGTCACTGCTGTGC
GGCTACATCGCCGAGCACTACGTGAGCAATGGTGAAGATGTCGTGGTGGTATCCCCCGACTCCGGCCGCGTGCGCGTTGC
CGAGAAGTGGGCCGACTCCCTTGGTGGGGTGCCGCTGGCCTTCATCCACAAGACCCGTGATCCGCGAGTGCCCAATCAGG
TCAAGGCCAATCGCGTCGTTGGCGACGTGACCGGCAAGACCTGTGTCATCACCGACGACATGATCGATACCGGCGGCACC
ATCGCCGGTGCGGTCGGCCTGCTGCACGAGGCGGGCGCCAAGGACGTGGTGATCGCCGCCACTCACGGCGTGCTCTCCGA
CCCCGCCGCCGAGCGTCTGGCCAACTGCGGCGCCCGTGAAGTGCTGGTCACCAACACCCTGCCGATCGGCGAGGAGAAGC
GGTTCCCGCAGCTGACCGTGCTGTCGATCGCACCGCTGCTGGCCAGCACCATCCGCGAGGTCTTCGAGAACGGTTCGGTG
ACAGGGCTTTTCGACGGAAACGCCTAG

Upstream 100 bases:

>100_bases
TCTTCCGGGAAAGGTCCGTACCATTACCCCGACGGGCGGTACCCGATCCGCCCGATTCAAAGCCCACGATACGACCCAAA
CCAAGAGGACTAGCTGCGCC

Downstream 100 bases:

>100_bases
CCCTGCCCCGAACCGATCGAGCTTAGACCTCGTCGTTGTCCGACGTCAGGACGGTTCCACTCTCATCTCCGCCGCACGCC
GTACCCGCGTTCTCGCATTC

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MSTDWTDNRKNLMLFSGRAHPELAEQVAKELDVQVTAQTARDFANGEIFVRFEESVRGCDAFVLQSHPAPLNTWLMEQLI
MIDALKRGSAKRITAILPFYPYARQDKKHRGREPISARLVADLYKTAGADRIVTVDLHTDQIQGFFDGPVDHMRAQSLLC
GYIAEHYVSNGEDVVVVSPDSGRVRVAEKWADSLGGVPLAFIHKTRDPRVPNQVKANRVVGDVTGKTCVITDDMIDTGGT
IAGAVGLLHEAGAKDVVIAATHGVLSDPAAERLANCGAREVLVTNTLPIGEEKRFPQLTVLSIAPLLASTIREVFENGSV
TGLFDGNA

Sequences:

>Translated_328_residues
MSTDWTDNRKNLMLFSGRAHPELAEQVAKELDVQVTAQTARDFANGEIFVRFEESVRGCDAFVLQSHPAPLNTWLMEQLI
MIDALKRGSAKRITAILPFYPYARQDKKHRGREPISARLVADLYKTAGADRIVTVDLHTDQIQGFFDGPVDHMRAQSLLC
GYIAEHYVSNGEDVVVVSPDSGRVRVAEKWADSLGGVPLAFIHKTRDPRVPNQVKANRVVGDVTGKTCVITDDMIDTGGT
IAGAVGLLHEAGAKDVVIAATHGVLSDPAAERLANCGAREVLVTNTLPIGEEKRFPQLTVLSIAPLLASTIREVFENGSV
TGLFDGNA
>Mature_327_residues
STDWTDNRKNLMLFSGRAHPELAEQVAKELDVQVTAQTARDFANGEIFVRFEESVRGCDAFVLQSHPAPLNTWLMEQLIM
IDALKRGSAKRITAILPFYPYARQDKKHRGREPISARLVADLYKTAGADRIVTVDLHTDQIQGFFDGPVDHMRAQSLLCG
YIAEHYVSNGEDVVVVSPDSGRVRVAEKWADSLGGVPLAFIHKTRDPRVPNQVKANRVVGDVTGKTCVITDDMIDTGGTI
AGAVGLLHEAGAKDVVIAATHGVLSDPAAERLANCGAREVLVTNTLPIGEEKRFPQLTVLSIAPLLASTIREVFENGSVT
GLFDGNA

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=315, Percent_Identity=42.5396825396825, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI4506127, Length=315, Percent_Identity=42.5396825396825, Blast_Score=241, Evalue=5e-64,
Organism=Homo sapiens, GI28557709, Length=315, Percent_Identity=41.9047619047619, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI84875539, Length=318, Percent_Identity=42.1383647798742, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI194018537, Length=338, Percent_Identity=33.7278106508876, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI4506133, Length=357, Percent_Identity=31.6526610644258, Blast_Score=161, Evalue=7e-40,
Organism=Homo sapiens, GI310128524, Length=144, Percent_Identity=31.25, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI310115209, Length=144, Percent_Identity=31.25, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI310118259, Length=144, Percent_Identity=31.25, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI310119946, Length=144, Percent_Identity=31.25, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1787458, Length=317, Percent_Identity=42.5867507886435, Blast_Score=245, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI25149168, Length=315, Percent_Identity=42.8571428571429, Blast_Score=247, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI17554702, Length=315, Percent_Identity=42.8571428571429, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI71989924, Length=315, Percent_Identity=42.8571428571429, Blast_Score=244, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17554704, Length=312, Percent_Identity=42.9487179487179, Blast_Score=244, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17570245, Length=347, Percent_Identity=32.5648414985591, Blast_Score=179, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321776, Length=316, Percent_Identity=43.6708860759494, Blast_Score=240, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6319403, Length=316, Percent_Identity=39.873417721519, Blast_Score=233, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6320946, Length=317, Percent_Identity=38.4858044164038, Blast_Score=223, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6322667, Length=197, Percent_Identity=41.1167512690355, Blast_Score=149, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6324511, Length=95, Percent_Identity=37.8947368421053, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355239, Length=315, Percent_Identity=42.2222222222222, Blast_Score=245, Evalue=3e-65,
Organism=Drosophila melanogaster, GI45551540, Length=338, Percent_Identity=39.6449704142012, Blast_Score=234, Evalue=8e-62,
Organism=Drosophila melanogaster, GI24651458, Length=356, Percent_Identity=30.6179775280899, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24651456, Length=356, Percent_Identity=30.6179775280899, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI281362873, Length=356, Percent_Identity=30.6179775280899, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24651454, Length=356, Percent_Identity=30.6179775280899, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24651462, Length=193, Percent_Identity=35.7512953367876, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24651464, Length=193, Percent_Identity=35.7512953367876, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI45552010, Length=193, Percent_Identity=35.7512953367876, Blast_Score=125, Evalue=3e-29,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 35667; Mature: 35536

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00144 ASN_GLN_ASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTDWTDNRKNLMLFSGRAHPELAEQVAKELDVQVTAQTARDFANGEIFVRFEESVRGCD
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCEEEEEHHHHHCCCCEEEEEEHHHCCCCE
AFVLQSHPAPLNTWLMEQLIMIDALKRGSAKRITAILPFYPYARQDKKHRGREPISARLV
EEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHCCCCCHHHHHH
ADLYKTAGADRIVTVDLHTDQIQGFFDGPVDHMRAQSLLCGYIAEHYVSNGEDVVVVSPD
HHHHHHCCCCEEEEEEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
SGRVRVAEKWADSLGGVPLAFIHKTRDPRVPNQVKANRVVGDVTGKTCVITDDMIDTGGT
CCCEEEHHHHHHHHCCCEEEEEECCCCCCCCCHHHHCCEEEECCCCEEEEECCCCCCCCH
IAGAVGLLHEAGAKDVVIAATHGVLSDPAAERLANCGAREVLVTNTLPIGEEKRFPQLTV
HHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHH
LSIAPLLASTIREVFENGSVTGLFDGNA
HHHHHHHHHHHHHHHHCCCEEEEECCCC
>Mature Secondary Structure 
STDWTDNRKNLMLFSGRAHPELAEQVAKELDVQVTAQTARDFANGEIFVRFEESVRGCD
CCCCCCCCCCEEEEECCCCHHHHHHHHHHCCEEEEEHHHHHCCCCEEEEEEHHHCCCCE
AFVLQSHPAPLNTWLMEQLIMIDALKRGSAKRITAILPFYPYARQDKKHRGREPISARLV
EEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHCCCCCHHHHHH
ADLYKTAGADRIVTVDLHTDQIQGFFDGPVDHMRAQSLLCGYIAEHYVSNGEDVVVVSPD
HHHHHHCCCCEEEEEEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
SGRVRVAEKWADSLGGVPLAFIHKTRDPRVPNQVKANRVVGDVTGKTCVITDDMIDTGGT
CCCEEEHHHHHHHHCCCEEEEEECCCCCCCCCHHHHCCEEEECCCCEEEEECCCCCCCCH
IAGAVGLLHEAGAKDVVIAATHGVLSDPAAERLANCGAREVLVTNTLPIGEEKRFPQLTV
HHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHH
LSIAPLLASTIREVFENGSVTGLFDGNA
HHHHHHHHHHHHHHHHCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]