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The map label for this gene is yngJ [H]

Identifier: 169627717

GI number: 169627717

Start: 613140

End: 614201

Strand: Direct

Name: yngJ [H]

Synonym: MAB_0614

Alternate gene names: 169627717

Gene position: 613140-614201 (Clockwise)

Preceding gene: 169627716

Following gene: 169627718

Centisome position: 12.1

GC content: 64.5

Gene sequence:

>1062_bases
ATGGATTTCGCTTTCGCGGAGGAGCAGCAGGCCGTCTCCGATGTGGTCGAAGCAGTGCTTGCCGATCGCGAGTTCGTCGG
TGTGGTACCCGAGATCGGATACGACGAAGCCGCCTGGCGGGCCCTAGCCGCCAATGGCGTCCTGAGTCTGGCTCTGCCTG
AACGGCTGGGCGGTGATGGTCTGGGCCTGGCTGAGGTGTCGGTAGCGCTCCGGGTGCTTGGCAAGCACGGCGCCCTCACT
CCGGCGCTGGCCACGCTCGGATTTGGCGTGGTTCCGCTGGTGGAGCTGGCCTCCGGCGAGCAGCAGGATCGCTACCTTGC
CGGTGTCGGCGACGGTGCGATTCTCACGGCGGCCCTCGATGAGCCGGGCCGCGCGGTGCCGTCGGCACCTGCGGTTTCCG
CGGTGCGGGACGGGTCCTCGCTGGTGTTGAACGGACGCAAGATTGGCGTTCTTCATGCCGCCGAGGCACATTGGATACTT
GTCACCACCGACAATGGCGTCGTTGTGGTGGCACCCAACACCCCGGGCGTGACGATCACCCGGACACCGACGGCAAGCAA
GGCCGCAGAGTACGCGGTGACCTTCTCTGATGTGTCGGTGCCCGCCGCGGATCAGTTGAGCGGGTCGGTGCAGAGGCTGA
ACGAGCTTGCGCTCGCGGCCATCGGCTCCTACGCCGACGGGTTGGTGTCCGGTGCATTGCGTCTGACGGCCGACCACGTG
TCGAATCGGGTGCAGTTCGGTAAGCCACTGGCCACCTTCCAAGCCGTGTCACAGCAGCTGGCGGATGTCTATGTGGTCTC
GAGGACCTTGAATCTCGGTGTCACATCTGCTGTTTGGCGCCTATGTGAGGGGTTGGACGCCACCGAGGATCTGGACATTG
TGTCCTTCTGGATGGCGGCCGAGGCGCAGCGGGTGATGCAGATCTGCCACCACTTGCATGGTGGTCTCGGTGTGGACATC
ACATACCCGATGAATCGTTACTACTCGACGATCAAGGATCTGAGCCGTCTGGTCGGCGGGTCCTCCGAGCGCCTAGACGT
CCTTGCCGCGGCGCAGGGTTAG

Upstream 100 bases:

>100_bases
CAGTCCGGTTGGCTCAACGGCATCAAGCACTGGCAGGTCGATTTCACCGGCGCCAGTGGCTGCCCGGTTCTGCAGTAGTT
TTCAAAGGGAAACGAGCATA

Downstream 100 bases:

>100_bases
GAGCCAGCGATGCTAATTGACCTCACGCCGGAACAGGCGAAGCTACAAAATGATCTGCGGCACTACTTCTCGAATCTGGT
GACCGCCGAAGAGACCCGCG

Product: acyl-CoA dehydrogenase FadE

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MDFAFAEEQQAVSDVVEAVLADREFVGVVPEIGYDEAAWRALAANGVLSLALPERLGGDGLGLAEVSVALRVLGKHGALT
PALATLGFGVVPLVELASGEQQDRYLAGVGDGAILTAALDEPGRAVPSAPAVSAVRDGSSLVLNGRKIGVLHAAEAHWIL
VTTDNGVVVVAPNTPGVTITRTPTASKAAEYAVTFSDVSVPAADQLSGSVQRLNELALAAIGSYADGLVSGALRLTADHV
SNRVQFGKPLATFQAVSQQLADVYVVSRTLNLGVTSAVWRLCEGLDATEDLDIVSFWMAAEAQRVMQICHHLHGGLGVDI
TYPMNRYYSTIKDLSRLVGGSSERLDVLAAAQG

Sequences:

>Translated_353_residues
MDFAFAEEQQAVSDVVEAVLADREFVGVVPEIGYDEAAWRALAANGVLSLALPERLGGDGLGLAEVSVALRVLGKHGALT
PALATLGFGVVPLVELASGEQQDRYLAGVGDGAILTAALDEPGRAVPSAPAVSAVRDGSSLVLNGRKIGVLHAAEAHWIL
VTTDNGVVVVAPNTPGVTITRTPTASKAAEYAVTFSDVSVPAADQLSGSVQRLNELALAAIGSYADGLVSGALRLTADHV
SNRVQFGKPLATFQAVSQQLADVYVVSRTLNLGVTSAVWRLCEGLDATEDLDIVSFWMAAEAQRVMQICHHLHGGLGVDI
TYPMNRYYSTIKDLSRLVGGSSERLDVLAAAQG
>Mature_353_residues
MDFAFAEEQQAVSDVVEAVLADREFVGVVPEIGYDEAAWRALAANGVLSLALPERLGGDGLGLAEVSVALRVLGKHGALT
PALATLGFGVVPLVELASGEQQDRYLAGVGDGAILTAALDEPGRAVPSAPAVSAVRDGSSLVLNGRKIGVLHAAEAHWIL
VTTDNGVVVVAPNTPGVTITRTPTASKAAEYAVTFSDVSVPAADQLSGSVQRLNELALAAIGSYADGLVSGALRLTADHV
SNRVQFGKPLATFQAVSQQLADVYVVSRTLNLGVTSAVWRLCEGLDATEDLDIVSFWMAAEAQRVMQICHHLHGGLGVDI
TYPMNRYYSTIKDLSRLVGGSSERLDVLAAAQG

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=357, Percent_Identity=24.3697478991597, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI4557231, Length=380, Percent_Identity=23.6842105263158, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI187960098, Length=380, Percent_Identity=23.6842105263158, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4501859, Length=336, Percent_Identity=23.5119047619048, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI7656849, Length=327, Percent_Identity=25.0764525993884, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786223, Length=369, Percent_Identity=24.390243902439, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17508101, Length=330, Percent_Identity=23.6363636363636, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356377, Length=344, Percent_Identity=24.4186046511628, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24666513, Length=342, Percent_Identity=23.3918128654971, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24646207, Length=326, Percent_Identity=24.5398773006135, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24660351, Length=376, Percent_Identity=23.4042553191489, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 36763; Mature: 36763

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFAFAEEQQAVSDVVEAVLADREFVGVVPEIGYDEAAWRALAANGVLSLALPERLGGDG
CCCCCCHHHHHHHHHHHHHHCCCHHEECCCCCCCCHHHHHHHHHCCEEEEECHHHCCCCC
LGLAEVSVALRVLGKHGALTPALATLGFGVVPLVELASGEQQDRYLAGVGDGAILTAALD
CCHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCCEEEEEECC
EPGRAVPSAPAVSAVRDGSSLVLNGRKIGVLHAAEAHWILVTTDNGVVVVAPNTPGVTIT
CCCCCCCCCCCHHHHCCCCEEEECCCEEEEEEECCCEEEEEECCCCEEEEECCCCCEEEE
RTPTASKAAEYAVTFSDVSVPAADQLSGSVQRLNELALAAIGSYADGLVSGALRLTADHV
ECCCCHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHH
SNRVQFGKPLATFQAVSQQLADVYVVSRTLNLGVTSAVWRLCEGLDATEDLDIVSFWMAA
HCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHH
EAQRVMQICHHLHGGLGVDITYPMNRYYSTIKDLSRLVGGSSERLDVLAAAQG
HHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCEEEEEECCC
>Mature Secondary Structure
MDFAFAEEQQAVSDVVEAVLADREFVGVVPEIGYDEAAWRALAANGVLSLALPERLGGDG
CCCCCCHHHHHHHHHHHHHHCCCHHEECCCCCCCCHHHHHHHHHCCEEEEECHHHCCCCC
LGLAEVSVALRVLGKHGALTPALATLGFGVVPLVELASGEQQDRYLAGVGDGAILTAALD
CCHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCCEEEEEECC
EPGRAVPSAPAVSAVRDGSSLVLNGRKIGVLHAAEAHWILVTTDNGVVVVAPNTPGVTIT
CCCCCCCCCCCHHHHCCCCEEEECCCEEEEEEECCCEEEEEECCCCEEEEECCCCCEEEE
RTPTASKAAEYAVTFSDVSVPAADQLSGSVQRLNELALAAIGSYADGLVSGALRLTADHV
ECCCCHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHH
SNRVQFGKPLATFQAVSQQLADVYVVSRTLNLGVTSAVWRLCEGLDATEDLDIVSFWMAA
HCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHH
EAQRVMQICHHLHGGLGVDITYPMNRYYSTIKDLSRLVGGSSERLDVLAAAQG
HHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]