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The map label for this gene is kstR2 [H]

Identifier: 169627702

GI number: 169627702

Start: 600259

End: 600915

Strand: Direct

Name: kstR2 [H]

Synonym: MAB_0599

Alternate gene names: 169627702

Gene position: 600259-600915 (Clockwise)

Preceding gene: 169627701

Following gene: 169627703

Centisome position: 11.85

GC content: 62.86

Gene sequence:

>657_bases
GTGGACAAGGTGTCAGAGGTGCGAGAGTCGGACGCACTGCGCGCGGGCGGCTCACCGCAGCCGTCTCGGCGCGATGAGCT
GTTGAGCCTTGCCGCCGAGATGTTCGCCGAGCGCGGTCTGCGGGCGACCACCGTGCGGGATATCGCCGACGCCGCCGGCA
TTCTGTCGGGCAGCCTCTATCACCATTTCGACTCCAAGGAAGCGATCGTCGACGAGCTGCTGCGTGACTTTCTCGAGGGT
TTGTTCGCGCGTTATCGCGAAATTGCCGCCGCGAATCTGAATCCTGTCGACACCCTCAAGGGCCTGTTCCTGGCGTCCTT
CGACGCTATCGAGACCAAGCACGCGCAGGTCGCCATCTATCAGGCGGAGGCGCCCCGACTGCTCTCGCAAGAACGGTTCG
CCTACCTCAACGAGCTCAACACCGAGCAGCGCCAGCTATGGCTGGAAGTGCTGCGTGACGGCATTGCGCAGGGTTACTTC
CGCCCCGACCTGGATGTGGCGGTGGTGTACCGATTCATCCGCGACGCCACCTGGGTGTCGGTGCGGTGGTTCCGTCCCGG
TGGCTCACGTACGGCGCAGGAAGTCGCCGAACAGTATCTTTCGATCGTTCTCGGCGGGATCACCGTCGGGTCATTCTCGA
ATAGCCCTGAAAAATAA

Upstream 100 bases:

>100_bases
CGAGCTACCTGACCGGCGAGGTCATCTCGGTATCCAGCCAGCGGGCGTGACATCGCGCACGCGTTCGACCAAACAAGCGC
TTGGTTGATACAGTGAGGAG

Downstream 100 bases:

>100_bases
GGAGATTCACCATGTCTGAGGCGTACATCATTGACGCTGTGCGTACCGCTGTCGGTAAGCGCAACGGCGCGCTGTCCAAG
GTGCACCCGCTGGATCTGGG

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MDKVSEVRESDALRAGGSPQPSRRDELLSLAAEMFAERGLRATTVRDIADAAGILSGSLYHHFDSKEAIVDELLRDFLEG
LFARYREIAAANLNPVDTLKGLFLASFDAIETKHAQVAIYQAEAPRLLSQERFAYLNELNTEQRQLWLEVLRDGIAQGYF
RPDLDVAVVYRFIRDATWVSVRWFRPGGSRTAQEVAEQYLSIVLGGITVGSFSNSPEK

Sequences:

>Translated_218_residues
MDKVSEVRESDALRAGGSPQPSRRDELLSLAAEMFAERGLRATTVRDIADAAGILSGSLYHHFDSKEAIVDELLRDFLEG
LFARYREIAAANLNPVDTLKGLFLASFDAIETKHAQVAIYQAEAPRLLSQERFAYLNELNTEQRQLWLEVLRDGIAQGYF
RPDLDVAVVYRFIRDATWVSVRWFRPGGSRTAQEVAEQYLSIVLGGITVGSFSNSPEK
>Mature_218_residues
MDKVSEVRESDALRAGGSPQPSRRDELLSLAAEMFAERGLRATTVRDIADAAGILSGSLYHHFDSKEAIVDELLRDFLEG
LFARYREIAAANLNPVDTLKGLFLASFDAIETKHAQVAIYQAEAPRLLSQERFAYLNELNTEQRQLWLEVLRDGIAQGYF
RPDLDVAVVYRFIRDATWVSVRWFRPGGSRTAQEVAEQYLSIVLGGITVGSFSNSPEK

Specific function: Controls the expression of a small regulon that may play a role in the utilization of cholesterol [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787904, Length=159, Percent_Identity=27.6729559748428, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24412; Mature: 24412

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKVSEVRESDALRAGGSPQPSRRDELLSLAAEMFAERGLRATTVRDIADAAGILSGSLY
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHH
HHFDSKEAIVDELLRDFLEGLFARYREIAAANLNPVDTLKGLFLASFDAIETKHAQVAIY
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEE
QAEAPRLLSQERFAYLNELNTEQRQLWLEVLRDGIAQGYFRPDLDVAVVYRFIRDATWVS
ECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEE
VRWFRPGGSRTAQEVAEQYLSIVLGGITVGSFSNSPEK
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MDKVSEVRESDALRAGGSPQPSRRDELLSLAAEMFAERGLRATTVRDIADAAGILSGSLY
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHH
HHFDSKEAIVDELLRDFLEGLFARYREIAAANLNPVDTLKGLFLASFDAIETKHAQVAIY
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEE
QAEAPRLLSQERFAYLNELNTEQRQLWLEVLRDGIAQGYFRPDLDVAVVYRFIRDATWVS
ECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEE
VRWFRPGGSRTAQEVAEQYLSIVLGGITVGSFSNSPEK
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]