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The map label for this gene is fadA [H]

Identifier: 169627703

GI number: 169627703

Start: 600927

End: 602075

Strand: Direct

Name: fadA [H]

Synonym: MAB_0600

Alternate gene names: 169627703

Gene position: 600927-602075 (Clockwise)

Preceding gene: 169627702

Following gene: 169627704

Centisome position: 11.86

GC content: 65.19

Gene sequence:

>1149_bases
ATGTCTGAGGCGTACATCATTGACGCTGTGCGTACCGCTGTCGGTAAGCGCAACGGCGCGCTGTCCAAGGTGCACCCGCT
GGATCTGGGTGCGGCCACCTTCAAGGGGTTGTTCGACCGCGTGGACGTGGATCCCGACGCCATCGACGACGTGTACATGG
GTGTGCTTGATGCCATCGGCGGGCAGGCCGGAAATGCCGGACGTCTGGCCTGGCTCGCGGGCGGATACCCGGAAGAGGTG
CCGGGTGCCACCGTCGATCGGCAGTGTGGCTCGAGTCAGCAGGCCATTTCCTTTGCCGCCCAAGCTGTTATGTCCGGCAC
CGCGGACCTGATCGTGGCGGGTGGTTTTCAGAACATGAGCCAGATTCCGATCTCGGCCGCCATGCTCGTTGGCAAGGAAT
ATGGATTCACCTCGCCCACGGCCGAGTCCGAGGGCTGGCTGCACCGCTACGGCGATCAGGAGATCTCCCAGTTCCGCGGT
GCGGAAATGATCGCCGAGAAGTGGGACATCAGCCGTGAGGAGATGGAGCGTTTCGCGCTCTCCAGTCATGAGAAGGCCTT
CGCCGCAATCCGTAACGGGCACTTCGACAACGAGATCATCCCGGTCGGCGACTTCCGCGTCGACGAGGGGCCGCGCGAAT
CCACCCTGGAGAAGCTGGCCAGCCTGAATCCCCTGGTCGAGGGCGGCCGTCTCACCGCGGCGTTGGCTTCGCAGATTTCC
GATGGCGGCAGCGCCACGCTGGTCGCCTCGGAGCGGGCCGTCAAGGCGCACGGGCTTACGCCGAGGGCGCGGGTCCACCA
CATCAGTGCCCGGGGCGACGACCCGGTGTTCATGCTGACCGGACCGATCCCTGCCACCCGGTACGCGCTGGAGAAGACCG
GTCTGACCATGGATGACATCGACGTCGTGGAGATCAACGAGGCATTTGCGCCCGTCGTGCTGGCCTGGGCCAAGGAGCTC
GACGTCGACCTGAAGAAGGTCAACCCGAACGGCGGGGCGATGGCTTTGGGGCACCCGCTGGGTGCCACCGGGGCCAAGCT
GTTCGCCACCATGCTCAACGAGTTGGAGCGCACCGGCGGCCGCTATGGCCTGCAGACGATGTGCGAAGGCGGTGGCACGG
CCAACGTCACCATCATCGAACGCCTGTGA

Upstream 100 bases:

>100_bases
GTACGGCGCAGGAAGTCGCCGAACAGTATCTTTCGATCGTTCTCGGCGGGATCACCGTCGGGTCATTCTCGAATAGCCCT
GAAAAATAAGGAGATTCACC

Downstream 100 bases:

>100_bases
TCGAGGCGGGCGTAGCCTGAGAGGCATGCGCGCAGGAATTCTGATCGGCACGGCCGTGGCGGCGTTAGGTGTCGTCGCAG
GCGTCGCCCCGGCGCACGCC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MSEAYIIDAVRTAVGKRNGALSKVHPLDLGAATFKGLFDRVDVDPDAIDDVYMGVLDAIGGQAGNAGRLAWLAGGYPEEV
PGATVDRQCGSSQQAISFAAQAVMSGTADLIVAGGFQNMSQIPISAAMLVGKEYGFTSPTAESEGWLHRYGDQEISQFRG
AEMIAEKWDISREEMERFALSSHEKAFAAIRNGHFDNEIIPVGDFRVDEGPRESTLEKLASLNPLVEGGRLTAALASQIS
DGGSATLVASERAVKAHGLTPRARVHHISARGDDPVFMLTGPIPATRYALEKTGLTMDDIDVVEINEAFAPVVLAWAKEL
DVDLKKVNPNGGAMALGHPLGATGAKLFATMLNELERTGGRYGLQTMCEGGGTANVTIIERL

Sequences:

>Translated_382_residues
MSEAYIIDAVRTAVGKRNGALSKVHPLDLGAATFKGLFDRVDVDPDAIDDVYMGVLDAIGGQAGNAGRLAWLAGGYPEEV
PGATVDRQCGSSQQAISFAAQAVMSGTADLIVAGGFQNMSQIPISAAMLVGKEYGFTSPTAESEGWLHRYGDQEISQFRG
AEMIAEKWDISREEMERFALSSHEKAFAAIRNGHFDNEIIPVGDFRVDEGPRESTLEKLASLNPLVEGGRLTAALASQIS
DGGSATLVASERAVKAHGLTPRARVHHISARGDDPVFMLTGPIPATRYALEKTGLTMDDIDVVEINEAFAPVVLAWAKEL
DVDLKKVNPNGGAMALGHPLGATGAKLFATMLNELERTGGRYGLQTMCEGGGTANVTIIERL
>Mature_381_residues
SEAYIIDAVRTAVGKRNGALSKVHPLDLGAATFKGLFDRVDVDPDAIDDVYMGVLDAIGGQAGNAGRLAWLAGGYPEEVP
GATVDRQCGSSQQAISFAAQAVMSGTADLIVAGGFQNMSQIPISAAMLVGKEYGFTSPTAESEGWLHRYGDQEISQFRGA
EMIAEKWDISREEMERFALSSHEKAFAAIRNGHFDNEIIPVGDFRVDEGPRESTLEKLASLNPLVEGGRLTAALASQISD
GGSATLVASERAVKAHGLTPRARVHHISARGDDPVFMLTGPIPATRYALEKTGLTMDDIDVVEINEAFAPVVLAWAKELD
VDLKKVNPNGGAMALGHPLGATGAKLFATMLNELERTGGRYGLQTMCEGGGTANVTIIERL

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=392, Percent_Identity=38.0102040816327, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI167614485, Length=389, Percent_Identity=37.2750642673522, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI4557237, Length=397, Percent_Identity=34.0050377833753, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=35.8585858585859, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=31.7647058823529, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI194353979, Length=382, Percent_Identity=29.0575916230367, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1787663, Length=407, Percent_Identity=41.031941031941, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=39.75, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1788554, Length=400, Percent_Identity=41, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI87082165, Length=396, Percent_Identity=38.1313131313131, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1788683, Length=406, Percent_Identity=27.8325123152709, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI133906874, Length=392, Percent_Identity=37.7551020408163, Blast_Score=237, Evalue=8e-63,
Organism=Caenorhabditis elegans, GI25147385, Length=390, Percent_Identity=31.5384615384615, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17535921, Length=404, Percent_Identity=31.9306930693069, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=29.4117647058824, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17535917, Length=386, Percent_Identity=29.7927461139896, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=35.5163727959698, Blast_Score=209, Evalue=8e-55,
Organism=Saccharomyces cerevisiae, GI6322031, Length=394, Percent_Identity=34.010152284264, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24655093, Length=396, Percent_Identity=36.8686868686869, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=36.6666666666667, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24640423, Length=396, Percent_Identity=32.3232323232323, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI17137578, Length=424, Percent_Identity=31.6037735849057, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 40542; Mature: 40411

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAYIIDAVRTAVGKRNGALSKVHPLDLGAATFKGLFDRVDVDPDAIDDVYMGVLDAIG
CCCCEEHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
GQAGNAGRLAWLAGGYPEEVPGATVDRQCGSSQQAISFAAQAVMSGTADLIVAGGFQNMS
CCCCCCCCEEEEECCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCH
QIPISAAMLVGKEYGFTSPTAESEGWLHRYGDQEISQFRGAEMIAEKWDISREEMERFAL
HCCHHHHHHHHHHCCCCCCCCCCCCHHHHCCCHHHHHHCCHHHHHHHHCCCHHHHHHHHH
SSHEKAFAAIRNGHFDNEIIPVGDFRVDEGPRESTLEKLASLNPLVEGGRLTAALASQIS
HCHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCHHCCCHHHHHHHHHHC
DGGSATLVASERAVKAHGLTPRARVHHISARGDDPVFMLTGPIPATRYALEKTGLTMDDI
CCCCEEEEECCCHHHHCCCCCHHHEEEEECCCCCCEEEEECCCCHHHHHHHHCCCCCCCC
DVVEINEAFAPVVLAWAKELDVDLKKVNPNGGAMALGHPLGATGAKLFATMLNELERTGG
EEEEECHHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCC
RYGLQTMCEGGGTANVTIIERL
CCCHHHHHCCCCEEEEEEEECC
>Mature Secondary Structure 
SEAYIIDAVRTAVGKRNGALSKVHPLDLGAATFKGLFDRVDVDPDAIDDVYMGVLDAIG
CCCEEHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
GQAGNAGRLAWLAGGYPEEVPGATVDRQCGSSQQAISFAAQAVMSGTADLIVAGGFQNMS
CCCCCCCCEEEEECCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCH
QIPISAAMLVGKEYGFTSPTAESEGWLHRYGDQEISQFRGAEMIAEKWDISREEMERFAL
HCCHHHHHHHHHHCCCCCCCCCCCCHHHHCCCHHHHHHCCHHHHHHHHCCCHHHHHHHHH
SSHEKAFAAIRNGHFDNEIIPVGDFRVDEGPRESTLEKLASLNPLVEGGRLTAALASQIS
HCHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCHHCCCHHHHHHHHHHC
DGGSATLVASERAVKAHGLTPRARVHHISARGDDPVFMLTGPIPATRYALEKTGLTMDDI
CCCCEEEEECCCHHHHCCCCCHHHEEEEECCCCCCEEEEECCCCHHHHHHHHCCCCCCCC
DVVEINEAFAPVVLAWAKELDVDLKKVNPNGGAMALGHPLGATGAKLFATMLNELERTGG
EEEEECHHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCC
RYGLQTMCEGGGTANVTIIERL
CCCHHHHHCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA