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The map label for this gene is disA [H]

Identifier: 169627665

GI number: 169627665

Start: 563182

End: 564267

Strand: Reverse

Name: disA [H]

Synonym: MAB_0562c

Alternate gene names: 169627665

Gene position: 564267-563182 (Counterclockwise)

Preceding gene: 169627667

Following gene: 169627661

Centisome position: 11.14

GC content: 64.18

Gene sequence:

>1086_bases
ATGGACAACGCGGAAGCCAACGCACGAATGCGGGAAACCCTGGCCCGATTGGCGCCGGGCACACCCCTGCGCGACGGCCT
GGAACGCATTCTTCGTGGTCGCACCGGGGCGCTGATCGTGCTCGGCTACGACGACAAGGTGGAGAGCATCTGCGACGGCG
GCTTCTCGCTGGACGTCGCGTTCGCTCCCACCCGGCTTCGCGAACTGTCGAAGATGGACGGCGCCGTGGTGTTGTCCACG
GATGGCTCGCGCATCGTGCGCGCCAATGTGCAGCTGGTGCCCGATCCGTCCATTCCGACGGACGAATCCGGCACCCGGCA
CCGCTCCGCGGAACGCACCGCCATACAGACGGACTATCCCGTTGTGTCTGTGAGCCATTCGATGAACATCGTGAGCGTGT
ACACCGCCGGAATCCGCCACGTCGTCATGGATTCGGCCACGGTTATGTCACGGGTAAACCAGGCGGTCTCGACCCTCGAG
CGCTACAAAACCCGGCTGGACGAGGTGACCTCGTCGCTGTCCACCGCCGAGATCGAAGACTTCGTGACGCTGCGCGACGT
CATGACGGTGGCGCAACGTCTGGAGCTGGTGCGCCGGATCAGCCAGGACATCGAGCTCGATGTCATCGAGCTCGGCACAG
ACGGTCGCCAGCTCAAGCTACAGATCGGCGAGCTGGTCGGCGATAACGACACCGAACGTGAGTTACTGGTCAGGGACTAT
CACGCCAATCCCGAACCACCTACACAAGCGCAGATCGCCTCGACACTGGAGGATCTGGACGCGCTCTCCGACACCGACCT
GCTGGACCTCACGGTGCTCTCGCGTACGTTCGGATACCCGTCCACCGTCGAAGCCCAGGACACCGCCATGAGCTCCCGTG
GCTACCGGGCCATGACACACATCCCGCGGCTTCAGTTTGCGCACATCGACAGGCTGGTGCGGGCATTCGGGTCCTTGCAA
GGACTATTGGCCGCCAGCGCGACCGATCTGCAGTCGGTGGAAGGCATCGGGGCGATGTGGGCCCGACACATCCGTGAGGG
CCTGTCCCGGCTTGCCGAGTCGACGCTTACCGAGCAGACCGGCTAG

Upstream 100 bases:

>100_bases
CAACATCCGGTGCTGCCGGTCTTCGCCCGAGCGGCTCATCCACGTCGACATGACCACGTAATCTAACTGCGGCGAACCGA
GCCTGGAGAGGAGGGGCATG

Downstream 100 bases:

>100_bases
GCCGGTGGCCCTGCCGGCGGCGGCGCGTCGGCCGGCTTCTCGCCGATGATGAAAGGCACTGGTGCACTGCGTAGGTCACC
AAGCTGCACCACCAACGAAT

Product: DNA integrity scanning protein DisA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MDNAEANARMRETLARLAPGTPLRDGLERILRGRTGALIVLGYDDKVESICDGGFSLDVAFAPTRLRELSKMDGAVVLST
DGSRIVRANVQLVPDPSIPTDESGTRHRSAERTAIQTDYPVVSVSHSMNIVSVYTAGIRHVVMDSATVMSRVNQAVSTLE
RYKTRLDEVTSSLSTAEIEDFVTLRDVMTVAQRLELVRRISQDIELDVIELGTDGRQLKLQIGELVGDNDTERELLVRDY
HANPEPPTQAQIASTLEDLDALSDTDLLDLTVLSRTFGYPSTVEAQDTAMSSRGYRAMTHIPRLQFAHIDRLVRAFGSLQ
GLLAASATDLQSVEGIGAMWARHIREGLSRLAESTLTEQTG

Sequences:

>Translated_361_residues
MDNAEANARMRETLARLAPGTPLRDGLERILRGRTGALIVLGYDDKVESICDGGFSLDVAFAPTRLRELSKMDGAVVLST
DGSRIVRANVQLVPDPSIPTDESGTRHRSAERTAIQTDYPVVSVSHSMNIVSVYTAGIRHVVMDSATVMSRVNQAVSTLE
RYKTRLDEVTSSLSTAEIEDFVTLRDVMTVAQRLELVRRISQDIELDVIELGTDGRQLKLQIGELVGDNDTERELLVRDY
HANPEPPTQAQIASTLEDLDALSDTDLLDLTVLSRTFGYPSTVEAQDTAMSSRGYRAMTHIPRLQFAHIDRLVRAFGSLQ
GLLAASATDLQSVEGIGAMWARHIREGLSRLAESTLTEQTG
>Mature_361_residues
MDNAEANARMRETLARLAPGTPLRDGLERILRGRTGALIVLGYDDKVESICDGGFSLDVAFAPTRLRELSKMDGAVVLST
DGSRIVRANVQLVPDPSIPTDESGTRHRSAERTAIQTDYPVVSVSHSMNIVSVYTAGIRHVVMDSATVMSRVNQAVSTLE
RYKTRLDEVTSSLSTAEIEDFVTLRDVMTVAQRLELVRRISQDIELDVIELGTDGRQLKLQIGELVGDNDTERELLVRDY
HANPEPPTQAQIASTLEDLDALSDTDLLDLTVLSRTFGYPSTVEAQDTAMSSRGYRAMTHIPRLQFAHIDRLVRAFGSLQ
GLLAASATDLQSVEGIGAMWARHIREGLSRLAESTLTEQTG

Specific function: Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions [H]

COG id: COG1623

COG function: function code R; Predicted nucleic-acid-binding protein (contains the HHH domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the disA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018906
- InterPro:   IPR003390
- InterPro:   IPR010994 [H]

Pfam domain/function: PF10635 DisA-linker; PF02457 DisA_N [H]

EC number: NA

Molecular weight: Translated: 39606; Mature: 39606

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNAEANARMRETLARLAPGTPLRDGLERILRGRTGALIVLGYDDKVESICDGGFSLDVA
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHCCCCEEEEE
FAPTRLRELSKMDGAVVLSTDGSRIVRANVQLVPDPSIPTDESGTRHRSAERTAIQTDYP
ECHHHHHHHHHCCCEEEEECCCCEEEEEEEEEECCCCCCCCCCCCCCCCHHHCEEECCCC
VVSVSHSMNIVSVYTAGIRHVVMDSATVMSRVNQAVSTLERYKTRLDEVTSSLSTAEIED
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVTLRDVMTVAQRLELVRRISQDIELDVIELGTDGRQLKLQIGELVGDNDTERELLVRDY
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEHHHHCCCCCHHHHHHHHC
HANPEPPTQAQIASTLEDLDALSDTDLLDLTVLSRTFGYPSTVEAQDTAMSSRGYRAMTH
CCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHH
IPRLQFAHIDRLVRAFGSLQGLLAASATDLQSVEGIGAMWARHIREGLSRLAESTLTEQT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
G
C
>Mature Secondary Structure
MDNAEANARMRETLARLAPGTPLRDGLERILRGRTGALIVLGYDDKVESICDGGFSLDVA
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHCCCCEEEEE
FAPTRLRELSKMDGAVVLSTDGSRIVRANVQLVPDPSIPTDESGTRHRSAERTAIQTDYP
ECHHHHHHHHHCCCEEEEECCCCEEEEEEEEEECCCCCCCCCCCCCCCCHHHCEEECCCC
VVSVSHSMNIVSVYTAGIRHVVMDSATVMSRVNQAVSTLERYKTRLDEVTSSLSTAEIED
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVTLRDVMTVAQRLELVRRISQDIELDVIELGTDGRQLKLQIGELVGDNDTERELLVRDY
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEHHHHCCCCCHHHHHHHHC
HANPEPPTQAQIASTLEDLDALSDTDLLDLTVLSRTFGYPSTVEAQDTAMSSRGYRAMTH
CCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHH
IPRLQFAHIDRLVRAFGSLQGLLAASATDLQSVEGIGAMWARHIREGLSRLAESTLTEQT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]