BacMap

Definition	Mycobacterium abscessus ATCC 19977 chromosome chromosome 1, complete sequence.
Accession	NC_010397
Length	5,067,172

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The map label for this gene is limC [H]

Identifier: 169627177

GI number: 169627177

Start: 68434

End: 69264

Strand: Reverse

Name: limC [H]

Synonym: MAB_0072c

Alternate gene names: 169627177

Gene position: 69264-68434 (Counterclockwise)

Preceding gene: 169627178

Following gene: 169627176

Centisome position: 1.37

GC content: 67.03

Gene sequence:

>831_bases
GTGACGGGACGATTGACGGGCAAGGTGGCCCTGGTGACCGGCGCCGCCCGGGGCATCGGGCGCGCCCAGGCGGTGCGTTT
CGCGCAGGAGGGCGCCGACATCATCGCGCTCGATATCTGCGCCCCGGTACACACCACCATCACCCCGCCGGCCACTCGCG
CCGACCTCGACAAGACCTCGGAGCTCGTCGAGTCGGCCGGACGCCGGGTCATTCCCGGGGTGGTGGACGTGCGCAATCTG
CGCGATGTGCAGACCTTCACCCAGGACGCGGTCACCGAGTTCGGTGGCCTGGATATCGTGTGCGCCACCGCCGGCATCAC
CTCGCGCAGGATGCTGCTGGATATGCCCGAAAGTGATTGGCAGACAATGCTTGACGTCAATCTGACCGGAGTGTGGCACA
CCACCCGCGCGGCCACACCGCACCTGATCGCGCGTGGCGGCGGCGCGATGGTGCTGGTCAGCTCCATCGCCGGCCTGCGC
GGACTGGTCGGGGTCTCGCACTACGTGGCGGCCAAGCACGGCGTGGTCGGCCTGATGCGCTCGCTGGCGATCGAACTCGC
GCCCCACAAGATTCGCGTCAACACGGTGCACCCCACCAACGTCGATACCCCCATGATTCAGAACGAATTTGTACGCACAC
TGTTCCGGCCCGATCTCGAGCAACCCACCCGCGAGGATTTCGCGGCGGCCGCCAAGACCATGAACCTGCTCGACCTACCG
TGGGTAGAGCCGCTCGATATCGCCAACGCCTCGCTGTTCCTGGCCTCGGACGAGGCGCGGTACATCACCTCGGTGAGCCT
TCCCGTCGACGCGGGCAGCACCCAACGATAG

Upstream 100 bases:

>100_bases
GACATCAGCAATGCGGTGGTCTTCCTGGCCTCCGACGAAGCGCGGTACATCACCGGCACCCAGCTGGTGGTCGACGCCGG
ACTGACACAGAAGGCATAAC

Downstream 100 bases:

>100_bases
GAGCCATCAGCGCGTACCGTCACCGGTATGGACGTGCTCATCTCGCCCTCCGAACTCGCTGACCGGCTAACCGACTTCCG
GCTGCTGGACGTGCGCTGGA

Product: putative short chain dehydrogenase/reductase

Products: NA

Alternate protein names: (4R,6S)-carveol dehydrogenase; CDH; Carveol dehydrogenase [H]

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MTGRLTGKVALVTGAARGIGRAQAVRFAQEGADIIALDICAPVHTTITPPATRADLDKTSELVESAGRRVIPGVVDVRNL
RDVQTFTQDAVTEFGGLDIVCATAGITSRRMLLDMPESDWQTMLDVNLTGVWHTTRAATPHLIARGGGAMVLVSSIAGLR
GLVGVSHYVAAKHGVVGLMRSLAIELAPHKIRVNTVHPTNVDTPMIQNEFVRTLFRPDLEQPTREDFAAAAKTMNLLDLP
WVEPLDIANASLFLASDEARYITSVSLPVDAGSTQR

Sequences:

>Translated_276_residues
MTGRLTGKVALVTGAARGIGRAQAVRFAQEGADIIALDICAPVHTTITPPATRADLDKTSELVESAGRRVIPGVVDVRNL
RDVQTFTQDAVTEFGGLDIVCATAGITSRRMLLDMPESDWQTMLDVNLTGVWHTTRAATPHLIARGGGAMVLVSSIAGLR
GLVGVSHYVAAKHGVVGLMRSLAIELAPHKIRVNTVHPTNVDTPMIQNEFVRTLFRPDLEQPTREDFAAAAKTMNLLDLP
WVEPLDIANASLFLASDEARYITSVSLPVDAGSTQR
>Mature_275_residues
TGRLTGKVALVTGAARGIGRAQAVRFAQEGADIIALDICAPVHTTITPPATRADLDKTSELVESAGRRVIPGVVDVRNLR
DVQTFTQDAVTEFGGLDIVCATAGITSRRMLLDMPESDWQTMLDVNLTGVWHTTRAATPHLIARGGGAMVLVSSIAGLRG
LVGVSHYVAAKHGVVGLMRSLAIELAPHKIRVNTVHPTNVDTPMIQNEFVRTLFRPDLEQPTREDFAAAAKTMNLLDLPW
VEPLDIANASLFLASDEARYITSVSLPVDAGSTQR

Specific function: Catalyzes the oxidation of carveol to carvone, with a strong stereoselectivity since it efficiently converts only the (6S)-stereoisomers, of which (-)-(4R,6S)-trans-carveol is the better substrate. Displays a broad substrate specificity with a preference

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=281, Percent_Identity=33.8078291814947, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI32483357, Length=273, Percent_Identity=32.2344322344322, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI4504505, Length=226, Percent_Identity=32.3008849557522, Blast_Score=107, Evalue=9e-24,
Organism=Homo sapiens, GI66933014, Length=271, Percent_Identity=31.7343173431734, Blast_Score=104, Evalue=7e-23,
Organism=Homo sapiens, GI126723750, Length=276, Percent_Identity=29.3478260869565, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI126723191, Length=200, Percent_Identity=35.5, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI40254986, Length=199, Percent_Identity=30.1507537688442, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI7705925, Length=271, Percent_Identity=32.4723247232472, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI40254992, Length=270, Percent_Identity=31.8518518518519, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI10190704, Length=271, Percent_Identity=28.4132841328413, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI310128830, Length=230, Percent_Identity=28.2608695652174, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI310115468, Length=230, Percent_Identity=28.2608695652174, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI40807363, Length=205, Percent_Identity=28.780487804878, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI31542939, Length=211, Percent_Identity=33.175355450237, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI5031737, Length=274, Percent_Identity=27.7372262773723, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI4758504, Length=234, Percent_Identity=29.0598290598291, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI19923817, Length=282, Percent_Identity=26.241134751773, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI59889578, Length=221, Percent_Identity=29.8642533936652, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI142976729, Length=207, Percent_Identity=27.0531400966184, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI33667109, Length=214, Percent_Identity=30.8411214953271, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI302344755, Length=109, Percent_Identity=41.2844036697248, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI25282469, Length=239, Percent_Identity=28.0334728033473, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI224922801, Length=183, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI109715829, Length=264, Percent_Identity=28.7878787878788, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI210032110, Length=205, Percent_Identity=25.8536585365854, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI83715985, Length=196, Percent_Identity=29.0816326530612, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI7706318, Length=207, Percent_Identity=26.5700483091787, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI223718074, Length=206, Percent_Identity=28.6407766990291, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI87082100, Length=273, Percent_Identity=35.5311355311355, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1789208, Length=277, Percent_Identity=32.4909747292419, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1787335, Length=268, Percent_Identity=31.7164179104478, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1790717, Length=268, Percent_Identity=27.9850746268657, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787905, Length=279, Percent_Identity=26.1648745519713, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI87082160, Length=272, Percent_Identity=27.5735294117647, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1786812, Length=274, Percent_Identity=31.3868613138686, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788459, Length=268, Percent_Identity=29.4776119402985, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1789378, Length=267, Percent_Identity=27.7153558052434, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1787526, Length=273, Percent_Identity=26.3736263736264, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1789057, Length=272, Percent_Identity=26.1029411764706, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1788891, Length=254, Percent_Identity=27.5590551181102, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787820, Length=216, Percent_Identity=27.3148148148148, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI2367365, Length=202, Percent_Identity=27.7227722772277, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI2367175, Length=278, Percent_Identity=26.978417266187, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=226, Percent_Identity=34.070796460177, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17564282, Length=204, Percent_Identity=31.3725490196078, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25147288, Length=278, Percent_Identity=31.6546762589928, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17560676, Length=276, Percent_Identity=29.3478260869565, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17555706, Length=278, Percent_Identity=32.3741007194245, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17561402, Length=275, Percent_Identity=26.5454545454545, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17562908, Length=283, Percent_Identity=30.7420494699647, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17562904, Length=283, Percent_Identity=28.2685512367491, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI193203117, Length=205, Percent_Identity=29.2682926829268, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17544670, Length=284, Percent_Identity=30.2816901408451, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17562910, Length=287, Percent_Identity=28.5714285714286, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71982365, Length=200, Percent_Identity=30, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994600, Length=275, Percent_Identity=30.5454545454545, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17560150, Length=281, Percent_Identity=29.8932384341637, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI193203115, Length=202, Percent_Identity=28.7128712871287, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71994604, Length=268, Percent_Identity=30.2238805970149, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17562906, Length=284, Percent_Identity=31.3380281690141, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17559104, Length=284, Percent_Identity=32.3943661971831, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17538480, Length=291, Percent_Identity=30.9278350515464, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17560220, Length=288, Percent_Identity=29.5138888888889, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193204405, Length=282, Percent_Identity=29.7872340425532, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17567345, Length=209, Percent_Identity=26.7942583732057, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17531453, Length=285, Percent_Identity=29.8245614035088, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17551412, Length=290, Percent_Identity=27.2413793103448, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562990, Length=282, Percent_Identity=29.4326241134752, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17508895, Length=209, Percent_Identity=29.1866028708134, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=286, Percent_Identity=29.3706293706294, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17555612, Length=232, Percent_Identity=29.7413793103448, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=282, Percent_Identity=29.7872340425532, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17558628, Length=200, Percent_Identity=30, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115534694, Length=275, Percent_Identity=29.0909090909091, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=288, Percent_Identity=27.4305555555556, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71997099, Length=244, Percent_Identity=27.4590163934426, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17538182, Length=239, Percent_Identity=28.0334728033473, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=215, Percent_Identity=31.1627906976744, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17507613, Length=209, Percent_Identity=25.3588516746411, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32563809, Length=209, Percent_Identity=25.3588516746411, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=204, Percent_Identity=31.3725490196078, Blast_Score=93, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324126, Length=271, Percent_Identity=25.830258302583, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323882, Length=225, Percent_Identity=28, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24644339, Length=271, Percent_Identity=32.4723247232472, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI18859837, Length=196, Percent_Identity=33.6734693877551, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24639444, Length=281, Percent_Identity=31.6725978647687, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21357041, Length=269, Percent_Identity=31.2267657992565, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI23397609, Length=269, Percent_Identity=30.4832713754647, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28571526, Length=266, Percent_Identity=28.5714285714286, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24640492, Length=231, Percent_Identity=26.8398268398268, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357673, Length=212, Percent_Identity=29.7169811320755, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17737361, Length=230, Percent_Identity=29.1304347826087, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355319, Length=278, Percent_Identity=28.0575539568345, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24643142, Length=201, Percent_Identity=33.8308457711443, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI281364892, Length=212, Percent_Identity=26.8867924528302, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24581726, Length=220, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21355631, Length=183, Percent_Identity=30.0546448087432, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24649181, Length=202, Percent_Identity=28.2178217821782, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24644337, Length=180, Percent_Identity=29.4444444444444, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24665243, Length=226, Percent_Identity=28.3185840707965, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI221510726, Length=183, Percent_Identity=27.8688524590164, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 29578; Mature: 29447

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGRLTGKVALVTGAARGIGRAQAVRFAQEGADIIALDICAPVHTTITPPATRADLDKTS
CCCCCCEEEEEEECCHHCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHH
ELVESAGRRVIPGVVDVRNLRDVQTFTQDAVTEFGGLDIVCATAGITSRRMLLDMPESDW
HHHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCC
QTMLDVNLTGVWHTTRAATPHLIARGGGAMVLVSSIAGLRGLVGVSHYVAAKHGVVGLMR
CEEEEEEEEEEEECCCCCCCCEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLAIELAPHKIRVNTVHPTNVDTPMIQNEFVRTLFRPDLEQPTREDFAAAAKTMNLLDLP
HHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCC
WVEPLDIANASLFLASDEARYITSVSLPVDAGSTQR
CCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
TGRLTGKVALVTGAARGIGRAQAVRFAQEGADIIALDICAPVHTTITPPATRADLDKTS
CCCCCEEEEEEECCHHCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHH
ELVESAGRRVIPGVVDVRNLRDVQTFTQDAVTEFGGLDIVCATAGITSRRMLLDMPESDW
HHHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCC
QTMLDVNLTGVWHTTRAATPHLIARGGGAMVLVSSIAGLRGLVGVSHYVAAKHGVVGLMR
CEEEEEEEEEEEECCCCCCCCEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLAIELAPHKIRVNTVHPTNVDTPMIQNEFVRTLFRPDLEQPTREDFAAAAKTMNLLDLP
HHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCC
WVEPLDIANASLFLASDEARYITSVSLPVDAGSTQR
CCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10473585 [H]