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The map label for this gene is mmgC [H]

Identifier: 169627170

GI number: 169627170

Start: 62293

End: 63438

Strand: Reverse

Name: mmgC [H]

Synonym: MAB_0065c

Alternate gene names: 169627170

Gene position: 63438-62293 (Counterclockwise)

Preceding gene: 169627171

Following gene: 169627169

Centisome position: 1.25

GC content: 64.49

Gene sequence:

>1146_bases
ATGCAACGGACCATCTACACCGAGGACCACGAGGCATTCCGCGAGTCCGTGAAGGCGTTTGTGCAACGCCACGTCGACCC
GCGCGCCGAGACATTCATCGAGCAGCGCTACATTGACCGCGAGCTCTGGGAAGAGGCCGGTAAGCAGGGTTACCTGGGCC
TCGACGTCCCCGAGGAGTTCGGCGGCAGCAGCGCCGGCGACTACCGCTACAACGCGGTACTGCAGGAGGAACTGGCCCGC
TCCAGCGCGGCCCTGGCCTCCTCGATGTCCATTCACTTCGACATCGTCGCCCCGTACCTCGTCGAGCTGACCACCGACGA
GCAGAAGCAACGCTGGCTGCCCAAGTTCTGTAGCGGCGAGATGATCACCGCGATCGGCATGACCGAGCCCTCGGGTGGCT
CCGATCTGGCGGCCCTCAAGACAACGGCCGTCAAGGACGGCGACGACTGGGTCATCAACGGCTCCAAGACGTTCATCACC
AACGGTGCGCGAGCCGATCTCGTCGTCGTCGCGGCACGCACCGCGCCCGAGCTGAAGGCCAAGGGCATCACCCTGTTCGC
GGTCGAGGAGGGCATGCCCGGCTTCGAGCGCGGCCGCAAGCTGGACAAAGTGGGCCAGCCCGAGGCCGATACCGCCGAGT
TGTTCTTCACCGATGTGCGGGTGCCCGCCGAGAACGTCATCGGCGAGGTCAACCAGGGATTCATCTCGATGATGCAGCGC
CTGCCTCAGGAGCGGATGGGCTGTGCGGTCGCCAACATCGCACACGCGGTCGCCGTGCTGGAGGAGACCGTCGAATACGC
CAAGGAGCGCAAGGCGTTCGGTCAGCAGATCGGCAGCCTGCAGTACAACAAGTTCCTCATCGCCGAGCTCGTCACCAAGC
TGGAAGCGGCACAGGTGTACGTCGATCAGGCAGTACTGGCCCACAGCAAGGGCGAGCTCACCGCGATTGACGCGGCCAAG
GCCAAGTGGTGGTCGTCGCAGGTCCAGAACGAGGTCATCGACGCCTGCGTACAGCTACACGGCGGGTACGGCTACATGAA
GGAGTACCGGGTCGCACGCGCTTGGATGGACGCGCGCGTCACCAAGATCTGGGCAGGCTCCAACGAGATCATGAAGGAAC
TCATCGGCCGCGACCTGGGCTTCTGA

Upstream 100 bases:

>100_bases
CGAGATGTTCGGCATCACCCCGGTGGAGCTGCACCGCAGTGTGCAGCTGAGCTAGCGGAGCCCGGTGCGCATGGATTTAG
ACGCGTGCTTCGATAACACC

Downstream 100 bases:

>100_bases
GGCCGCAGAACGGGGTCGGGTAGGAAGGAATTCATGACCGCCAGCGACCAAGCCGGACGCATCCGAGTTCCCGCCGATCT
GGACTCGGTGACGGATATCG

Product: acyl-CoA dehydrogenase FadE

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MQRTIYTEDHEAFRESVKAFVQRHVDPRAETFIEQRYIDRELWEEAGKQGYLGLDVPEEFGGSSAGDYRYNAVLQEELAR
SSAALASSMSIHFDIVAPYLVELTTDEQKQRWLPKFCSGEMITAIGMTEPSGGSDLAALKTTAVKDGDDWVINGSKTFIT
NGARADLVVVAARTAPELKAKGITLFAVEEGMPGFERGRKLDKVGQPEADTAELFFTDVRVPAENVIGEVNQGFISMMQR
LPQERMGCAVANIAHAVAVLEETVEYAKERKAFGQQIGSLQYNKFLIAELVTKLEAAQVYVDQAVLAHSKGELTAIDAAK
AKWWSSQVQNEVIDACVQLHGGYGYMKEYRVARAWMDARVTKIWAGSNEIMKELIGRDLGF

Sequences:

>Translated_381_residues
MQRTIYTEDHEAFRESVKAFVQRHVDPRAETFIEQRYIDRELWEEAGKQGYLGLDVPEEFGGSSAGDYRYNAVLQEELAR
SSAALASSMSIHFDIVAPYLVELTTDEQKQRWLPKFCSGEMITAIGMTEPSGGSDLAALKTTAVKDGDDWVINGSKTFIT
NGARADLVVVAARTAPELKAKGITLFAVEEGMPGFERGRKLDKVGQPEADTAELFFTDVRVPAENVIGEVNQGFISMMQR
LPQERMGCAVANIAHAVAVLEETVEYAKERKAFGQQIGSLQYNKFLIAELVTKLEAAQVYVDQAVLAHSKGELTAIDAAK
AKWWSSQVQNEVIDACVQLHGGYGYMKEYRVARAWMDARVTKIWAGSNEIMKELIGRDLGF
>Mature_381_residues
MQRTIYTEDHEAFRESVKAFVQRHVDPRAETFIEQRYIDRELWEEAGKQGYLGLDVPEEFGGSSAGDYRYNAVLQEELAR
SSAALASSMSIHFDIVAPYLVELTTDEQKQRWLPKFCSGEMITAIGMTEPSGGSDLAALKTTAVKDGDDWVINGSKTFIT
NGARADLVVVAARTAPELKAKGITLFAVEEGMPGFERGRKLDKVGQPEADTAELFFTDVRVPAENVIGEVNQGFISMMQR
LPQERMGCAVANIAHAVAVLEETVEYAKERKAFGQQIGSLQYNKFLIAELVTKLEAAQVYVDQAVLAHSKGELTAIDAAK
AKWWSSQVQNEVIDACVQLHGGYGYMKEYRVARAWMDARVTKIWAGSNEIMKELIGRDLGF

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501857, Length=381, Percent_Identity=45.6692913385827, Blast_Score=338, Evalue=4e-93,
Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=36.2666666666667, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI226958414, Length=346, Percent_Identity=37.8612716763006, Blast_Score=244, Evalue=8e-65,
Organism=Homo sapiens, GI4557233, Length=381, Percent_Identity=33.8582677165354, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=30.2139037433155, Blast_Score=201, Evalue=9e-52,
Organism=Homo sapiens, GI7656849, Length=375, Percent_Identity=32.5333333333333, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI4557235, Length=374, Percent_Identity=33.6898395721925, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI76496475, Length=374, Percent_Identity=33.6898395721925, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI187960098, Length=376, Percent_Identity=30.5851063829787, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI4557231, Length=376, Percent_Identity=30.5851063829787, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI21361497, Length=376, Percent_Identity=32.7127659574468, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI4503943, Length=380, Percent_Identity=27.3684210526316, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI7669494, Length=360, Percent_Identity=27.7777777777778, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI38505218, Length=387, Percent_Identity=26.3565891472868, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI211971008, Length=289, Percent_Identity=26.9896193771626, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI48976061, Length=289, Percent_Identity=26.9896193771626, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1786223, Length=331, Percent_Identity=29.9093655589124, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI87081958, Length=379, Percent_Identity=28.7598944591029, Blast_Score=141, Evalue=6e-35,
Organism=Escherichia coli, GI87081702, Length=360, Percent_Identity=25, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17538396, Length=370, Percent_Identity=34.0540540540541, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17570075, Length=376, Percent_Identity=33.7765957446808, Blast_Score=211, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI17505929, Length=377, Percent_Identity=32.0954907161804, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17551932, Length=381, Percent_Identity=31.758530183727, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17508101, Length=372, Percent_Identity=31.1827956989247, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI17506239, Length=375, Percent_Identity=30.9333333333333, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17533517, Length=377, Percent_Identity=33.42175066313, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17534899, Length=356, Percent_Identity=32.3033707865169, Blast_Score=184, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI17569725, Length=376, Percent_Identity=30.5851063829787, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71990804, Length=279, Percent_Identity=35.1254480286738, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71985184, Length=354, Percent_Identity=29.6610169491525, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=34.1991341991342, Blast_Score=144, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71982178, Length=271, Percent_Identity=29.8892988929889, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17534353, Length=374, Percent_Identity=25.1336898395722, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71985192, Length=310, Percent_Identity=29.0322580645161, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=28.0334728033473, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17562446, Length=289, Percent_Identity=23.8754325259516, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355753, Length=378, Percent_Identity=34.1269841269841, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI21356377, Length=369, Percent_Identity=32.7913279132791, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24666513, Length=374, Percent_Identity=30.4812834224599, Blast_Score=195, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24646207, Length=378, Percent_Identity=31.4814814814815, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24660351, Length=376, Percent_Identity=30.5851063829787, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI281363737, Length=344, Percent_Identity=32.2674418604651, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI19920834, Length=379, Percent_Identity=26.3852242744063, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24652780, Length=309, Percent_Identity=22.3300970873786, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42278; Mature: 42278

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRTIYTEDHEAFRESVKAFVQRHVDPRAETFIEQRYIDRELWEEAGKQGYLGLDVPEEF
CCCCEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHH
GGSSAGDYRYNAVLQEELARSSAALASSMSIHFDIVAPYLVELTTDEQKQRWLPKFCSGE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHEEECCCHHHHHHCHHHCCCC
MITAIGMTEPSGGSDLAALKTTAVKDGDDWVINGSKTFITNGARADLVVVAARTAPELKA
EEEEEECCCCCCCCCHHHHHHHHCCCCCCEEECCCEEEEECCCCCCEEEEEECCCCCHHH
KGITLFAVEEGMPGFERGRKLDKVGQPEADTAELFFTDVRVPAENVIGEVNQGFISMMQR
CCEEEEEECCCCCCHHHCCCHHHCCCCCCCCHHEEEEECCCCHHHHHHHHHHHHHHHHHH
LPQERMGCAVANIAHAVAVLEETVEYAKERKAFGQQIGSLQYNKFLIAELVTKLEAAQVY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
VDQAVLAHSKGELTAIDAAKAKWWSSQVQNEVIDACVQLHGGYGYMKEYRVARAWMDARV
HHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
TKIWAGSNEIMKELIGRDLGF
HHEECCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MQRTIYTEDHEAFRESVKAFVQRHVDPRAETFIEQRYIDRELWEEAGKQGYLGLDVPEEF
CCCCEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHH
GGSSAGDYRYNAVLQEELARSSAALASSMSIHFDIVAPYLVELTTDEQKQRWLPKFCSGE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHEEECCCHHHHHHCHHHCCCC
MITAIGMTEPSGGSDLAALKTTAVKDGDDWVINGSKTFITNGARADLVVVAARTAPELKA
EEEEEECCCCCCCCCHHHHHHHHCCCCCCEEECCCEEEEECCCCCCEEEEEECCCCCHHH
KGITLFAVEEGMPGFERGRKLDKVGQPEADTAELFFTDVRVPAENVIGEVNQGFISMMQR
CCEEEEEECCCCCCHHHCCCHHHCCCCCCCCHHEEEEECCCCHHHHHHHHHHHHHHHHHH
LPQERMGCAVANIAHAVAVLEETVEYAKERKAFGQQIGSLQYNKFLIAELVTKLEAAQVY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
VDQAVLAHSKGELTAIDAAKAKWWSSQVQNEVIDACVQLHGGYGYMKEYRVARAWMDARV
HHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
TKIWAGSNEIMKELIGRDLGF
HHEECCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]