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The map label for this gene is gyrA [H]

Identifier: 169627127

GI number: 169627127

Start: 18389

End: 20908

Strand: Direct

Name: gyrA [H]

Synonym: MAB_0019

Alternate gene names: 169627127

Gene position: 18389-20908 (Clockwise)

Preceding gene: 169627125

Following gene: 169627128

Centisome position: 0.36

GC content: 64.09

Gene sequence:

>2520_bases
ATGACTGACACAACGCTGCCCCCCGGCGGTGATGACGCCGTCGACCGCATCGAACCGGTAGACATCCAGCAGGAGATGCA
GCGCAGCTACATCGATTACGCCATGAGTGTGATCGTGGGCCGCGCCCTCCCCGAGGTCCGCGATGGCCTCAAGCCAGTGC
ACCGCCGCGTCCTGTACGCGATGTATGACTCCGGCTTCCGCCCCGACCGCAGCCATGCCAAGTCGGCGCGCTCGGTTGCC
GAGACCATGGGTAACTATCACCCCCACGGTGACGCGTCCATCTACGACACCCTCGTGCGTATGGCCCAGCCTTGGTCGCT
GCGCTACCCGCTGGTGGACGGACAGGGCAACTTCGGCTCACCGGGTAACGACCCGGCGGCCGCCATGCGTTACACCGAGG
CTCGGCTCACGCCGCTGGCCATGGAGATGTTGCGTGAAATCGATGAGGAAACAGTCGATTTCATTCCGAACTACGACGGC
CGCGTCATGGAGCCGACGGTGTTGCCGAGCCGGTTTCCGAACCTGCTGGCCAACGGTTCGGGCGGTATCGCCGTCGGTAT
GGCCACCAACATGCCGCCGCACAACCTGCGTGAGTTGGCCGAAGCCGTCTACTGGGCGTTGGACAACCACGAGGCGGACG
AGGAGACCACTCTCAAGGCGGTCTGCGAAAAGATCACCGGTCCCGACTTCCCGACGTCGGGATTGATCGTTGGGACGCAG
GGTATTCACGACGCCTACACCACGGGCCGTGGCTCCATCCGGATGCGGGGTGTGGCCGAGATCGAGGAAGACTCCAAGGG
CAGAACGTCTTTGGTGATCACCGAGCTGCCGTACCAGGTCAACCACGACAACTTCATCACCTCCATCGCCGAGCAGGTGC
GCGACGGCAAGATTGCGGGCATCTCCAACATCGAGGACCAGAGCTCCGATCGTGTCGGCCTGCGAATCGTGGTGGTACTC
AAGCGCGATGCCGTGGCCAAGGTGGTGCTGAACAACCTCTACAAGCACACCCAGCTGCAGACCAGCTTTGGTGCGAACAT
GCTGTCGATCGTCGACGGCGTGCCGCGCACGCTGCGTCTGGACCAGTTGATCCGGCTCTACGTCAATCACCAGTTGGACG
TCATCATTCGGCGCACCCGGTACCGGTTGCGCAAGGCGAACGAGCGCGCGCACATCTTGCGCGGTTTGGTCAAAGCCCTT
GACGCCCTTGATGAAGTGATCGCGTTGATTCGGGCGTCGCAGACGGTGGACATCGCCCGCACGGGCCTGATCGAGTTGCT
GGACGTCGATGAGATCCAGGCCCAGGCCATCCTCGACATGCAGCTGCGTCGCCTGGCGGCCCTGGAGCGGCAGAAGATCA
TCGACGACCTCGCCAAGATCGAGGCCGAGATCGCCGACCTCGAGGACATCCTGGCCAAGCCGGAACGTCAGCGCGCCATC
GTCAAGGACGAACTCGCCGAGATCACCGAGAAGTACGGCGACGACCGCCGGACCCGCATCATCTCGGCGGACGGGGACGT
CGCCGACGAGGACCTCATCGCGCGTGAGGACGTCGTCGTCACCATCACCGAAACCGGGTACGCCAAGCGCACCAAGACCG
ACCTGTACCGCAGCCAGAAGCGCGGTGGCAAGGGCGTGCAGGGTGCCGGCCTGAAGCAGGATGACATCGTCAAGCACTTC
TTTGTGTGCTCGACGCATGACTGGATCCTGTTCTTCACCACCAAGGGCCGCGTCTATCGCGCCAAGGCGTATGACTTGCC
CGAGGCTGCCCGCACCGCGCGCGGCCAGCACGTCGCCAATCTGCTGGCCTTCCAGCCGGAAGAGCGCATCGCGCAGGTCA
TCCAGATCAAGAGCTACGAGGACGCGCCATACCTGGTGCTCGCCACCAAGAACGGCTTGGTCAAGAAGTCCAAACTCACC
GAGTTCGACTCCAACCGCAGCGGTGGCCTGGTGGCCGTCAACCTGCGTGACGGCGACGAGTTGGTGGGTGCGGTGCTGTG
CTCGGCCGAGGACGATCTGCTGCTGGTCTCGGCCCATGGGCAGTCCATCCGATTCAGTGCCACCGACGAGGCGTTGCGGC
CGATGGGCCGCGCCACTTCCGGTGTGCAGGGCATGCGCTTCAACGGCGAGGACGACTTGTTGTCGCTCAACGTCGTCCGT
GAGGGCACCTACCTGCTGGTGGCCACTTCGGGCGGTTACTCCAAGCGCACCGCCATCGAGGAGTACCCAGTACAGGGACG
TGGCGGTAAGGGTGTGCTGACGGTTCAGTACGACCCGCGCCGTGGCTCCCTGGTGGGTGCGCTCGTCGTGGACGAGGAAT
CCGAGCTGTACGCCATCACCTCCGGCGGAGGCGTCATCCGCACCATCGCGAAGCAGGTCCGCAAGGCCGGCCGCCAAACC
AAGGGCGTGCGGCTGATGAACCTCGGCGAGGGCGACACCCTTTTGGCGATCGCGCATAATGCCGATGAGGGAGATGCTGA
CCCCGATGAGGATGCAGCCGGCACGACCGCAGGCGAGTAA

Upstream 100 bases:

>100_bases
AGAACGACGCACGGGGCCGCATCCGGGAAAGCCGCCGGCCAAGTGACTAGGCTGGTGAGGTTGCCCGGCTTTCTCCGGGC
GGAGCATGAACGAGGAGCAC

Downstream 100 bases:

>100_bases
GGAGCTGTAGGTGAGTTCACCGAACGATCCGGGGGAGTCTGGCGCAAACGAACGCCCCGTGGACCAGGCGGACTTGCCTC
CCTGGCAGCGGGCGGAGCGG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 839; Mature: 838

Protein sequence:

>839_residues
MTDTTLPPGGDDAVDRIEPVDIQQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMYDSGFRPDRSHAKSARSVA
ETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNDPAAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDG
RVMEPTVLPSRFPNLLANGSGGIAVGMATNMPPHNLRELAEAVYWALDNHEADEETTLKAVCEKITGPDFPTSGLIVGTQ
GIHDAYTTGRGSIRMRGVAEIEEDSKGRTSLVITELPYQVNHDNFITSIAEQVRDGKIAGISNIEDQSSDRVGLRIVVVL
KRDAVAKVVLNNLYKHTQLQTSFGANMLSIVDGVPRTLRLDQLIRLYVNHQLDVIIRRTRYRLRKANERAHILRGLVKAL
DALDEVIALIRASQTVDIARTGLIELLDVDEIQAQAILDMQLRRLAALERQKIIDDLAKIEAEIADLEDILAKPERQRAI
VKDELAEITEKYGDDRRTRIISADGDVADEDLIAREDVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVKHF
FVCSTHDWILFFTTKGRVYRAKAYDLPEAARTARGQHVANLLAFQPEERIAQVIQIKSYEDAPYLVLATKNGLVKKSKLT
EFDSNRSGGLVAVNLRDGDELVGAVLCSAEDDLLLVSAHGQSIRFSATDEALRPMGRATSGVQGMRFNGEDDLLSLNVVR
EGTYLLVATSGGYSKRTAIEEYPVQGRGGKGVLTVQYDPRRGSLVGALVVDEESELYAITSGGGVIRTIAKQVRKAGRQT
KGVRLMNLGEGDTLLAIAHNADEGDADPDEDAAGTTAGE

Sequences:

>Translated_839_residues
MTDTTLPPGGDDAVDRIEPVDIQQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMYDSGFRPDRSHAKSARSVA
ETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNDPAAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDG
RVMEPTVLPSRFPNLLANGSGGIAVGMATNMPPHNLRELAEAVYWALDNHEADEETTLKAVCEKITGPDFPTSGLIVGTQ
GIHDAYTTGRGSIRMRGVAEIEEDSKGRTSLVITELPYQVNHDNFITSIAEQVRDGKIAGISNIEDQSSDRVGLRIVVVL
KRDAVAKVVLNNLYKHTQLQTSFGANMLSIVDGVPRTLRLDQLIRLYVNHQLDVIIRRTRYRLRKANERAHILRGLVKAL
DALDEVIALIRASQTVDIARTGLIELLDVDEIQAQAILDMQLRRLAALERQKIIDDLAKIEAEIADLEDILAKPERQRAI
VKDELAEITEKYGDDRRTRIISADGDVADEDLIAREDVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVKHF
FVCSTHDWILFFTTKGRVYRAKAYDLPEAARTARGQHVANLLAFQPEERIAQVIQIKSYEDAPYLVLATKNGLVKKSKLT
EFDSNRSGGLVAVNLRDGDELVGAVLCSAEDDLLLVSAHGQSIRFSATDEALRPMGRATSGVQGMRFNGEDDLLSLNVVR
EGTYLLVATSGGYSKRTAIEEYPVQGRGGKGVLTVQYDPRRGSLVGALVVDEESELYAITSGGGVIRTIAKQVRKAGRQT
KGVRLMNLGEGDTLLAIAHNADEGDADPDEDAAGTTAGE
>Mature_838_residues
TDTTLPPGGDDAVDRIEPVDIQQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMYDSGFRPDRSHAKSARSVAE
TMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNDPAAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGR
VMEPTVLPSRFPNLLANGSGGIAVGMATNMPPHNLRELAEAVYWALDNHEADEETTLKAVCEKITGPDFPTSGLIVGTQG
IHDAYTTGRGSIRMRGVAEIEEDSKGRTSLVITELPYQVNHDNFITSIAEQVRDGKIAGISNIEDQSSDRVGLRIVVVLK
RDAVAKVVLNNLYKHTQLQTSFGANMLSIVDGVPRTLRLDQLIRLYVNHQLDVIIRRTRYRLRKANERAHILRGLVKALD
ALDEVIALIRASQTVDIARTGLIELLDVDEIQAQAILDMQLRRLAALERQKIIDDLAKIEAEIADLEDILAKPERQRAIV
KDELAEITEKYGDDRRTRIISADGDVADEDLIAREDVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVKHFF
VCSTHDWILFFTTKGRVYRAKAYDLPEAARTARGQHVANLLAFQPEERIAQVIQIKSYEDAPYLVLATKNGLVKKSKLTE
FDSNRSGGLVAVNLRDGDELVGAVLCSAEDDLLLVSAHGQSIRFSATDEALRPMGRATSGVQGMRFNGEDDLLSLNVVRE
GTYLLVATSGGYSKRTAIEEYPVQGRGGKGVLTVQYDPRRGSLVGALVVDEESELYAITSGGGVIRTIAKQVRKAGRQTK
GVRLMNLGEGDTLLAIAHNADEGDADPDEDAAGTTAGE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=377, Percent_Identity=25.1989389920424, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI19913408, Length=356, Percent_Identity=25.8426966292135, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1788562, Length=854, Percent_Identity=45.6674473067916, Blast_Score=744, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=777, Percent_Identity=33.7194337194337, Blast_Score=393, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17535065, Length=167, Percent_Identity=32.3353293413174, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI212645657, Length=166, Percent_Identity=31.3253012048193, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI212645845, Length=226, Percent_Identity=27.8761061946903, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI115534553, Length=163, Percent_Identity=31.2883435582822, Blast_Score=72, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=384, Percent_Identity=23.4375, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136538, Length=324, Percent_Identity=25, Blast_Score=80, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 92312; Mature: 92181

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTTLPPGGDDAVDRIEPVDIQQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYA
CCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
MYDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGS
HHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEECCEECCCCCCCC
PGNDPAAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVMEPTVLPSRFPNLLANGS
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHCHHHHCCCC
GGIAVGMATNMPPHNLRELAEAVYWALDNHEADEETTLKAVCEKITGPDFPTSGLIVGTQ
CCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECC
GIHDAYTTGRGSIRMRGVAEIEEDSKGRTSLVITELPYQVNHDNFITSIAEQVRDGKIAG
CCCHHHHCCCCCEEEEECCCCCCCCCCCEEEEEEECCCEECCCHHHHHHHHHHCCCCEEC
ISNIEDQSSDRVGLRIVVVLKRDAVAKVVLNNLYKHTQLQTSFGANMLSIVDGVPRTLRL
CCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHH
DQLIRLYVNHQLDVIIRRTRYRLRKANERAHILRGLVKALDALDEVIALIRASQTVDIAR
HHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
TGLIELLDVDEIQAQAILDMQLRRLAALERQKIIDDLAKIEAEIADLEDILAKPERQRAI
HCHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
VKDELAEITEKYGDDRRTRIISADGDVADEDLIAREDVVVTITETGYAKRTKTDLYRSQK
HHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHEECCCEEEEEECCCCCHHHHHHHHHHHH
RGGKGVQGAGLKQDDIVKHFFVCSTHDWILFFTTKGRVYRAKAYDLPEAARTARGQHVAN
CCCCCCCCCCCCHHHHHHHHEEEECCCEEEEEEECCEEEEEECCCCCHHHHHHCHHHHHH
LLAFQPEERIAQVIQIKSYEDAPYLVLATKNGLVKKSKLTEFDSNRSGGLVAVNLRDGDE
HHHCCCHHHHHHHHHHCCCCCCCEEEEECCCCCEEHHHCCCCCCCCCCCEEEEEECCCHH
LVGAVLCSAEDDLLLVSAHGQSIRFSATDEALRPMGRATSGVQGMRFNGEDDLLSLNVVR
HHHHHHCCCCCCEEEEEECCCEEEECCCHHHHHHHCCCCCCCCCCEECCCCCEEEEEEEE
EGTYLLVATSGGYSKRTAIEEYPVQGRGGKGVLTVQYDPRRGSLVGALVVDEESELYAIT
CCCEEEEEECCCCCCCCHHHHCCCCCCCCCEEEEEEECCCCCCEEEEEEEECCCCEEEEE
SGGGVIRTIAKQVRKAGRQTKGVRLMNLGEGDTLLAIAHNADEGDADPDEDAAGTTAGE
CCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TDTTLPPGGDDAVDRIEPVDIQQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYA
CCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
MYDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGS
HHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEECCEECCCCCCCC
PGNDPAAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVMEPTVLPSRFPNLLANGS
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHCHHHHCCCC
GGIAVGMATNMPPHNLRELAEAVYWALDNHEADEETTLKAVCEKITGPDFPTSGLIVGTQ
CCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECC
GIHDAYTTGRGSIRMRGVAEIEEDSKGRTSLVITELPYQVNHDNFITSIAEQVRDGKIAG
CCCHHHHCCCCCEEEEECCCCCCCCCCCEEEEEEECCCEECCCHHHHHHHHHHCCCCEEC
ISNIEDQSSDRVGLRIVVVLKRDAVAKVVLNNLYKHTQLQTSFGANMLSIVDGVPRTLRL
CCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHH
DQLIRLYVNHQLDVIIRRTRYRLRKANERAHILRGLVKALDALDEVIALIRASQTVDIAR
HHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
TGLIELLDVDEIQAQAILDMQLRRLAALERQKIIDDLAKIEAEIADLEDILAKPERQRAI
HCHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
VKDELAEITEKYGDDRRTRIISADGDVADEDLIAREDVVVTITETGYAKRTKTDLYRSQK
HHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHEECCCEEEEEECCCCCHHHHHHHHHHHH
RGGKGVQGAGLKQDDIVKHFFVCSTHDWILFFTTKGRVYRAKAYDLPEAARTARGQHVAN
CCCCCCCCCCCCHHHHHHHHEEEECCCEEEEEEECCEEEEEECCCCCHHHHHHCHHHHHH
LLAFQPEERIAQVIQIKSYEDAPYLVLATKNGLVKKSKLTEFDSNRSGGLVAVNLRDGDE
HHHCCCHHHHHHHHHHCCCCCCCEEEEECCCCCEEHHHCCCCCCCCCCCEEEEEECCCHH
LVGAVLCSAEDDLLLVSAHGQSIRFSATDEALRPMGRATSGVQGMRFNGEDDLLSLNVVR
HHHHHHCCCCCCEEEEEECCCEEEECCCHHHHHHHCCCCCCCCCCEECCCCCEEEEEEEE
EGTYLLVATSGGYSKRTAIEEYPVQGRGGKGVLTVQYDPRRGSLVGALVVDEESELYAIT
CCCEEEEEECCCCCCCCHHHHCCCCCCCCCEEEEEEECCCCCCEEEEEEEECCCCEEEEE
SGGGVIRTIAKQVRKAGRQTKGVRLMNLGEGDTLLAIAHNADEGDADPDEDAAGTTAGE
CCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8878580 [H]