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The map label for this gene is yeiG [H]

Identifier: 16765524

GI number: 16765524

Start: 2291442

End: 2292179

Strand: Direct

Name: yeiG [H]

Synonym: STM2194

Alternate gene names: 16765524

Gene position: 2291442-2292179 (Clockwise)

Preceding gene: 16765517

Following gene: 16765527

Centisome position: 47.17

GC content: 57.86

Gene sequence:

>738_bases
ATGGAAATGCTCGAAGAGCACCGATGTTTTGGCGGCTGGCAGCAGCGCTGGCGTCATCATGCCGCCACGCTAAACTGCGC
CATGACATTCAGCATTTTTCTTCCGCCGACTCAGGATAATGAACCGCCTCCGGTACTGTACTGGTTGTCTGGGTTGACCT
GCAATGATGAGAACTTTACCACCAAAGCAGGCGCGCAGCGTATCGCAGCAGAACTGGGCATTGTATTGGTGATGCCGGAT
ACCAGTCCACGCGGTGAACAGGTCGCCGACGATAGCGGATACGATTTAGGCCACGGCGCCGGGTTTTATCTCAATGCCAC
ACAGCCGCCCTGGGCCAGCCATTATCGCATGTACGATTACCTGCGCGATGAGCTTCCGGCGCTTATCCAGACACAGTTTA
ACGTCAGCGACCGTTGCGCCATCAGCGGGCACTCGATGGGCGGCCACGGCGCATTAATCATGGCGCTGAAAAATCCGGGC
AAATACACCAGCGTCTCTGCTTTTGCGCCTATCGTCAACCCCAGCCGCGTGCCGTGGGGAATCAAAGCGCTTACCGCTTA
TCTCGGCGAAGATGAATCAGCCTGGACTGAGTGGGATAGCTGCGAATTAATGCTGGCCAGCCAGCCGCAGGACGCCATTC
CTGTGCTCATCGATCAGGGCGACAGCGATCAATTCCTCGCCGATCAGCTTCAGCCCGCCGTACTGGCGGAAGCCGCGCGC
AAACCGCCTGGCCGATGA

Upstream 100 bases:

>100_bases
TATGTATTACGGAAGTGAAAGTTACTCACAACGCGGTGAATAATCTGTATTATGAAGAATCTGCATACCTTATCAGGTTC
ACTATAAAAGGAGCCCCCGC

Downstream 100 bases:

>100_bases
CGCTAAGAATCCAGCCTGGCTACGATCATAGCTATTATTTTATTGCGTCCTTCATTGAGGACCATCTGCGCTTTCATGCC
CGGTATTTACGGGACGAGCG

Product: esterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MEMLEEHRCFGGWQQRWRHHAATLNCAMTFSIFLPPTQDNEPPPVLYWLSGLTCNDENFTTKAGAQRIAAELGIVLVMPD
TSPRGEQVADDSGYDLGHGAGFYLNATQPPWASHYRMYDYLRDELPALIQTQFNVSDRCAISGHSMGGHGALIMALKNPG
KYTSVSAFAPIVNPSRVPWGIKALTAYLGEDESAWTEWDSCELMLASQPQDAIPVLIDQGDSDQFLADQLQPAVLAEAAR
KPPGR

Sequences:

>Translated_245_residues
MEMLEEHRCFGGWQQRWRHHAATLNCAMTFSIFLPPTQDNEPPPVLYWLSGLTCNDENFTTKAGAQRIAAELGIVLVMPD
TSPRGEQVADDSGYDLGHGAGFYLNATQPPWASHYRMYDYLRDELPALIQTQFNVSDRCAISGHSMGGHGALIMALKNPG
KYTSVSAFAPIVNPSRVPWGIKALTAYLGEDESAWTEWDSCELMLASQPQDAIPVLIDQGDSDQFLADQLQPAVLAEAAR
KPPGR
>Mature_245_residues
MEMLEEHRCFGGWQQRWRHHAATLNCAMTFSIFLPPTQDNEPPPVLYWLSGLTCNDENFTTKAGAQRIAAELGIVLVMPD
TSPRGEQVADDSGYDLGHGAGFYLNATQPPWASHYRMYDYLRDELPALIQTQFNVSDRCAISGHSMGGHGALIMALKNPG
KYTSVSAFAPIVNPSRVPWGIKALTAYLGEDESAWTEWDSCELMLASQPQDAIPVLIDQGDSDQFLADQLQPAVLAEAAR
KPPGR

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=235, Percent_Identity=51.9148936170213, Blast_Score=256, Evalue=2e-68,
Organism=Escherichia coli, GI1788477, Length=241, Percent_Identity=86.7219917012448, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1786551, Length=231, Percent_Identity=57.1428571428571, Blast_Score=291, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI17510185, Length=238, Percent_Identity=48.3193277310924, Blast_Score=219, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6322393, Length=258, Percent_Identity=43.7984496124031, Blast_Score=209, Evalue=5e-55,
Organism=Drosophila melanogaster, GI45551932, Length=245, Percent_Identity=50.2040816326531, Blast_Score=236, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24648347, Length=245, Percent_Identity=50.2040816326531, Blast_Score=235, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 27009; Mature: 27009

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMLEEHRCFGGWQQRWRHHAATLNCAMTFSIFLPPTQDNEPPPVLYWLSGLTCNDENFT
CCHHHHHHCCCCHHHHHHHHHHEEEEEEEEEEEECCCCCCCCCCEEEEECCEEECCCCCC
TKAGAQRIAAELGIVLVMPDTSPRGEQVADDSGYDLGHGAGFYLNATQPPWASHYRMYDY
CHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHH
LRDELPALIQTQFNVSDRCAISGHSMGGHGALIMALKNPGKYTSVSAFAPIVNPSRVPWG
HHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCCHHHCCCCCCCCCCCHH
IKALTAYLGEDESAWTEWDSCELMLASQPQDAIPVLIDQGDSDQFLADQLQPAVLAEAAR
HHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCHHHHHHCCHHHHHHHHC
KPPGR
CCCCC
>Mature Secondary Structure
MEMLEEHRCFGGWQQRWRHHAATLNCAMTFSIFLPPTQDNEPPPVLYWLSGLTCNDENFT
CCHHHHHHCCCCHHHHHHHHHHEEEEEEEEEEEECCCCCCCCCCEEEEECCEEECCCCCC
TKAGAQRIAAELGIVLVMPDTSPRGEQVADDSGYDLGHGAGFYLNATQPPWASHYRMYDY
CHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHH
LRDELPALIQTQFNVSDRCAISGHSMGGHGALIMALKNPGKYTSVSAFAPIVNPSRVPWG
HHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCCHHHCCCCCCCCCCCHH
IKALTAYLGEDESAWTEWDSCELMLASQPQDAIPVLIDQGDSDQFLADQLQPAVLAEAAR
HHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCHHHHHHCCHHHHHHHHC
KPPGR
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA