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The map label for this gene is yeiA [H]

Identifier: 16765517

GI number: 16765517

Start: 2282628

End: 2283863

Strand: Direct

Name: yeiA [H]

Synonym: STM2187

Alternate gene names: 16765517

Gene position: 2282628-2283863 (Clockwise)

Preceding gene: 16765516

Following gene: 16765524

Centisome position: 46.99

GC content: 51.13

Gene sequence:

>1236_bases
ATGTTAACAAAAGATTTGTCTGTTACCTTTTGCGGCGTTAAGTTTCCCAATCCGTTTTGTCTTTCTTCTTCTCCGGTAGG
CAATTGTTATGAGATGTGCGCCAAAGCCTATGATACCGGCTGGGGCGGGATCGTTTTTAAAACCATTGGTTTTTTTATTG
CCAACGAAGTCTCTCCACGTTTTGATCACCTGACGAAAGAAGATACCGGTTTTATTGGCTTCAAAAACATGGAGCAAATT
GCTGAGCATCCGCTGGAAGAGAATCTGGCCGCCATTCGACGGCTAAAACAGGATTATCCGGATAAGGTGCTGATTGCTTC
CATCATGGGAGAAAATGAACAGCAGTGGCAGGAACTGGCGCGTCTGGTTGAAGAAGCCGGCGCGGATATGATTGAGTGTA
ACTTCTCTTGCCCGCAGATGACCTCGCACGCCATGGGAAGCGATGTAGGGCAAAGCCCGGAACTGGTTGAAAAATACTGC
CGCGCCGTAAAACGCGGTTCATCTTTGCCAATGCTGGCGAAAATGACGCCGAATATTGGCGATATGTGCGAAGTCGCGCT
GGCCGCCAAACGCGGCGGAGCCGACGGTATCGCCACCATCAACACCGTGAAATCCATTACTAACATCGACCTGAACCGCA
AAATCGGGATGCCGGTGGTTAACGGTAAATCCAGTATCTCCGGTTATTCAGGAAAAGCGGTGAAACCCATTGCGCTGCGT
TTTATCCAGCAGTTGCGAATGCACCCTGAACTGCGCGATTTCCCGATTAGCGGTATCGGCGGCATTGAAACCTGGGAAGA
CGCTGCCGAATTTCTGCTGCTGGGCGCGGCGACCCTACAGGTGACGACAGGCATTATGCAATACGGTTATCGCATTGTAG
AAGATATGGCGAGCGGCCTCAGCCACTATCTGGCCGATCAGGGATTTGCCTCATTACAGGAGATGATCGGGCTGGCGAAT
GGCAATATTATCCCGGCGGAAGACCTGGATCGCAGCTATATCGTCTATCCGCGGATTAATCAGGAGAAATGCGTCGGCTG
CGGACGTTGCTATATCTCCTGCTATGACGGCGGTCATCAGGCGATGGAGTGGGATGAACACAGCCGCACGCCGCATTGCA
ATACGGAAAAATGCGTCGGTTGTCTGCTGTGCGGTCATGTCTGCCCGGTCGCCTGTATTGATTTAGGCGAGGTCAAATTT
AAAAAAGGCGAAAAAGAGCACGCGTTAACACTGTAG

Upstream 100 bases:

>100_bases
CTGGCGATATTGTTAAAGGTGATAAGACCGTCGTTTATGCGGTAAAAACCGGAAAAGAAGCCGCTCAGGCTATTCATCAT
TATTTAGAGGAGGCCTGCTC

Downstream 100 bases:

>100_bases
CTCTCGGTATGAAGCCCGGCGCGCAGTTTCGCTGCGCCGGGTTATCTGATAAGCAAGGCAATAGGTCTGGATAACTACTT
CTTACGCGCGTATTTCAGCG

Product: dihydropyrimidine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MLTKDLSVTFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGIVFKTIGFFIANEVSPRFDHLTKEDTGFIGFKNMEQI
AEHPLEENLAAIRRLKQDYPDKVLIASIMGENEQQWQELARLVEEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYC
RAVKRGSSLPMLAKMTPNIGDMCEVALAAKRGGADGIATINTVKSITNIDLNRKIGMPVVNGKSSISGYSGKAVKPIALR
FIQQLRMHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFASLQEMIGLAN
GNIIPAEDLDRSYIVYPRINQEKCVGCGRCYISCYDGGHQAMEWDEHSRTPHCNTEKCVGCLLCGHVCPVACIDLGEVKF
KKGEKEHALTL

Sequences:

>Translated_411_residues
MLTKDLSVTFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGIVFKTIGFFIANEVSPRFDHLTKEDTGFIGFKNMEQI
AEHPLEENLAAIRRLKQDYPDKVLIASIMGENEQQWQELARLVEEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYC
RAVKRGSSLPMLAKMTPNIGDMCEVALAAKRGGADGIATINTVKSITNIDLNRKIGMPVVNGKSSISGYSGKAVKPIALR
FIQQLRMHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFASLQEMIGLAN
GNIIPAEDLDRSYIVYPRINQEKCVGCGRCYISCYDGGHQAMEWDEHSRTPHCNTEKCVGCLLCGHVCPVACIDLGEVKF
KKGEKEHALTL
>Mature_411_residues
MLTKDLSVTFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGIVFKTIGFFIANEVSPRFDHLTKEDTGFIGFKNMEQI
AEHPLEENLAAIRRLKQDYPDKVLIASIMGENEQQWQELARLVEEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYC
RAVKRGSSLPMLAKMTPNIGDMCEVALAAKRGGADGIATINTVKSITNIDLNRKIGMPVVNGKSSISGYSGKAVKPIALR
FIQQLRMHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFASLQEMIGLAN
GNIIPAEDLDRSYIVYPRINQEKCVGCGRCYISCYDGGHQAMEWDEHSRTPHCNTEKCVGCLLCGHVCPVACIDLGEVKF
KKGEKEHALTL

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=361, Percent_Identity=35.1800554016621, Blast_Score=198, Evalue=9e-51,
Organism=Escherichia coli, GI87082059, Length=411, Percent_Identity=93.6739659367397, Blast_Score=819, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984108, Length=476, Percent_Identity=34.8739495798319, Blast_Score=249, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6322633, Length=240, Percent_Identity=27.9166666666667, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24640763, Length=310, Percent_Identity=39.0322580645161, Blast_Score=208, Evalue=5e-54,
Organism=Drosophila melanogaster, GI18858217, Length=310, Percent_Identity=39.0322580645161, Blast_Score=208, Evalue=5e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 45079; Mature: 45079

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
8.3 %Cys+Met (Translated Protein)
4.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
8.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTKDLSVTFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGIVFKTIGFFIANEVSPR
CCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHH
FDHLTKEDTGFIGFKNMEQIAEHPLEENLAAIRRLKQDYPDKVLIASIMGENEQQWQELA
HHHCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCEEHHHHHCCCHHHHHHHH
RLVEEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSSLPMLAKMTPNIG
HHHHHCCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCHH
DMCEVALAAKRGGADGIATINTVKSITNIDLNRKIGMPVVNGKSSISGYSGKAVKPIALR
HHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCCCCHHHHHH
FIQQLRMHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL
HHHHHHCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHYLADQGFASLQEMIGLANGNIIPAEDLDRSYIVYPRINQEKCVGCGRCYISCYDGGHQ
HHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCEEEEECCCHHHHCCCCEEEEEEECCCCC
AMEWDEHSRTPHCNTEKCVGCLLCGHVCPVACIDLGEVKFKKGEKEHALTL
CCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCC
>Mature Secondary Structure
MLTKDLSVTFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGIVFKTIGFFIANEVSPR
CCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHH
FDHLTKEDTGFIGFKNMEQIAEHPLEENLAAIRRLKQDYPDKVLIASIMGENEQQWQELA
HHHCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCEEHHHHHCCCHHHHHHHH
RLVEEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSSLPMLAKMTPNIG
HHHHHCCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCHH
DMCEVALAAKRGGADGIATINTVKSITNIDLNRKIGMPVVNGKSSISGYSGKAVKPIALR
HHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCCCCHHHHHH
FIQQLRMHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL
HHHHHHCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHYLADQGFASLQEMIGLANGNIIPAEDLDRSYIVYPRINQEKCVGCGRCYISCYDGGHQ
HHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCEEEEECCCHHHHCCCCEEEEEEECCCCC
AMEWDEHSRTPHCNTEKCVGCLLCGHVCPVACIDLGEVKFKKGEKEHALTL
CCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]