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The map label for this gene is umuC

Identifier: 16765333

GI number: 16765333

Start: 2079892

End: 2081160

Strand: Reverse

Name: umuC

Synonym: STM1997

Alternate gene names: 16765333

Gene position: 2081160-2079892 (Counterclockwise)

Preceding gene: 16765334

Following gene: 16765332

Centisome position: 42.84

GC content: 54.85

Gene sequence:

>1269_bases
ATGTTCGCGCTCTGCGATGTTAATAGCTTTTACGCCTCCTGCGAAACGGTCTTTCGTCCTGATTTATGTGGCCGACCGGT
GGTGGTGTTATCAAACAATGATGGCTGCGTTATCGCGTGTAGCGCCGAGGCGAAACAGCTCGGTATCGCACCAGGTGAGC
CATACTTCAAACAGAAAGAACGCTTCCGGCGATCCGGTGTTGTTTGCTTCAGCAGTAATTACGAGCTTTACGCTGATATG
TCGAACCGGGTAATGACCACACTCGAGGAGATGGTGCCGCGGGTAGAAATTTACAGCATTGATGAGGCCTTTTGTGATCT
GACGGGGGTACGAAACTGCCGGGATCTGACAGATTTCGGGCGCGAGATAAGAGCGACGGTCCTGAAGCGCACGCACCTGA
CTGTCGGTGTAGGCATTGCCCAGACGAAAACCCTTGCCAAGCTGGCTAACCATGCTGCGAAAAAGTGGCAGCGCCAGACC
GACGGGGTGGTTGACTTGTCGAACATCGATCGCCAGCGTCGGCTGCTGGCCCTGATACCCGTGGAGGATGTCTGGGGTGT
CGGCAGGCGCATCAGTAAGAAGCTCAATGCCCTGGGCATCAAGACTGCTCTCGATCTCTCTGAACAAAGTACCTGGATCA
TCAGGAAACACTTCAATGTCGTGCTGGAGCGTACCGTGAGAGAGCTTCGCGGAGAGCCATGTCTGGAGCTCGAAGAGTTT
GCGCCGGCAAAGCAGGAAATCGTTTGTAGTCGCTCTTTCGGCGAGCGGGTCACAGACTATGAGGAAATGCGCCAGGCTGT
TTACAGCTACGCTGCGCGCGCGGCAGAAAAACTCCGCGGCGAGCACCAGTACTGCCGTTTCATTTCAACATTCGTCAAAA
CATCACCCTTTGCCCTGAACGAGCCCTACTACGGTAACAGCGCCGCGGTGACGCTTCTCACCCCCACGCAGGATTCACGT
GACATTATCAATGCGGCTGTGAAATGCCTGGATAAAATATGGCGCGACGGCCATCGCTACCAGAAAGCGGGGGTGATGCT
GGGTGACTTCTTCAGTCAGGGCGTAGCGCAACTCAACCTTTTCGACGATAACGCGCCGCGCGCCGGTAGTGCGAAGTTGA
TGGAAGTACTGGACCATCTTAACGCAAAAGACGGGAAGGGGACGCTGTACTTCGCCGGGCAGGGGATGTCGCAACAGTGG
GCTATGAAGCGAGAAATGCTTTCGCCTCGGTACACCACAAGATACTCTGATCTACTGCGTGTTAAGTAA

Upstream 100 bases:

>100_bases
TCCCCATGAACGGCGCCTATCGACCTATACCTGTCGGCAGTGAAGACACGCTCGACATATTCGGGGTGGTGACCTTTATC
ATTAAAGCGGTCAGTTGATT

Downstream 100 bases:

>100_bases
CTTGTGCGATCAATGCCTGAGATGGTTGCCAAATCATCCCCGTTCTCTAACCGGTTTTGGTCGCACAAGATCACAGGAAC
CTCTCACGATGAGGCGCATG

Product: DNA polymerase V subunit UmuC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MFALCDVNSFYASCETVFRPDLCGRPVVVLSNNDGCVIACSAEAKQLGIAPGEPYFKQKERFRRSGVVCFSSNYELYADM
SNRVMTTLEEMVPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRATVLKRTHLTVGVGIAQTKTLAKLANHAAKKWQRQT
DGVVDLSNIDRQRRLLALIPVEDVWGVGRRISKKLNALGIKTALDLSEQSTWIIRKHFNVVLERTVRELRGEPCLELEEF
APAKQEIVCSRSFGERVTDYEEMRQAVYSYAARAAEKLRGEHQYCRFISTFVKTSPFALNEPYYGNSAAVTLLTPTQDSR
DIINAAVKCLDKIWRDGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRAGSAKLMEVLDHLNAKDGKGTLYFAGQGMSQQW
AMKREMLSPRYTTRYSDLLRVK

Sequences:

>Translated_422_residues
MFALCDVNSFYASCETVFRPDLCGRPVVVLSNNDGCVIACSAEAKQLGIAPGEPYFKQKERFRRSGVVCFSSNYELYADM
SNRVMTTLEEMVPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRATVLKRTHLTVGVGIAQTKTLAKLANHAAKKWQRQT
DGVVDLSNIDRQRRLLALIPVEDVWGVGRRISKKLNALGIKTALDLSEQSTWIIRKHFNVVLERTVRELRGEPCLELEEF
APAKQEIVCSRSFGERVTDYEEMRQAVYSYAARAAEKLRGEHQYCRFISTFVKTSPFALNEPYYGNSAAVTLLTPTQDSR
DIINAAVKCLDKIWRDGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRAGSAKLMEVLDHLNAKDGKGTLYFAGQGMSQQW
AMKREMLSPRYTTRYSDLLRVK
>Mature_422_residues
MFALCDVNSFYASCETVFRPDLCGRPVVVLSNNDGCVIACSAEAKQLGIAPGEPYFKQKERFRRSGVVCFSSNYELYADM
SNRVMTTLEEMVPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRATVLKRTHLTVGVGIAQTKTLAKLANHAAKKWQRQT
DGVVDLSNIDRQRRLLALIPVEDVWGVGRRISKKLNALGIKTALDLSEQSTWIIRKHFNVVLERTVRELRGEPCLELEEF
APAKQEIVCSRSFGERVTDYEEMRQAVYSYAARAAEKLRGEHQYCRFISTFVKTSPFALNEPYYGNSAAVTLLTPTQDSR
DIINAAVKCLDKIWRDGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRAGSAKLMEVLDHLNAKDGKGTLYFAGQGMSQQW
AMKREMLSPRYTTRYSDLLRVK

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain

Homologues:

Organism=Escherichia coli, GI1787432, Length=422, Percent_Identity=83.6492890995261, Blast_Score=752, Evalue=0.0,
Organism=Escherichia coli, GI1786425, Length=217, Percent_Identity=23.963133640553, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UMUC_SALTY (P22494)

Other databases:

- EMBL:   M57431
- EMBL:   AE006468
- PIR:   B36713
- RefSeq:   NP_460948.1
- ProteinModelPortal:   P22494
- SMR:   P22494
- GeneID:   1253518
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM1997
- NMPDR:   fig|99287.1.peg.1929
- HOGENOM:   HBG679885
- OMA:   PGEPYFK
- ProtClustDB:   PRK03609
- BioCyc:   STYP99287:STM1997-MONOMER
- HAMAP:   MF_01113
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- PANTHER:   PTHR11076

Pfam domain/function: PF00817 IMS; SSF100879 DNA_pol_Y-fam_little_finger

EC number: 3.4.21.-

Molecular weight: Translated: 47728; Mature: 47728

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFALCDVNSFYASCETVFRPDLCGRPVVVLSNNDGCVIACSAEAKQLGIAPGEPYFKQKE
CEEEECCHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCHHHCCCCCCCCHHHHHH
RFRRSGVVCFSSNYELYADMSNRVMTTLEEMVPRVEIYSIDEAFCDLTGVRNCRDLTDFG
HHHHCCEEEEECCCEEEECHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCHHHHHHHH
REIRATVLKRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTDGVVDLSNIDRQRRLLALIP
HHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHCCCHHHEEEEEC
VEDVWGVGRRISKKLNALGIKTALDLSEQSTWIIRKHFNVVLERTVRELRGEPCLELEEF
CHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
APAKQEIVCSRSFGERVTDYEEMRQAVYSYAARAAEKLRGEHQYCRFISTFVKTSPFALN
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCC
EPYYGNSAAVTLLTPTQDSRDIINAAVKCLDKIWRDGHRYQKAGVMLGDFFSQGVAQLNL
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHCCHHEEEE
FDDNAPRAGSAKLMEVLDHLNAKDGKGTLYFAGQGMSQQWAMKREMLSPRYTTRYSDLLR
ECCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHC
VK
CC
>Mature Secondary Structure
MFALCDVNSFYASCETVFRPDLCGRPVVVLSNNDGCVIACSAEAKQLGIAPGEPYFKQKE
CEEEECCHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCHHHCCCCCCCCHHHHHH
RFRRSGVVCFSSNYELYADMSNRVMTTLEEMVPRVEIYSIDEAFCDLTGVRNCRDLTDFG
HHHHCCEEEEECCCEEEECHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCHHHHHHHH
REIRATVLKRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTDGVVDLSNIDRQRRLLALIP
HHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHCCCHHHEEEEEC
VEDVWGVGRRISKKLNALGIKTALDLSEQSTWIIRKHFNVVLERTVRELRGEPCLELEEF
CHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
APAKQEIVCSRSFGERVTDYEEMRQAVYSYAARAAEKLRGEHQYCRFISTFVKTSPFALN
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCC
EPYYGNSAAVTLLTPTQDSRDIINAAVKCLDKIWRDGHRYQKAGVMLGDFFSQGVAQLNL
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHCCHHEEEE
FDDNAPRAGSAKLMEVLDHLNAKDGKGTLYFAGQGMSQQWAMKREMLSPRYTTRYSDLLR
ECCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHC
VK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2144275; 2203737; 11677609