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The map label for this gene is umuD

Identifier: 16765334

GI number: 16765334

Start: 2081163

End: 2081582

Strand: Reverse

Name: umuD

Synonym: STM1998

Alternate gene names: 16765334

Gene position: 2081582-2081163 (Counterclockwise)

Preceding gene: 16765335

Following gene: 16765333

Centisome position: 42.85

GC content: 50.24

Gene sequence:

>420_bases
ATGGAATTTTTCAGACCTACAGAGTTGCGCGAAATTATTCCTCTCCCATTTTTCAGTTACTTAGTGCCGTGTGGATTCCC
CAGCCCCGCGGCGGACTACATTGAGCAGCGTATCGATCTTAATGAGTTGCTCGTTTCTCATCCCAGCTCAACATATTTTG
TCAAAGCCTCGGGGGATTCAATGATTGAAGCAGGCATCAGCGACGGTGACCTGCTGGTGGTGGATAGCTCACGGAACGCT
GACCACGGTGACATTGTAATTGCGGCAATTGAAGGAGAGTTCACCGTAAAACGGTTGCAGTTGCGCCCGACAGTGCAGTT
AATCCCCATGAACGGCGCCTATCGACCTATACCTGTCGGCAGTGAAGACACGCTCGACATATTCGGGGTGGTGACCTTTA
TCATTAAAGCGGTCAGTTGA

Upstream 100 bases:

>100_bases
CGAAGCGACGAAGATTTAAACAGTCGTAGCGACTCCGGTATCTTGCGCGCATGTTCAAATAACACTACTGTATATAAAAA
CAGTATTCGAGGTATGGATT

Downstream 100 bases:

>100_bases
TTATGTTCGCGCTCTGCGATGTTAATAGCTTTTACGCCTCCTGCGAAACGGTCTTTCGTCCTGATTTATGTGGCCGACCG
GTGGTGGTGTTATCAAACAA

Product: DNA polymerase V subunit UmuD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 139; Mature: 139

Protein sequence:

>139_residues
MEFFRPTELREIIPLPFFSYLVPCGFPSPAADYIEQRIDLNELLVSHPSSTYFVKASGDSMIEAGISDGDLLVVDSSRNA
DHGDIVIAAIEGEFTVKRLQLRPTVQLIPMNGAYRPIPVGSEDTLDIFGVVTFIIKAVS

Sequences:

>Translated_139_residues
MEFFRPTELREIIPLPFFSYLVPCGFPSPAADYIEQRIDLNELLVSHPSSTYFVKASGDSMIEAGISDGDLLVVDSSRNA
DHGDIVIAAIEGEFTVKRLQLRPTVQLIPMNGAYRPIPVGSEDTLDIFGVVTFIIKAVS
>Mature_139_residues
MEFFRPTELREIIPLPFFSYLVPCGFPSPAADYIEQRIDLNELLVSHPSSTYFVKASGDSMIEAGISDGDLLVVDSSRNA
DHGDIVIAAIEGEFTVKRLQLRPTVQLIPMNGAYRPIPVGSEDTLDIFGVVTFIIKAVS

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family

Homologues:

Organism=Escherichia coli, GI1787431, Length=138, Percent_Identity=73.1884057971015, Blast_Score=218, Evalue=8e-59,
Organism=Escherichia coli, GI1790476, Length=117, Percent_Identity=34.1880341880342, Blast_Score=65, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UMUD_SALTY (P22493)

Other databases:

- EMBL:   M57431
- EMBL:   AE006468
- PIR:   A36713
- RefSeq:   NP_460949.1
- ProteinModelPortal:   P22493
- SMR:   P22493
- MEROPS:   S24.003
- GeneID:   1253519
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM1998
- NMPDR:   fig|99287.1.peg.1930
- HOGENOM:   HBG679610
- OMA:   DIAVCFL
- ProtClustDB:   PRK10276
- BioCyc:   STYP99287:STM1998-MONOMER
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- Gene3D:   G3DSA:2.10.109.10
- PRINTS:   PR00726

Pfam domain/function: PF00717 Peptidase_S24; SSF51306 Pept_S24_S26_C

EC number: 3.4.21.-

Molecular weight: Translated: 15289; Mature: 15289

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: NA

Important sites: ACT_SITE 60-60 ACT_SITE 97-97

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFFRPTELREIIPLPFFSYLVPCGFPSPAADYIEQRIDLNELLVSHPSSTYFVKASGDS
CCCCCCCCHHHHCCCCHHHHHHCCCCCCCHHHHHHHHCCHHHHHHCCCCCEEEEEECCCC
MIEAGISDGDLLVVDSSRNADHGDIVIAAIEGEFTVKRLQLRPTVQLIPMNGAYRPIPVG
EEECCCCCCCEEEEECCCCCCCCCEEEEEECCCEEEEEEEECCCEEEEECCCCCCCCCCC
SEDTLDIFGVVTFIIKAVS
CCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEFFRPTELREIIPLPFFSYLVPCGFPSPAADYIEQRIDLNELLVSHPSSTYFVKASGDS
CCCCCCCCHHHHCCCCHHHHHHCCCCCCCHHHHHHHHCCHHHHHHCCCCCEEEEEECCCC
MIEAGISDGDLLVVDSSRNADHGDIVIAAIEGEFTVKRLQLRPTVQLIPMNGAYRPIPVG
EEECCCCCCCEEEEECCCCCCCCCEEEEEECCCEEEEEEEECCCEEEEECCCCCCCCCCC
SEDTLDIFGVVTFIIKAVS
CCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2144275; 2203737; 11677609; 1910151