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The map label for this gene is frdB [H]

Identifier: 167625801

GI number: 167625801

Start: 4729259

End: 4730002

Strand: Reverse

Name: frdB [H]

Synonym: Shal_3896

Alternate gene names: 167625801

Gene position: 4730002-4729259 (Counterclockwise)

Preceding gene: 167625802

Following gene: 167625800

Centisome position: 90.49

GC content: 48.12

Gene sequence:

>744_bases
ATGAGCCAAGAAACGGCAAAGGGCCGTACCTTAACTTTCAATATTTTTAGATATGATCCGCAGGTACCGGGCGACAAACC
TAAGATGGTGAAATACCAGCTTGAAGAGGCGCCTGGCATGACGGTGTTTATTGCACTGAATCGTTTGCGCGAGGAGCAAG
ACACCTCATTGCAGTTTGACTTCGTTTGCCGTGCAGGGATCTGCGGTAGCTGCGCCATGGTGATCAACGGTTTTCCTACC
TTGGCTTGTCGTACACTGACCGCTAAGTACCCTAAAGGTGAAATCAACCTAATGCCATTACCTGGGTTTGAGCTAATAGG
CGATCTATCGGTGAATACGGGTAAGTTTATGCGTGAACTTGCTGAGCGTCTAAAGCTCTGGTTACACCCAATTAGTGATG
ACATCGATGTGCATCGTTTAGAAGCACCAATGGATCCAGCCGAAGCCGCTAAGCTGTATGAGCTAGAACGCTGCGTTGAA
TGTGGTGTGTGCGTTTCTGCCTGTGCGACTAAGCAGATGCGTGACACCTTTGTGGGCGCTGTGGGTATGATGAAGTTGGC
ACGTTTTGAACTCGATAGCCGAGATGGACGTGAGCTTGAAGATTTTTATCACGTGATTGGTAATCAAGATGGAGTGTTTG
GTTGTATGACGCTACTGGGTTGCCAAGATAACTGCCCTAAAGACTTACCGCACATGCAGCAGATTGCGTATCTACGTCGT
AAGATGGCTGTGACATTAGTCTAG

Upstream 100 bases:

>100_bases
AAAATGCATTAATGCCGTTTGATGTGCCAGAATCATTAAAACCAAAGAATGAACGCTTGAGTGAGATGCTTGAAAACTTG
AGCGCAGGAGAGATCGCTAA

Downstream 100 bases:

>100_bases
TTCATACCAGATTATAATGATGTTATAACGTTTAAAGCCTGCTTTCGCAGGCTTTTTTAATGGGTGACGTTTAGCGCAGT
ATTATCTACAATTTGCTTTA

Product: fumarate reductase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MSQETAKGRTLTFNIFRYDPQVPGDKPKMVKYQLEEAPGMTVFIALNRLREEQDTSLQFDFVCRAGICGSCAMVINGFPT
LACRTLTAKYPKGEINLMPLPGFELIGDLSVNTGKFMRELAERLKLWLHPISDDIDVHRLEAPMDPAEAAKLYELERCVE
CGVCVSACATKQMRDTFVGAVGMMKLARFELDSRDGRELEDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRR
KMAVTLV

Sequences:

>Translated_247_residues
MSQETAKGRTLTFNIFRYDPQVPGDKPKMVKYQLEEAPGMTVFIALNRLREEQDTSLQFDFVCRAGICGSCAMVINGFPT
LACRTLTAKYPKGEINLMPLPGFELIGDLSVNTGKFMRELAERLKLWLHPISDDIDVHRLEAPMDPAEAAKLYELERCVE
CGVCVSACATKQMRDTFVGAVGMMKLARFELDSRDGRELEDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRR
KMAVTLV
>Mature_246_residues
SQETAKGRTLTFNIFRYDPQVPGDKPKMVKYQLEEAPGMTVFIALNRLREEQDTSLQFDFVCRAGICGSCAMVINGFPTL
ACRTLTAKYPKGEINLMPLPGFELIGDLSVNTGKFMRELAERLKLWLHPISDDIDVHRLEAPMDPAEAAKLYELERCVEC
GVCVSACATKQMRDTFVGAVGMMKLARFELDSRDGRELEDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRRK
MAVTLV

Specific function: The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=240, Percent_Identity=31.6666666666667, Blast_Score=110, Evalue=8e-25,
Organism=Escherichia coli, GI1786943, Length=234, Percent_Identity=33.7606837606838, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1790596, Length=224, Percent_Identity=28.125, Blast_Score=106, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17533915, Length=234, Percent_Identity=29.4871794871795, Blast_Score=113, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6322987, Length=238, Percent_Identity=29.8319327731092, Blast_Score=112, Evalue=7e-26,
Organism=Drosophila melanogaster, GI17137106, Length=247, Percent_Identity=28.3400809716599, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24643156, Length=244, Percent_Identity=29.0983606557377, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 27773; Mature: 27642

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00197 2FE2S_FER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
9.7 %Cys+Met (Translated Protein)
4.5 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
9.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQETAKGRTLTFNIFRYDPQVPGDKPKMVKYQLEEAPGMTVFIALNRLREEQDTSLQFD
CCCCCCCCCEEEEEEEEECCCCCCCCCCCEEEECCCCCCCEEEEEEHHHHHHHCCCEEEE
FVCRAGICGSCAMVINGFPTLACRTLTAKYPKGEINLMPLPGFELIGDLSVNTGKFMREL
EEECCCCCHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEECCCHHHEECCCCCHHHHHHHH
AERLKLWLHPISDDIDVHRLEAPMDPAEAAKLYELERCVECGVCVSACATKQMRDTFVGA
HHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGMMKLARFELDSRDGRELEDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRR
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
KMAVTLV
HHHHCCC
>Mature Secondary Structure 
SQETAKGRTLTFNIFRYDPQVPGDKPKMVKYQLEEAPGMTVFIALNRLREEQDTSLQFD
CCCCCCCCEEEEEEEEECCCCCCCCCCCEEEECCCCCCCEEEEEEHHHHHHHCCCEEEE
FVCRAGICGSCAMVINGFPTLACRTLTAKYPKGEINLMPLPGFELIGDLSVNTGKFMREL
EEECCCCCHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEECCCHHHEECCCCCHHHHHHHH
AERLKLWLHPISDDIDVHRLEAPMDPAEAAKLYELERCVECGVCVSACATKQMRDTFVGA
HHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGMMKLARFELDSRDGRELEDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRR
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
KMAVTLV
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2244791; 9492313; 14500908; 10586875; 11248702 [H]