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The map label for this gene is frdA [H]

Identifier: 167625802

GI number: 167625802

Start: 4729999

End: 4731999

Strand: Reverse

Name: frdA [H]

Synonym: Shal_3897

Alternate gene names: 167625802

Gene position: 4731999-4729999 (Counterclockwise)

Preceding gene: 167625803

Following gene: 167625801

Centisome position: 90.53

GC content: 49.58

Gene sequence:

>2001_bases
GTGAAACTGATATATACCGATTCATTAGTGATCGGCGCCGGACTTGCTGGATTACGAGTAGCTATCGCATCTAAAGAGCG
TGGCCTAGATACTGTTGTATTGTCATTAATTCCTGCTAAACGCTCGCACTCTGCGGCGGCGCAAGGTGGTATGCAAGCGA
GTTTGGGCAATACCGTAAAAGGCATGGGAGATGATGAGGATGTCCATTTCCAAGATACGGTAAAAGGTTCTGACTGGGGC
TGCGATCAAGATGTGGCGCGTATGTTTGCTCATTGTGCGCCGAAAGCCGTGCGTGAACTAGCGAACTGGGGCGTACCTTG
GACGCGTGTAACCGCTGGCCCACGTCAAGTAGTCGTGAATGCAGAGAAGGTCACCATTGAGGAAGCCGAGAGTGCTCATG
GTCTTATCAACGCCCGAGACTTTGGTGGCACTAAGAAGTGGCGTACTTGCTACACGGCAGATGGTACCGGTCACTCGTTA
CTTTACGCGGTAGATAACAAAGCCATTTCGATGGATATTCCTGTGCATGAGCGCATGGAAGCGTTATCACTTATTCATGA
CGGTACACGCTGTCACGGTGTGGTGGCTCGTTGCCTGATCACTGGCGAGCTGCATGCCTATGTGGCTAAGTCGACCACCA
TAGCAACCGGCGGCTATGGTCGTATTTATGAAGTGTCTACCAATGCGATTATTTGTGAAGGCGTTGGTCAAGCGTTGGCA
CTCGAAACTGGCGTTGCTAAGCTCGGTAACATGGAAGCGGTGCAGTTCCACCCAACGGCGATTGTTCCAGTCGGTATTTT
GACGACCGAGGGTTGTCGTGGTGATGGTGGTTTATTGCGTGACAAAGACGGTCACCGTTTTATGCCAGATTACGAGCCAG
AGAAGAAAGAGCTGGCCTCACGTGATGTGGTATCACGCCGTATGACCGAACATATGCGTAAAGGCAAAGGTGTCGATAGC
CCCTATGGTCCACACTTATGGCTGGATATCACCTTGCTTGGACGTAAGCATGTTGAAACTAACCTACGAGAAGTGAAAGA
GATCTGTGAGAACTTCTTAGGTATCGATCCGGCTAAAGATTGGATCCCGGTAAGACCGACTCAGCATTACTCTATGGGTG
GTATTCGTACCGATAAGACAGGACAAAGCCCACAACTTAAAGGTCTGTTCAGTGTTGGTGAGGCCGCCTGTTGGGATATG
CATGGCTTTAACCGTCTTGGTGGTAACTCGCTAGCCGAAACGGTTGTTGGTGGCATGATTATCGGTAAGTATGTGGCCGA
TTTCTGTCAGGACAATACCTTAGAGATCAACACTGGGCTTGTTGAGACGTTTGTCGACAAGGTGCGCAGTGAAATTGATG
AACTAGTCGAAGGTCAAGGCACTGAGAGTCCATTTGTTATCCGTAAAGAGATGGAGCGGATCATGATGGATTACGTCGGT
ATTTTCCGTAACGGTCCAGAGCTAGAAAAAGCGGTGGCTGAGCTGCAAGAGTTACTTAAGCGCTCACGTGTTATCGGCCT
TAAATGTAAGAAGCGTCATGCGAACCCTGAGCTGGTAGAAGCATTGCGTGTTAAACGTATGATTAAAGTTGCATTGACTG
TTGCGTCAGGCGCAGCAGCACGTACAGAGAGCCGTGGTGCCCATGCCCGAGAAGACTTCCCGCAGCGTAACGATAAAGAT
TGGTTAAACCGCACCTTATCGAGCTGGCCTGATGAGAATAGTTTGTCACCTGAGCTTGAGTATGAGCAACTAGATGTGAT
GAAGATGGAGCTGCCTCCGGGTTATCGCGGTTACGGTATCGATAATGCGATTGCCCACCCAGATACGGCCAAGCGTGAGC
AGGAGATCAGTGAGATCTTAGCTCAGCTAGGGACTGATGCCGACAGGCATCAGCAGCAAAATGCATTAATGCCGTTTGAT
GTGCCAGAATCATTAAAACCAAAGAATGAACGCTTGAGTGAGATGCTTGAAAACTTGAGCGCAGGAGAGATCGCTAAATG
A

Upstream 100 bases:

>100_bases
GCCTGGCGTCACTACTGGCGTTCTTGCCTTACGCCAATGTGTAAACTGCTGATAATAAAAAAACATAAACTGACTCTGCA
CCCTACTTTAAGGAGCACGT

Downstream 100 bases:

>100_bases
GCCAAGAAACGGCAAAGGGCCGTACCTTAACTTTCAATATTTTTAGATATGATCCGCAGGTACCGGGCGACAAACCTAAG
ATGGTGAAATACCAGCTTGA

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 666; Mature: 666

Protein sequence:

>666_residues
MKLIYTDSLVIGAGLAGLRVAIASKERGLDTVVLSLIPAKRSHSAAAQGGMQASLGNTVKGMGDDEDVHFQDTVKGSDWG
CDQDVARMFAHCAPKAVRELANWGVPWTRVTAGPRQVVVNAEKVTIEEAESAHGLINARDFGGTKKWRTCYTADGTGHSL
LYAVDNKAISMDIPVHERMEALSLIHDGTRCHGVVARCLITGELHAYVAKSTTIATGGYGRIYEVSTNAIICEGVGQALA
LETGVAKLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGHRFMPDYEPEKKELASRDVVSRRMTEHMRKGKGVDS
PYGPHLWLDITLLGRKHVETNLREVKEICENFLGIDPAKDWIPVRPTQHYSMGGIRTDKTGQSPQLKGLFSVGEAACWDM
HGFNRLGGNSLAETVVGGMIIGKYVADFCQDNTLEINTGLVETFVDKVRSEIDELVEGQGTESPFVIRKEMERIMMDYVG
IFRNGPELEKAVAELQELLKRSRVIGLKCKKRHANPELVEALRVKRMIKVALTVASGAAARTESRGAHAREDFPQRNDKD
WLNRTLSSWPDENSLSPELEYEQLDVMKMELPPGYRGYGIDNAIAHPDTAKREQEISEILAQLGTDADRHQQQNALMPFD
VPESLKPKNERLSEMLENLSAGEIAK

Sequences:

>Translated_666_residues
MKLIYTDSLVIGAGLAGLRVAIASKERGLDTVVLSLIPAKRSHSAAAQGGMQASLGNTVKGMGDDEDVHFQDTVKGSDWG
CDQDVARMFAHCAPKAVRELANWGVPWTRVTAGPRQVVVNAEKVTIEEAESAHGLINARDFGGTKKWRTCYTADGTGHSL
LYAVDNKAISMDIPVHERMEALSLIHDGTRCHGVVARCLITGELHAYVAKSTTIATGGYGRIYEVSTNAIICEGVGQALA
LETGVAKLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGHRFMPDYEPEKKELASRDVVSRRMTEHMRKGKGVDS
PYGPHLWLDITLLGRKHVETNLREVKEICENFLGIDPAKDWIPVRPTQHYSMGGIRTDKTGQSPQLKGLFSVGEAACWDM
HGFNRLGGNSLAETVVGGMIIGKYVADFCQDNTLEINTGLVETFVDKVRSEIDELVEGQGTESPFVIRKEMERIMMDYVG
IFRNGPELEKAVAELQELLKRSRVIGLKCKKRHANPELVEALRVKRMIKVALTVASGAAARTESRGAHAREDFPQRNDKD
WLNRTLSSWPDENSLSPELEYEQLDVMKMELPPGYRGYGIDNAIAHPDTAKREQEISEILAQLGTDADRHQQQNALMPFD
VPESLKPKNERLSEMLENLSAGEIAK
>Mature_666_residues
MKLIYTDSLVIGAGLAGLRVAIASKERGLDTVVLSLIPAKRSHSAAAQGGMQASLGNTVKGMGDDEDVHFQDTVKGSDWG
CDQDVARMFAHCAPKAVRELANWGVPWTRVTAGPRQVVVNAEKVTIEEAESAHGLINARDFGGTKKWRTCYTADGTGHSL
LYAVDNKAISMDIPVHERMEALSLIHDGTRCHGVVARCLITGELHAYVAKSTTIATGGYGRIYEVSTNAIICEGVGQALA
LETGVAKLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGHRFMPDYEPEKKELASRDVVSRRMTEHMRKGKGVDS
PYGPHLWLDITLLGRKHVETNLREVKEICENFLGIDPAKDWIPVRPTQHYSMGGIRTDKTGQSPQLKGLFSVGEAACWDM
HGFNRLGGNSLAETVVGGMIIGKYVADFCQDNTLEINTGLVETFVDKVRSEIDELVEGQGTESPFVIRKEMERIMMDYVG
IFRNGPELEKAVAELQELLKRSRVIGLKCKKRHANPELVEALRVKRMIKVALTVASGAAARTESRGAHAREDFPQRNDKD
WLNRTLSSWPDENSLSPELEYEQLDVMKMELPPGYRGYGIDNAIAHPDTAKREQEISEILAQLGTDADRHQQQNALMPFD
VPESLKPKNERLSEMLENLSAGEIAK

Specific function: The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=545, Percent_Identity=37.4311926605505, Blast_Score=324, Evalue=1e-88,
Organism=Escherichia coli, GI1786942, Length=606, Percent_Identity=37.1287128712871, Blast_Score=329, Evalue=3e-91,
Organism=Escherichia coli, GI1790597, Length=583, Percent_Identity=36.3636363636364, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI1788928, Length=561, Percent_Identity=29.7682709447415, Blast_Score=179, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17505833, Length=552, Percent_Identity=38.2246376811594, Blast_Score=327, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI17550100, Length=546, Percent_Identity=37.9120879120879, Blast_Score=316, Evalue=3e-86,
Organism=Saccharomyces cerevisiae, GI6322701, Length=597, Percent_Identity=36.1809045226131, Blast_Score=332, Evalue=8e-92,
Organism=Saccharomyces cerevisiae, GI6322416, Length=590, Percent_Identity=36.1016949152542, Blast_Score=329, Evalue=7e-91,
Organism=Drosophila melanogaster, GI17137288, Length=607, Percent_Identity=36.7380560131796, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI24655642, Length=607, Percent_Identity=36.7380560131796, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI24655647, Length=607, Percent_Identity=36.7380560131796, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI24663005, Length=574, Percent_Identity=34.8432055749129, Blast_Score=287, Evalue=1e-77,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 73228; Mature: 73228

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIYTDSLVIGAGLAGLRVAIASKERGLDTVVLSLIPAKRSHSAAAQGGMQASLGNTVK
CEEEEECCHHHHCCHHHHEEEECCCCCCHHHHHHHHHCCCCCCHHHHHCCCHHHCCCCCC
GMGDDEDVHFQDTVKGSDWGCDQDVARMFAHCAPKAVRELANWGVPWTRVTAGPRQVVVN
CCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCCCCEEECCCCCEEEEE
AEKVTIEEAESAHGLINARDFGGTKKWRTCYTADGTGHSLLYAVDNKAISMDIPVHERME
CHHEEHHHHHHHCCCEECCCCCCCCCCCEEEECCCCCCEEEEEECCCEEEEECCHHHHHH
ALSLIHDGTRCHGVVARCLITGELHAYVAKSTTIATGGYGRIYEVSTNAIICEGVGQALA
HHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCEEEECCCCEEEEEECCEEEECCCCCHHH
LETGVAKLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGHRFMPDYEPEKKELAS
HHHHHHHHCCCCEEEECCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
RDVVSRRMTEHMRKGKGVDSPYGPHLWLDITLLGRKHVETNLREVKEICENFLGIDPAKD
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
WIPVRPTQHYSMGGIRTDKTGQSPQLKGLFSVGEAACWDMHGFNRLGGNSLAETVVGGMI
CCCCCCCCCCCCCCEECCCCCCCCCHHHHHHHCCHHHHCCCCCHHCCCHHHHHHHHHHHH
IGKYVADFCQDNTLEINTGLVETFVDKVRSEIDELVEGQGTESPFVIRKEMERIMMDYVG
HHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
IFRNGPELEKAVAELQELLKRSRVIGLKCKKRHANPELVEALRVKRMIKVALTVASGAAA
HHCCCHHHHHHHHHHHHHHHHCCEECEEHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHH
RTESRGAHAREDFPQRNDKDWLNRTLSSWPDENSLSPELEYEQLDVMKMELPPGYRGYGI
CCCCCCCCCHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHCEEEEECCCCCCCCCC
DNAIAHPDTAKREQEISEILAQLGTDADRHQQQNALMPFDVPESLKPKNERLSEMLENLS
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCC
AGEIAK
CCCCCC
>Mature Secondary Structure
MKLIYTDSLVIGAGLAGLRVAIASKERGLDTVVLSLIPAKRSHSAAAQGGMQASLGNTVK
CEEEEECCHHHHCCHHHHEEEECCCCCCHHHHHHHHHCCCCCCHHHHHCCCHHHCCCCCC
GMGDDEDVHFQDTVKGSDWGCDQDVARMFAHCAPKAVRELANWGVPWTRVTAGPRQVVVN
CCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCCCCEEECCCCCEEEEE
AEKVTIEEAESAHGLINARDFGGTKKWRTCYTADGTGHSLLYAVDNKAISMDIPVHERME
CHHEEHHHHHHHCCCEECCCCCCCCCCCEEEECCCCCCEEEEEECCCEEEEECCHHHHHH
ALSLIHDGTRCHGVVARCLITGELHAYVAKSTTIATGGYGRIYEVSTNAIICEGVGQALA
HHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCEEEECCCCEEEEEECCEEEECCCCCHHH
LETGVAKLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGHRFMPDYEPEKKELAS
HHHHHHHHCCCCEEEECCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
RDVVSRRMTEHMRKGKGVDSPYGPHLWLDITLLGRKHVETNLREVKEICENFLGIDPAKD
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
WIPVRPTQHYSMGGIRTDKTGQSPQLKGLFSVGEAACWDMHGFNRLGGNSLAETVVGGMI
CCCCCCCCCCCCCCEECCCCCCCCCHHHHHHHCCHHHHCCCCCHHCCCHHHHHHHHHHHH
IGKYVADFCQDNTLEINTGLVETFVDKVRSEIDELVEGQGTESPFVIRKEMERIMMDYVG
HHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
IFRNGPELEKAVAELQELLKRSRVIGLKCKKRHANPELVEALRVKRMIKVALTVASGAAA
HHCCCHHHHHHHHHHHHHHHHCCEECEEHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHH
RTESRGAHAREDFPQRNDKDWLNRTLSSWPDENSLSPELEYEQLDVMKMELPPGYRGYGI
CCCCCCCCCHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHCEEEEECCCCCCCCCC
DNAIAHPDTAKREQEISEILAQLGTDADRHQQQNALMPFDVPESLKPKNERLSEMLENLS
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCC
AGEIAK
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2244791; 9492313; 14500908; 3609021; 10586875; 11248702 [H]