Click here to switch to the map view.

The map label for this gene is mepA [H]

Identifier: 167625002

GI number: 167625002

Start: 3769546

End: 3770922

Strand: Reverse

Name: mepA [H]

Synonym: Shal_3089

Alternate gene names: 167625002

Gene position: 3770922-3769546 (Counterclockwise)

Preceding gene: 167625003

Following gene: 167625001

Centisome position: 72.14

GC content: 49.31

Gene sequence:

>1377_bases
ATGGCCATGACCCACCCAATGCCGCCAGCTGACGTAAACCGAGTCGCAGTCGACTCGCCTATGATCACCGAGCCAATAGG
CAAGCTATTTTGGCGTTATAGCATACCGACAATTCTATCTATGCTGGTGACGGGGATTTACGTCACCATCGACGGTATGT
TTATCGGCCATTACTTGGGCGAAGTTGGCCTAGCGGGCATGATCTTGGCCTATCCCATCGCTGCCGTGCTCTATGCTATT
GGCGCAACACTAGGAATGGGGGGCGCCGCCTTGGTGTCCATTCATCAAGGGCAAGGTGAGCCCCATATTGCCCGGCGTAT
ACTGGGTAACACTTTTAGTTTGTGCTTGATCTCAGGGCTTATCACTACGGTACTCGGTTGTTATTTCTCAAGGGATATCT
TGGTGTTGCTTGGCGCCGAGGGCGAGATCCTAAGCAGTGCTGATGACTATCTATTTTGGTATTTTGCCTTAGGCACATTT
CCCATCGTGTCGATGGCATTTACCACACTACTGCGAAATGACGGTCGCCCCGGGTTCGTTACCTTTGTTTTAATTTTAGG
AGGCGTGCTCAATACCGTCCTCGATTGGTTGTTAATCGTAGTGTTCCCTTATGGATTGATGGGAGCGGCGATTGCGACCA
TGATTTCCCAAGCCGTGACGGGCGCGCTGTGCCTACAGCATTTCTTTTCGAGTCGAACCGAAATCGGTATTAACCTTGAG
CAGATGAAGCTCAAGTGGGATCACTGCGTCAATATTATCCGTGTTGGCACACCAAGCTTCTTAATGAATATGTACCTGAC
CGTGGTGCTGACCCTGCACAATGTGGCATTTCTCACGGTGGGTACGCCGCTGCATGTTGCTGCATATGGAGTGGTGAGTT
ATACCGAGGCCTTCTTTTACCTGTTGTTTGAAGGTATCGCCTTTGGTGTACAGCCGATCTTAAGTTTTAACGCTGGGGCA
AAACGCTTTGATAGAGTGAAACAGGCGTTGAAGATGGCTTTTTCTGTGACCTTGGTTTGTGCGGCGCTTGGATTAGTCTT
TATCTATTCGGTGCCACAGCTGTTTGTGTATATCTTTGCTGGCGATAACGCCTTACTCACGCCGATTGCCACTGAGGGAA
TGCGCTGGTATTTCTGGGGTTTACCGATGGAGGGCTTGTTATTAGTTGGCGCCTCTTTCTTCCAAGCGATCAATTATTCA
AAAGAGGCCTCGATTTTAACTGGGGCCAAACTGATCCTGTTTGCAGCTATTTTGTATCTGTTTGCTTGGGCTTTCGGTGT
GCCGGGGGTATGGATTTCACTGGCAACCTGTAGCACTATTTTGGTTATCTGGATGGCGTGGATAATGAAGCGCACCCATG
CAAAACTATCAGCATGA

Upstream 100 bases:

>100_bases
ACCTGTTTTACGCTCTTGCATGTTAACTCTTAGATATTTCGAGTATCTTATGAGTGATTAAAGAGCTGTAAATCGGCGAA
AAAATAACAATAATAAGAGA

Downstream 100 bases:

>100_bases
GAATTAGCCTAACGCTTGTCTGGCATTAGCTATAGAAGCTTGCCATTGGAGATGGCATAGAATACGCCTAAGCCATTAAT
TTTAGTCTATTCATCATTCG

Product: MATE efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MAMTHPMPPADVNRVAVDSPMITEPIGKLFWRYSIPTILSMLVTGIYVTIDGMFIGHYLGEVGLAGMILAYPIAAVLYAI
GATLGMGGAALVSIHQGQGEPHIARRILGNTFSLCLISGLITTVLGCYFSRDILVLLGAEGEILSSADDYLFWYFALGTF
PIVSMAFTTLLRNDGRPGFVTFVLILGGVLNTVLDWLLIVVFPYGLMGAAIATMISQAVTGALCLQHFFSSRTEIGINLE
QMKLKWDHCVNIIRVGTPSFLMNMYLTVVLTLHNVAFLTVGTPLHVAAYGVVSYTEAFFYLLFEGIAFGVQPILSFNAGA
KRFDRVKQALKMAFSVTLVCAALGLVFIYSVPQLFVYIFAGDNALLTPIATEGMRWYFWGLPMEGLLLVGASFFQAINYS
KEASILTGAKLILFAAILYLFAWAFGVPGVWISLATCSTILVIWMAWIMKRTHAKLSA

Sequences:

>Translated_458_residues
MAMTHPMPPADVNRVAVDSPMITEPIGKLFWRYSIPTILSMLVTGIYVTIDGMFIGHYLGEVGLAGMILAYPIAAVLYAI
GATLGMGGAALVSIHQGQGEPHIARRILGNTFSLCLISGLITTVLGCYFSRDILVLLGAEGEILSSADDYLFWYFALGTF
PIVSMAFTTLLRNDGRPGFVTFVLILGGVLNTVLDWLLIVVFPYGLMGAAIATMISQAVTGALCLQHFFSSRTEIGINLE
QMKLKWDHCVNIIRVGTPSFLMNMYLTVVLTLHNVAFLTVGTPLHVAAYGVVSYTEAFFYLLFEGIAFGVQPILSFNAGA
KRFDRVKQALKMAFSVTLVCAALGLVFIYSVPQLFVYIFAGDNALLTPIATEGMRWYFWGLPMEGLLLVGASFFQAINYS
KEASILTGAKLILFAAILYLFAWAFGVPGVWISLATCSTILVIWMAWIMKRTHAKLSA
>Mature_457_residues
AMTHPMPPADVNRVAVDSPMITEPIGKLFWRYSIPTILSMLVTGIYVTIDGMFIGHYLGEVGLAGMILAYPIAAVLYAIG
ATLGMGGAALVSIHQGQGEPHIARRILGNTFSLCLISGLITTVLGCYFSRDILVLLGAEGEILSSADDYLFWYFALGTFP
IVSMAFTTLLRNDGRPGFVTFVLILGGVLNTVLDWLLIVVFPYGLMGAAIATMISQAVTGALCLQHFFSSRTEIGINLEQ
MKLKWDHCVNIIRVGTPSFLMNMYLTVVLTLHNVAFLTVGTPLHVAAYGVVSYTEAFFYLLFEGIAFGVQPILSFNAGAK
RFDRVKQALKMAFSVTLVCAALGLVFIYSVPQLFVYIFAGDNALLTPIATEGMRWYFWGLPMEGLLLVGASFFQAINYSK
EASILTGAKLILFAAILYLFAWAFGVPGVWISLATCSTILVIWMAWIMKRTHAKLSA

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49953; Mature: 49822

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMTHPMPPADVNRVAVDSPMITEPIGKLFWRYSIPTILSMLVTGIYVTIDGMFIGHYLG
CCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVGLAGMILAYPIAAVLYAIGATLGMGGAALVSIHQGQGEPHIARRILGNTFSLCLISGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEECCCCCHHHHHHHHCCHHHHHHHHHH
ITTVLGCYFSRDILVLLGAEGEILSSADDYLFWYFALGTFPIVSMAFTTLLRNDGRPGFV
HHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
TFVLILGGVLNTVLDWLLIVVFPYGLMGAAIATMISQAVTGALCLQHFFSSRTEIGINLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
QMKLKWDHCVNIIRVGTPSFLMNMYLTVVLTLHNVAFLTVGTPLHVAAYGVVSYTEAFFY
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHH
LLFEGIAFGVQPILSFNAGAKRFDRVKQALKMAFSVTLVCAALGLVFIYSVPQLFVYIFA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEE
GDNALLTPIATEGMRWYFWGLPMEGLLLVGASFFQAINYSKEASILTGAKLILFAAILYL
CCCEEECCHHCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
FAWAFGVPGVWISLATCSTILVIWMAWIMKRTHAKLSA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AMTHPMPPADVNRVAVDSPMITEPIGKLFWRYSIPTILSMLVTGIYVTIDGMFIGHYLG
CCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVGLAGMILAYPIAAVLYAIGATLGMGGAALVSIHQGQGEPHIARRILGNTFSLCLISGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEECCCCCHHHHHHHHCCHHHHHHHHHH
ITTVLGCYFSRDILVLLGAEGEILSSADDYLFWYFALGTFPIVSMAFTTLLRNDGRPGFV
HHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
TFVLILGGVLNTVLDWLLIVVFPYGLMGAAIATMISQAVTGALCLQHFFSSRTEIGINLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
QMKLKWDHCVNIIRVGTPSFLMNMYLTVVLTLHNVAFLTVGTPLHVAAYGVVSYTEAFFY
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHH
LLFEGIAFGVQPILSFNAGAKRFDRVKQALKMAFSVTLVCAALGLVFIYSVPQLFVYIFA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEE
GDNALLTPIATEGMRWYFWGLPMEGLLLVGASFFQAINYSKEASILTGAKLILFAAILYL
CCCEEECCHHCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
FAWAFGVPGVWISLATCSTILVIWMAWIMKRTHAKLSA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA