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The map label for this gene is bioF [H]

Identifier: 167624398

GI number: 167624398

Start: 2977034

End: 2978227

Strand: Reverse

Name: bioF [H]

Synonym: Shal_2476

Alternate gene names: 167624398

Gene position: 2978227-2977034 (Counterclockwise)

Preceding gene: 167624399

Following gene: 167624397

Centisome position: 56.98

GC content: 45.56

Gene sequence:

>1194_bases
ATGTCAGAAAGTTCCAAATACCAGCCGTTAGTTGAGTCCTTGAGTGCTAGAGTCATCAATAAAAACCAAGCGCTAGAGCA
ACAAGGCCTACTTCGACGACGCATTAATCTTGTGCTGGACCCTAATCAGTCAAATTACTTTGAAGCCGATGCGCTGCCAT
ATGTTAATTTCAGTAGTAACGACTATCTAGGCCTATCAACATCCCCAGAGTTAGCCGAGGCGCTTTATCAAGGTGCCAAA
CAGCACGGTGTTGGCAGTACTGCCTCGCCATTGGTTGTTGGTTATAGCGAAGCACATTTACAACTAGAACAAGCCTTATG
TGAAGCGACTGGACATGAAGCCGCACTATTATTTTGCTCAGGTTTTAGCGCCAATAACGCACTAATGAAGACCTTGTTCA
ATGAAAATGACCTAGTGCTGGCCGACAAATTGATCCATGCCTCTGTGATCGATGGTATTCAGGACAGTGGCGCTAAGCTG
AAACGCTTTAGCCATAACGATGTCGATAGTGCTAAGAGCCATTTAGAGCGATTCTCGCCAAGTGCATTGCTGACCGAAAG
TCTATTTAGTATGGATGGTGATATTGCCCCTTTGGCTGAGCTGTCTGCGCTTTGTCAGCAGCATAATGCTTGGTTGATAG
TCGACGATGCTCATGGTTTTGGGGTGCTAGGCGAAAATGGTTTTGGTGCAACAAGGATTGCAAACGATATTAATATTGAC
GCTCAGTTAGTGACGTTCGGTAAGGCAATGGGAGGCCAAGGCGCAGCAATTCTTGGAAGCCAAGCATTAATTGATTTCTT
AGTGGCAAATTCTCGTCACTATATATACTCAACAGCTTTGTCGCCAGCTTGCGCTGCAGCGGCCTTGGCCGCAATCAATA
TGATTAAGCAGCAACCAGAACTTCGACAGAAATTGAATGATAATATTGCCTGCTTTAGAGCCGCTTGCTTAGAAAGTAAT
ATTGAACTTTCAGACTCGCAAACGGCAATTCAGCCAATCTTACTCGGCGATACAACTAAGACGATGGCGGTGGCTAAAAG
GCTAAAAGAGCACGGTTTCTGGTTAGGCGCGATTCGGCCGCCAACCGTACCAGTCGGAAGCGCAAGATTAAGATTGACCT
TAAATGCTAATCACTGCCAGCAAGATATTCTGGCGTTAGTGGATGTGTTGGCCGCTATCTTAAATGATGAATGA

Upstream 100 bases:

>100_bases
TGCGCTTTAATTTAATTGTCATAAGCCAATATTACAAAAACCCGCCAAAGATAAACGGTGGGTTTACAAGGCCACAGAGC
CTTTTAACTGAGCATACTAA

Downstream 100 bases:

>100_bases
TTAGGATCCAATGCAGTGAATACAGGATCAAGTAAACTTAATCACCAAGTTGCAGCGTGCTTCTCTGCCGCCGCAGCACA
TTACCATAGCTATGATGTAC

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MSESSKYQPLVESLSARVINKNQALEQQGLLRRRINLVLDPNQSNYFEADALPYVNFSSNDYLGLSTSPELAEALYQGAK
QHGVGSTASPLVVGYSEAHLQLEQALCEATGHEAALLFCSGFSANNALMKTLFNENDLVLADKLIHASVIDGIQDSGAKL
KRFSHNDVDSAKSHLERFSPSALLTESLFSMDGDIAPLAELSALCQQHNAWLIVDDAHGFGVLGENGFGATRIANDINID
AQLVTFGKAMGGQGAAILGSQALIDFLVANSRHYIYSTALSPACAAAALAAINMIKQQPELRQKLNDNIACFRAACLESN
IELSDSQTAIQPILLGDTTKTMAVAKRLKEHGFWLGAIRPPTVPVGSARLRLTLNANHCQQDILALVDVLAAILNDE

Sequences:

>Translated_397_residues
MSESSKYQPLVESLSARVINKNQALEQQGLLRRRINLVLDPNQSNYFEADALPYVNFSSNDYLGLSTSPELAEALYQGAK
QHGVGSTASPLVVGYSEAHLQLEQALCEATGHEAALLFCSGFSANNALMKTLFNENDLVLADKLIHASVIDGIQDSGAKL
KRFSHNDVDSAKSHLERFSPSALLTESLFSMDGDIAPLAELSALCQQHNAWLIVDDAHGFGVLGENGFGATRIANDINID
AQLVTFGKAMGGQGAAILGSQALIDFLVANSRHYIYSTALSPACAAAALAAINMIKQQPELRQKLNDNIACFRAACLESN
IELSDSQTAIQPILLGDTTKTMAVAKRLKEHGFWLGAIRPPTVPVGSARLRLTLNANHCQQDILALVDVLAAILNDE
>Mature_396_residues
SESSKYQPLVESLSARVINKNQALEQQGLLRRRINLVLDPNQSNYFEADALPYVNFSSNDYLGLSTSPELAEALYQGAKQ
HGVGSTASPLVVGYSEAHLQLEQALCEATGHEAALLFCSGFSANNALMKTLFNENDLVLADKLIHASVIDGIQDSGAKLK
RFSHNDVDSAKSHLERFSPSALLTESLFSMDGDIAPLAELSALCQQHNAWLIVDDAHGFGVLGENGFGATRIANDINIDA
QLVTFGKAMGGQGAAILGSQALIDFLVANSRHYIYSTALSPACAAAALAAINMIKQQPELRQKLNDNIACFRAACLESNI
ELSDSQTAIQPILLGDTTKTMAVAKRLKEHGFWLGAIRPPTVPVGSARLRLTLNANHCQQDILALVDVLAAILNDE

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=363, Percent_Identity=30.0275482093664, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI284448556, Length=344, Percent_Identity=30.8139534883721, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI83977442, Length=343, Percent_Identity=32.6530612244898, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI83977440, Length=343, Percent_Identity=32.6530612244898, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI83977444, Length=343, Percent_Identity=32.6530612244898, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI4502025, Length=334, Percent_Identity=32.0359281437126, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI40316939, Length=334, Percent_Identity=32.0359281437126, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI4758668, Length=349, Percent_Identity=27.5071633237822, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI119220554, Length=358, Percent_Identity=26.2569832402235, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI5454084, Length=261, Percent_Identity=28.735632183908, Blast_Score=102, Evalue=6e-22,
Organism=Escherichia coli, GI1786993, Length=354, Percent_Identity=46.3276836158192, Blast_Score=285, Evalue=3e-78,
Organism=Escherichia coli, GI1790046, Length=384, Percent_Identity=31.5104166666667, Blast_Score=211, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI71994529, Length=347, Percent_Identity=32.2766570605187, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI32566772, Length=414, Percent_Identity=24.1545893719807, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17560912, Length=381, Percent_Identity=25.7217847769029, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17560914, Length=381, Percent_Identity=25.7217847769029, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71982625, Length=277, Percent_Identity=24.187725631769, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71982617, Length=277, Percent_Identity=24.187725631769, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320438, Length=378, Percent_Identity=28.5714285714286, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6320267, Length=364, Percent_Identity=23.9010989010989, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323954, Length=252, Percent_Identity=26.1904761904762, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24662918, Length=333, Percent_Identity=33.9339339339339, Blast_Score=204, Evalue=8e-53,
Organism=Drosophila melanogaster, GI17137420, Length=391, Percent_Identity=31.7135549872123, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI17136286, Length=366, Percent_Identity=28.9617486338798, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24653280, Length=274, Percent_Identity=25.9124087591241, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24653276, Length=274, Percent_Identity=25.9124087591241, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24653278, Length=274, Percent_Identity=25.9124087591241, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 42656; Mature: 42525

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESSKYQPLVESLSARVINKNQALEQQGLLRRRINLVLDPNQSNYFEADALPYVNFSSN
CCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEECCCCCCCEECCCCEEEECCCC
DYLGLSTSPELAEALYQGAKQHGVGSTASPLVVGYSEAHLQLEQALCEATGHEAALLFCS
CEECCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHCCCCCEEEEEEE
GFSANNALMKTLFNENDLVLADKLIHASVIDGIQDSGAKLKRFSHNDVDSAKSHLERFSP
CCCCCHHHHHHHCCCCCEEEHHHHHHHHHHHCHHCCCHHHHHCCCCCHHHHHHHHHHCCC
SALLTESLFSMDGDIAPLAELSALCQQHNAWLIVDDAHGFGVLGENGFGATRIANDINID
HHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEECCCCCEEECCCCCCHHHCCCCCCCC
AQLVTFGKAMGGQGAAILGSQALIDFLVANSRHYIYSTALSPACAAAALAAINMIKQQPE
EEEEEHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHCCHH
LRQKLNDNIACFRAACLESNIELSDSQTAIQPILLGDTTKTMAVAKRLKEHGFWLGAIRP
HHHHHCCCHHHHHHHHHHCCCCCCCCCHHHCEEEECCCHHHHHHHHHHHHCCEEEECCCC
PTVPVGSARLRLTLNANHCQQDILALVDVLAAILNDE
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SESSKYQPLVESLSARVINKNQALEQQGLLRRRINLVLDPNQSNYFEADALPYVNFSSN
CCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEECCCCCCCEECCCCEEEECCCC
DYLGLSTSPELAEALYQGAKQHGVGSTASPLVVGYSEAHLQLEQALCEATGHEAALLFCS
CEECCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHCCCCCEEEEEEE
GFSANNALMKTLFNENDLVLADKLIHASVIDGIQDSGAKLKRFSHNDVDSAKSHLERFSP
CCCCCHHHHHHHCCCCCEEEHHHHHHHHHHHCHHCCCHHHHHCCCCCHHHHHHHHHHCCC
SALLTESLFSMDGDIAPLAELSALCQQHNAWLIVDDAHGFGVLGENGFGATRIANDINID
HHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEECCCCCEEECCCCCCHHHCCCCCCCC
AQLVTFGKAMGGQGAAILGSQALIDFLVANSRHYIYSTALSPACAAAALAAINMIKQQPE
EEEEEHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHCCHH
LRQKLNDNIACFRAACLESNIELSDSQTAIQPILLGDTTKTMAVAKRLKEHGFWLGAIRP
HHHHHCCCHHHHHHHHHHCCCCCCCCCHHHCEEEECCCHHHHHHHHHHHHCCEEEECCCC
PTVPVGSARLRLTLNANHCQQDILALVDVLAAILNDE
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA