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The map label for this gene is edd [H]

Identifier: 167623881

GI number: 167623881

Start: 2344974

End: 2346800

Strand: Direct

Name: edd [H]

Synonym: Shal_1951

Alternate gene names: 167623881

Gene position: 2344974-2346800 (Clockwise)

Preceding gene: 167623880

Following gene: 167623882

Centisome position: 44.86

GC content: 48.44

Gene sequence:

>1827_bases
ATGCACAGCGTTGTACAATCTGTTACCGACAGAATTATTGAACGAAGCAAAGATTCTCGCGCTAAATACTTAGCGGCGCT
CGATGATGCTAAAAATAAAGGTGTTCACCGCAGTGCATTAAGCTGCGGTAACTTAGCGCACGGTTTCGCAGCATGTAATC
CAGCCGACAAGTCTTCTATCAAGCAATTGAATAAGGCCAATATCGGTATCATCACCTCATTTAACGATATGCTGTCAGCA
CACCAACCTTATGGTGAATATCCTGACTTGTTGAAACAAGCCTGTCATGACGTCGGCAGTGTTGCCCAAGTCGCCGGTGG
CGTTCCCGCTATGTGTGACGGCGTAACACAAGGCCAGCCTGGTATGGAACTGAGTCTGCTAAGCCGCGAAGTGATTGCCA
TGGCAACTGCTGTGGGCTTATCTCACAACATGTTCGATGGTGCACTATTACTGGGTATCTGTGACAAGATTGTGCCAGGT
CTATTGATTGGCGCACTTAGCTTCGGTCACCTACCTATGTTGTTTGTGCCTGCGGGTCCAATGAAGTCAGGTATTCCAAA
CAAAGAAAAGGCACGTATTCGTCAGCAATATGCCCAAGGTGAAGTCGACAGGGCAGCGCTTTTAGAGGCAGAGTCTAAGT
CTTACCACAGTGCGGGGACTTGTACTTTCTACGGTACAGCCAACAGTAATCAGTTAATGCTCGAGGTCATGGGCCTTCAG
CTACCAGGTTCATCTTTTGTCAATCCTGATGACCCATTGCGCGAAGTATTAAGTAAAACTGCCGCTAAGCAGGTTTGCCG
TCTAACCGAAATGGGCACCCAGTACACACCTATCGGTAAAGTGGTATCTGAAAAGTCAGTAGTGAACGGTATTGTGGCGT
TATTGGCTACGGGTGGTTCAACTAACCTAACCATGCACATCGTTGCCGCAGCGCGCGCTGCAGGTATCATAGTAAACTGG
GATGATTTCTCAGAGCTTTCGGATGCCGTGCCTCTACTTGCACGCGTTTACCCGAACGGACACGCTGACATTAACCATTT
CCACGCCGCTGGCGGTATGGCGTTCTTGATTAAAGAGCTGTTAGATGGTGGCTTGCTACATGAAGATGTCGACACCGTGG
CAGGCTTTGGACTTAAGCGTTATACCCAAGAGCCGCAAATTCGTGATGGCGAACTAACATGGGTTGATGGTCAGCAAACA
AGTTTAGACACTGAAGTGCTAACGAGTCTCGATAAGCCATTCCAGAGTAATGGCGGTCTTAAACTGCTTAAAGGTAACCT
TGGCCGCGCAGTGATTAAAGTCTCTGCAGTACAAGAGCAGCATCGAGTTGTTGAAGCGCCAGCCGTTGTTATTGACGATC
AAAACAAGCTTGAAGCCATTTTCAAAGCTGGTGATTTAGACAAAGATTGCGTGGTTGTGGTCAAAGGCCAAGGCCCTAAA
GCCATTGGTATGCCGGAGCTACATAAGCTGACGCCAATCTTAGGTACGCTGCAAGATAGAGGCTTCAAGGTTGCATTACT
GACTGACGGTCGTATGTCGGGCGCATCGGGCAAAGTACCAGCCGCTATCCATTTAACGCCAGAGGCGCTAGATGGCGGTT
TAATTGCTAAGATCCATACTGGCGACTTAGTACGAGTGAACGCCACAACGGGAGAGTTAACGCTACTGGTTGATGAAGCG
GAACTTAATGCAAGAACGGCTGAGAAGGTCGATTTGCATAAGACGAGTTACGGTATGGGTCGAGAGTTATTCGGTGCACT
GCGCGCTAACCTAAGTAGTCCTGAAACTGGTGCCCGTTGCACTAGCGCAATTGATGAAAACTATTAA

Upstream 100 bases:

>100_bases
AGCACTAGCAAGCGATGACTGTCGTGAAATGCCTATCCGAGCGGTGCTCGGCCAGCATAAAACGCCTGTTGATGTTTACT
GGAGCGCTTAAGGAGTAATT

Downstream 100 bases:

>100_bases
CGTTTAAGGAAGAGTAACGCAATGCTTGAGAATAACTGGTCAATACAGCCACAAGATATTTTTAAACGCAGCCCTATTGT
TCCTGTCATGGTGATCAATA

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MHSVVQSVTDRIIERSKDSRAKYLAALDDAKNKGVHRSALSCGNLAHGFAACNPADKSSIKQLNKANIGIITSFNDMLSA
HQPYGEYPDLLKQACHDVGSVAQVAGGVPAMCDGVTQGQPGMELSLLSREVIAMATAVGLSHNMFDGALLLGICDKIVPG
LLIGALSFGHLPMLFVPAGPMKSGIPNKEKARIRQQYAQGEVDRAALLEAESKSYHSAGTCTFYGTANSNQLMLEVMGLQ
LPGSSFVNPDDPLREVLSKTAAKQVCRLTEMGTQYTPIGKVVSEKSVVNGIVALLATGGSTNLTMHIVAAARAAGIIVNW
DDFSELSDAVPLLARVYPNGHADINHFHAAGGMAFLIKELLDGGLLHEDVDTVAGFGLKRYTQEPQIRDGELTWVDGQQT
SLDTEVLTSLDKPFQSNGGLKLLKGNLGRAVIKVSAVQEQHRVVEAPAVVIDDQNKLEAIFKAGDLDKDCVVVVKGQGPK
AIGMPELHKLTPILGTLQDRGFKVALLTDGRMSGASGKVPAAIHLTPEALDGGLIAKIHTGDLVRVNATTGELTLLVDEA
ELNARTAEKVDLHKTSYGMGRELFGALRANLSSPETGARCTSAIDENY

Sequences:

>Translated_608_residues
MHSVVQSVTDRIIERSKDSRAKYLAALDDAKNKGVHRSALSCGNLAHGFAACNPADKSSIKQLNKANIGIITSFNDMLSA
HQPYGEYPDLLKQACHDVGSVAQVAGGVPAMCDGVTQGQPGMELSLLSREVIAMATAVGLSHNMFDGALLLGICDKIVPG
LLIGALSFGHLPMLFVPAGPMKSGIPNKEKARIRQQYAQGEVDRAALLEAESKSYHSAGTCTFYGTANSNQLMLEVMGLQ
LPGSSFVNPDDPLREVLSKTAAKQVCRLTEMGTQYTPIGKVVSEKSVVNGIVALLATGGSTNLTMHIVAAARAAGIIVNW
DDFSELSDAVPLLARVYPNGHADINHFHAAGGMAFLIKELLDGGLLHEDVDTVAGFGLKRYTQEPQIRDGELTWVDGQQT
SLDTEVLTSLDKPFQSNGGLKLLKGNLGRAVIKVSAVQEQHRVVEAPAVVIDDQNKLEAIFKAGDLDKDCVVVVKGQGPK
AIGMPELHKLTPILGTLQDRGFKVALLTDGRMSGASGKVPAAIHLTPEALDGGLIAKIHTGDLVRVNATTGELTLLVDEA
ELNARTAEKVDLHKTSYGMGRELFGALRANLSSPETGARCTSAIDENY
>Mature_608_residues
MHSVVQSVTDRIIERSKDSRAKYLAALDDAKNKGVHRSALSCGNLAHGFAACNPADKSSIKQLNKANIGIITSFNDMLSA
HQPYGEYPDLLKQACHDVGSVAQVAGGVPAMCDGVTQGQPGMELSLLSREVIAMATAVGLSHNMFDGALLLGICDKIVPG
LLIGALSFGHLPMLFVPAGPMKSGIPNKEKARIRQQYAQGEVDRAALLEAESKSYHSAGTCTFYGTANSNQLMLEVMGLQ
LPGSSFVNPDDPLREVLSKTAAKQVCRLTEMGTQYTPIGKVVSEKSVVNGIVALLATGGSTNLTMHIVAAARAAGIIVNW
DDFSELSDAVPLLARVYPNGHADINHFHAAGGMAFLIKELLDGGLLHEDVDTVAGFGLKRYTQEPQIRDGELTWVDGQQT
SLDTEVLTSLDKPFQSNGGLKLLKGNLGRAVIKVSAVQEQHRVVEAPAVVIDDQNKLEAIFKAGDLDKDCVVVVKGQGPK
AIGMPELHKLTPILGTLQDRGFKVALLTDGRMSGASGKVPAAIHLTPEALDGGLIAKIHTGDLVRVNATTGELTLLVDEA
ELNARTAEKVDLHKTSYGMGRELFGALRANLSSPETGARCTSAIDENY

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=602, Percent_Identity=66.6112956810631, Blast_Score=849, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=572, Percent_Identity=29.020979020979, Blast_Score=183, Evalue=3e-47,
Organism=Escherichia coli, GI2367371, Length=480, Percent_Identity=31.25, Blast_Score=161, Evalue=9e-41,
Organism=Escherichia coli, GI1786464, Length=471, Percent_Identity=28.6624203821656, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6322476, Length=476, Percent_Identity=29.4117647058824, Blast_Score=169, Evalue=9e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 64535; Mature: 64535

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSVVQSVTDRIIERSKDSRAKYLAALDDAKNKGVHRSALSCGNLAHGFAACNPADKSSI
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCHHHCHHCCCCCCHHHH
KQLNKANIGIITSFNDMLSAHQPYGEYPDLLKQACHDVGSVAQVAGGVPAMCDGVTQGQP
HHHHCCCCEEEECHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCC
GMELSLLSREVIAMATAVGLSHNMFDGALLLGICDKIVPGLLIGALSFGHLPMLFVPAGP
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
MKSGIPNKEKARIRQQYAQGEVDRAALLEAESKSYHSAGTCTFYGTANSNQLMLEVMGLQ
CCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCEEEEECCCCCEEEEEEECEE
LPGSSFVNPDDPLREVLSKTAAKQVCRLTEMGTQYTPIGKVVSEKSVVNGIVALLATGGS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
TNLTMHIVAAARAAGIIVNWDDFSELSDAVPLLARVYPNGHADINHFHAAGGMAFLIKEL
CCEEEEEEEEHHHCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHH
LDGGLLHEDVDTVAGFGLKRYTQEPQIRDGELTWVDGQQTSLDTEVLTSLDKPFQSNGGL
HCCCCCHHHHHHHHCCCHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCCE
KLLKGNLGRAVIKVSAVQEQHRVVEAPAVVIDDQNKLEAIFKAGDLDKDCVVVVKGQGPK
EEEECCCCCEEEEHHHHHHHHHHHHCCEEEECCCHHHHHHHHCCCCCCCEEEEEECCCCC
AIGMPELHKLTPILGTLQDRGFKVALLTDGRMSGASGKVPAAIHLTPEALDGGLIAKIHT
CCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECHHHCCCCEEEEEEC
GDLVRVNATTGELTLLVDEAELNARTAEKVDLHKTSYGMGRELFGALRANLSSPETGARC
CCEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHH
TSAIDENY
HHHHCCCC
>Mature Secondary Structure
MHSVVQSVTDRIIERSKDSRAKYLAALDDAKNKGVHRSALSCGNLAHGFAACNPADKSSI
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCHHHCHHCCCCCCHHHH
KQLNKANIGIITSFNDMLSAHQPYGEYPDLLKQACHDVGSVAQVAGGVPAMCDGVTQGQP
HHHHCCCCEEEECHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCC
GMELSLLSREVIAMATAVGLSHNMFDGALLLGICDKIVPGLLIGALSFGHLPMLFVPAGP
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
MKSGIPNKEKARIRQQYAQGEVDRAALLEAESKSYHSAGTCTFYGTANSNQLMLEVMGLQ
CCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCEEEEECCCCCEEEEEEECEE
LPGSSFVNPDDPLREVLSKTAAKQVCRLTEMGTQYTPIGKVVSEKSVVNGIVALLATGGS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
TNLTMHIVAAARAAGIIVNWDDFSELSDAVPLLARVYPNGHADINHFHAAGGMAFLIKEL
CCEEEEEEEEHHHCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHH
LDGGLLHEDVDTVAGFGLKRYTQEPQIRDGELTWVDGQQTSLDTEVLTSLDKPFQSNGGL
HCCCCCHHHHHHHHCCCHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCCE
KLLKGNLGRAVIKVSAVQEQHRVVEAPAVVIDDQNKLEAIFKAGDLDKDCVVVVKGQGPK
EEEECCCCCEEEEHHHHHHHHHHHHCCEEEECCCHHHHHHHHCCCCCCCEEEEEECCCCC
AIGMPELHKLTPILGTLQDRGFKVALLTDGRMSGASGKVPAAIHLTPEALDGGLIAKIHT
CCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECHHHCCCCEEEEEEC
GDLVRVNATTGELTLLVDEAELNARTAEKVDLHKTSYGMGRELFGALRANLSSPETGARC
CCEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHH
TSAIDENY
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]