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The map label for this gene is zwf [H]

Identifier: 167623879

GI number: 167623879

Start: 2342777

End: 2344249

Strand: Direct

Name: zwf [H]

Synonym: Shal_1949

Alternate gene names: 167623879

Gene position: 2342777-2344249 (Clockwise)

Preceding gene: 167623876

Following gene: 167623880

Centisome position: 44.82

GC content: 45.96

Gene sequence:

>1473_bases
ATGGGCATAACGACACCAAAAGCCAAAGCTTGTGATTTTGTTCTATTTGGTACCAAGGGAGATCTTGCCAAGCGTAAGTT
ACTTCCTTCTTTATACCAACTTGATAAAGCAAACTTACTGAATGTCGATACGAAGATCCTCGGCGTTGCAAAAGATGACT
TTAGTCAGGAAGAATATCGCGAGTTAGTCATCACCGCATTAAACACCTTTGTTAAAGATGAACTCTGTGAAGAGACAGTG
AATCGCTTCTTGGACCGTTGTCACTATATCGGAACAAACTTCACGGTTTCTGATGGTTACCAAGCTTTCCATGATATTTT
AGAGCCCGAGAAGCGGGTCATGGTGAGTTACTTCGCGACGCCGCCAGCCATCTTCGGCGATATTTGTCGTTGCCTCCACG
AACAAAATCTTATCTTCCCTGACTCTCGTGTTGTTTTAGAAAAGCCAATCGGCTCCGATCTCGAAAGCTCTCGCATCATT
AACGACCAAGTCTCAGCTTATTTCGAAGAAAACCAAGTCTATCGCATCGACCATTACCTAGGTAAAGAGACGGTACAGAA
TTTACTTGCACTGCGTTTTGCTAACTCTTTATTTGCCTCTAAGTGGGATAACCGTACTATTGACCATGTGCAACTCACCG
TTGCTGAAGAAGTGGGTATCGAAGGCCGTTGGGGTTATTTCGATAAAGCGGGTCAGATGCGCGATATGATCCAAAACCAC
TTGCTACAGGTATTAACCCTTGTGGCGATGGATCCTCCCGTTAACTTAGATGCTGACAACATCCGTGATGAAAAAGTAAA
AGTACTTAAGTCACTGCGTCCAATTAACGCCGACAACATCTATGAGAACACGGTTCGTGGCCAATATAGTTCAGGCTTCC
TTAAAGGCGCACCGGTTCCTGGTTATCTCGAAGAAGAGGGTGCGAACGTTCAGTCTAAGGCTGAAACTTTTGTTGCACTT
CGCGTCGATATCGATAACTGGCGTTGGGCTGGCGTGCCATTCTACTTACGTAGTGGTAAGCGTATGCCGTTTAAGAGCTC
AGAAATTGTGGTCTATTTTAAGAACCCACCGCACAACCTATACAGCTCGAACTACCGTAACCTGCCACCAAACAAATTGA
CGATTCGATTACAGCCTCATGAAGGGGTTGAAATCCAGATGCTTAACAAGGTGCCAGGTCTTGGTGAAAAGCAACGCTTG
CAAACCACTAAACTGGATTTAAGCTTCTCTGAGACCTTCAAAAACGAACGTATTGCCGATGCCTACGAGCGTTTATTACT
TGAAGCTATGCTTGGCAATCAGGCGTTATTTGTGCGCCGTGATGAAGTTGAGCAAGCTTGGAGCTGGGTAGACGGCATTA
TTCAGGCGTGGGAAGAGACCGACGAAAAGCCAAAGCCTTACCCTGCGGGTACATGGGGACCTGTGGCGTCTGTCGCGCTT
ATCACTAAAGATGGCCGTTCTTGGGACGAGTAA

Upstream 100 bases:

>100_bases
ATTTAGATGCAATTACTGATTTCTGTTGTTATATTACAACAAACGTGTGAATTCTCGTCAAACATGATGAGGCACAGTGT
CAAAAGGAGATTTTGAAGCT

Downstream 100 bases:

>100_bases
GGTGAAACCGATGATTAAAGAAACTGTTTTCAAATCATTTGACAATAAAGAAGCACTCGAAGCACAACTGGCGGAGCGTA
TTGCCAATCAACTGCAAGAC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MGITTPKAKACDFVLFGTKGDLAKRKLLPSLYQLDKANLLNVDTKILGVAKDDFSQEEYRELVITALNTFVKDELCEETV
NRFLDRCHYIGTNFTVSDGYQAFHDILEPEKRVMVSYFATPPAIFGDICRCLHEQNLIFPDSRVVLEKPIGSDLESSRII
NDQVSAYFEENQVYRIDHYLGKETVQNLLALRFANSLFASKWDNRTIDHVQLTVAEEVGIEGRWGYFDKAGQMRDMIQNH
LLQVLTLVAMDPPVNLDADNIRDEKVKVLKSLRPINADNIYENTVRGQYSSGFLKGAPVPGYLEEEGANVQSKAETFVAL
RVDIDNWRWAGVPFYLRSGKRMPFKSSEIVVYFKNPPHNLYSSNYRNLPPNKLTIRLQPHEGVEIQMLNKVPGLGEKQRL
QTTKLDLSFSETFKNERIADAYERLLLEAMLGNQALFVRRDEVEQAWSWVDGIIQAWEETDEKPKPYPAGTWGPVASVAL
ITKDGRSWDE

Sequences:

>Translated_490_residues
MGITTPKAKACDFVLFGTKGDLAKRKLLPSLYQLDKANLLNVDTKILGVAKDDFSQEEYRELVITALNTFVKDELCEETV
NRFLDRCHYIGTNFTVSDGYQAFHDILEPEKRVMVSYFATPPAIFGDICRCLHEQNLIFPDSRVVLEKPIGSDLESSRII
NDQVSAYFEENQVYRIDHYLGKETVQNLLALRFANSLFASKWDNRTIDHVQLTVAEEVGIEGRWGYFDKAGQMRDMIQNH
LLQVLTLVAMDPPVNLDADNIRDEKVKVLKSLRPINADNIYENTVRGQYSSGFLKGAPVPGYLEEEGANVQSKAETFVAL
RVDIDNWRWAGVPFYLRSGKRMPFKSSEIVVYFKNPPHNLYSSNYRNLPPNKLTIRLQPHEGVEIQMLNKVPGLGEKQRL
QTTKLDLSFSETFKNERIADAYERLLLEAMLGNQALFVRRDEVEQAWSWVDGIIQAWEETDEKPKPYPAGTWGPVASVAL
ITKDGRSWDE
>Mature_489_residues
GITTPKAKACDFVLFGTKGDLAKRKLLPSLYQLDKANLLNVDTKILGVAKDDFSQEEYRELVITALNTFVKDELCEETVN
RFLDRCHYIGTNFTVSDGYQAFHDILEPEKRVMVSYFATPPAIFGDICRCLHEQNLIFPDSRVVLEKPIGSDLESSRIIN
DQVSAYFEENQVYRIDHYLGKETVQNLLALRFANSLFASKWDNRTIDHVQLTVAEEVGIEGRWGYFDKAGQMRDMIQNHL
LQVLTLVAMDPPVNLDADNIRDEKVKVLKSLRPINADNIYENTVRGQYSSGFLKGAPVPGYLEEEGANVQSKAETFVALR
VDIDNWRWAGVPFYLRSGKRMPFKSSEIVVYFKNPPHNLYSSNYRNLPPNKLTIRLQPHEGVEIQMLNKVPGLGEKQRLQ
TTKLDLSFSETFKNERIADAYERLLLEAMLGNQALFVRRDEVEQAWSWVDGIIQAWEETDEKPKPYPAGTWGPVASVALI
TKDGRSWDE

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=483, Percent_Identity=35.4037267080745, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI109389365, Length=483, Percent_Identity=35.4037267080745, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI52145310, Length=509, Percent_Identity=27.7013752455796, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI1788158, Length=491, Percent_Identity=64.7657841140529, Blast_Score=655, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17538218, Length=485, Percent_Identity=37.9381443298969, Blast_Score=327, Evalue=9e-90,
Organism=Saccharomyces cerevisiae, GI6324088, Length=473, Percent_Identity=36.7864693446089, Blast_Score=300, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24643350, Length=470, Percent_Identity=35.7446808510638, Blast_Score=298, Evalue=7e-81,
Organism=Drosophila melanogaster, GI24643352, Length=470, Percent_Identity=35.7446808510638, Blast_Score=298, Evalue=8e-81,
Organism=Drosophila melanogaster, GI221513548, Length=488, Percent_Identity=26.844262295082, Blast_Score=183, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 55942; Mature: 55811

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGITTPKAKACDFVLFGTKGDLAKRKLLPSLYQLDKANLLNVDTKILGVAKDDFSQEEYR
CCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCEEECCCEEEEECCCCCCHHHHH
ELVITALNTFVKDELCEETVNRFLDRCHYIGTNFTVSDGYQAFHDILEPEKRVMVSYFAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHCHHHHEEEHHHCC
PPAIFGDICRCLHEQNLIFPDSRVVLEKPIGSDLESSRIINDQVSAYFEENQVYRIDHYL
CHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEHHHHH
GKETVQNLLALRFANSLFASKWDNRTIDHVQLTVAEEVGIEGRWGYFDKAGQMRDMIQNH
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHCCCCCCCCCCCCCHHHHHHHHHH
LLQVLTLVAMDPPVNLDADNIRDEKVKVLKSLRPINADNIYENTVRGQYSSGFLKGAPVP
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCC
GYLEEEGANVQSKAETFVALRVDIDNWRWAGVPFYLRSGKRMPFKSSEIVVYFKNPPHNL
CCHHCCCCCCHHCCCEEEEEEEECCCCEECCCCCEECCCCCCCCCCCCEEEEECCCCCCH
YSSNYRNLPPNKLTIRLQPHEGVEIQMLNKVPGLGEKQRLQTTKLDLSFSETFKNERIAD
HCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHEECCCHHHHHCCCHHHH
AYERLLLEAMLGNQALFVRRDEVEQAWSWVDGIIQAWEETDEKPKPYPAGTWGPVASVAL
HHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEEE
ITKDGRSWDE
EEECCCCCCC
>Mature Secondary Structure 
GITTPKAKACDFVLFGTKGDLAKRKLLPSLYQLDKANLLNVDTKILGVAKDDFSQEEYR
CCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCEEECCCEEEEECCCCCCHHHHH
ELVITALNTFVKDELCEETVNRFLDRCHYIGTNFTVSDGYQAFHDILEPEKRVMVSYFAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHCHHHHEEEHHHCC
PPAIFGDICRCLHEQNLIFPDSRVVLEKPIGSDLESSRIINDQVSAYFEENQVYRIDHYL
CHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEHHHHH
GKETVQNLLALRFANSLFASKWDNRTIDHVQLTVAEEVGIEGRWGYFDKAGQMRDMIQNH
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHCCCCCCCCCCCCCHHHHHHHHHH
LLQVLTLVAMDPPVNLDADNIRDEKVKVLKSLRPINADNIYENTVRGQYSSGFLKGAPVP
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCC
GYLEEEGANVQSKAETFVALRVDIDNWRWAGVPFYLRSGKRMPFKSSEIVVYFKNPPHNL
CCHHCCCCCCHHCCCEEEEEEEECCCCEECCCCCEECCCCCCCCCCCCEEEEECCCCCCH
YSSNYRNLPPNKLTIRLQPHEGVEIQMLNKVPGLGEKQRLQTTKLDLSFSETFKNERIAD
HCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHEECCCHHHHHCCCHHHH
AYERLLLEAMLGNQALFVRRDEVEQAWSWVDGIIQAWEETDEKPKPYPAGTWGPVASVAL
HHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEEE
ITKDGRSWDE
EEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8145647 [H]