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The map label for this gene is hisI [H]

Identifier: 167623747

GI number: 167623747

Start: 2174102

End: 2174743

Strand: Reverse

Name: hisI [H]

Synonym: Shal_1817

Alternate gene names: 167623747

Gene position: 2174743-2174102 (Counterclockwise)

Preceding gene: 167623748

Following gene: 167623746

Centisome position: 41.61

GC content: 45.33

Gene sequence:

>642_bases
ATGACTAAGCTTGACCAATCAAAGCCGGTAGACAGCAACCTTATTGGTCTATTGGACTGGAAAAAAACGGAGGGGTTAAT
CCCTACCGTGGTACAAAACTTCCTCACGGGTAAAGTACTGATGCTCGGCTACATGGATAAAGCCGCATTAGATAAGACCT
TATCGACTAAGCAGGTAACCTTTTTTAGTCGCAGCAAGCAAAGACTTTGGACCAAGGGAGAAACCTCTGGCAACACTCTT
GAGTTAATAGCGATCAATATGGACTGCGACAACGATAGCCTGCTAGTACAAGTACTTCCCAATGGACCGACTTGCCACAA
AGGCACCGAGAGTTGCTGGAAAGACGGTAACGCGCATAGCTTTATCGATAACTTGGCAGGCTTAATTGCATCACGTAAAG
GCCAAGACCCGGAGTCGAGCTATACCGCTCACCTGTTTGAACGTGGCACTAAACGTATCGCTCAAAAGGTCGGTGAAGAG
GGCTTAGAAACGGCATTAGCCGCAGCAACTCACGACAAGCCTGAACTGATAGATGAGGCATCGGATCTTATCTATCACCT
GCTGGTTTTGTTAGAAGATCAAGATTTAAGCATGCAAGATATCAACTTAAATCTGATGAAAAGACACAATAAAACCAAGT
AG

Upstream 100 bases:

>100_bases
AGAGTTAAAACAGTATCTTAAAGATAATCAGATTGCAGTACGCGTTTAGGCTAAATCTAAAAGATTTAATTAAACGAGTT
TATCCAATTAGGGACATAAT

Downstream 100 bases:

>100_bases
CCGAATTGACGGGCGTAAGCTAAGTTTACGCCCTTTACCTTTGGCGATAATTAATCGGTAGCAATAACGCGCAACAGCAT
AATATTTCAATTCATCCCCC

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 213; Mature: 212

Protein sequence:

>213_residues
MTKLDQSKPVDSNLIGLLDWKKTEGLIPTVVQNFLTGKVLMLGYMDKAALDKTLSTKQVTFFSRSKQRLWTKGETSGNTL
ELIAINMDCDNDSLLVQVLPNGPTCHKGTESCWKDGNAHSFIDNLAGLIASRKGQDPESSYTAHLFERGTKRIAQKVGEE
GLETALAAATHDKPELIDEASDLIYHLLVLLEDQDLSMQDINLNLMKRHNKTK

Sequences:

>Translated_213_residues
MTKLDQSKPVDSNLIGLLDWKKTEGLIPTVVQNFLTGKVLMLGYMDKAALDKTLSTKQVTFFSRSKQRLWTKGETSGNTL
ELIAINMDCDNDSLLVQVLPNGPTCHKGTESCWKDGNAHSFIDNLAGLIASRKGQDPESSYTAHLFERGTKRIAQKVGEE
GLETALAAATHDKPELIDEASDLIYHLLVLLEDQDLSMQDINLNLMKRHNKTK
>Mature_212_residues
TKLDQSKPVDSNLIGLLDWKKTEGLIPTVVQNFLTGKVLMLGYMDKAALDKTLSTKQVTFFSRSKQRLWTKGETSGNTLE
LIAINMDCDNDSLLVQVLPNGPTCHKGTESCWKDGNAHSFIDNLAGLIASRKGQDPESSYTAHLFERGTKRIAQKVGEEG
LETALAAATHDKPELIDEASDLIYHLLVLLEDQDLSMQDINLNLMKRHNKTK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=195, Percent_Identity=63.5897435897436, Blast_Score=252, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6319819, Length=200, Percent_Identity=33.5, Blast_Score=90, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 23670; Mature: 23539

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKLDQSKPVDSNLIGLLDWKKTEGLIPTVVQNFLTGKVLMLGYMDKAALDKTLSTKQVT
CCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHH
FFSRSKQRLWTKGETSGNTLELIAINMDCDNDSLLVQVLPNGPTCHKGTESCWKDGNAHS
HHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCEEEEECCCCCCCCCCCHHHHCCCCHHH
FIDNLAGLIASRKGQDPESSYTAHLFERGTKRIAQKVGEEGLETALAAATHDKPELIDEA
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
SDLIYHLLVLLEDQDLSMQDINLNLMKRHNKTK
HHHHHHHHHHHCCCCCCHHHCCHHHHHHCCCCC
>Mature Secondary Structure 
TKLDQSKPVDSNLIGLLDWKKTEGLIPTVVQNFLTGKVLMLGYMDKAALDKTLSTKQVT
CCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHH
FFSRSKQRLWTKGETSGNTLELIAINMDCDNDSLLVQVLPNGPTCHKGTESCWKDGNAHS
HHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCEEEEECCCCCCCCCCCHHHHCCCCHHH
FIDNLAGLIASRKGQDPESSYTAHLFERGTKRIAQKVGEEGLETALAAATHDKPELIDEA
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
SDLIYHLLVLLEDQDLSMQDINLNLMKRHNKTK
HHHHHHHHHHHCCCCCCHHHCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]