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The map label for this gene is relA [H]

Identifier: 167623153

GI number: 167623153

Start: 1481771

End: 1483978

Strand: Direct

Name: relA [H]

Synonym: Shal_1219

Alternate gene names: 167623153

Gene position: 1481771-1483978 (Clockwise)

Preceding gene: 167623152

Following gene: 167623154

Centisome position: 28.35

GC content: 45.06

Gene sequence:

>2208_bases
ATGGTATCTGTTCGTGAAGCACATTTTAGCGACCCTGATTTTCAACTCGAAGAGTGGGTGCAACGTTATATAAGTGATGC
TTCAGAAGCTCAAACTCTTTTGGCCTTAATTGAACAGGTCGAGTTGCTTGTGGGGCAAAAGCAAGAGGCGAGCGTTACCG
TGTTAAAGCGTGCGCGTGAGATGATAGAAATTCTTGCGCCGCTCAATATGGATATTGAAACCTTACAGGCCGCGATTTTA
TTTGTCGTCTTCGATGCAGGGCTTATCACTCAAGAAGATATTGAAGAAGGTTTTGGCGGCAAACTAGCCATATTAGTCTC
GAGTGTTGAGACCATGAATGCCATTGGCGCGCTAAAAGTTGATAATCAGACTCGTAATGGTGAACCGCAGATCGATAATA
TCCGCAAGATGTTATTGGCCATGGTGGAAGATGTGCGTGCGGTGGTGATTAAACTTGCCGAGCGCATCTGCTTACTGCGA
GAGATTAAGAATGCCGATGAGGAAGTTAAAGTCCTTATCGCCCGTGAAATTGCTGATATTTATGCACCGCTGGCTAACAG
ATTGGGCATTGGACAGCTTAAGTGGGAACTGGAAGATATTTCGTTTCGCTATCTGCATCCACAGACCTATAAAGATATCG
CTAAACAGCTTGATGGCAAGCGACTTGATAGAGAAACCTTTATTGATGACTTTGTCAGCCAGCTGCAGGCTCGTTTAGAC
AAAGATCAGATCCGTGCAAAAGTATACGGTCGACCAAAGCATATTTACAGTATTTGGAAGAAGATGAAAGGCAAGCAGCT
TAAGTTCGACGAGCTGTTTGACGTGCGTGCGGTGCGGATAGTCACCGACCGCTTGCAAGATTGTTATGGTGCTTTAGGTG
TGGTGCATACACTTTGGCAGCATATTTCACGCGAATTTGATGATTACGTCGCTAACCCAAAACCAAATGGTTACCAGTCT
ATTCATACGGTTGTTGTTGGGCCTGAAGATAAAACGGTTGAGATCCAAATCCGTACTGAGCAGATGCATGAAGATGCTGA
GCTTGGCGTGGCGGCGCATTGGAAATATAAAGAAGGTAGCGCAAGCGGTAAGCAAAGCGGCTATGAAGAGAAAATCAACT
GGCTACGTAAAATCCTGCAGTGGCAAGAAGATGTGGCTGAAAGCGGTAACTTAGTCGATGAAGTGCGTAGTCAAGTCTTT
GAAGACAGAGTCTATGTCTTTACCCCAAGCGGTGAAGTGGTTGATTTGCCTTTAGGCTCAACGGTGCTTGATTTTGCCTA
CTATATTCATTCCCATGTTGGGCATAAGTGTATTGGCGCTAAAGTTGATGGCCGCATTGTGCAGTTTACCTATCAAGTGG
AAACTGGGCAGCGAATTGAGATTATCACCTCTAAACACCCTAACCCGAAGCGAGATTGGCTTAACCCTAATTTAGGCTAT
ATTCGCACCTCGCGTGCACGATCGAAAATTTTGCACTGGTTTAAGCAGCAAGATAGAGATAAAAATATTGTTGCTGGACG
TGAGATGCTTGAAACCGAATTGGTTAAAATTCATCTACAGATTAAAGATGCACAATCAGCCGTAGAGCGCTTTAACTTAG
TGAGCATGGATGATCTGCTCGCTGGTATCGGTGGCGGCGATATCCGCCTTAACCAAGTGGTTAATCATGTTCAAAGTCGT
CTGCGCACTAAAGATTTAAGTGATGAAGCCGCGGTTGAAGATTTAGTTAAAAAGAGCCAAAGCAAGTCAGTAAAAAGCGG
TAAGGGCCAAGTCGAAGTCAACGGCGTCGGCAACCTTATGAGCCATATTGCTAAGTGTTGTCAGCCTGTACCTGGCGATG
AGATTTTTGGTTTTATTACCAAGGGCCGTGGTATTTCGGTACACAGGGCCGATTGCGATCAGGTTAAAGAGTTAATTCGC
GCCTCTCCTGAACGCTCTGTGGAAGTGGTCTGGGGCGAGAATTATTCCGGTGGCTACAAAATTCGCTTAAGTATTCTAGC
TAATGATCAGTCAGGTTTGCTGCGAGACTTAACTTCGGTACTTGCGGCAGAGAAAACCCATGTGATGGCGATGAGTTCGA
CCTCTGATGTGAAAACTCAAACCGCGATAATCGAGTTGGAGCTTGAGCTATATAACTTAGATGGTTTGTCTAAAGTGTTA
TCGAAAATAAATCAGGTCGAAGGGGTGATGCAGGCCAGAAGGCTTTAA

Upstream 100 bases:

>100_bases
ACAATAACGGCTGAATGGCGAATATAGTGCTTATCAATTTAAAAGGTAGAGTTAAACTTTTGTTAATCTCTATCTGCGGT
ATGTAAAGGGATTAAATACT

Downstream 100 bases:

>100_bases
TACCGATAGGTATCACTAGAAAATTAGCGGCAACCCAATGGTTGCCGTTTTTATATGGTTTACTTTTAAAGTAAACGTTG
GCAAACATGTATTCAGCCCT

Product: (p)ppGpp synthetase I SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 735; Mature: 735

Protein sequence:

>735_residues
MVSVREAHFSDPDFQLEEWVQRYISDASEAQTLLALIEQVELLVGQKQEASVTVLKRAREMIEILAPLNMDIETLQAAIL
FVVFDAGLITQEDIEEGFGGKLAILVSSVETMNAIGALKVDNQTRNGEPQIDNIRKMLLAMVEDVRAVVIKLAERICLLR
EIKNADEEVKVLIAREIADIYAPLANRLGIGQLKWELEDISFRYLHPQTYKDIAKQLDGKRLDRETFIDDFVSQLQARLD
KDQIRAKVYGRPKHIYSIWKKMKGKQLKFDELFDVRAVRIVTDRLQDCYGALGVVHTLWQHISREFDDYVANPKPNGYQS
IHTVVVGPEDKTVEIQIRTEQMHEDAELGVAAHWKYKEGSASGKQSGYEEKINWLRKILQWQEDVAESGNLVDEVRSQVF
EDRVYVFTPSGEVVDLPLGSTVLDFAYYIHSHVGHKCIGAKVDGRIVQFTYQVETGQRIEIITSKHPNPKRDWLNPNLGY
IRTSRARSKILHWFKQQDRDKNIVAGREMLETELVKIHLQIKDAQSAVERFNLVSMDDLLAGIGGGDIRLNQVVNHVQSR
LRTKDLSDEAAVEDLVKKSQSKSVKSGKGQVEVNGVGNLMSHIAKCCQPVPGDEIFGFITKGRGISVHRADCDQVKELIR
ASPERSVEVVWGENYSGGYKIRLSILANDQSGLLRDLTSVLAAEKTHVMAMSSTSDVKTQTAIIELELELYNLDGLSKVL
SKINQVEGVMQARRL

Sequences:

>Translated_735_residues
MVSVREAHFSDPDFQLEEWVQRYISDASEAQTLLALIEQVELLVGQKQEASVTVLKRAREMIEILAPLNMDIETLQAAIL
FVVFDAGLITQEDIEEGFGGKLAILVSSVETMNAIGALKVDNQTRNGEPQIDNIRKMLLAMVEDVRAVVIKLAERICLLR
EIKNADEEVKVLIAREIADIYAPLANRLGIGQLKWELEDISFRYLHPQTYKDIAKQLDGKRLDRETFIDDFVSQLQARLD
KDQIRAKVYGRPKHIYSIWKKMKGKQLKFDELFDVRAVRIVTDRLQDCYGALGVVHTLWQHISREFDDYVANPKPNGYQS
IHTVVVGPEDKTVEIQIRTEQMHEDAELGVAAHWKYKEGSASGKQSGYEEKINWLRKILQWQEDVAESGNLVDEVRSQVF
EDRVYVFTPSGEVVDLPLGSTVLDFAYYIHSHVGHKCIGAKVDGRIVQFTYQVETGQRIEIITSKHPNPKRDWLNPNLGY
IRTSRARSKILHWFKQQDRDKNIVAGREMLETELVKIHLQIKDAQSAVERFNLVSMDDLLAGIGGGDIRLNQVVNHVQSR
LRTKDLSDEAAVEDLVKKSQSKSVKSGKGQVEVNGVGNLMSHIAKCCQPVPGDEIFGFITKGRGISVHRADCDQVKELIR
ASPERSVEVVWGENYSGGYKIRLSILANDQSGLLRDLTSVLAAEKTHVMAMSSTSDVKTQTAIIELELELYNLDGLSKVL
SKINQVEGVMQARRL
>Mature_735_residues
MVSVREAHFSDPDFQLEEWVQRYISDASEAQTLLALIEQVELLVGQKQEASVTVLKRAREMIEILAPLNMDIETLQAAIL
FVVFDAGLITQEDIEEGFGGKLAILVSSVETMNAIGALKVDNQTRNGEPQIDNIRKMLLAMVEDVRAVVIKLAERICLLR
EIKNADEEVKVLIAREIADIYAPLANRLGIGQLKWELEDISFRYLHPQTYKDIAKQLDGKRLDRETFIDDFVSQLQARLD
KDQIRAKVYGRPKHIYSIWKKMKGKQLKFDELFDVRAVRIVTDRLQDCYGALGVVHTLWQHISREFDDYVANPKPNGYQS
IHTVVVGPEDKTVEIQIRTEQMHEDAELGVAAHWKYKEGSASGKQSGYEEKINWLRKILQWQEDVAESGNLVDEVRSQVF
EDRVYVFTPSGEVVDLPLGSTVLDFAYYIHSHVGHKCIGAKVDGRIVQFTYQVETGQRIEIITSKHPNPKRDWLNPNLGY
IRTSRARSKILHWFKQQDRDKNIVAGREMLETELVKIHLQIKDAQSAVERFNLVSMDDLLAGIGGGDIRLNQVVNHVQSR
LRTKDLSDEAAVEDLVKKSQSKSVKSGKGQVEVNGVGNLMSHIAKCCQPVPGDEIFGFITKGRGISVHRADCDQVKELIR
ASPERSVEVVWGENYSGGYKIRLSILANDQSGLLRDLTSVLAAEKTHVMAMSSTSDVKTQTAIIELELELYNLDGLSKVL
SKINQVEGVMQARRL

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=741, Percent_Identity=58.2995951417004, Blast_Score=876, Evalue=0.0,
Organism=Escherichia coli, GI1790082, Length=676, Percent_Identity=33.2840236686391, Blast_Score=401, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 83063; Mature: 83063

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSVREAHFSDPDFQLEEWVQRYISDASEAQTLLALIEQVELLVGQKQEASVTVLKRARE
CCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
MIEILAPLNMDIETLQAAILFVVFDAGLITQEDIEEGFGGKLAILVSSVETMNAIGALKV
HHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEEEHHHHHHHHHCEEEE
DNQTRNGEPQIDNIRKMLLAMVEDVRAVVIKLAERICLLREIKNADEEVKVLIAREIADI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
YAPLANRLGIGQLKWELEDISFRYLHPQTYKDIAKQLDGKRLDRETFIDDFVSQLQARLD
HHHHHHCCCCCCEEEEEECCEEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHC
KDQIRAKVYGRPKHIYSIWKKMKGKQLKFDELFDVRAVRIVTDRLQDCYGALGVVHTLWQ
HHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HISREFDDYVANPKPNGYQSIHTVVVGPEDKTVEIQIRTEQMHEDAELGVAAHWKYKEGS
HHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEEEEHHHHCCHHHCCEEEEEEECCCC
ASGKQSGYEEKINWLRKILQWQEDVAESGNLVDEVRSQVFEDRVYVFTPSGEVVDLPLGS
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEECCCCCEEECCCCH
TVLDFAYYIHSHVGHKCIGAKVDGRIVQFTYQVETGQRIEIITSKHPNPKRDWLNPNLGY
HHHHHHHHHHHHCCCCEECCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCC
IRTSRARSKILHWFKQQDRDKNIVAGREMLETELVKIHLQIKDAQSAVERFNLVSMDDLL
EECHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEHEEEEEEHHHHHHHHHHCCCCHHHHH
AGIGGGDIRLNQVVNHVQSRLRTKDLSDEAAVEDLVKKSQSKSVKSGKGQVEVNGVGNLM
HCCCCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHCCCCEEEECCHHHHH
SHIAKCCQPVPGDEIFGFITKGRGISVHRADCDQVKELIRASPERSVEVVWGENYSGGYK
HHHHHHCCCCCCCHHEEEEECCCCCEEECCCHHHHHHHHHCCCCCCEEEEECCCCCCCEE
IRLSILANDQSGLLRDLTSVLAAEKTHVMAMSSTSDVKTQTAIIELELELYNLDGLSKVL
EEEEEEECCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEEEEEEEEECCCCHHHHH
SKINQVEGVMQARRL
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MVSVREAHFSDPDFQLEEWVQRYISDASEAQTLLALIEQVELLVGQKQEASVTVLKRARE
CCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
MIEILAPLNMDIETLQAAILFVVFDAGLITQEDIEEGFGGKLAILVSSVETMNAIGALKV
HHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEEEHHHHHHHHHCEEEE
DNQTRNGEPQIDNIRKMLLAMVEDVRAVVIKLAERICLLREIKNADEEVKVLIAREIADI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
YAPLANRLGIGQLKWELEDISFRYLHPQTYKDIAKQLDGKRLDRETFIDDFVSQLQARLD
HHHHHHCCCCCCEEEEEECCEEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHC
KDQIRAKVYGRPKHIYSIWKKMKGKQLKFDELFDVRAVRIVTDRLQDCYGALGVVHTLWQ
HHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HISREFDDYVANPKPNGYQSIHTVVVGPEDKTVEIQIRTEQMHEDAELGVAAHWKYKEGS
HHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEEEEHHHHCCHHHCCEEEEEEECCCC
ASGKQSGYEEKINWLRKILQWQEDVAESGNLVDEVRSQVFEDRVYVFTPSGEVVDLPLGS
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEECCCCCEEECCCCH
TVLDFAYYIHSHVGHKCIGAKVDGRIVQFTYQVETGQRIEIITSKHPNPKRDWLNPNLGY
HHHHHHHHHHHHCCCCEECCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCC
IRTSRARSKILHWFKQQDRDKNIVAGREMLETELVKIHLQIKDAQSAVERFNLVSMDDLL
EECHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEHEEEEEEHHHHHHHHHHCCCCHHHHH
AGIGGGDIRLNQVVNHVQSRLRTKDLSDEAAVEDLVKKSQSKSVKSGKGQVEVNGVGNLM
HCCCCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHCCCCEEEECCHHHHH
SHIAKCCQPVPGDEIFGFITKGRGISVHRADCDQVKELIRASPERSVEVVWGENYSGGYK
HHHHHHCCCCCCCHHEEEEECCCCCEEECCCHHHHHHHHHCCCCCCEEEEECCCCCCCEE
IRLSILANDQSGLLRDLTSVLAAEKTHVMAMSSTSDVKTQTAIIELELELYNLDGLSKVL
EEEEEEECCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEEEEEEEEECCCCHHHHH
SKINQVEGVMQARRL
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]