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The map label for this gene is tpm

Identifier: 167622615

GI number: 167622615

Start: 832887

End: 833546

Strand: Direct

Name: tpm

Synonym: Shal_0675

Alternate gene names: 167622615

Gene position: 832887-833546 (Clockwise)

Preceding gene: 167622614

Following gene: 167622618

Centisome position: 15.93

GC content: 45.91

Gene sequence:

>660_bases
ATGCAGCCAAGTTTTTGGCATGAAAAATGGGATGCCCAGCAGATAGGCTTTCATTTGAGTGCGGTAAACCCCCTTCTTGT
AAAATACTGGCAACAGCTTGAACTTGACGCCGATTCTCAGGTTTTTGTTCCCCTTTGTGGTAAGTCTTTAGATATGTGCT
TTTTGGCTGAGCAAGGTCACGATGTTTTGGGTTGTGAGTTAAACGAGCTGGCTGTGCAGCAGTTTTATCGAGAAAACGCA
CTTGCCTTTGATGTCACTAAGCTTGCAGAGCATCAGCGTTTCCATACCGAGCAGGTGACCATCTATCAGGGGGATATCTT
TAGCCTTGATGTTGCTGAGATGCCTAGTACGACAGCTTTTTATGATCGTGCGGCATTAATCGCCTGGCCCGAGGAGATGC
GTTTAGCCTATGCGCGTCAGCTTGCTAAGCTCATTCCAGCTAATAGTGTGGGCTTATTGATCACCTTAGATTACCCCCAA
GCCGAGTTAAATGGTCCGCCTTTTGCGGTATCTGATGATTGGGTTCAGGCCAACTTAAGCCAAGACTTTAAGATTGAACG
TCTCGCGAGTGAAGATGTACTCAGAGATAACCCTCGTTTTGTTAAAAAGCAGGTTTCCTGGTTGACTGAATCGGTCTATA
GGTTAATTCGAAAAGGCTGA

Upstream 100 bases:

>100_bases
CTTGAGTCATCACTTCTTTTAGTGAGATCTTGCTAGCTCCTCTCCTAATTTTATTCAAGTACTCGGTCATACCTTGGTTT
CTTTGATATGGATCTTGAAT

Downstream 100 bases:

>100_bases
CAAGAAGGTTCTAGGAAAAGCAGGTCCTAGGTACTAGCAAAGGCAAAGACGGAAAAGCTAAGACGATAAAAGCAGAACGG
CCTGCGGCCTAGCGAACGCT

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MQPSFWHEKWDAQQIGFHLSAVNPLLVKYWQQLELDADSQVFVPLCGKSLDMCFLAEQGHDVLGCELNELAVQQFYRENA
LAFDVTKLAEHQRFHTEQVTIYQGDIFSLDVAEMPSTTAFYDRAALIAWPEEMRLAYARQLAKLIPANSVGLLITLDYPQ
AELNGPPFAVSDDWVQANLSQDFKIERLASEDVLRDNPRFVKKQVSWLTESVYRLIRKG

Sequences:

>Translated_219_residues
MQPSFWHEKWDAQQIGFHLSAVNPLLVKYWQQLELDADSQVFVPLCGKSLDMCFLAEQGHDVLGCELNELAVQQFYRENA
LAFDVTKLAEHQRFHTEQVTIYQGDIFSLDVAEMPSTTAFYDRAALIAWPEEMRLAYARQLAKLIPANSVGLLITLDYPQ
AELNGPPFAVSDDWVQANLSQDFKIERLASEDVLRDNPRFVKKQVSWLTESVYRLIRKG
>Mature_219_residues
MQPSFWHEKWDAQQIGFHLSAVNPLLVKYWQQLELDADSQVFVPLCGKSLDMCFLAEQGHDVLGCELNELAVQQFYRENA
LAFDVTKLAEHQRFHTEQVTIYQGDIFSLDVAEMPSTTAFYDRAALIAWPEEMRLAYARQLAKLIPANSVGLLITLDYPQ
AELNGPPFAVSDDWVQANLSQDFKIERLASEDVLRDNPRFVKKQVSWLTESVYRLIRKG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family

Homologues:

Organism=Homo sapiens, GI4507653, Length=223, Percent_Identity=28.6995515695067, Blast_Score=91, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TPMT_SHEHH (B0TSS5)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001672909.1
- ProteinModelPortal:   B0TSS5
- SMR:   B0TSS5
- GeneID:   5906647
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_0675
- HOGENOM:   HBG444929
- OMA:   PPFAVSP
- ProtClustDB:   PRK13255
- BioCyc:   SHAL458817:SHAL_0675-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00812
- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822
- PIRSF:   PIRSF023956
- TIGRFAMs:   TIGR03840

Pfam domain/function: PF05724 TPMT

EC number: =2.1.1.67

Molecular weight: Translated: 25139; Mature: 25139

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: BINDING 10-10 BINDING 45-45 BINDING 66-66 BINDING 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPSFWHEKWDAQQIGFHLSAVNPLLVKYWQQLELDADSQVFVPLCGKSLDMCFLAEQGH
CCCCCCCCCCCHHHHCEEHHHCCHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCC
DVLGCELNELAVQQFYRENALAFDVTKLAEHQRFHTEQVTIYQGDIFSLDVAEMPSTTAF
CEECCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCEEEEEECCEEEEEHHHCCCCHHH
YDRAALIAWPEEMRLAYARQLAKLIPANSVGLLITLDYPQAELNGPPFAVSDDWVQANLS
HHCEEEEECHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHCCCCCEECCCHHHCCCCC
QDFKIERLASEDVLRDNPRFVKKQVSWLTESVYRLIRKG
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQPSFWHEKWDAQQIGFHLSAVNPLLVKYWQQLELDADSQVFVPLCGKSLDMCFLAEQGH
CCCCCCCCCCCHHHHCEEHHHCCHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCC
DVLGCELNELAVQQFYRENALAFDVTKLAEHQRFHTEQVTIYQGDIFSLDVAEMPSTTAF
CEECCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCEEEEEECCEEEEEHHHCCCCHHH
YDRAALIAWPEEMRLAYARQLAKLIPANSVGLLITLDYPQAELNGPPFAVSDDWVQANLS
HHCEEEEECHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHCCCCCEECCCHHHCCCCC
QDFKIERLASEDVLRDNPRFVKKQVSWLTESVYRLIRKG
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA