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The map label for this gene is galK [H]

Identifier: 167622605

GI number: 167622605

Start: 817855

End: 819009

Strand: Reverse

Name: galK [H]

Synonym: Shal_0665

Alternate gene names: 167622605

Gene position: 819009-817855 (Counterclockwise)

Preceding gene: 167622606

Following gene: 167622604

Centisome position: 15.67

GC content: 49.87

Gene sequence:

>1155_bases
ATGTCCAATCCAGCTCAGCGAGCAAACAAACTGTTTGTGCAAACTTTTGGCACCCAAGCCGATGAGCTTTATTGTGCCCC
TGGACGCGTCAACCTTATTGGTGAGCATACAGATTACAACGATGGCTTTGTACTTCCCGCTGCTATCAACTTCCACACTG
CTATTGTAGTAAAACGCCGCGATGACTTACGCTTTCGCGCCGTCTCCGATGCCTTTCCCGGTGAGATTGAGGAGTGGATA
TTTGGTGAAGAAGGCACGCCAGTTAAGAATCATTGGTCGAACTACCTAAAAGGCTTTACCGCAGCAATGGCCACCTCGGG
CCTAACGGCAAAAGGACTCGATCTGGCCGTTGTCAGTAACGTACCAATGGGCGCGGGCCTTTCATCCTCCGCAGCCTTAG
AGATTGCTTTTGGCACCGCCGTTAACGATTGCAGCCAAATACAACTCTCACCACTTGCCATCGCTCAGCTGGCCCAGCGC
GGAGAGAATCAATTTGTCGGCTGCGCCTGCGGCATTATGGATCAGATGATCAGCGCACTGGGTCAGCAGGACCATGCGCT
GCTTATCGACTGTCTCGATTTAGACAGTGAAGCGGTCAGTATTCCCGACAGCCTAAGCCTGATTATTATCAACTCGAATG
TTCAGCGCGGTCTCGTTGACTCCGAATATAACCTTCGCCGCGAGCAGTGTGAGCAAGCAGCAACTCATTTTGGCCTTGAG
TCACTACGAGATCTTGATTTGGCCAGCCTCGAAGCTGGTAAATCTGAATTAACTGCAGCTTGTTATAAACGAGCAAAACA
TGTGGTCACTGAAAATCGACGCACCCAAAATGCCGCATGGGCACTAGAGTCTGGTGACATAGGAAAAGTCAGTCTTTTAA
TGGCACAGTCGCATGCATCAATGCGTGATGATTTTGAGATCACCACCAGCGAGATCGACTACCTTGTCGAGATAATATCA
GAAGTCATCGGTAATCGCGGAGGTGTACGCATGACAGGTGGTGGCTTTGGCGGCTGCGTTGTCGCGCTAGTCGATCACGA
ACTAACCGATTCAGTTGTCTCGATCATTGAACAAAAATACGCAGATAAGACTGGGCTAGAAGCCGACATATATCTGTGTT
CAGCCAGCGATGGTGCTAAGCGCATCGATAATTAA

Upstream 100 bases:

>100_bases
CTGTTATTAAATTGGTCACCAGAATCAAACTCAGCAACCAAAGAGTTTATTGCAATGTTTTGTGCTAAACGTAAATATTA
ACATTCGGAAATTTGAAATT

Downstream 100 bases:

>100_bases
CAGGACTAATAATGGTACGTATTCGCTCTCTCGAACCTTGGACCGATCCACGTGGTGGACAAATTGAGCGACTGCTCATC
GACAACGGCACGCTCGCCAT

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MSNPAQRANKLFVQTFGTQADELYCAPGRVNLIGEHTDYNDGFVLPAAINFHTAIVVKRRDDLRFRAVSDAFPGEIEEWI
FGEEGTPVKNHWSNYLKGFTAAMATSGLTAKGLDLAVVSNVPMGAGLSSSAALEIAFGTAVNDCSQIQLSPLAIAQLAQR
GENQFVGCACGIMDQMISALGQQDHALLIDCLDLDSEAVSIPDSLSLIIINSNVQRGLVDSEYNLRREQCEQAATHFGLE
SLRDLDLASLEAGKSELTAACYKRAKHVVTENRRTQNAAWALESGDIGKVSLLMAQSHASMRDDFEITTSEIDYLVEIIS
EVIGNRGGVRMTGGGFGGCVVALVDHELTDSVVSIIEQKYADKTGLEADIYLCSASDGAKRIDN

Sequences:

>Translated_384_residues
MSNPAQRANKLFVQTFGTQADELYCAPGRVNLIGEHTDYNDGFVLPAAINFHTAIVVKRRDDLRFRAVSDAFPGEIEEWI
FGEEGTPVKNHWSNYLKGFTAAMATSGLTAKGLDLAVVSNVPMGAGLSSSAALEIAFGTAVNDCSQIQLSPLAIAQLAQR
GENQFVGCACGIMDQMISALGQQDHALLIDCLDLDSEAVSIPDSLSLIIINSNVQRGLVDSEYNLRREQCEQAATHFGLE
SLRDLDLASLEAGKSELTAACYKRAKHVVTENRRTQNAAWALESGDIGKVSLLMAQSHASMRDDFEITTSEIDYLVEIIS
EVIGNRGGVRMTGGGFGGCVVALVDHELTDSVVSIIEQKYADKTGLEADIYLCSASDGAKRIDN
>Mature_383_residues
SNPAQRANKLFVQTFGTQADELYCAPGRVNLIGEHTDYNDGFVLPAAINFHTAIVVKRRDDLRFRAVSDAFPGEIEEWIF
GEEGTPVKNHWSNYLKGFTAAMATSGLTAKGLDLAVVSNVPMGAGLSSSAALEIAFGTAVNDCSQIQLSPLAIAQLAQRG
ENQFVGCACGIMDQMISALGQQDHALLIDCLDLDSEAVSIPDSLSLIIINSNVQRGLVDSEYNLRREQCEQAATHFGLES
LRDLDLASLEAGKSELTAACYKRAKHVVTENRRTQNAAWALESGDIGKVSLLMAQSHASMRDDFEITTSEIDYLVEIISE
VIGNRGGVRMTGGGFGGCVVALVDHELTDSVVSIIEQKYADKTGLEADIYLCSASDGAKRIDN

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=383, Percent_Identity=43.0809399477807, Blast_Score=281, Evalue=7e-76,
Organism=Homo sapiens, GI4503897, Length=418, Percent_Identity=28.4688995215311, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI48527957, Length=418, Percent_Identity=28.4688995215311, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1786972, Length=375, Percent_Identity=49.6, Blast_Score=377, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI71989053, Length=414, Percent_Identity=26.5700483091787, Blast_Score=91, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6320212, Length=241, Percent_Identity=29.8755186721992, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24661292, Length=432, Percent_Identity=27.3148148148148, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21355577, Length=432, Percent_Identity=27.3148148148148, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24661285, Length=432, Percent_Identity=27.3148148148148, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 41358; Mature: 41227

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPAQRANKLFVQTFGTQADELYCAPGRVNLIGEHTDYNDGFVLPAAINFHTAIVVKRR
CCCHHHHHHHEEHHHCCCCCCEEEECCCCEEEEECCCCCCCCEEEEEEECEEEEEEEEEC
DDLRFRAVSDAFPGEIEEWIFGEEGTPVKNHWSNYLKGFTAAMATSGLTAKGLDLAVVSN
CCCEEEEECCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEC
VPMGAGLSSSAALEIAFGTAVNDCSQIQLSPLAIAQLAQRGENQFVGCACGIMDQMISAL
CCCCCCCCCCCEEEEEECCCCCCCCCEEECHHHHHHHHHCCCCCEEEHHHHHHHHHHHHH
GQQDHALLIDCLDLDSEAVSIPDSLSLIIINSNVQRGLVDSEYNLRREQCEQAATHFGLE
CCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCHH
SLRDLDLASLEAGKSELTAACYKRAKHVVTENRRTQNAAWALESGDIGKVSLLMAQSHAS
HHHCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEEEEEHHHCC
MRDDFEITTSEIDYLVEIISEVIGNRGGVRMTGGGFGGCVVALVDHELTDSVVSIIEQKY
CCCCCEEEHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEEECCCHHHHHHHHHHHHHH
ADKTGLEADIYLCSASDGAKRIDN
CCCCCCEEEEEEEECCCCHHCCCC
>Mature Secondary Structure 
SNPAQRANKLFVQTFGTQADELYCAPGRVNLIGEHTDYNDGFVLPAAINFHTAIVVKRR
CCHHHHHHHEEHHHCCCCCCEEEECCCCEEEEECCCCCCCCEEEEEEECEEEEEEEEEC
DDLRFRAVSDAFPGEIEEWIFGEEGTPVKNHWSNYLKGFTAAMATSGLTAKGLDLAVVSN
CCCEEEEECCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEC
VPMGAGLSSSAALEIAFGTAVNDCSQIQLSPLAIAQLAQRGENQFVGCACGIMDQMISAL
CCCCCCCCCCCEEEEEECCCCCCCCCEEECHHHHHHHHHCCCCCEEEHHHHHHHHHHHHH
GQQDHALLIDCLDLDSEAVSIPDSLSLIIINSNVQRGLVDSEYNLRREQCEQAATHFGLE
CCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCHH
SLRDLDLASLEAGKSELTAACYKRAKHVVTENRRTQNAAWALESGDIGKVSLLMAQSHAS
HHHCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEEEEEHHHCC
MRDDFEITTSEIDYLVEIISEVIGNRGGVRMTGGGFGGCVVALVDHELTDSVVSIIEQKY
CCCCCEEEHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEEECCCHHHHHHHHHHHHHH
ADKTGLEADIYLCSASDGAKRIDN
CCCCCCEEEEEEEECCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA