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The map label for this gene is galM [H]

Identifier: 167622604

GI number: 167622604

Start: 816812

End: 817843

Strand: Reverse

Name: galM [H]

Synonym: Shal_0664

Alternate gene names: 167622604

Gene position: 817843-816812 (Counterclockwise)

Preceding gene: 167622605

Following gene: 167622586

Centisome position: 15.65

GC content: 48.16

Gene sequence:

>1032_bases
ATGGTACGTATTCGCTCTCTCGAACCTTGGACCGATCCACGTGGTGGACAAATTGAGCGACTGCTCATCGACAACGGCAC
GCTCGCCATTGAGGTATTAAGCCTAGGTGGGATTATTCGCTCTTTATGGGCTCCGGATAGAGACGGCGAACGCGCCAACT
TAGTTTTGGGCTGTGATAGCGCCGAGGGTTATCTAACACAAGACGCCTACTTAGGCGCTATTGTTGGCCGATATGCAAAC
CGAATTGCCAATGGGCAATTTAATGTTGGCCAAACTCAGTACCCTCTCGATACCAACCAAGACAGCAACTGTTTACACGG
CGGCAGAGAAGGCTTTCACCGCCAGCAGTGGCAACTTGGTACTCTCCCCGATGGTGTTCGCCTCAGCCTAAGAAGCCCTG
ATGGGGATATGGGCTTTCCGGGAAACTGCAATGTGCAGCTAGATTATCGCCTCGTGGGCAATAATCTCTATGTGGAGATC
TTAGCCAGCTCTGATAAACCTTGCCCCATCAGCTTAACTCAACATAGTTATTTCAATTTAGATGCCAGTGAATCAAGCCT
AGATCATCAACTGCAAGTCGATGCGACTCAGTATCTCGAAATGAATAACGTGGGAATCCCTAGCGCAATTCGCCAAACCC
ATGGCAGCGGCTTAGACCTGTCTTTACCGACTCAATTACAGTCGCTAATAGGTAGAGAAGAGTTAACTACGACATCGGGA
ATCGATCACTGCTTTTTAATGCCAAGCACTGAGTCGAAGTTACAGCGATTTGGCAGTTTAAGCTCACCGCTCAGTGGTCG
CAGCATGACGCTATATACTAATCAGCCTGGTGTACAAGTATATGGAGGAAATGGCTTAGAGGGTGTGGTTGGTAAGAACC
AACATAGATTGAATCAGTATCAGGGGGTTTGTTTGGAGCCTCAACAGATCCCAGATGCACCTAACCAACCGCATATTGCG
GGTGATGCCTTGATAGCACCGGGGGAGATTTATCATCACATCAGTCGCTATCAATTTGAAAATGATGCTTAA

Upstream 100 bases:

>100_bases
TTGAACAAAAATACGCAGATAAGACTGGGCTAGAAGCCGACATATATCTGTGTTCAGCCAGCGATGGTGCTAAGCGCATC
GATAATTAACAGGACTAATA

Downstream 100 bases:

>100_bases
TCAAAAGAAACAAAAAAACAGCGCCTAGGCGCTGTTATTTTTATTGATTAATCATCGTAATCGTCTGACCAATCATCATC
GTAGTCATCGTCGTCTGCAG

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MVRIRSLEPWTDPRGGQIERLLIDNGTLAIEVLSLGGIIRSLWAPDRDGERANLVLGCDSAEGYLTQDAYLGAIVGRYAN
RIANGQFNVGQTQYPLDTNQDSNCLHGGREGFHRQQWQLGTLPDGVRLSLRSPDGDMGFPGNCNVQLDYRLVGNNLYVEI
LASSDKPCPISLTQHSYFNLDASESSLDHQLQVDATQYLEMNNVGIPSAIRQTHGSGLDLSLPTQLQSLIGREELTTTSG
IDHCFLMPSTESKLQRFGSLSSPLSGRSMTLYTNQPGVQVYGGNGLEGVVGKNQHRLNQYQGVCLEPQQIPDAPNQPHIA
GDALIAPGEIYHHISRYQFENDA

Sequences:

>Translated_343_residues
MVRIRSLEPWTDPRGGQIERLLIDNGTLAIEVLSLGGIIRSLWAPDRDGERANLVLGCDSAEGYLTQDAYLGAIVGRYAN
RIANGQFNVGQTQYPLDTNQDSNCLHGGREGFHRQQWQLGTLPDGVRLSLRSPDGDMGFPGNCNVQLDYRLVGNNLYVEI
LASSDKPCPISLTQHSYFNLDASESSLDHQLQVDATQYLEMNNVGIPSAIRQTHGSGLDLSLPTQLQSLIGREELTTTSG
IDHCFLMPSTESKLQRFGSLSSPLSGRSMTLYTNQPGVQVYGGNGLEGVVGKNQHRLNQYQGVCLEPQQIPDAPNQPHIA
GDALIAPGEIYHHISRYQFENDA
>Mature_343_residues
MVRIRSLEPWTDPRGGQIERLLIDNGTLAIEVLSLGGIIRSLWAPDRDGERANLVLGCDSAEGYLTQDAYLGAIVGRYAN
RIANGQFNVGQTQYPLDTNQDSNCLHGGREGFHRQQWQLGTLPDGVRLSLRSPDGDMGFPGNCNVQLDYRLVGNNLYVEI
LASSDKPCPISLTQHSYFNLDASESSLDHQLQVDATQYLEMNNVGIPSAIRQTHGSGLDLSLPTQLQSLIGREELTTTSG
IDHCFLMPSTESKLQRFGSLSSPLSGRSMTLYTNQPGVQVYGGNGLEGVVGKNQHRLNQYQGVCLEPQQIPDAPNQPHIA
GDALIAPGEIYHHISRYQFENDA

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=329, Percent_Identity=37.9939209726444, Blast_Score=219, Evalue=3e-57,
Organism=Escherichia coli, GI1786971, Length=332, Percent_Identity=35.2409638554217, Blast_Score=200, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17557428, Length=321, Percent_Identity=30.8411214953271, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI115533334, Length=321, Percent_Identity=30.8411214953271, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6319493, Length=311, Percent_Identity=26.6881028938907, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6322004, Length=354, Percent_Identity=27.1186440677966, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324399, Length=316, Percent_Identity=24.6835443037975, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24659048, Length=352, Percent_Identity=31.8181818181818, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24668278, Length=335, Percent_Identity=29.8507462686567, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24641876, Length=337, Percent_Identity=29.3768545994065, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24583720, Length=343, Percent_Identity=27.9883381924198, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24668282, Length=351, Percent_Identity=27.3504273504274, Blast_Score=135, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 37616; Mature: 37616

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRIRSLEPWTDPRGGQIERLLIDNGTLAIEVLSLGGIIRSLWAPDRDGERANLVLGCDS
CEEECCCCCCCCCCCCCEEEEEEECCCEEEEEEHHHHHHHHHCCCCCCCCCEEEEEEECC
AEGYLTQDAYLGAIVGRYANRIANGQFNVGQTQYPLDTNQDSNCLHGGREGFHRQQWQLG
CCCCEECHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCCHHCCCCCCEECC
TLPDGVRLSLRSPDGDMGFPGNCNVQLDYRLVGNNLYVEILASSDKPCPISLTQHSYFNL
CCCCCCEEEEECCCCCCCCCCCCEEEEEEEEECCCEEEEEEECCCCCCEEEEECCCEEEC
DASESSLDHQLQVDATQYLEMNNVGIPSAIRQTHGSGLDLSLPTQLQSLIGREELTTTSG
CCCCCCCCCEEEECHHHEEEECCCCCCHHHHHHCCCCCEEECHHHHHHHHCHHHHHHCCC
IDHCFLMPSTESKLQRFGSLSSPLSGRSMTLYTNQPGVQVYGGNGLEGVVGKNQHRLNQY
CCEEEEECCCHHHHHHHCCCCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCHHHHHHH
QGVCLEPQQIPDAPNQPHIAGDALIAPGEIYHHISRYQFENDA
CCEEECHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MVRIRSLEPWTDPRGGQIERLLIDNGTLAIEVLSLGGIIRSLWAPDRDGERANLVLGCDS
CEEECCCCCCCCCCCCCEEEEEEECCCEEEEEEHHHHHHHHHCCCCCCCCCEEEEEEECC
AEGYLTQDAYLGAIVGRYANRIANGQFNVGQTQYPLDTNQDSNCLHGGREGFHRQQWQLG
CCCCEECHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCCHHCCCCCCEECC
TLPDGVRLSLRSPDGDMGFPGNCNVQLDYRLVGNNLYVEILASSDKPCPISLTQHSYFNL
CCCCCCEEEEECCCCCCCCCCCCEEEEEEEEECCCEEEEEEECCCCCCEEEEECCCEEEC
DASESSLDHQLQVDATQYLEMNNVGIPSAIRQTHGSGLDLSLPTQLQSLIGREELTTTSG
CCCCCCCCCEEEECHHHEEEECCCCCCHHHHHHCCCCCEEECHHHHHHHHCHHHHHHCCC
IDHCFLMPSTESKLQRFGSLSSPLSGRSMTLYTNQPGVQVYGGNGLEGVVGKNQHRLNQY
CCEEEEECCCHHHHHHHCCCCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCHHHHHHH
QGVCLEPQQIPDAPNQPHIAGDALIAPGEIYHHISRYQFENDA
CCEEECHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7966338; 8905232; 9278503 [H]