Click here to switch to the map view.

The map label for this gene is uvrD [H]

Identifier: 167622483

GI number: 167622483

Start: 652884

End: 655049

Strand: Direct

Name: uvrD [H]

Synonym: Shal_0543

Alternate gene names: 167622483

Gene position: 652884-655049 (Clockwise)

Preceding gene: 167622482

Following gene: 167622484

Centisome position: 12.49

GC content: 49.35

Gene sequence:

>2166_bases
ATGGACGTATCTTCTTTACTCGACGGCCTAAACGACAAGCAGCGTGAAGCTGTTGGTGCACCGCAATCTAGCATGCTAGT
TTTGGCGGGAGCTGGTAGTGGCAAAACGCGGGTGTTAACCCACAGAATTGCCTGGTTGATGCAGGTTGAACAGCAAAGCC
CTTATGCCATTTTAGCGGTAACCTTTACCAATAAAGCGGCAAAAGAGATGCGTGAGCGTGTTGAAAAGGTCGCTGGTGGC
AACATGAGCCGCATGTGGATCGGTACCTTCCACGGCTTAGCACATCGTTTACTACGCACCCATTATAAAGATGCTAATCT
GCCTGAGAGCTTTCAAATCTTAGACTCAGACGATCAACTGCGTCTGATCAAACGAATTCTAAAAAGCCTTAACTTGGACG
AGAAACAGTATCCGCCAAGACAAGCGCAAGGCTATATCAACGGCAAGAAAGACTTAGGTCTACGCCCATCGCATATCGAT
GCGGGCGGTTTCCCGATTGAGCAAAATTTACTGAAGATCTACCAGATCTATCAAGACTCTTGCGATCGTGCCGGCTTAGT
GGATTTTGCAGAGATCTTACTCAGAGCCCATGAGCTATGGCTTAACAAACCACATATTTTGGATCACTACCAAGATAGAT
TTAAGCATATATTAGTCGACGAGTTTCAAGATACTAACGCCATCCAATATGCGTGGATCCGTGTGCTTGCCGGGTCAACG
GCTAACGTGATGATTGTGGGTGATGACGATCAGTCTATCTACGGCTGGCGTGGCGCTCAGGTGGAGAACCTGCATAAGTT
TTTAGCCGACTTCCCTGCGGCGCAAACCATTCGTTTAGAGCAGAACTATCGCTCGAGCGGTAATATTCTTAACGCATCGA
ACCAGCTGATTGCCAATAATCCAGATCGTATGGGCAAGAAGCTGTGGACCGATGATAAAGACGGTGAGCCGATTGGGCTT
TATTGCGCCTTCAATGAGATGGATGAAGCGCGCTTTATCGTGGGTAGGATCACTGACTGGCAGGATGAAGGCGGTAAGTT
AGAGGATTGCGCCATTCTTTATCGCTCTAACGCTCAGTCTCGAGTGCTGGAAGAAGCCTTATTACATAAGGGCATCGCCT
ATCGTATCTATGGTGGCCTACGCTTCTTCGAACGCCAAGAGATTAAAGATGCCATGGGCTACCTGCGGCTAATCAACAAC
AAGAATGATGATGCCGCCTTTGAGCGTGTGGTGAATACCCCAACCCGTGGTATTGGCGATCGCACCTTAGAGATTATTCG
TACCACGGCGCGTCAGCAAGAGATGACGCTGTGGGAAGCGAGTCTTCGCTTAATCGAGGAGAAGGTCCTCAATGGTCGCG
CCGCTAATGCGGTTCGTGGCTTTATGGACTTGATTATCGCCATGAGAATGGACTCCGATGAGCTATCGCTGCAGCGCACG
ACTGACCATGTTATTCAAACATCGGGTCTTAAGGCGATGTATGAGGCAGAAAAGAGCGAGAAAGCGCGTGCACGTGTCGA
AAACTTAGAGGAACTCGTCACTGCTGCCCGTAGCTTTGTGATGCCAGAAGAAATTGAAGATATGGGCGAGCTTAACGCCT
TCCTATCCCATGCCGCGTTAGAGGCGGGTGAAGGGCAGGCCGATGAGTTTACCGATGCCGTACAATTGATGACATTGCAC
TCGGCTAAAGGTCTTGAGTTCCCAATGGTATTTATGGCTGGTGTGGAGGAAGGTTTGTTCCCGAGCCAGATGGCAATTGA
TGAAGGGGATCGTCTCGATGAAGAGCGTCGTCTTTGTTATGTGGGTATGACCCGCGCCATGCAGAAGCTGTATATCACCT
ATGCCGAGTCGAGACGTATCTATGGCCGTGAGAGCTTTGCTAGACCTTCGCGCTTCGTTAAAGAGATCCCTGAGCAATAT
GTGCAAGAGATCCGTATGCGAACTCAGGTTTCAGCGCCGGCCGTTAGCAGTCGCTTTAGTAAACAAGATGATAGCTTTAA
TGACTCCGGCTTTAAGATTGGCCAACGTGTGATGCACCCCAAATTCGGTGAGGGCACGGTAACAAATTATGAGGGAAGTG
GAGCTCAGGCGCGCATCCAGGTTAACTTTTTCGATGTTGGCAGCAAGTGGTTAGTAATCGCTTACGCTCGCTTGGAGGCG
CTTTAA

Upstream 100 bases:

>100_bases
TAATTCTCTCTTCTGCTTTTAACCCCTGCTCTTCGCGCGAATTCTATCCCCGAGTTCTCAGGTTCTGTTATACTGCCCGC
TTGATTTTTTGGAGGCAATA

Downstream 100 bases:

>100_bases
TCAAATCGGCTCATTAACAGGCTCTCTTATAAGCAAAGTTATCGCTACAAATTATTCTCAATACTGGTTGAATACTGTTA
CAGCTCAGTCATAATGCGGG

Product: DNA-dependent helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 721; Mature: 721

Protein sequence:

>721_residues
MDVSSLLDGLNDKQREAVGAPQSSMLVLAGAGSGKTRVLTHRIAWLMQVEQQSPYAILAVTFTNKAAKEMRERVEKVAGG
NMSRMWIGTFHGLAHRLLRTHYKDANLPESFQILDSDDQLRLIKRILKSLNLDEKQYPPRQAQGYINGKKDLGLRPSHID
AGGFPIEQNLLKIYQIYQDSCDRAGLVDFAEILLRAHELWLNKPHILDHYQDRFKHILVDEFQDTNAIQYAWIRVLAGST
ANVMIVGDDDQSIYGWRGAQVENLHKFLADFPAAQTIRLEQNYRSSGNILNASNQLIANNPDRMGKKLWTDDKDGEPIGL
YCAFNEMDEARFIVGRITDWQDEGGKLEDCAILYRSNAQSRVLEEALLHKGIAYRIYGGLRFFERQEIKDAMGYLRLINN
KNDDAAFERVVNTPTRGIGDRTLEIIRTTARQQEMTLWEASLRLIEEKVLNGRAANAVRGFMDLIIAMRMDSDELSLQRT
TDHVIQTSGLKAMYEAEKSEKARARVENLEELVTAARSFVMPEEIEDMGELNAFLSHAALEAGEGQADEFTDAVQLMTLH
SAKGLEFPMVFMAGVEEGLFPSQMAIDEGDRLDEERRLCYVGMTRAMQKLYITYAESRRIYGRESFARPSRFVKEIPEQY
VQEIRMRTQVSAPAVSSRFSKQDDSFNDSGFKIGQRVMHPKFGEGTVTNYEGSGAQARIQVNFFDVGSKWLVIAYARLEA
L

Sequences:

>Translated_721_residues
MDVSSLLDGLNDKQREAVGAPQSSMLVLAGAGSGKTRVLTHRIAWLMQVEQQSPYAILAVTFTNKAAKEMRERVEKVAGG
NMSRMWIGTFHGLAHRLLRTHYKDANLPESFQILDSDDQLRLIKRILKSLNLDEKQYPPRQAQGYINGKKDLGLRPSHID
AGGFPIEQNLLKIYQIYQDSCDRAGLVDFAEILLRAHELWLNKPHILDHYQDRFKHILVDEFQDTNAIQYAWIRVLAGST
ANVMIVGDDDQSIYGWRGAQVENLHKFLADFPAAQTIRLEQNYRSSGNILNASNQLIANNPDRMGKKLWTDDKDGEPIGL
YCAFNEMDEARFIVGRITDWQDEGGKLEDCAILYRSNAQSRVLEEALLHKGIAYRIYGGLRFFERQEIKDAMGYLRLINN
KNDDAAFERVVNTPTRGIGDRTLEIIRTTARQQEMTLWEASLRLIEEKVLNGRAANAVRGFMDLIIAMRMDSDELSLQRT
TDHVIQTSGLKAMYEAEKSEKARARVENLEELVTAARSFVMPEEIEDMGELNAFLSHAALEAGEGQADEFTDAVQLMTLH
SAKGLEFPMVFMAGVEEGLFPSQMAIDEGDRLDEERRLCYVGMTRAMQKLYITYAESRRIYGRESFARPSRFVKEIPEQY
VQEIRMRTQVSAPAVSSRFSKQDDSFNDSGFKIGQRVMHPKFGEGTVTNYEGSGAQARIQVNFFDVGSKWLVIAYARLEA
L
>Mature_721_residues
MDVSSLLDGLNDKQREAVGAPQSSMLVLAGAGSGKTRVLTHRIAWLMQVEQQSPYAILAVTFTNKAAKEMRERVEKVAGG
NMSRMWIGTFHGLAHRLLRTHYKDANLPESFQILDSDDQLRLIKRILKSLNLDEKQYPPRQAQGYINGKKDLGLRPSHID
AGGFPIEQNLLKIYQIYQDSCDRAGLVDFAEILLRAHELWLNKPHILDHYQDRFKHILVDEFQDTNAIQYAWIRVLAGST
ANVMIVGDDDQSIYGWRGAQVENLHKFLADFPAAQTIRLEQNYRSSGNILNASNQLIANNPDRMGKKLWTDDKDGEPIGL
YCAFNEMDEARFIVGRITDWQDEGGKLEDCAILYRSNAQSRVLEEALLHKGIAYRIYGGLRFFERQEIKDAMGYLRLINN
KNDDAAFERVVNTPTRGIGDRTLEIIRTTARQQEMTLWEASLRLIEEKVLNGRAANAVRGFMDLIIAMRMDSDELSLQRT
TDHVIQTSGLKAMYEAEKSEKARARVENLEELVTAARSFVMPEEIEDMGELNAFLSHAALEAGEGQADEFTDAVQLMTLH
SAKGLEFPMVFMAGVEEGLFPSQMAIDEGDRLDEERRLCYVGMTRAMQKLYITYAESRRIYGRESFARPSRFVKEIPEQY
VQEIRMRTQVSAPAVSSRFSKQDDSFNDSGFKIGQRVMHPKFGEGTVTNYEGSGAQARIQVNFFDVGSKWLVIAYARLEA
L

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=721, Percent_Identity=69.0707350901526, Blast_Score=1053, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=635, Percent_Identity=38.8976377952756, Blast_Score=401, Evalue=1e-113,
Organism=Escherichia coli, GI1787196, Length=91, Percent_Identity=43.956043956044, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322369, Length=757, Percent_Identity=28.4015852047556, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6324477, Length=688, Percent_Identity=22.9651162790698, Blast_Score=124, Evalue=6e-29,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 81814; Mature: 81814

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVSSLLDGLNDKQREAVGAPQSSMLVLAGAGSGKTRVLTHRIAWLMQVEQQSPYAILAV
CCHHHHHHCCCHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
TFTNKAAKEMRERVEKVAGGNMSRMWIGTFHGLAHRLLRTHYKDANLPESFQILDSDDQL
EECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHH
RLIKRILKSLNLDEKQYPPRQAQGYINGKKDLGLRPSHIDAGGFPIEQNLLKIYQIYQDS
HHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
CDRAGLVDFAEILLRAHELWLNKPHILDHYQDRFKHILVDEFQDTNAIQYAWIRVLAGST
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCC
ANVMIVGDDDQSIYGWRGAQVENLHKFLADFPAAQTIRLEQNYRSSGNILNASNQLIANN
CEEEEEECCCCCEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCEECCCCCEECCC
PDRMGKKLWTDDKDGEPIGLYCAFNEMDEARFIVGRITDWQDEGGKLEDCAILYRSNAQS
HHHHHHHHCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCHH
RVLEEALLHKGIAYRIYGGLRFFERQEIKDAMGYLRLINNKNDDAAFERVVNTPTRGIGD
HHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCH
RTLEIIRTTARQQEMTLWEASLRLIEEKVLNGRAANAVRGFMDLIIAMRMDSDELSLQRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
TDHVIQTSGLKAMYEAEKSEKARARVENLEELVTAARSFVMPEEIEDMGELNAFLSHAAL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
EAGEGQADEFTDAVQLMTLHSAKGLEFPMVFMAGVEEGLFPSQMAIDEGDRLDEERRLCY
HCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCHHCCCCCCCCCHHHHEEH
VGMTRAMQKLYITYAESRRIYGRESFARPSRFVKEIPEQYVQEIRMRTQVSAPAVSSRFS
HHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHC
KQDDSFNDSGFKIGQRVMHPKFGEGTVTNYEGSGAQARIQVNFFDVGSKWLVIAYARLEA
CCCCCCCCCHHHHHHHHCCCCCCCCCEECCCCCCCEEEEEEEEEECCCCEEEEEEHHHHC
L
C
>Mature Secondary Structure
MDVSSLLDGLNDKQREAVGAPQSSMLVLAGAGSGKTRVLTHRIAWLMQVEQQSPYAILAV
CCHHHHHHCCCHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
TFTNKAAKEMRERVEKVAGGNMSRMWIGTFHGLAHRLLRTHYKDANLPESFQILDSDDQL
EECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHH
RLIKRILKSLNLDEKQYPPRQAQGYINGKKDLGLRPSHIDAGGFPIEQNLLKIYQIYQDS
HHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
CDRAGLVDFAEILLRAHELWLNKPHILDHYQDRFKHILVDEFQDTNAIQYAWIRVLAGST
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCC
ANVMIVGDDDQSIYGWRGAQVENLHKFLADFPAAQTIRLEQNYRSSGNILNASNQLIANN
CEEEEEECCCCCEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCEECCCCCEECCC
PDRMGKKLWTDDKDGEPIGLYCAFNEMDEARFIVGRITDWQDEGGKLEDCAILYRSNAQS
HHHHHHHHCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCHH
RVLEEALLHKGIAYRIYGGLRFFERQEIKDAMGYLRLINNKNDDAAFERVVNTPTRGIGD
HHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCH
RTLEIIRTTARQQEMTLWEASLRLIEEKVLNGRAANAVRGFMDLIIAMRMDSDELSLQRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
TDHVIQTSGLKAMYEAEKSEKARARVENLEELVTAARSFVMPEEIEDMGELNAFLSHAAL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
EAGEGQADEFTDAVQLMTLHSAKGLEFPMVFMAGVEEGLFPSQMAIDEGDRLDEERRLCY
HCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCHHCCCCCCCCCHHHHEEH
VGMTRAMQKLYITYAESRRIYGRESFARPSRFVKEIPEQYVQEIRMRTQVSAPAVSSRFS
HHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHC
KQDDSFNDSGFKIGQRVMHPKFGEGTVTNYEGSGAQARIQVNFFDVGSKWLVIAYARLEA
CCCCCCCCCHHHHHHHHCCCCCCCCCEECCCCCCCEEEEEEEEEECCCCEEEEEEHHHHC
L
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]