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The map label for this gene is hemN [H]

Identifier: 167622057

GI number: 167622057

Start: 132396

End: 133724

Strand: Direct

Name: hemN [H]

Synonym: Shal_0116

Alternate gene names: 167622057

Gene position: 132396-133724 (Clockwise)

Preceding gene: 167622056

Following gene: 167622058

Centisome position: 2.53

GC content: 44.7

Gene sequence:

>1329_bases
ATGTCTTCAATTATTTTGCCTGAAACTGCTCAACCATATAACGCAGATATCACCACACCTAACTGGATGATTAGCGGTAT
GGAGAAAGTCATGCAGTTTTATGTTGATCGCAATCTAAGACTGGACACGGTTTCGGCTGAGATGATGCCTAATCCTATCG
AAGGCAAGAAGTACATGCTGTATGCGCATATTCCTTTCTGTCACACCCTATGCTCATTCTGTACTTTCCACCGCTTTCTG
TTTAAAGAAGATAAGGCGCGCGCGTATTTTATCTCTTTGCGTAAAGAGATGGATATGGTTAAAGCCCTAGGTTACGACTT
TGAGTCCATGTATATCGGTGGTGGCACCACAACCGTATTAGAAGATGAGCTTGCCCGTACCATTGAGCACGCAAAAAAGC
TATTCCCGAGTATCAAAGAGGTGTCGTGTGAGTCAGATCCACAGCATCTTGATAGCCCTGGCTTTAAACAGCTTGAAGGC
TTGGTCGATCGTATGTCTATCGGCGTACAAAGCTTTAACGATGATATTCTGACCATGACAGATCGCATCGAGAAGTTTGG
CTCGGGTCAGCAAACTTTTGATAAGATCATGGCGGCAAAAGAGCTATTTCCAATTATCAACGTAGACTTGATTTTTGGCT
TCCGCGGTCAAACCGATGAAGTGATTCAGCATGACTTGGATATGGCGTCTCGTTTGGATCCACGCCAAATCACCACTTAT
CCGCTGATGATTACTCACCAAACACGTAAGAGCGTAAAGGGTAAGTTGGCGGCCCCACATGGCGATATGGCGCGTCAGTA
CCGCCAGATCCTAAATAGTTTGAATGGTCAGTATAACCAGCTATCGGCATGGGCATTTGGTAAGGCGAATAATGAAGGCT
TCGACGAATACGTTATCGATTACGATGAGTATTTAGGTGTAGGTTCGGGCTCGTTTAGTTTCTTAAACGATACACTCTAT
GTGAATACCTTCTCATTAAGAAATTACCAAGAGCGGATTGCAACTGGTCGTATGGGCGTGGATCAGCAGAAGAATTATGG
CCGCAAGGAAGTGATGCAATACCGCTTTTTACTGGGTATGTTCTCTGGTCGTCTGTCGCGTAAGTATTTCCGTGAGACCT
TTGGGGTGAATCTCGATACTGCCTTGTTCAAAGAGATGGCATCGATGAAAGCCATTGGCGCCATTAAAAATGATCCAACA
GACCCGGATAAGTTGATCGTTACCGATAACGGTAAGATGATGGGACTGCTGATGATGAAAGAGTTCTATTCGGGTATGGA
TAACGTACGTGCTCAGCTACGTAAGCCACTTAAAGCTTGCGATATGTAA

Upstream 100 bases:

>100_bases
ATCACGTTTTGTGCTTATTTAAAGTGCTAATTTTGCCTCCCGCTAGTGCATTCCAATTTTTCGGTTCTTTTGTAATTAGC
ATTCTTCTATAGGAACTTTT

Downstream 100 bases:

>100_bases
TCGTATGCTGATTTAATTTTGATAGGCTGGTGATGATACCGATTGGGATTACAGGCCTAGACCAAAGAAAGGGTGATGCT
TAAGGGCTCACCCTTTTTGT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MSSIILPETAQPYNADITTPNWMISGMEKVMQFYVDRNLRLDTVSAEMMPNPIEGKKYMLYAHIPFCHTLCSFCTFHRFL
FKEDKARAYFISLRKEMDMVKALGYDFESMYIGGGTTTVLEDELARTIEHAKKLFPSIKEVSCESDPQHLDSPGFKQLEG
LVDRMSIGVQSFNDDILTMTDRIEKFGSGQQTFDKIMAAKELFPIINVDLIFGFRGQTDEVIQHDLDMASRLDPRQITTY
PLMITHQTRKSVKGKLAAPHGDMARQYRQILNSLNGQYNQLSAWAFGKANNEGFDEYVIDYDEYLGVGSGSFSFLNDTLY
VNTFSLRNYQERIATGRMGVDQQKNYGRKEVMQYRFLLGMFSGRLSRKYFRETFGVNLDTALFKEMASMKAIGAIKNDPT
DPDKLIVTDNGKMMGLLMMKEFYSGMDNVRAQLRKPLKACDM

Sequences:

>Translated_442_residues
MSSIILPETAQPYNADITTPNWMISGMEKVMQFYVDRNLRLDTVSAEMMPNPIEGKKYMLYAHIPFCHTLCSFCTFHRFL
FKEDKARAYFISLRKEMDMVKALGYDFESMYIGGGTTTVLEDELARTIEHAKKLFPSIKEVSCESDPQHLDSPGFKQLEG
LVDRMSIGVQSFNDDILTMTDRIEKFGSGQQTFDKIMAAKELFPIINVDLIFGFRGQTDEVIQHDLDMASRLDPRQITTY
PLMITHQTRKSVKGKLAAPHGDMARQYRQILNSLNGQYNQLSAWAFGKANNEGFDEYVIDYDEYLGVGSGSFSFLNDTLY
VNTFSLRNYQERIATGRMGVDQQKNYGRKEVMQYRFLLGMFSGRLSRKYFRETFGVNLDTALFKEMASMKAIGAIKNDPT
DPDKLIVTDNGKMMGLLMMKEFYSGMDNVRAQLRKPLKACDM
>Mature_441_residues
SSIILPETAQPYNADITTPNWMISGMEKVMQFYVDRNLRLDTVSAEMMPNPIEGKKYMLYAHIPFCHTLCSFCTFHRFLF
KEDKARAYFISLRKEMDMVKALGYDFESMYIGGGTTTVLEDELARTIEHAKKLFPSIKEVSCESDPQHLDSPGFKQLEGL
VDRMSIGVQSFNDDILTMTDRIEKFGSGQQTFDKIMAAKELFPIINVDLIFGFRGQTDEVIQHDLDMASRLDPRQITTYP
LMITHQTRKSVKGKLAAPHGDMARQYRQILNSLNGQYNQLSAWAFGKANNEGFDEYVIDYDEYLGVGSGSFSFLNDTLYV
NTFSLRNYQERIATGRMGVDQQKNYGRKEVMQYRFLLGMFSGRLSRKYFRETFGVNLDTALFKEMASMKAIGAIKNDPTD
PDKLIVTDNGKMMGLLMMKEFYSGMDNVRAQLRKPLKACDM

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=287, Percent_Identity=26.4808362369338, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI87082341, Length=303, Percent_Identity=27.7227722772277, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789325, Length=262, Percent_Identity=26.7175572519084, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 50615; Mature: 50484

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
6.1 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSIILPETAQPYNADITTPNWMISGMEKVMQFYVDRNLRLDTVSAEMMPNPIEGKKYML
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCCCCCEEEE
YAHIPFCHTLCSFCTFHRFLFKEDKARAYFISLRKEMDMVKALGYDFESMYIGGGTTTVL
EEECHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHEEECCCCHHHH
EDELARTIEHAKKLFPSIKEVSCESDPQHLDSPGFKQLEGLVDRMSIGVQSFNDDILTMT
HHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHH
DRIEKFGSGQQTFDKIMAAKELFPIINVDLIFGFRGQTDEVIQHDLDMASRLDPRQITTY
HHHHHHCCCHHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEE
PLMITHQTRKSVKGKLAAPHGDMARQYRQILNSLNGQYNQLSAWAFGKANNEGFDEYVID
EEEEEECHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHEEEECCCCCCCCHHHHCC
YDEYLGVGSGSFSFLNDTLYVNTFSLRNYQERIATGRMGVDQQKNYGRKEVMQYRFLLGM
HHHHHCCCCCCCHHCCCEEEEEEEHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHH
FSGRLSRKYFRETFGVNLDTALFKEMASMKAIGAIKNDPTDPDKLIVTDNGKMMGLLMMK
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHH
EFYSGMDNVRAQLRKPLKACDM
HHHCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSIILPETAQPYNADITTPNWMISGMEKVMQFYVDRNLRLDTVSAEMMPNPIEGKKYML
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCCCCCEEEE
YAHIPFCHTLCSFCTFHRFLFKEDKARAYFISLRKEMDMVKALGYDFESMYIGGGTTTVL
EEECHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHEEECCCCHHHH
EDELARTIEHAKKLFPSIKEVSCESDPQHLDSPGFKQLEGLVDRMSIGVQSFNDDILTMT
HHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHH
DRIEKFGSGQQTFDKIMAAKELFPIINVDLIFGFRGQTDEVIQHDLDMASRLDPRQITTY
HHHHHHCCCHHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEE
PLMITHQTRKSVKGKLAAPHGDMARQYRQILNSLNGQYNQLSAWAFGKANNEGFDEYVID
EEEEEECHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHEEEECCCCCCCCHHHHCC
YDEYLGVGSGSFSFLNDTLYVNTFSLRNYQERIATGRMGVDQQKNYGRKEVMQYRFLLGM
HHHHHCCCCCCCHHCCCEEEEEEEHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHH
FSGRLSRKYFRETFGVNLDTALFKEMASMKAIGAIKNDPTDPDKLIVTDNGKMMGLLMMK
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHH
EFYSGMDNVRAQLRKPLKACDM
HHHCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]