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Identifier: 16752390

GI number: 16752390

Start: 108084

End: 108923

Strand: Direct

Name: Not Available

Synonym: CP0097

Alternate gene names: 16752390

Gene position: 108084-108923 (Clockwise)

Preceding gene: 16752389

Following gene: 16752391

Centisome position: 8.79

GC content: 42.14

Gene sequence:

>840_bases
ATGGCGAGCATTCACCCAACTGCAATTATCGAGCCAGGAGCTAAAATTGGAAAGGATGTTGTTATTGAACCGTACGTTGT
TATAAAAGCTACGGTAACCCTTTGTGACAACGTTGTTGTTAAGTCCTACGCATATATCGATGGCAATACAACCATAGGCA
AGGGGACAACAATATGGCCCTCTGCAATGATCGGTAATAAACCCCAAGATTTAAAGTATCAAGGGGAAAAAACCTATGTG
ACTATTGGTGAAAATTGCGAAATTCGAGAGTTCGCTATCATCACGTCTTCAACATTCGAAGGTACAACAGTCTCTATCGG
GAATAATTGTTTGATTATGCCCTGGGCTCATGTTGCCCATAACTGTACTATTGGAAATAATGTCGTTCTAAGTAACCATG
CACAACTTGCAGGACATGTTCAAGTCGGTGATTACGCTATTCTTGGTGGGATGGTTGGAGTGCACCAGTTTGTTCGCATC
GGAGCGCATGCTATGGTAGGAGCCCTCAGTGGGATTCGTCGTGATGTTCCTCCCTATACCATTGGAAGTGGAAACCCTTA
CCAACTCGCTGGTATTAATAAAGTAGGACTACAACGTAGGCAGGTTCCTTTTGCTACGCGATTAGCCCTCATTAAGGCTT
TTAAAAAGATTTATCGTGCTGACGGATGTTTTTTTGAATCTCTAGAAGAAACTCTAGAAGAATATGGAGACATTCCAGAA
GTAAAAAACTTCATTGAGTTTTGTCAAAGCCCAAGTAAGCGCGGCATCGAACGAAGCATAGATAAGCAAGCCCTTGAAGA
AGAAAGCGCAGACAAAGAAGGAGTTTTGATTGAATCTTAA

Upstream 100 bases:

>100_bases
TAAAGCTTGGGCACAGGCGCGTGTAGATTCACAGCTAGTCACTGAAGCAGAGCTGAGCTTTGCTCTGGTAGATAAGGAAT
CCATATAATCACGGAGAAAC

Downstream 100 bases:

>100_bases
GGTTGTCTATTTCGGCACACCCACATTTGCAGCCACCGTTTTGCAAGATTTGTTGCATCACAAAATCCAAATTACAGCTG
TTGTTACCCGAGTTGATAAG

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MASIHPTAIIEPGAKIGKDVVIEPYVVIKATVTLCDNVVVKSYAYIDGNTTIGKGTTIWPSAMIGNKPQDLKYQGEKTYV
TIGENCEIREFAIITSSTFEGTTVSIGNNCLIMPWAHVAHNCTIGNNVVLSNHAQLAGHVQVGDYAILGGMVGVHQFVRI
GAHAMVGALSGIRRDVPPYTIGSGNPYQLAGINKVGLQRRQVPFATRLALIKAFKKIYRADGCFFESLEETLEEYGDIPE
VKNFIEFCQSPSKRGIERSIDKQALEEESADKEGVLIES

Sequences:

>Translated_279_residues
MASIHPTAIIEPGAKIGKDVVIEPYVVIKATVTLCDNVVVKSYAYIDGNTTIGKGTTIWPSAMIGNKPQDLKYQGEKTYV
TIGENCEIREFAIITSSTFEGTTVSIGNNCLIMPWAHVAHNCTIGNNVVLSNHAQLAGHVQVGDYAILGGMVGVHQFVRI
GAHAMVGALSGIRRDVPPYTIGSGNPYQLAGINKVGLQRRQVPFATRLALIKAFKKIYRADGCFFESLEETLEEYGDIPE
VKNFIEFCQSPSKRGIERSIDKQALEEESADKEGVLIES
>Mature_278_residues
ASIHPTAIIEPGAKIGKDVVIEPYVVIKATVTLCDNVVVKSYAYIDGNTTIGKGTTIWPSAMIGNKPQDLKYQGEKTYVT
IGENCEIREFAIITSSTFEGTTVSIGNNCLIMPWAHVAHNCTIGNNVVLSNHAQLAGHVQVGDYAILGGMVGVHQFVRIG
AHAMVGALSGIRRDVPPYTIGSGNPYQLAGINKVGLQRRQVPFATRLALIKAFKKIYRADGCFFESLEETLEEYGDIPEV
KNFIEFCQSPSKRGIERSIDKQALEEESADKEGVLIES

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=258, Percent_Identity=44.1860465116279, Blast_Score=205, Evalue=3e-54,
Organism=Escherichia coli, GI1786376, Length=212, Percent_Identity=25.9433962264151, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_CHLPN (Q9Z7Q4)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   C72051
- PIR:   G86571
- RefSeq:   NP_224846.1
- RefSeq:   NP_300706.1
- RefSeq:   NP_444649.1
- RefSeq:   NP_876948.1
- ProteinModelPortal:   Q9Z7Q4
- SMR:   Q9Z7Q4
- GeneID:   1467355
- GeneID:   895282
- GeneID:   919411
- GeneID:   963035
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0097
- KEGG:   cpn:CPn0650
- KEGG:   cpt:CpB0676
- TIGR:   CP_0097
- HOGENOM:   HBG659295
- OMA:   DLKYQGE
- PhylomeDB:   Q9Z7Q4
- ProtClustDB:   PRK05289
- BioCyc:   CPNE115711:CP_0097-MONOMER
- BioCyc:   CPNE115713:CPN0650-MONOMER
- BioCyc:   CPNE138677:CPJ0650-MONOMER
- BioCyc:   CPNE182082:CPB0676-MONOMER
- BRENDA:   2.3.1.129
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: PF00132 Hexapep; SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 30345; Mature: 30214

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASIHPTAIIEPGAKIGKDVVIEPYVVIKATVTLCDNVVVKSYAYIDGNTTIGKGTTIWP
CCCCCCCEEECCCHHCCCCEEECCEEEEEEHHHHHHHHHHHEEEEECCCCEECCCCEECC
SAMIGNKPQDLKYQGEKTYVTIGENCEIREFAIITSSTFEGTTVSIGNNCLIMPWAHVAH
HHHHCCCCCCCEECCCEEEEEECCCCCEEEEEEEECCCCCCEEEEECCCEEEEEHHHHHC
NCTIGNNVVLSNHAQLAGHVQVGDYAILGGMVGVHQFVRIGAHAMVGALSGIRRDVPPYT
CCCCCCCEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
IGSGNPYQLAGINKVGLQRRQVPFATRLALIKAFKKIYRADGCFFESLEETLEEYGDIPE
ECCCCCEEEECCCHHCCHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHH
VKNFIEFCQSPSKRGIERSIDKQALEEESADKEGVLIES
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEECC
>Mature Secondary Structure 
ASIHPTAIIEPGAKIGKDVVIEPYVVIKATVTLCDNVVVKSYAYIDGNTTIGKGTTIWP
CCCCCCEEECCCHHCCCCEEECCEEEEEEHHHHHHHHHHHEEEEECCCCEECCCCEECC
SAMIGNKPQDLKYQGEKTYVTIGENCEIREFAIITSSTFEGTTVSIGNNCLIMPWAHVAH
HHHHCCCCCCCEECCCEEEEEECCCCCEEEEEEEECCCCCCEEEEECCCEEEEEHHHHHC
NCTIGNNVVLSNHAQLAGHVQVGDYAILGGMVGVHQFVRIGAHAMVGALSGIRRDVPPYT
CCCCCCCEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
IGSGNPYQLAGINKVGLQRRQVPFATRLALIKAFKKIYRADGCFFESLEETLEEYGDIPE
ECCCCCEEEECCCHHCCHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHH
VKNFIEFCQSPSKRGIERSIDKQALEEESADKEGVLIES
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362