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The map label for this gene is lpxC

Identifier: 16752388

GI number: 16752388

Start: 106735

End: 107598

Strand: Direct

Name: lpxC

Synonym: CP0095

Alternate gene names: 16752388

Gene position: 106735-107598 (Clockwise)

Preceding gene: 16752387

Following gene: 16752389

Centisome position: 8.68

GC content: 39.35

Gene sequence:

>864_bases
TTGTCAGGTTTTTACATGTTAGAACGAACTCAAAGAACGTTAAAGCGAGAGGTTCGCTATTCTGGAGTGGGAATTCACTT
AGGGAAGTCCTCAACTCTCCATTTGCAACCTGCACAAACAAATACAGGTATTGTTTTTCAAAGACAGTCTGCCTCAGGTA
ACTACGAAAATGTCCCTGCTTTACTAGATCATGTCTACACTACAGGAAGAAGTACAACATTATCTAGGGGTAGTGCTGTA
ATCGCCACTGTCGAACATCTTATGGCAGCATTGCGATCTAACAATATAGATAATCTAATTATCCAATGTAGTGGAGAGGA
AATCCCCATAGGGGATGGAAGCTCAAATGTCTTTGTTGAGTTAATCGATCAAGCAGGTATTTGTGAACAAGAAGATAAGG
TTTCCATTGCGAGACTAACACGTCCTGTATATTATCAACATCAGGACATTTTTTTAGCAGCCTTTCCCTCTGATGAGCTG
AAGATTTCCTATACGTTGCATTATCCTCAAAGTTCAACAATAGGGACTCAATACAAATCTTTGGTGATTAATGAAGAGTC
TTTTCGCCAGGAAATTGCTCCTTGTAGAACATTTGCTCTATACAATGAGCTATGTTTCTTAATGGAAAAGGGGCTAATTG
GAGGGGGATGTTTGGATAATGCTGTAGTTTTTAAGGACGATGGTATTATTAGTAGAGGACAATTAAGATTTGCCGATGAA
CCAGTACGACATAAAATACTGGATCTGATTGGAGATCTTTCCTTAGTTGGCAGGCCTTTTGTTGCGCATGTATTAGCTGT
CGGCTCCGGCCACTCCTCCAATATTGCTTTTGGTAAAAAAATTTTGGAAGCATTAGAACTATAA

Upstream 100 bases:

>100_bases
TGATTTTGATAGCTTTCTGTGCAGTCAGTTATCTAGGAGGAGGATTCTTAGGATATCGCTTGCTTGCTAAAAAAGAAATT
CGATAATATACGGAGACTCG

Downstream 100 bases:

>100_bases
AGAAAGAATAAATGAATCAACCCTCTGTCATCAAATTACGCGAATTATTAGATTTACTCCCCCACAGATATCCTTTTTTA
TTAGTGGATAAAGTTTTATC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MSGFYMLERTQRTLKREVRYSGVGIHLGKSSTLHLQPAQTNTGIVFQRQSASGNYENVPALLDHVYTTGRSTTLSRGSAV
IATVEHLMAALRSNNIDNLIIQCSGEEIPIGDGSSNVFVELIDQAGICEQEDKVSIARLTRPVYYQHQDIFLAAFPSDEL
KISYTLHYPQSSTIGTQYKSLVINEESFRQEIAPCRTFALYNELCFLMEKGLIGGGCLDNAVVFKDDGIISRGQLRFADE
PVRHKILDLIGDLSLVGRPFVAHVLAVGSGHSSNIAFGKKILEALEL

Sequences:

>Translated_287_residues
MSGFYMLERTQRTLKREVRYSGVGIHLGKSSTLHLQPAQTNTGIVFQRQSASGNYENVPALLDHVYTTGRSTTLSRGSAV
IATVEHLMAALRSNNIDNLIIQCSGEEIPIGDGSSNVFVELIDQAGICEQEDKVSIARLTRPVYYQHQDIFLAAFPSDEL
KISYTLHYPQSSTIGTQYKSLVINEESFRQEIAPCRTFALYNELCFLMEKGLIGGGCLDNAVVFKDDGIISRGQLRFADE
PVRHKILDLIGDLSLVGRPFVAHVLAVGSGHSSNIAFGKKILEALEL
>Mature_286_residues
SGFYMLERTQRTLKREVRYSGVGIHLGKSSTLHLQPAQTNTGIVFQRQSASGNYENVPALLDHVYTTGRSTTLSRGSAVI
ATVEHLMAALRSNNIDNLIIQCSGEEIPIGDGSSNVFVELIDQAGICEQEDKVSIARLTRPVYYQHQDIFLAAFPSDELK
ISYTLHYPQSSTIGTQYKSLVINEESFRQEIAPCRTFALYNELCFLMEKGLIGGGCLDNAVVFKDDGIISRGQLRFADEP
VRHKILDLIGDLSLVGRPFVAHVLAVGSGHSSNIAFGKKILEALEL

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=277, Percent_Identity=36.101083032491, Blast_Score=157, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 31622; Mature: 31491

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGFYMLERTQRTLKREVRYSGVGIHLGKSSTLHLQPAQTNTGIVFQRQSASGNYENVPA
CCCCHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEECCCCCCCEEEEECCCCCCCCCHHH
LLDHVYTTGRSTTLSRGSAVIATVEHLMAALRSNNIDNLIIQCSGEEIPIGDGSSNVFVE
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCEEECCCCCCCHHHE
LIDQAGICEQEDKVSIARLTRPVYYQHQDIFLAAFPSDELKISYTLHYPQSSTIGTQYKS
EEHHCCCCCCCCCHHHHHHCCCCEEECCEEEEEECCCCCEEEEEEEECCCCCCCCCHHHH
LVINEESFRQEIAPCRTFALYNELCFLMEKGLIGGGCLDNAVVFKDDGIISRGQLRFADE
EEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEECCEEEECCC
PVRHKILDLIGDLSLVGRPFVAHVLAVGSGHSSNIAFGKKILEALEL
HHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SGFYMLERTQRTLKREVRYSGVGIHLGKSSTLHLQPAQTNTGIVFQRQSASGNYENVPA
CCCHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEECCCCCCCEEEEECCCCCCCCCHHH
LLDHVYTTGRSTTLSRGSAVIATVEHLMAALRSNNIDNLIIQCSGEEIPIGDGSSNVFVE
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCEEECCCCCCCHHHE
LIDQAGICEQEDKVSIARLTRPVYYQHQDIFLAAFPSDELKISYTLHYPQSSTIGTQYKS
EEHHCCCCCCCCCHHHHHHCCCCEEECCEEEEEECCCCCEEEEEEEECCCCCCCCCHHHH
LVINEESFRQEIAPCRTFALYNELCFLMEKGLIGGGCLDNAVVFKDDGIISRGQLRFADE
EEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEECCEEEECCC
PVRHKILDLIGDLSLVGRPFVAHVLAVGSGHSSNIAFGKKILEALEL
HHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]