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The map label for this gene is csd [H]

Identifier: 167040940

GI number: 167040940

Start: 2370598

End: 2371827

Strand: Reverse

Name: csd [H]

Synonym: Teth514_2329

Alternate gene names: 167040940

Gene position: 2371827-2370598 (Counterclockwise)

Preceding gene: 167040941

Following gene: 167040939

Centisome position: 96.52

GC content: 36.99

Gene sequence:

>1230_bases
GTGAAAAATATCGATATTGAAAGAATAAAAAAAGACTTTCCTATATTGAGTGTTAAGCCCCATGGAAAAAGGCTTGTATA
TCTTGACAATGCCGCTACAACACAAAAGCCAATTGAAGTAATAAAGGCTATGGATAAATATTATGAAGAGCTAAATGCCA
ATGTGTACAGAAGCCCCCATTATTTAAGTGTACTTTCAACACAAGCCTATGAAGAGGCAAGAGAAAGGGTAAAAAAATTT
ATAAACGCAAAAAGAGGAGAGTCTATAGTTTTCACAAGAAATACAACAGAGTCTATAAACTTTATAGCCTACACTTGGGG
TATGAAGCATATAAACGAAGGAGACGAAATACTACTTACCATAGCTGAACACCACAGTAATATACTCCCATGGCAGATGG
TAGCAGAAGCTAAAGGGGCAAAGCTTAAATATGTCTATCTTGATGAAAATTTTAGGCTTTCTATGAAAGATTTCAAAGAA
AAAATGTCTGAAAAAGTAAAATTAGTTGCTGTGCAACACATGTCGAATGTTTTGGGAATAATAAATCCTGTGGAGGAGAT
TACACATATTGCCCACAAATACGGGGCAAAAGTGTTAATAGATGGAGCACAAAGTGTACCTCATATGCCTGTTGATGTAC
AAAAGATAGATTGTGACTTTTTTGCCTTCTCTGGTCACAAGATGTTAGGACCTATGGGGATTGGGGTTTTATATATAAAA
GAAGATTTACTTAAAGAGGTACCGCCATTTTTAAGAGGAGGAGAAATGATAGACGAGGTTTACGAGGACCATTCCACATT
TGCACCTTCCCCTCTTAAATTTGAAGCAGGTACTCCTAATATAGAGGGAGCGTATGTGCTTATTTCTGCCATAGATTATA
TAGAAAAAATTGGGCTTACCAATATATATAAACACGAAGGCGAGCTTTTGGAGTATGGTCTTCAAAAAATGAAAGAATTA
GACTTTGTAAAATTGTATGGCCCCAAAGACGCGAAGGAAAGAGGAGGAATAATTTCCTTCAATGTAGAAGGAGTTCATCC
TCACGATGTTGCTACAATTCTCGATGAAGAAGGAGTTGCTGTAAGAAGTGGGCATCACTGTTGCCAGCCCTTAATGAGAT
ACTTAGGCGTTCCTGCAACTGTAAGAGCAAGCTTTTATCTCTACAACGATTTTGAGGATATTGATGCCCTTGTGGAAGGA
CTAAAAAAAGTCAGGAAGTGGTTTAAATGA

Upstream 100 bases:

>100_bases
TAATGGTTCAAGCCATATTAAATCCTGTTATAGACTTGATTCCTTATGACCCTGTAAGAGAAATCATCATAAAGGGTCAT
ATAGGAAGGAGGATTATAAA

Downstream 100 bases:

>100_bases
GCGATTTAAATCAGCTTTATTCTGAAGTTATAATGGAACACTATGAAAACTCCCCTCATAGGAGAGAGCTTAAAGATGCT
ACTCACAAAGAAAGGGGGCA

Product: SufS subfamily cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MKNIDIERIKKDFPILSVKPHGKRLVYLDNAATTQKPIEVIKAMDKYYEELNANVYRSPHYLSVLSTQAYEEARERVKKF
INAKRGESIVFTRNTTESINFIAYTWGMKHINEGDEILLTIAEHHSNILPWQMVAEAKGAKLKYVYLDENFRLSMKDFKE
KMSEKVKLVAVQHMSNVLGIINPVEEITHIAHKYGAKVLIDGAQSVPHMPVDVQKIDCDFFAFSGHKMLGPMGIGVLYIK
EDLLKEVPPFLRGGEMIDEVYEDHSTFAPSPLKFEAGTPNIEGAYVLISAIDYIEKIGLTNIYKHEGELLEYGLQKMKEL
DFVKLYGPKDAKERGGIISFNVEGVHPHDVATILDEEGVAVRSGHHCCQPLMRYLGVPATVRASFYLYNDFEDIDALVEG
LKKVRKWFK

Sequences:

>Translated_409_residues
MKNIDIERIKKDFPILSVKPHGKRLVYLDNAATTQKPIEVIKAMDKYYEELNANVYRSPHYLSVLSTQAYEEARERVKKF
INAKRGESIVFTRNTTESINFIAYTWGMKHINEGDEILLTIAEHHSNILPWQMVAEAKGAKLKYVYLDENFRLSMKDFKE
KMSEKVKLVAVQHMSNVLGIINPVEEITHIAHKYGAKVLIDGAQSVPHMPVDVQKIDCDFFAFSGHKMLGPMGIGVLYIK
EDLLKEVPPFLRGGEMIDEVYEDHSTFAPSPLKFEAGTPNIEGAYVLISAIDYIEKIGLTNIYKHEGELLEYGLQKMKEL
DFVKLYGPKDAKERGGIISFNVEGVHPHDVATILDEEGVAVRSGHHCCQPLMRYLGVPATVRASFYLYNDFEDIDALVEG
LKKVRKWFK
>Mature_409_residues
MKNIDIERIKKDFPILSVKPHGKRLVYLDNAATTQKPIEVIKAMDKYYEELNANVYRSPHYLSVLSTQAYEEARERVKKF
INAKRGESIVFTRNTTESINFIAYTWGMKHINEGDEILLTIAEHHSNILPWQMVAEAKGAKLKYVYLDENFRLSMKDFKE
KMSEKVKLVAVQHMSNVLGIINPVEEITHIAHKYGAKVLIDGAQSVPHMPVDVQKIDCDFFAFSGHKMLGPMGIGVLYIK
EDLLKEVPPFLRGGEMIDEVYEDHSTFAPSPLKFEAGTPNIEGAYVLISAIDYIEKIGLTNIYKHEGELLEYGLQKMKEL
DFVKLYGPKDAKERGGIISFNVEGVHPHDVATILDEEGVAVRSGHHCCQPLMRYLGVPATVRASFYLYNDFEDIDALVEG
LKKVRKWFK

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=231, Percent_Identity=29.8701298701299, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI156713448, Length=262, Percent_Identity=29.0076335877863, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1787970, Length=403, Percent_Identity=45.1612903225806, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1789175, Length=405, Percent_Identity=38.2716049382716, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI48994898, Length=231, Percent_Identity=26.8398268398268, Blast_Score=96, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI25143064, Length=237, Percent_Identity=25.7383966244726, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI193211090, Length=386, Percent_Identity=23.8341968911917, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319831, Length=239, Percent_Identity=30.1255230125523, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI20129463, Length=277, Percent_Identity=28.5198555956679, Blast_Score=108, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 46584; Mature: 46584

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIDIERIKKDFPILSVKPHGKRLVYLDNAATTQKPIEVIKAMDKYYEELNANVYRSPH
CCCCCHHHHHHCCCEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEECCCC
YLSVLSTQAYEEARERVKKFINAKRGESIVFTRNTTESINFIAYTWGMKHINEGDEILLT
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCHHHCCCCCEEEEE
IAEHHSNILPWQMVAEAKGAKLKYVYLDENFRLSMKDFKEKMSEKVKLVAVQHMSNVLGI
EEHHCCCCCCHHHHHHCCCCEEEEEEECCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHH
INPVEEITHIAHKYGAKVLIDGAQSVPHMPVDVQKIDCDFFAFSGHKMLGPMGIGVLYIK
CCHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEECCEEEEECCCCEECCCCCEEEEEE
EDLLKEVPPFLRGGEMIDEVYEDHSTFAPSPLKFEAGTPNIEGAYVLISAIDYIEKIGLT
HHHHHHCCHHHCCHHHHHHHHHCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCC
NIYKHEGELLEYGLQKMKELDFVKLYGPKDAKERGGIISFNVEGVHPHDVATILDEEGVA
HHHHCCCHHHHHHHHHHHHCCEEEEECCCCHHHCCCEEEEEECCCCCHHHHHHHCCCCCE
VRSGHHCCQPLMRYLGVPATVRASFYLYNDFEDIDALVEGLKKVRKWFK
ECCCCHHHHHHHHHHCCCHHHEEEEEEECCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNIDIERIKKDFPILSVKPHGKRLVYLDNAATTQKPIEVIKAMDKYYEELNANVYRSPH
CCCCCHHHHHHCCCEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEECCCC
YLSVLSTQAYEEARERVKKFINAKRGESIVFTRNTTESINFIAYTWGMKHINEGDEILLT
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCHHHCCCCCEEEEE
IAEHHSNILPWQMVAEAKGAKLKYVYLDENFRLSMKDFKEKMSEKVKLVAVQHMSNVLGI
EEHHCCCCCCHHHHHHCCCCEEEEEEECCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHH
INPVEEITHIAHKYGAKVLIDGAQSVPHMPVDVQKIDCDFFAFSGHKMLGPMGIGVLYIK
CCHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEECCEEEEECCCCEECCCCCEEEEEE
EDLLKEVPPFLRGGEMIDEVYEDHSTFAPSPLKFEAGTPNIEGAYVLISAIDYIEKIGLT
HHHHHHCCHHHCCHHHHHHHHHCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCC
NIYKHEGELLEYGLQKMKELDFVKLYGPKDAKERGGIISFNVEGVHPHDVATILDEEGVA
HHHHCCCHHHHHHHHHHHHCCEEEEECCCCHHHCCCEEEEEECCCCCHHHHHHHCCCCCE
VRSGHHCCQPLMRYLGVPATVRASFYLYNDFEDIDALVEGLKKVRKWFK
ECCCCHHHHHHHHHHCCCHHHEEEEEEECCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]