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The map label for this gene is comEA [H]

Identifier: 167040727

GI number: 167040727

Start: 2112595

End: 2113200

Strand: Reverse

Name: comEA [H]

Synonym: Teth514_2104

Alternate gene names: 167040727

Gene position: 2113200-2112595 (Counterclockwise)

Preceding gene: 167040729

Following gene: 167040725

Centisome position: 86.0

GC content: 31.19

Gene sequence:

>606_bases
ATGACTTATTTTTCAAAGAGACAACAGTATGCCATAGTTGTTTTATTATCCTTTATCTTATTGTTTTCAGGGTATGTAAT
TTATAAAAATTACAAATTAAAAAATGATTTTGTTATTAGTACAAATGCTGATGATATATCAGAAGAGGTAAATAATAGTA
TTGAAGAGAATAAAAAAGAACCTTCGGAAATAAAAGTTTATGTGACGGGCCTAGTTAAAAATCCAGGAGTTTATCTTATG
GAAGAAGGAGAAAGAGTAATAGATGCTATAAATAAAGCTGGGGGTCCATTGGAAGAGGCAGACCTTACCAATATCAATCT
TGCGCAAAAAGTTAAAGATGAGCAGATGATAAAAGTGCCTAAAAAAGGTGAGGAAGCGATGGTTTCATTTTCTGATACTA
CAGCAAAAGATAAAAAAATAAATATAAACACAGCTACAAGAGAGGAATTACAGACATTGCCAGGGATAGGTCCTGTAACG
GCTGAAAGAATAATAGAATTTAGAGAAAGCAAAGGACCTTTTAAAAAAATAGAGGATATAGTGAATGTTTCTAGAATAGG
GCCTAAGATGTTTGAACAGATAAAGGATAAAATTACAGTTGATTAA

Upstream 100 bases:

>100_bases
TTTATGCTGATACTTAAAGTATAACAAAAAAACGCGAAAAATAAAAAGGAATTTTTTGATTTATGTAGAAATAAAGGAGC
TTGTAAAAAGAGGTGATAGC

Downstream 100 bases:

>100_bases
GTATTTGTTAAATAGTTCCACATAGAACAAAAAATGTTACAGTTAAACACGTATCATGAATCTTTCTTTTTGGAATGAGC
AATTCTAGCACAGGCCGCGG

Product: helix-hairpin-helix repeat-containing competence protein ComEA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MTYFSKRQQYAIVVLLSFILLFSGYVIYKNYKLKNDFVISTNADDISEEVNNSIEENKKEPSEIKVYVTGLVKNPGVYLM
EEGERVIDAINKAGGPLEEADLTNINLAQKVKDEQMIKVPKKGEEAMVSFSDTTAKDKKININTATREELQTLPGIGPVT
AERIIEFRESKGPFKKIEDIVNVSRIGPKMFEQIKDKITVD

Sequences:

>Translated_201_residues
MTYFSKRQQYAIVVLLSFILLFSGYVIYKNYKLKNDFVISTNADDISEEVNNSIEENKKEPSEIKVYVTGLVKNPGVYLM
EEGERVIDAINKAGGPLEEADLTNINLAQKVKDEQMIKVPKKGEEAMVSFSDTTAKDKKININTATREELQTLPGIGPVT
AERIIEFRESKGPFKKIEDIVNVSRIGPKMFEQIKDKITVD
>Mature_200_residues
TYFSKRQQYAIVVLLSFILLFSGYVIYKNYKLKNDFVISTNADDISEEVNNSIEENKKEPSEIKVYVTGLVKNPGVYLME
EGERVIDAINKAGGPLEEADLTNINLAQKVKDEQMIKVPKKGEEAMVSFSDTTAKDKKININTATREELQTLPGIGPVTA
ERIIEFRESKGPFKKIEDIVNVSRIGPKMFEQIKDKITVD

Specific function: Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect [H]

COG id: COG1555

COG function: function code L; DNA uptake protein and related DNA-binding proteins

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HhH domains [H]

Homologues:

Organism=Homo sapiens, GI71043966, Length=75, Percent_Identity=46.6666666666667, Blast_Score=70, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004787
- InterPro:   IPR004509
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR019554 [H]

Pfam domain/function: PF00633 HHH; PF10531 SLBB [H]

EC number: NA

Molecular weight: Translated: 22713; Mature: 22582

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYFSKRQQYAIVVLLSFILLFSGYVIYKNYKLKNDFVISTNADDISEEVNNSIEENKKE
CCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCEEEECCCHHHHHHHHHHHHHCCCC
PSEIKVYVTGLVKNPGVYLMEEGERVIDAINKAGGPLEEADLTNINLAQKVKDEQMIKVP
CCCEEEEEEEEECCCCEEEEECCHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCHHHEECC
KKGEEAMVSFSDTTAKDKKININTATREELQTLPGIGPVTAERIIEFRESKGPFKKIEDI
CCCCHHEEEECCCCCCCCEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHH
VNVSRIGPKMFEQIKDKITVD
HHHHHCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
TYFSKRQQYAIVVLLSFILLFSGYVIYKNYKLKNDFVISTNADDISEEVNNSIEENKKE
CCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCEEEECCCHHHHHHHHHHHHHCCCC
PSEIKVYVTGLVKNPGVYLMEEGERVIDAINKAGGPLEEADLTNINLAQKVKDEQMIKVP
CCCEEEEEEEEECCCCEEEEECCHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCHHHEECC
KKGEEAMVSFSDTTAKDKKININTATREELQTLPGIGPVTAERIIEFRESKGPFKKIEDI
CCCCHHEEEECCCCCCCCEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHH
VNVSRIGPKMFEQIKDKITVD
HHHHHCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377; 7768800 [H]