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The map label for this gene is moaA [H]

Identifier: 167040032

GI number: 167040032

Start: 1433498

End: 1434451

Strand: Direct

Name: moaA [H]

Synonym: Teth514_1392

Alternate gene names: 167040032

Gene position: 1433498-1434451 (Clockwise)

Preceding gene: 167040031

Following gene: 167040033

Centisome position: 58.34

GC content: 34.07

Gene sequence:

>954_bases
ATGAGAGATAGGTTAGGAAGAAATGTTGATTATTTAAGAGTTTCTGTTACGGATAGATGTAACTTAAGGTGCATTTATTG
TATGCCGGAGGAGGGAATACCCAAAAAAGATCATAATGAGATTCTAAGGAACGAAGAGATTTTAAAAATAATTAGGATTT
CAGCAGAACTTGGCATTAAAAAGGTAAGGTTTACAGGAGGCGAGCCACTTGTAAGGAAGGGAATTGAGAACATAATTTAT
GAAACATCAAAAATAAAAGGCATTGAAGACATTGCACTTACAACTAATGGAACAAAACTTTATGAAATGGCAGATACTTT
AAAAGAAGCAGGACTTAAAAGAGTTAACATAAGCCTTGATAGTCTTAAAAAAGATCGATACCGTATGATTACAAGGCTTG
GGAATATTGATGATGTATTTAGGGCTATTGACAAAAGTTTATCTATTGGACTTGAACCTGTAAAAATTAATACGGTTGTA
ATAAAAGGTATAAATGACGATGAAATTTTTGATTTTGTGAAGCTTGCCGATGAAAACCCGCTTCACATCCGATTTATTGA
AATAATGCCGATAGGTGAAGGAGCAAAATTCAAAGATAACTATATATCGTCGGATGATTTAATAAGTAGCATTCCCGGAC
TGACTCCGGTTGAAACAGAACCGGGTAACACTGCAAGGGTTTTTAAAAGAAAAGGAGCAAAGGGAACGGTTGGTTTTATT
ACACCTTTGTCATGTAAATTTTGTTCAAGTTGTAATAGGATTAGACTTACTGCAGCTGGAACTATAAAACCTTGTCTGCA
TTCAAAATATGAAGTAGATATTAAAAGTTTTTTAAATGATGAAGACAAGATAAGAGCAATGCTGGAACATGCAATCTTAA
GTAAGCCGGCAGGGCATAATCTTGAAAAGGAAATAAGCCAGAATCAAAAAATGATGTTTCAAATAGGAGGATAG

Upstream 100 bases:

>100_bases
TATAAATTCAGAAGAATTTAAAAATGAGCTTGATAAGCTTGGAGGGTATGACTATAGCAATTTAGGAGAAATTATCATTA
TCGAGTAAAGGAGAATTTTT

Downstream 100 bases:

>100_bases
TATATGAATTTAACACACATTAATGAAGAAGGTAGAGCAAGAATGGTCGATGTTAGCGATAAAGATGAGACAAAAAGGGA
AGCTGTTGCAATAGGAAGCA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MRDRLGRNVDYLRVSVTDRCNLRCIYCMPEEGIPKKDHNEILRNEEILKIIRISAELGIKKVRFTGGEPLVRKGIENIIY
ETSKIKGIEDIALTTNGTKLYEMADTLKEAGLKRVNISLDSLKKDRYRMITRLGNIDDVFRAIDKSLSIGLEPVKINTVV
IKGINDDEIFDFVKLADENPLHIRFIEIMPIGEGAKFKDNYISSDDLISSIPGLTPVETEPGNTARVFKRKGAKGTVGFI
TPLSCKFCSSCNRIRLTAAGTIKPCLHSKYEVDIKSFLNDEDKIRAMLEHAILSKPAGHNLEKEISQNQKMMFQIGG

Sequences:

>Translated_317_residues
MRDRLGRNVDYLRVSVTDRCNLRCIYCMPEEGIPKKDHNEILRNEEILKIIRISAELGIKKVRFTGGEPLVRKGIENIIY
ETSKIKGIEDIALTTNGTKLYEMADTLKEAGLKRVNISLDSLKKDRYRMITRLGNIDDVFRAIDKSLSIGLEPVKINTVV
IKGINDDEIFDFVKLADENPLHIRFIEIMPIGEGAKFKDNYISSDDLISSIPGLTPVETEPGNTARVFKRKGAKGTVGFI
TPLSCKFCSSCNRIRLTAAGTIKPCLHSKYEVDIKSFLNDEDKIRAMLEHAILSKPAGHNLEKEISQNQKMMFQIGG
>Mature_317_residues
MRDRLGRNVDYLRVSVTDRCNLRCIYCMPEEGIPKKDHNEILRNEEILKIIRISAELGIKKVRFTGGEPLVRKGIENIIY
ETSKIKGIEDIALTTNGTKLYEMADTLKEAGLKRVNISLDSLKKDRYRMITRLGNIDDVFRAIDKSLSIGLEPVKINTVV
IKGINDDEIFDFVKLADENPLHIRFIEIMPIGEGAKFKDNYISSDDLISSIPGLTPVETEPGNTARVFKRKGAKGTVGFI
TPLSCKFCSSCNRIRLTAAGTIKPCLHSKYEVDIKSFLNDEDKIRAMLEHAILSKPAGHNLEKEISQNQKMMFQIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=326, Percent_Identity=38.9570552147239, Blast_Score=238, Evalue=5e-63,
Organism=Homo sapiens, GI22027536, Length=326, Percent_Identity=38.9570552147239, Blast_Score=238, Evalue=5e-63,
Organism=Escherichia coli, GI1786999, Length=325, Percent_Identity=32.3076923076923, Blast_Score=189, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI32566331, Length=307, Percent_Identity=39.413680781759, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI32566329, Length=307, Percent_Identity=39.413680781759, Blast_Score=235, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17561210, Length=307, Percent_Identity=39.7394136807818, Blast_Score=226, Evalue=1e-59,
Organism=Drosophila melanogaster, GI28574488, Length=326, Percent_Identity=39.2638036809816, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI28574490, Length=285, Percent_Identity=41.7543859649123, Blast_Score=236, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 35702; Mature: 35702

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDRLGRNVDYLRVSVTDRCNLRCIYCMPEEGIPKKDHNEILRNEEILKIIRISAELGIK
CCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCE
KVRFTGGEPLVRKGIENIIYETSKIKGIEDIALTTNGTKLYEMADTLKEAGLKRVNISLD
EEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEHH
SLKKDRYRMITRLGNIDDVFRAIDKSLSIGLEPVKINTVVIKGINDDEIFDFVKLADENP
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHCCCCC
LHIRFIEIMPIGEGAKFKDNYISSDDLISSIPGLTPVETEPGNTARVFKRKGAKGTVGFI
EEEEEEEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCEEEE
TPLSCKFCSSCNRIRLTAAGTIKPCLHSKYEVDIKSFLNDEDKIRAMLEHAILSKPAGHN
CCCCHHHHCCCCEEEEEECCCCCHHHCCCCEEEHHHHCCCHHHHHHHHHHHHHCCCCCCC
LEKEISQNQKMMFQIGG
HHHHHCCCCEEEEEECC
>Mature Secondary Structure
MRDRLGRNVDYLRVSVTDRCNLRCIYCMPEEGIPKKDHNEILRNEEILKIIRISAELGIK
CCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCE
KVRFTGGEPLVRKGIENIIYETSKIKGIEDIALTTNGTKLYEMADTLKEAGLKRVNISLD
EEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEHH
SLKKDRYRMITRLGNIDDVFRAIDKSLSIGLEPVKINTVVIKGINDDEIFDFVKLADENP
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHCCCCC
LHIRFIEIMPIGEGAKFKDNYISSDDLISSIPGLTPVETEPGNTARVFKRKGAKGTVGFI
EEEEEEEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCEEEE
TPLSCKFCSSCNRIRLTAAGTIKPCLHSKYEVDIKSFLNDEDKIRAMLEHAILSKPAGHN
CCCCHHHHCCCCEEEEEECCCCCHHHCCCCEEEHHHHCCCHHHHHHHHHHHHHCCCCCCC
LEKEISQNQKMMFQIGG
HHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA