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The map label for this gene is uvrA [H]

Identifier: 167039703

GI number: 167039703

Start: 1087901

End: 1090684

Strand: Direct

Name: uvrA [H]

Synonym: Teth514_1053

Alternate gene names: 167039703

Gene position: 1087901-1090684 (Clockwise)

Preceding gene: 167039702

Following gene: 167039704

Centisome position: 44.27

GC content: 36.89

Gene sequence:

>2784_bases
ATGGCGAAAGACAAAATTGTAATTAAAGGGGCAAGAGTTCATAATTTAAAAAATGTAGATTTGGAGATTCCACGAGATAA
ATTAACTGTGATAACGGGTTTATCAGGTTCTGGTAAGTCTTCTCTTGCCTTTGATACCATTTATGCTGAAGGTCAGAGAA
GATATGTGGAGTCGTTGTCAGCTTATGCAAGGCAATTTTTAGGACAAATGGACAAACCAGACGTTGATTATATAGAAGGT
CTTTCACCGGCAATATCTATAGACCAAAAGACCACAAATAAAAACCCTCGTTCTACGGTAGGAACGATAACTGAGATTTA
CGACTATCTAAGACTTTTATATGCAAGGGCTGGGATTCCCCATTGTCCTGTTTGTGGAAAAGAGATTAGCATGCAAACTA
TAGATCAGATGGTAGACAGAGTCAAAGAATTGCCAGAAGGTACAAGGATACAGGTACTGGCTCCTGTTATTAGAGGAAGA
AAAGGGGAATATGCTAAGCTTTTAAATGACATAAAAAAGAGCGGATATGTCAGAGTGAAAATTGATGGAGTCATGTACGA
TGTAAATGAGGAGATTAAACTTGACAAAAATAAAAAGCATACTATTGAAGTTGTGGTAGACAGGGTTATTATAAAACCGG
GAATAGACATGAGGTTGACAGACTCTATAGAAACAGCTTTAAAATTAGCAGATGGGATAGTTTCTATTGATGTAATAGAC
GGAGAAAGCTTTACACTCTCTGAAAAATACGCTTGTACAGAGTGCAACATAAGTATTGAAGAACTTTCCCCGAGAATGTT
TTCCTTCAATAGCCCTTATGGGGTTTGCCCTGTTTGCACTGGATTGGGAGAATTTATGAAGGTAGATCCAGAGCTTTTAA
TACAAGACCCTAAAAAATCATTAGCAAATGGGTTGTTGCCGGGGATTGTTGCTTCACAGGATAGTTATGCTTATTACAAC
ATTTTAAGATTAATTGAACATTTTGGATATACAGAGAATACTCCTTATGAAAAGTTTAGTGAAGATTTAAAGAATGTACT
GCTTTATGGCAAAGATACAAAAGGTAAGTCCTATGGATTTGAAGGTATAGTAAACAATCTTGAAAGAAGGTACAACAATA
CTTCTTCAGATTTTATAAAAGAAGAGATAGAGAAATATATGAGACCGGTTACTTGTCCTGCATGCCATGGGGCTAGATTA
AAGCCAGAAGCGCTAGCTGTGACTGTTGGTGGACTTTCCATAAAAGAAATGACAGACCTTTCTGTTGGCGAGCTTATAAA
ATTTATTGAGGAACTCAAATTAACAGAAAAACAAGAGATTATTGCAAAGCCAATTTTAAAAGAAATAAAGGCAAGGCTTA
ATTTTCTTGTGGATGTAGGACTGGATTATTTGACTCTTTCAAGACCTGCAGCTACTTTATCAGGTGGAGAAGCACAAAGG
ATAAGATTGGCAAGCCAGATAGGCTCTGGGCTTGTAGGAGTCACATACATCCTGGACGAGCCGAGCATTGGACTTCATCA
AAGAGATAATGAAAGGCTTATAAATTCCTTGAAAAAATTAAGAGACCAAGGCAATACTCTTATAGTAGTAGAGCACGATG
AGGATACAATATATGCGGCAGACTACATTGTGGATGTAGGACCAGGCGCAGGTGAGCATGGAGGAGAAATTGTAATTGCG
GGTACGATAGAAGATGTGTTAAAATGTGAAAAATCAATTACAGGCCAGTATTTAAGTGGTAAAATAAAGATAGAAGTGCC
AAAACAGAGGAGAAAACCTAATGGAAAAGCTTTAATAGTGAAAGGAGCTAAGGAAAACAATTTAAAGAATATAGATGTGG
TTTTCCCCCTCGGAGTATTTATATGTGTTACAGGGGTTTCTGGCTCAGGCAAAAGCACCCTTATAAATGAGATACTGTAC
AAAGCATTGGCACAGAAGATTTATAAGTCCAAAGATAAACCAGGTATGCACGATGCAATAGAGGGTATCGATAATATAGA
TAAAGTAATAAATATTGACCAGTCTCCTATAGGCAGGACTCCTCGCTCAAATCCTGCTACCTATACAGGAGTTTTCGACT
ATATAAGAGAGGTTTTTGCAAATACTCCAGAAGCTAAAATGAGAGGCTATAAACCAGGAAGATTTAGTTTTAATGTTAAA
GGTGGAAGGTGTGAAGCCTGTGGTGGAGATGGTATAATTAAAATTGAGATGAACTTTTTGCCGGATGTGTATGTCCCTTG
TGAAGTCTGCAAAGGGCAAAGGTATAATAGGGAAACATTGGAAGTAAAATATAAAGGGAAAAATATTTCGGATGTACTTA
ATATGACGGTAGAAGAGGCGTTAGAATTTTTTGAAAATATACCCAGGATAAAAAATAAATTGATGACTTTATATGATGTG
GGTTTAGGATATATTAAGCTAGGGCAACCTTCTACTCAGCTTTCAGGAGGAGAAGCACAAAGAGTAAAATTAGCTACTGA
ACTTTCTAAAAGGCCTACAGGTAAAACACTATATATTTTGGATGAGCCTACAACTGGATTACATTTTGCAGATGTGCATA
GGCTTCTTGAAGTTTTAAATAGATTAACTGATGCGGGCAATACTGTTATTGTAATTGAACACAACTTAGATATCATAAAA
AGTGCAGACTATATCATTGACTTAGGACCAGAAGGTGGAGACAAGGGTGGAAGGGTAATAGCTACAGGGACACCTGAAGA
AGTTGCTGCTAATGAGAATTCTTATACAGGCCATTTTTTGAAAAAAGTCCTTTCTCAAAAATGA

Upstream 100 bases:

>100_bases
AGAAGCTGCAATTGAGCTGCAGTTTGAAAAGGCTGCAAAATTGAGAGATGTGATTTTTGAATTGAAGAAACAGTTGGAGG
AAGTAGTTTGAGGTGAAATC

Downstream 100 bases:

>100_bases
GGTGAATTTATGTATTATGCCATAGCTTCTCAGATATTAAAATATGTCCTTATTTTTCTCATCTACCTGTTTTTATACAG
GGTTTTTAAAATAGTGTATA

Product: excinuclease ABC subunit A

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 927; Mature: 926

Protein sequence:

>927_residues
MAKDKIVIKGARVHNLKNVDLEIPRDKLTVITGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDYIEG
LSPAISIDQKTTNKNPRSTVGTITEIYDYLRLLYARAGIPHCPVCGKEISMQTIDQMVDRVKELPEGTRIQVLAPVIRGR
KGEYAKLLNDIKKSGYVRVKIDGVMYDVNEEIKLDKNKKHTIEVVVDRVIIKPGIDMRLTDSIETALKLADGIVSIDVID
GESFTLSEKYACTECNISIEELSPRMFSFNSPYGVCPVCTGLGEFMKVDPELLIQDPKKSLANGLLPGIVASQDSYAYYN
ILRLIEHFGYTENTPYEKFSEDLKNVLLYGKDTKGKSYGFEGIVNNLERRYNNTSSDFIKEEIEKYMRPVTCPACHGARL
KPEALAVTVGGLSIKEMTDLSVGELIKFIEELKLTEKQEIIAKPILKEIKARLNFLVDVGLDYLTLSRPAATLSGGEAQR
IRLASQIGSGLVGVTYILDEPSIGLHQRDNERLINSLKKLRDQGNTLIVVEHDEDTIYAADYIVDVGPGAGEHGGEIVIA
GTIEDVLKCEKSITGQYLSGKIKIEVPKQRRKPNGKALIVKGAKENNLKNIDVVFPLGVFICVTGVSGSGKSTLINEILY
KALAQKIYKSKDKPGMHDAIEGIDNIDKVINIDQSPIGRTPRSNPATYTGVFDYIREVFANTPEAKMRGYKPGRFSFNVK
GGRCEACGGDGIIKIEMNFLPDVYVPCEVCKGQRYNRETLEVKYKGKNISDVLNMTVEEALEFFENIPRIKNKLMTLYDV
GLGYIKLGQPSTQLSGGEAQRVKLATELSKRPTGKTLYILDEPTTGLHFADVHRLLEVLNRLTDAGNTVIVIEHNLDIIK
SADYIIDLGPEGGDKGGRVIATGTPEEVAANENSYTGHFLKKVLSQK

Sequences:

>Translated_927_residues
MAKDKIVIKGARVHNLKNVDLEIPRDKLTVITGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDYIEG
LSPAISIDQKTTNKNPRSTVGTITEIYDYLRLLYARAGIPHCPVCGKEISMQTIDQMVDRVKELPEGTRIQVLAPVIRGR
KGEYAKLLNDIKKSGYVRVKIDGVMYDVNEEIKLDKNKKHTIEVVVDRVIIKPGIDMRLTDSIETALKLADGIVSIDVID
GESFTLSEKYACTECNISIEELSPRMFSFNSPYGVCPVCTGLGEFMKVDPELLIQDPKKSLANGLLPGIVASQDSYAYYN
ILRLIEHFGYTENTPYEKFSEDLKNVLLYGKDTKGKSYGFEGIVNNLERRYNNTSSDFIKEEIEKYMRPVTCPACHGARL
KPEALAVTVGGLSIKEMTDLSVGELIKFIEELKLTEKQEIIAKPILKEIKARLNFLVDVGLDYLTLSRPAATLSGGEAQR
IRLASQIGSGLVGVTYILDEPSIGLHQRDNERLINSLKKLRDQGNTLIVVEHDEDTIYAADYIVDVGPGAGEHGGEIVIA
GTIEDVLKCEKSITGQYLSGKIKIEVPKQRRKPNGKALIVKGAKENNLKNIDVVFPLGVFICVTGVSGSGKSTLINEILY
KALAQKIYKSKDKPGMHDAIEGIDNIDKVINIDQSPIGRTPRSNPATYTGVFDYIREVFANTPEAKMRGYKPGRFSFNVK
GGRCEACGGDGIIKIEMNFLPDVYVPCEVCKGQRYNRETLEVKYKGKNISDVLNMTVEEALEFFENIPRIKNKLMTLYDV
GLGYIKLGQPSTQLSGGEAQRVKLATELSKRPTGKTLYILDEPTTGLHFADVHRLLEVLNRLTDAGNTVIVIEHNLDIIK
SADYIIDLGPEGGDKGGRVIATGTPEEVAANENSYTGHFLKKVLSQK
>Mature_926_residues
AKDKIVIKGARVHNLKNVDLEIPRDKLTVITGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDYIEGL
SPAISIDQKTTNKNPRSTVGTITEIYDYLRLLYARAGIPHCPVCGKEISMQTIDQMVDRVKELPEGTRIQVLAPVIRGRK
GEYAKLLNDIKKSGYVRVKIDGVMYDVNEEIKLDKNKKHTIEVVVDRVIIKPGIDMRLTDSIETALKLADGIVSIDVIDG
ESFTLSEKYACTECNISIEELSPRMFSFNSPYGVCPVCTGLGEFMKVDPELLIQDPKKSLANGLLPGIVASQDSYAYYNI
LRLIEHFGYTENTPYEKFSEDLKNVLLYGKDTKGKSYGFEGIVNNLERRYNNTSSDFIKEEIEKYMRPVTCPACHGARLK
PEALAVTVGGLSIKEMTDLSVGELIKFIEELKLTEKQEIIAKPILKEIKARLNFLVDVGLDYLTLSRPAATLSGGEAQRI
RLASQIGSGLVGVTYILDEPSIGLHQRDNERLINSLKKLRDQGNTLIVVEHDEDTIYAADYIVDVGPGAGEHGGEIVIAG
TIEDVLKCEKSITGQYLSGKIKIEVPKQRRKPNGKALIVKGAKENNLKNIDVVFPLGVFICVTGVSGSGKSTLINEILYK
ALAQKIYKSKDKPGMHDAIEGIDNIDKVINIDQSPIGRTPRSNPATYTGVFDYIREVFANTPEAKMRGYKPGRFSFNVKG
GRCEACGGDGIIKIEMNFLPDVYVPCEVCKGQRYNRETLEVKYKGKNISDVLNMTVEEALEFFENIPRIKNKLMTLYDVG
LGYIKLGQPSTQLSGGEAQRVKLATELSKRPTGKTLYILDEPTTGLHFADVHRLLEVLNRLTDAGNTVIVIEHNLDIIKS
ADYIIDLGPEGGDKGGRVIATGTPEEVAANENSYTGHFLKKVLSQK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=941, Percent_Identity=57.7045696068013, Blast_Score=1094, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR003593
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 102604; Mature: 102473

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKDKIVIKGARVHNLKNVDLEIPRDKLTVITGLSGSGKSSLAFDTIYAEGQRRYVESLS
CCCCCEEEECCEECCCCCCCEECCCCCEEEEEECCCCCCCCEEEHHHHHHHHHHHHHHHH
AYARQFLGQMDKPDVDYIEGLSPAISIDQKTTNKNPRSTVGTITEIYDYLRLLYARAGIP
HHHHHHHCCCCCCCHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
HCPVCGKEISMQTIDQMVDRVKELPEGTRIQVLAPVIRGRKGEYAKLLNDIKKSGYVRVK
CCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCCCHHHHHHHHHHCCEEEEE
IDGVMYDVNEEIKLDKNKKHTIEVVVDRVIIKPGIDMRLTDSIETALKLADGIVSIDVID
ECCEEEECCCCEEECCCCCHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHCCEEEEEEEC
GESFTLSEKYACTECNISIEELSPRMFSFNSPYGVCPVCTGLGEFMKVDPELLIQDPKKS
CCCEEECCCCEEEECCEEHHHCCCCCEECCCCCCCCHHHHCCHHHHHCCHHHEECCCHHH
LANGLLPGIVASQDSYAYYNILRLIEHFGYTENTPYEKFSEDLKNVLLYGKDTKGKSYGF
HHCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHEEECCCCCCCCCCH
EGIVNNLERRYNNTSSDFIKEEIEKYMRPVTCPACHGARLKPEALAVTVGGLSIKEMTDL
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHCC
SVGELIKFIEELKLTEKQEIIAKPILKEIKARLNFLVDVGLDYLTLSRPAATLSGGEAQR
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHH
IRLASQIGSGLVGVTYILDEPSIGLHQRDNERLINSLKKLRDQGNTLIVVEHDEDTIYAA
HHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEEE
DYIVDVGPGAGEHGGEIVIAGTIEDVLKCEKSITGQYLSGKIKIEVPKQRRKPNGKALIV
EEEEECCCCCCCCCCEEEEEECHHHHHHHHHHHCCCEECCEEEEECCHHHCCCCCCEEEE
KGAKENNLKNIDVVFPLGVFICVTGVSGSGKSTLINEILYKALAQKIYKSKDKPGMHDAI
ECCCCCCCCEEEEEECCCEEHEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
EGIDNIDKVINIDQSPIGRTPRSNPATYTGVFDYIREVFANTPEAKMRGYKPGRFSFNVK
HHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEC
GGRCEACGGDGIIKIEMNFLPDVYVPCEVCKGQRYNRETLEVKYKGKNISDVLNMTVEEA
CCEEEECCCCCEEEEEECCCCCCCCCHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
LEFFENIPRIKNKLMTLYDVGLGYIKLGQPSTQLSGGEAQRVKLATELSKRPTGKTLYIL
HHHHHHCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEE
DEPTTGLHFADVHRLLEVLNRLTDAGNTVIVIEHNLDIIKSADYIIDLGPEGGDKGGRVI
ECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCEEEEECCCCCCCCCEEE
ATGTPEEVAANENSYTGHFLKKVLSQK
ECCCCHHHHCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
AKDKIVIKGARVHNLKNVDLEIPRDKLTVITGLSGSGKSSLAFDTIYAEGQRRYVESLS
CCCCEEEECCEECCCCCCCEECCCCCEEEEEECCCCCCCCEEEHHHHHHHHHHHHHHHH
AYARQFLGQMDKPDVDYIEGLSPAISIDQKTTNKNPRSTVGTITEIYDYLRLLYARAGIP
HHHHHHHCCCCCCCHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
HCPVCGKEISMQTIDQMVDRVKELPEGTRIQVLAPVIRGRKGEYAKLLNDIKKSGYVRVK
CCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCCCHHHHHHHHHHCCEEEEE
IDGVMYDVNEEIKLDKNKKHTIEVVVDRVIIKPGIDMRLTDSIETALKLADGIVSIDVID
ECCEEEECCCCEEECCCCCHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHCCEEEEEEEC
GESFTLSEKYACTECNISIEELSPRMFSFNSPYGVCPVCTGLGEFMKVDPELLIQDPKKS
CCCEEECCCCEEEECCEEHHHCCCCCEECCCCCCCCHHHHCCHHHHHCCHHHEECCCHHH
LANGLLPGIVASQDSYAYYNILRLIEHFGYTENTPYEKFSEDLKNVLLYGKDTKGKSYGF
HHCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHEEECCCCCCCCCCH
EGIVNNLERRYNNTSSDFIKEEIEKYMRPVTCPACHGARLKPEALAVTVGGLSIKEMTDL
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHCC
SVGELIKFIEELKLTEKQEIIAKPILKEIKARLNFLVDVGLDYLTLSRPAATLSGGEAQR
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHH
IRLASQIGSGLVGVTYILDEPSIGLHQRDNERLINSLKKLRDQGNTLIVVEHDEDTIYAA
HHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEEE
DYIVDVGPGAGEHGGEIVIAGTIEDVLKCEKSITGQYLSGKIKIEVPKQRRKPNGKALIV
EEEEECCCCCCCCCCEEEEEECHHHHHHHHHHHCCCEECCEEEEECCHHHCCCCCCEEEE
KGAKENNLKNIDVVFPLGVFICVTGVSGSGKSTLINEILYKALAQKIYKSKDKPGMHDAI
ECCCCCCCCEEEEEECCCEEHEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
EGIDNIDKVINIDQSPIGRTPRSNPATYTGVFDYIREVFANTPEAKMRGYKPGRFSFNVK
HHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEC
GGRCEACGGDGIIKIEMNFLPDVYVPCEVCKGQRYNRETLEVKYKGKNISDVLNMTVEEA
CCEEEECCCCCEEEEEECCCCCCCCCHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
LEFFENIPRIKNKLMTLYDVGLGYIKLGQPSTQLSGGEAQRVKLATELSKRPTGKTLYIL
HHHHHHCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEE
DEPTTGLHFADVHRLLEVLNRLTDAGNTVIVIEHNLDIIKSADYIIDLGPEGGDKGGRVI
ECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCEEEEECCCCCCCCCEEE
ATGTPEEVAANENSYTGHFLKKVLSQK
ECCCCHHHHCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]