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The map label for this gene is hisD [H]

Identifier: 167039651

GI number: 167039651

Start: 1031743

End: 1033026

Strand: Direct

Name: hisD [H]

Synonym: Teth514_1001

Alternate gene names: 167039651

Gene position: 1031743-1033026 (Clockwise)

Preceding gene: 167039650

Following gene: 167039652

Centisome position: 41.99

GC content: 36.84

Gene sequence:

>1284_bases
ATGATTGAGATATTTGATTTTCGAAAGGGAATTGACAATGGTATTTTACAAAAGCTTCACAACAGAAGTAAATTAGAGAA
TAAAGAAATAGCAAAAAAAGTGGAAGAAATAATTTCAAACGTAAGAGAGAGAAAAGACAAGGCTTTGTTTGAGTATACTT
ACATGTTTGACGGAATAAATCTTGACAAAAGTACTGTAAAAGTTACGAAAGAGGAAATAAAAAATGCTTATAAAGAAGTG
GAAGGAGAATTTTTAAAAGCGATTGACAAAGCTATCAAAAACATAACAGAATTTCATGAAAAGCAAAAACAGTCTACATG
GATGGATTTTAAAGAAGGTATAGTTTATGGGCAGATAGTAAGACCTCTTTCTCAAGTTGGAATTTATGTGCCGGGGGGAA
CCGCTTCTTATCCTTCTTCAGTTTTGATGAATGGAATACCTGCAAAGGTGGCTGGTGTAGAGAAAATAGTGATGGTTTCT
CCAGCTGGTAAGAAGGGAATAAACCCTTATGTGTTAGTGGCTGCAGATAGGATAGGAATAGAGGATATATATAAAGTTGG
AGGCGCACAGGCTGTTGCAGCCTTGGCATTTGGGACAGAGTCAATACCTAAGGTTGATAAAATAGTTGGCCCGGGAAATA
TTTTTGTCGCACTGGCTAAAAGAGCTCTTTACGGACATGTGGATATTGATATGGTGGCAGGCCCCAGTGAAGTTTTAGTT
ATAGCTGACGAAACTGCTAATCCTAAATATGTGGCGGCGGACCTGTTGTCACAGGCGGAACATGATGTAATGGCATCTTC
AATACTTGTCACAACATCTTTGGAGGTTGCGCAACAAGTAAAAATAGAAATTGAAAGGCAAATGGAATATCTTGAAAGGA
AAGAAATAATTGAAAAGTCTTTAAAAAATTTTGGTGCGATAATTGTTGTAAATAATTTAAAAGAAGCAATTGGTATTGCA
AATGACATAGCTCCGGAGCATTTAGAGCTTAACATTTCCAATGCCTTTGAAATAATTGGTGAAATCAAGAATGCAGGAGC
AGTCTTTGTGGGAGAATATTCTCCAGAACCCTTAGGGGACTATCTTGCTGGCCCTAACCATGTGCTTCCTACTAGTGGAA
CAGCAAGGTTTTTCTCGCCTCTTTCTGTGACGGACTTTATCAAAAAGATGAATATTCTCTATTATTCTAAGGATTCTTTG
AGAGAGGTAAAAGAGGATGTAATAACTTTAGCAAATTCAGAAGGGCTTACCGCTCATGCTAATTCTATAAAAGTGAGGTT
TTAA

Upstream 100 bases:

>100_bases
TTGATAGTGAATAAAGCCAGTCTTAAAACTAAAAGCCAGAGAATAAAAGAGATAATTATAAAATTAAAAGAGGTTGTGGA
AACTTTTAAGGAGGTTTAAA

Downstream 100 bases:

>100_bases
AATGATTGAGAATTTGGTGAGAGAAGAAATTAAGGGATTTAAAAATTATGAAGTGCACAGTATTCCCTACAGATATAAGA
TGGATGCAAATGAAACGCCT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MIEIFDFRKGIDNGILQKLHNRSKLENKEIAKKVEEIISNVRERKDKALFEYTYMFDGINLDKSTVKVTKEEIKNAYKEV
EGEFLKAIDKAIKNITEFHEKQKQSTWMDFKEGIVYGQIVRPLSQVGIYVPGGTASYPSSVLMNGIPAKVAGVEKIVMVS
PAGKKGINPYVLVAADRIGIEDIYKVGGAQAVAALAFGTESIPKVDKIVGPGNIFVALAKRALYGHVDIDMVAGPSEVLV
IADETANPKYVAADLLSQAEHDVMASSILVTTSLEVAQQVKIEIERQMEYLERKEIIEKSLKNFGAIIVVNNLKEAIGIA
NDIAPEHLELNISNAFEIIGEIKNAGAVFVGEYSPEPLGDYLAGPNHVLPTSGTARFFSPLSVTDFIKKMNILYYSKDSL
REVKEDVITLANSEGLTAHANSIKVRF

Sequences:

>Translated_427_residues
MIEIFDFRKGIDNGILQKLHNRSKLENKEIAKKVEEIISNVRERKDKALFEYTYMFDGINLDKSTVKVTKEEIKNAYKEV
EGEFLKAIDKAIKNITEFHEKQKQSTWMDFKEGIVYGQIVRPLSQVGIYVPGGTASYPSSVLMNGIPAKVAGVEKIVMVS
PAGKKGINPYVLVAADRIGIEDIYKVGGAQAVAALAFGTESIPKVDKIVGPGNIFVALAKRALYGHVDIDMVAGPSEVLV
IADETANPKYVAADLLSQAEHDVMASSILVTTSLEVAQQVKIEIERQMEYLERKEIIEKSLKNFGAIIVVNNLKEAIGIA
NDIAPEHLELNISNAFEIIGEIKNAGAVFVGEYSPEPLGDYLAGPNHVLPTSGTARFFSPLSVTDFIKKMNILYYSKDSL
REVKEDVITLANSEGLTAHANSIKVRF
>Mature_427_residues
MIEIFDFRKGIDNGILQKLHNRSKLENKEIAKKVEEIISNVRERKDKALFEYTYMFDGINLDKSTVKVTKEEIKNAYKEV
EGEFLKAIDKAIKNITEFHEKQKQSTWMDFKEGIVYGQIVRPLSQVGIYVPGGTASYPSSVLMNGIPAKVAGVEKIVMVS
PAGKKGINPYVLVAADRIGIEDIYKVGGAQAVAALAFGTESIPKVDKIVGPGNIFVALAKRALYGHVDIDMVAGPSEVLV
IADETANPKYVAADLLSQAEHDVMASSILVTTSLEVAQQVKIEIERQMEYLERKEIIEKSLKNFGAIIVVNNLKEAIGIA
NDIAPEHLELNISNAFEIIGEIKNAGAVFVGEYSPEPLGDYLAGPNHVLPTSGTARFFSPLSVTDFIKKMNILYYSKDSL
REVKEDVITLANSEGLTAHANSIKVRF

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=427, Percent_Identity=42.6229508196721, Blast_Score=335, Evalue=4e-93,
Organism=Saccharomyces cerevisiae, GI6319819, Length=433, Percent_Identity=39.9538106235566, Blast_Score=300, Evalue=3e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46992; Mature: 46992

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEIFDFRKGIDNGILQKLHNRSKLENKEIAKKVEEIISNVRERKDKALFEYTYMFDGIN
CCEEECHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEHEECCCC
LDKSTVKVTKEEIKNAYKEVEGEFLKAIDKAIKNITEFHEKQKQSTWMDFKEGIVYGQIV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
RPLSQVGIYVPGGTASYPSSVLMNGIPAKVAGVEKIVMVSPAGKKGINPYVLVAADRIGI
HHHHHCCEEECCCCCCCCHHHHHCCCCHHHHCCEEEEEECCCCCCCCCCEEEEEECCCCH
EDIYKVGGAQAVAALAFGTESIPKVDKIVGPGNIFVALAKRALYGHVDIDMVAGPSEVLV
HHHHHCCCHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCEEEE
IADETANPKYVAADLLSQAEHDVMASSILVTTSLEVAQQVKIEIERQMEYLERKEIIEKS
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKNFGAIIVVNNLKEAIGIANDIAPEHLELNISNAFEIIGEIKNAGAVFVGEYSPEPLGD
HHHCCEEEEECCHHHHHCCHHCCCCCCEEEEHHHHHHHHHHHHCCCEEEEECCCCCCCHH
YLAGPNHVLPTSGTARFFSPLSVTDFIKKMNILYYSKDSLREVKEDVITLANSEGLTAHA
HHCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHEEECHHHHHHHHHHHHHHCCCCCCEEEC
NSIKVRF
CCEEEEC
>Mature Secondary Structure
MIEIFDFRKGIDNGILQKLHNRSKLENKEIAKKVEEIISNVRERKDKALFEYTYMFDGIN
CCEEECHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEHEECCCC
LDKSTVKVTKEEIKNAYKEVEGEFLKAIDKAIKNITEFHEKQKQSTWMDFKEGIVYGQIV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
RPLSQVGIYVPGGTASYPSSVLMNGIPAKVAGVEKIVMVSPAGKKGINPYVLVAADRIGI
HHHHHCCEEECCCCCCCCHHHHHCCCCHHHHCCEEEEEECCCCCCCCCCEEEEEECCCCH
EDIYKVGGAQAVAALAFGTESIPKVDKIVGPGNIFVALAKRALYGHVDIDMVAGPSEVLV
HHHHHCCCHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCEEEE
IADETANPKYVAADLLSQAEHDVMASSILVTTSLEVAQQVKIEIERQMEYLERKEIIEKS
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKNFGAIIVVNNLKEAIGIANDIAPEHLELNISNAFEIIGEIKNAGAVFVGEYSPEPLGD
HHHCCEEEEECCHHHHHCCHHCCCCCCEEEEHHHHHHHHHHHHCCCEEEEECCCCCCCHH
YLAGPNHVLPTSGTARFFSPLSVTDFIKKMNILYYSKDSLREVKEDVITLANSEGLTAHA
HHCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHEEECHHHHHHHHHHHHHHCCCCCCEEEC
NSIKVRF
CCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]