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The map label for this gene is hisG

Identifier: 167039650

GI number: 167039650

Start: 1031100

End: 1031741

Strand: Direct

Name: hisG

Synonym: Teth514_1000

Alternate gene names: 167039650

Gene position: 1031100-1031741 (Clockwise)

Preceding gene: 167039649

Following gene: 167039651

Centisome position: 41.96

GC content: 34.11

Gene sequence:

>642_bases
ATGGAAAATATTTCTATTGCACTGCCAAAAGGTAGAATGGCAGATAGTGCTATAACTTTGTTTGAAAAGGCAGGAATTGC
TGAGAATATTTTAAAAGATATTTCTCGAAAACTTGTTGTTAATGACCATAAAAATTTAATGAAGTTTATGTTGGTAAAGC
CGATGGATGTGCCCACATATGTAGAACACGGGGCAGCTGATTTGGGGATTTGTGGAAAAGATATTCTCTTAGAGCAAAAA
AAAGATTGCTATGAAGTTTTAGATTTAAAATTTGGTTTTTGTAAAATGGTGGTTGCGGGGCCTAAAGAGGCAAAGGACAG
TTTTCTTACTAATAAAAGAGTTGCAACAAAGTTTCCCAATATTGCAGAAGAATTTTTCAGGCAAAAGGGAGAAAATGTAG
AAATAATTAAGCTGAATGGTTCTGTGGAGCTTGCTCCTATTGTGGGGCTGTCAGAGGTAATTGTAGACATTGTAGAGACA
GGCAATACTTTAAGAGAAAATGGTCTTATAGTCATTGAAGAAATTTTTCCTTCCAGTGCGAGATTGATAGTGAATAAAGC
CAGTCTTAAAACTAAAAGCCAGAGAATAAAAGAGATAATTATAAAATTAAAAGAGGTTGTGGAAACTTTTAAGGAGGTTT
AA

Upstream 100 bases:

>100_bases
TTAAGAGGTGAGGGAAAAATTGTAGAGATGTATAGCTATGAAAAAGCGAAGCATGTTGATGAAAATAGCTTTGACGAAAT
TATAGATATGGAGGAATAAT

Downstream 100 bases:

>100_bases
AATGATTGAGATATTTGATTTTCGAAAGGGAATTGACAATGGTATTTTACAAAAGCTTCACAACAGAAGTAAATTAGAGA
ATAAAGAAATAGCAAAAAAA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MENISIALPKGRMADSAITLFEKAGIAENILKDISRKLVVNDHKNLMKFMLVKPMDVPTYVEHGAADLGICGKDILLEQK
KDCYEVLDLKFGFCKMVVAGPKEAKDSFLTNKRVATKFPNIAEEFFRQKGENVEIIKLNGSVELAPIVGLSEVIVDIVET
GNTLRENGLIVIEEIFPSSARLIVNKASLKTKSQRIKEIIIKLKEVVETFKEV

Sequences:

>Translated_213_residues
MENISIALPKGRMADSAITLFEKAGIAENILKDISRKLVVNDHKNLMKFMLVKPMDVPTYVEHGAADLGICGKDILLEQK
KDCYEVLDLKFGFCKMVVAGPKEAKDSFLTNKRVATKFPNIAEEFFRQKGENVEIIKLNGSVELAPIVGLSEVIVDIVET
GNTLRENGLIVIEEIFPSSARLIVNKASLKTKSQRIKEIIIKLKEVVETFKEV
>Mature_213_residues
MENISIALPKGRMADSAITLFEKAGIAENILKDISRKLVVNDHKNLMKFMLVKPMDVPTYVEHGAADLGICGKDILLEQK
KDCYEVLDLKFGFCKMVVAGPKEAKDSFLTNKRVATKFPNIAEEFFRQKGENVEIIKLNGSVELAPIVGLSEVIVDIVET
GNTLRENGLIVIEEIFPSSARLIVNKASLKTKSQRIKEIIIKLKEVVETFKEV

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=221, Percent_Identity=33.0316742081448, Blast_Score=107, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6320896, Length=198, Percent_Identity=33.3333333333333, Blast_Score=88, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_THEP3 (B0K733)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001664516.1
- ProteinModelPortal:   B0K733
- SMR:   B0K733
- GeneID:   5874026
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_0515
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- ProtClustDB:   PRK01686
- BioCyc:   TPSE340099:TETH39_0515-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 23761; Mature: 23761

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENISIALPKGRMADSAITLFEKAGIAENILKDISRKLVVNDHKNLMKFMLVKPMDVPTY
CCCCEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHH
VEHGAADLGICGKDILLEQKKDCYEVLDLKFGFCKMVVAGPKEAKDSFLTNKRVATKFPN
HHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHEECCCHHHHHHHHHCCHHHHCCCH
IAEEFFRQKGENVEIIKLNGSVELAPIVGLSEVIVDIVETGNTLRENGLIVIEEIFPSSA
HHHHHHHCCCCCEEEEEECCCEEEEHHCCHHHHHHHHHHCCCCCHHCCCEEEEECCCCCC
RLIVNKASLKTKSQRIKEIIIKLKEVVETFKEV
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MENISIALPKGRMADSAITLFEKAGIAENILKDISRKLVVNDHKNLMKFMLVKPMDVPTY
CCCCEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHH
VEHGAADLGICGKDILLEQKKDCYEVLDLKFGFCKMVVAGPKEAKDSFLTNKRVATKFPN
HHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHEECCCHHHHHHHHHCCHHHHCCCH
IAEEFFRQKGENVEIIKLNGSVELAPIVGLSEVIVDIVETGNTLRENGLIVIEEIFPSSA
HHHHHHHCCCCCEEEEEECCCEEEEHHCCHHHHHHHHHHCCCCCHHCCCEEEEECCCCCC
RLIVNKASLKTKSQRIKEIIIKLKEVVETFKEV
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA