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The map label for this gene is hom [H]

Identifier: 167039627

GI number: 167039627

Start: 995708

End: 997000

Strand: Direct

Name: hom [H]

Synonym: Teth514_0975

Alternate gene names: 167039627

Gene position: 995708-997000 (Clockwise)

Preceding gene: 167039623

Following gene: 167039628

Centisome position: 40.52

GC content: 32.95

Gene sequence:

>1293_bases
ATGAAAATAAAAATCGGATTATTAGGACTTGGAACAGTAGGAACAGGAGTATATAAATTGATAACTTCAAGAGGAGGTCA
TATGTGGGAGAGTACAGGGTTTTATCCTGAGATAAAGAAGATACTCGTGAAAAATCTCAATAAGCCAAGGAAAGTGAAGG
TAGAAGGACTACTTACCCAAAATGCTGAAGAAATTTTGAAAGATAAAGAGATAAAAATAGTTATTGAAGCAATAGGAGGT
ATTTCTCCAGCTTACGAATATGTGAAGGAAGCCTTGTCTTCAGGGAAGCATGTAATCACTGCAAATAAAGAATTGATGGC
TAAACATGGGGAAGATTTAAATGAAACAGCAAAAAAAAATGGAGTGTTTTTAAAATGCGAAGCAAGTGTTGGAGGAGCAA
TACCTATACTTCATCAAATTGATAGATTAAAAATCACAGATGAAATAGATTTTGTAGGAGGTATAGTAAACGGCACTACT
AACTACATTCTTACGCAAATGTCTACTAAAGGAAAAAGTTATGAAGAAGCACTTAAAGAAGCTCAGCAATTAGGTTATGC
AGAAGCAAATCCCGATTATGATGTAAAAGGTTTTGATTCACTGTATAAACTGATTATTCTAATGCGCAAAGTATTTAATG
TAAATGTGCCGGTAAATTCTATAAGGAGAAGTGGGATTGATGGGATTGCAAGAGAAGATTTAGATTATATCACTGAATGG
GGGTATAAATTAAAATTGTTTGCATGGGGAAAAAAGATAGAAAATGGTGTTTTTGCAGGAGTAGAACCCGTTTTGGTTGA
GGAAAGCAATATTTTGTCGAGGGTAAACGACGTAAATAATGCTGTTATTCTTAAAGGAGATAGTTTTGGCGAATATGTAT
TTGTGGGCAAAGGGGCAGGAGAGCTTCCTACTGGAGATGCAGTTGTCGCGGATTTAATTGATATACTGTTAAATTATAAT
ATCAAAGATAATGATGCAGCAAAGCTTCTTCCAGTTCGTCAAGGAAGCTTTACAGATACGTTTTATATAAGACTCAAAAT
GCATAAAGGAGATATTTTAAATCTACAAAAGATTTTGAATTTCTTTAAAAGAGAAGAAGCTTTAATCTTAGAGTCCTCTT
ACGAAAATGACACATTTGCTGCTGTAATTAAATTAAAGACAAATATTGATGTATTTGTAGAAAAGCTAAATGACAAAAAA
ATTGGAGAACTAAAAGCAATTTTTAAAGTGTTACAAGAGGATATAGATGAGTTACAGTTAAAAGAATTTGAAGATTTGGT
AGGAGTAATTTAG

Upstream 100 bases:

>100_bases
CAGGTTAGATTATTCTAACCTGAGAGATGAGAGGAGTGGCGGATTATTAGGCCCTCTTCTCATTGAGAAGAGGGCCTAAA
AATTTATTTGGAGGTGTGAC

Downstream 100 bases:

>100_bases
AAATCAAATATTTATATTTGATGAAAGGGGATAAAGATTATGTCTAAAAAATATGGTTTTTCAACTTTGGCAATTCATGA
AGGGTGGGAGCCTGACCCAA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MKIKIGLLGLGTVGTGVYKLITSRGGHMWESTGFYPEIKKILVKNLNKPRKVKVEGLLTQNAEEILKDKEIKIVIEAIGG
ISPAYEYVKEALSSGKHVITANKELMAKHGEDLNETAKKNGVFLKCEASVGGAIPILHQIDRLKITDEIDFVGGIVNGTT
NYILTQMSTKGKSYEEALKEAQQLGYAEANPDYDVKGFDSLYKLIILMRKVFNVNVPVNSIRRSGIDGIAREDLDYITEW
GYKLKLFAWGKKIENGVFAGVEPVLVEESNILSRVNDVNNAVILKGDSFGEYVFVGKGAGELPTGDAVVADLIDILLNYN
IKDNDAAKLLPVRQGSFTDTFYIRLKMHKGDILNLQKILNFFKREEALILESSYENDTFAAVIKLKTNIDVFVEKLNDKK
IGELKAIFKVLQEDIDELQLKEFEDLVGVI

Sequences:

>Translated_430_residues
MKIKIGLLGLGTVGTGVYKLITSRGGHMWESTGFYPEIKKILVKNLNKPRKVKVEGLLTQNAEEILKDKEIKIVIEAIGG
ISPAYEYVKEALSSGKHVITANKELMAKHGEDLNETAKKNGVFLKCEASVGGAIPILHQIDRLKITDEIDFVGGIVNGTT
NYILTQMSTKGKSYEEALKEAQQLGYAEANPDYDVKGFDSLYKLIILMRKVFNVNVPVNSIRRSGIDGIAREDLDYITEW
GYKLKLFAWGKKIENGVFAGVEPVLVEESNILSRVNDVNNAVILKGDSFGEYVFVGKGAGELPTGDAVVADLIDILLNYN
IKDNDAAKLLPVRQGSFTDTFYIRLKMHKGDILNLQKILNFFKREEALILESSYENDTFAAVIKLKTNIDVFVEKLNDKK
IGELKAIFKVLQEDIDELQLKEFEDLVGVI
>Mature_430_residues
MKIKIGLLGLGTVGTGVYKLITSRGGHMWESTGFYPEIKKILVKNLNKPRKVKVEGLLTQNAEEILKDKEIKIVIEAIGG
ISPAYEYVKEALSSGKHVITANKELMAKHGEDLNETAKKNGVFLKCEASVGGAIPILHQIDRLKITDEIDFVGGIVNGTT
NYILTQMSTKGKSYEEALKEAQQLGYAEANPDYDVKGFDSLYKLIILMRKVFNVNVPVNSIRRSGIDGIAREDLDYITEW
GYKLKLFAWGKKIENGVFAGVEPVLVEESNILSRVNDVNNAVILKGDSFGEYVFVGKGAGELPTGDAVVADLIDILLNYN
IKDNDAAKLLPVRQGSFTDTFYIRLKMHKGDILNLQKILNFFKREEALILESSYENDTFAAVIKLKTNIDVFVEKLNDKK
IGELKAIFKVLQEDIDELQLKEFEDLVGVI

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47868; Mature: 47868

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKIGLLGLGTVGTGVYKLITSRGGHMWESTGFYPEIKKILVKNLNKPRKVKVEGLLTQ
CEEEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEHHHC
NAEEILKDKEIKIVIEAIGGISPAYEYVKEALSSGKHVITANKELMAKHGEDLNETAKKN
CHHHHHCCCCCEEEEEHHCCCCHHHHHHHHHHHCCCEEEECCHHHHHHCCCCHHHHHHHC
GVFLKCEASVGGAIPILHQIDRLKITDEIDFVGGIVNGTTNYILTQMSTKGKSYEEALKE
CEEEEEECCCCCCCHHHHHHHHEEECCCHHHHCHHHCCCCCEEEEEECCCCCCHHHHHHH
AQQLGYAEANPDYDVKGFDSLYKLIILMRKVFNVNVPVNSIRRSGIDGIAREDLDYITEW
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHC
GYKLKLFAWGKKIENGVFAGVEPVLVEESNILSRVNDVNNAVILKGDSFGEYVFVGKGAG
CCEEEEEEECHHHCCCCCCCCCEEEECCHHHHHHHHCCCCEEEEECCCCCCEEEEECCCC
ELPTGDAVVADLIDILLNYNIKDNDAAKLLPVRQGSFTDTFYIRLKMHKGDILNLQKILN
CCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEEEEEECCCCCCCHHHHHH
FFKREEALILESSYENDTFAAVIKLKTNIDVFVEKLNDKKIGELKAIFKVLQEDIDELQL
HHHCCCEEEEECCCCCCEEEEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
KEFEDLVGVI
HHHHHHHCCC
>Mature Secondary Structure
MKIKIGLLGLGTVGTGVYKLITSRGGHMWESTGFYPEIKKILVKNLNKPRKVKVEGLLTQ
CEEEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEHHHC
NAEEILKDKEIKIVIEAIGGISPAYEYVKEALSSGKHVITANKELMAKHGEDLNETAKKN
CHHHHHCCCCCEEEEEHHCCCCHHHHHHHHHHHCCCEEEECCHHHHHHCCCCHHHHHHHC
GVFLKCEASVGGAIPILHQIDRLKITDEIDFVGGIVNGTTNYILTQMSTKGKSYEEALKE
CEEEEEECCCCCCCHHHHHHHHEEECCCHHHHCHHHCCCCCEEEEEECCCCCCHHHHHHH
AQQLGYAEANPDYDVKGFDSLYKLIILMRKVFNVNVPVNSIRRSGIDGIAREDLDYITEW
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHC
GYKLKLFAWGKKIENGVFAGVEPVLVEESNILSRVNDVNNAVILKGDSFGEYVFVGKGAG
CCEEEEEEECHHHCCCCCCCCCEEEECCHHHHHHHHCCCCEEEEECCCCCCEEEEECCCC
ELPTGDAVVADLIDILLNYNIKDNDAAKLLPVRQGSFTDTFYIRLKMHKGDILNLQKILN
CCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEEEEEECCCCCCCHHHHHH
FFKREEALILESSYENDTFAAVIKLKTNIDVFVEKLNDKKIGELKAIFKVLQEDIDELQL
HHHCCCEEEEECCCCCCEEEEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
KEFEDLVGVI
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3139660; 9384377; 3098560 [H]