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The map label for this gene is kbl [C]

Identifier: 167039434

GI number: 167039434

Start: 808971

End: 810158

Strand: Reverse

Name: kbl [C]

Synonym: Teth514_0779

Alternate gene names: 167039434

Gene position: 810158-808971 (Counterclockwise)

Preceding gene: 167039435

Following gene: 167039430

Centisome position: 32.97

GC content: 39.14

Gene sequence:

>1188_bases
ATGTCAAGCATTCATGACCTTGACTTTATAAAAGAAAAGCTGGAAGAACTCAAAAAAGCAGGTGTGTATAGAAAATTAAC
TGTCCTTGAAAGTCCCTCTGGCCCCCGTTCTATAATCGATGGAAAGAAAGTTATAAACCTTTCTTCAAACAACTACCTCG
GCCTTGCAAATCATCCGCGGTTAAAAAAAGCCGCAATAGAAGCTATTGAAAAATGGGGAGTTGGTGCTGGCGCCGTAAGA
ACGATAATAGGAAACATGACAATTCACGAAGAACTTGAAAGAAAATTAGCTGAATTTAAAAGAGAAGAAGCAGTTCTCAC
TTTCCAATCAGGTTTTACAGCAAACATGGGCGTCATTCAAGCAGTTGTTGACAAAGGAGACGTCATAATAAGTGACGAAT
TAAACCACGCCAGTATCATCGATGGCTGCAGATTAAGCCGAGCAGATGTGGTAATATACAAACACAGTGACATGGAGGAC
CTAGAAAGAGTATTAAAAGAAGTAAAAGATAAATACAGAGTCAAAATGATAATAACTGACGGAGTATTCAGCATGGATGG
CGATATAGCGAAACTCCCCGAAATAGTGAAATTGGCAGAAAAATACAGTGCAATAACTTATGTAGATGACGCACATGCCA
GTGGCGTTTTAGGTGAAAGCGGAAGAGGCTCTGCTGACCATTTCAACTTACACGGAAGAATTGATATACAAATAGGCACA
CTTTCCAAAGCAATCGGAGTTGTTGGAGGATATGTAGCTGGCAAAAGAGAGCTTATAGAATGGCTAAATCATAGAGGCAG
ACCCTTCCTCTTCAGTACAGCTCTACCTCCTGCGGCAGTTGCAGCATCAATAGAAGCTATAAATATTTTAAGTGAAAGTG
ATGCTCTCACTCGCAAGCTGTGGGATAACGCAAAATATTTCAAAGAAAAGTTAAAATCTTTAGGTTTTGATACCGGCAAG
AGTGAAACACCTATCACCCCTGTAATAATAGGCGAAGAAACTAAAGCTCTCGAATTTAGCAGAAAACTCTTTGAAGAAGG
AGTTTTCGCGCAAGGAATAGTATATCCAACTGTACCTAAAAACAAAGCCAGAGTAAGAACAATTGTAACAGCTGCCCATA
CAAAAGAAGACTTAGACGCTGCCTTAAAAGCTTTTGAAAAAGTCGGAAAACAATTGAATATAATTTAA

Upstream 100 bases:

>100_bases
ACCTTCCCTCTCACTGAATACCAAAAAGGGATGGAACTAATGATAAAAGGCCAATGTGGCAAAGTTGTATTATATCCATA
AACAAAAGGAGGTTTTTAAT

Downstream 100 bases:

>100_bases
AAAATTTGGTTCTCTAACAAATGTTGGGGTGGATAAAAATCATCCATAAAAAATAGCGCACTTATTCTGAATGCCTGTTA
TAATAAAATTGGTTAAATAA

Product: pyridoxal phosphate-dependent acyltransferase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MSSIHDLDFIKEKLEELKKAGVYRKLTVLESPSGPRSIIDGKKVINLSSNNYLGLANHPRLKKAAIEAIEKWGVGAGAVR
TIIGNMTIHEELERKLAEFKREEAVLTFQSGFTANMGVIQAVVDKGDVIISDELNHASIIDGCRLSRADVVIYKHSDMED
LERVLKEVKDKYRVKMIITDGVFSMDGDIAKLPEIVKLAEKYSAITYVDDAHASGVLGESGRGSADHFNLHGRIDIQIGT
LSKAIGVVGGYVAGKRELIEWLNHRGRPFLFSTALPPAAVAASIEAINILSESDALTRKLWDNAKYFKEKLKSLGFDTGK
SETPITPVIIGEETKALEFSRKLFEEGVFAQGIVYPTVPKNKARVRTIVTAAHTKEDLDAALKAFEKVGKQLNII

Sequences:

>Translated_395_residues
MSSIHDLDFIKEKLEELKKAGVYRKLTVLESPSGPRSIIDGKKVINLSSNNYLGLANHPRLKKAAIEAIEKWGVGAGAVR
TIIGNMTIHEELERKLAEFKREEAVLTFQSGFTANMGVIQAVVDKGDVIISDELNHASIIDGCRLSRADVVIYKHSDMED
LERVLKEVKDKYRVKMIITDGVFSMDGDIAKLPEIVKLAEKYSAITYVDDAHASGVLGESGRGSADHFNLHGRIDIQIGT
LSKAIGVVGGYVAGKRELIEWLNHRGRPFLFSTALPPAAVAASIEAINILSESDALTRKLWDNAKYFKEKLKSLGFDTGK
SETPITPVIIGEETKALEFSRKLFEEGVFAQGIVYPTVPKNKARVRTIVTAAHTKEDLDAALKAFEKVGKQLNII
>Mature_394_residues
SSIHDLDFIKEKLEELKKAGVYRKLTVLESPSGPRSIIDGKKVINLSSNNYLGLANHPRLKKAAIEAIEKWGVGAGAVRT
IIGNMTIHEELERKLAEFKREEAVLTFQSGFTANMGVIQAVVDKGDVIISDELNHASIIDGCRLSRADVVIYKHSDMEDL
ERVLKEVKDKYRVKMIITDGVFSMDGDIAKLPEIVKLAEKYSAITYVDDAHASGVLGESGRGSADHFNLHGRIDIQIGTL
SKAIGVVGGYVAGKRELIEWLNHRGRPFLFSTALPPAAVAASIEAINILSESDALTRKLWDNAKYFKEKLKSLGFDTGKS
ETPITPVIIGEETKALEFSRKLFEEGVFAQGIVYPTVPKNKARVRTIVTAAHTKEDLDAALKAFEKVGKQLNII

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=384, Percent_Identity=39.5833333333333, Blast_Score=317, Evalue=9e-87,
Organism=Homo sapiens, GI284448556, Length=410, Percent_Identity=37.0731707317073, Blast_Score=308, Evalue=7e-84,
Organism=Homo sapiens, GI4758668, Length=370, Percent_Identity=36.7567567567568, Blast_Score=258, Evalue=6e-69,
Organism=Homo sapiens, GI119220554, Length=370, Percent_Identity=32.972972972973, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI4502025, Length=399, Percent_Identity=33.0827067669173, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI40316939, Length=399, Percent_Identity=33.0827067669173, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI83977440, Length=385, Percent_Identity=31.6883116883117, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI83977442, Length=385, Percent_Identity=31.6883116883117, Blast_Score=208, Evalue=7e-54,
Organism=Homo sapiens, GI83977444, Length=385, Percent_Identity=31.6883116883117, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI5454084, Length=389, Percent_Identity=30.8483290488432, Blast_Score=188, Evalue=7e-48,
Organism=Escherichia coli, GI1790046, Length=389, Percent_Identity=44.2159383033419, Blast_Score=342, Evalue=3e-95,
Organism=Escherichia coli, GI1786993, Length=354, Percent_Identity=34.7457627118644, Blast_Score=212, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI71994529, Length=391, Percent_Identity=42.4552429667519, Blast_Score=320, Evalue=1e-87,
Organism=Caenorhabditis elegans, GI32566772, Length=366, Percent_Identity=35.5191256830601, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17560912, Length=364, Percent_Identity=32.4175824175824, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17560914, Length=364, Percent_Identity=32.4175824175824, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71982625, Length=330, Percent_Identity=30.9090909090909, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71982617, Length=380, Percent_Identity=28.9473684210526, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=32.3369565217391, Blast_Score=219, Evalue=9e-58,
Organism=Saccharomyces cerevisiae, GI6320438, Length=380, Percent_Identity=33.4210526315789, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6323954, Length=267, Percent_Identity=33.3333333333333, Blast_Score=157, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24662918, Length=391, Percent_Identity=40.6649616368286, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI17137420, Length=358, Percent_Identity=37.1508379888268, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI17136286, Length=370, Percent_Identity=33.2432432432432, Blast_Score=207, Evalue=7e-54,
Organism=Drosophila melanogaster, GI24653280, Length=384, Percent_Identity=27.6041666666667, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24653276, Length=384, Percent_Identity=27.6041666666667, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24653278, Length=384, Percent_Identity=27.6041666666667, Blast_Score=165, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43453; Mature: 43321

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSIHDLDFIKEKLEELKKAGVYRKLTVLESPSGPRSIIDGKKVINLSSNNYLGLANHPR
CCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHCCCCEEEEECCCCEEECCCCCH
LKKAAIEAIEKWGVGAGAVRTIIGNMTIHEELERKLAEFKREEAVLTFQSGFTANMGVIQ
HHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHH
AVVDKGDVIISDELNHASIIDGCRLSRADVVIYKHSDMEDLERVLKEVKDKYRVKMIITD
HHHCCCCEEEECCCCCHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHEEEEEEEC
GVFSMDGDIAKLPEIVKLAEKYSAITYVDDAHASGVLGESGRGSADHFNLHGRIDIQIGT
CEECCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCEEEECEEEEEEECH
LSKAIGVVGGYVAGKRELIEWLNHRGRPFLFSTALPPAAVAASIEAINILSESDALTRKL
HHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHH
WDNAKYFKEKLKSLGFDTGKSETPITPVIIGEETKALEFSRKLFEEGVFAQGIVYPTVPK
HCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCEECCCCC
NKARVRTIVTAAHTKEDLDAALKAFEKVGKQLNII
CCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SSIHDLDFIKEKLEELKKAGVYRKLTVLESPSGPRSIIDGKKVINLSSNNYLGLANHPR
CCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHCCCCEEEEECCCCEEECCCCCH
LKKAAIEAIEKWGVGAGAVRTIIGNMTIHEELERKLAEFKREEAVLTFQSGFTANMGVIQ
HHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHH
AVVDKGDVIISDELNHASIIDGCRLSRADVVIYKHSDMEDLERVLKEVKDKYRVKMIITD
HHHCCCCEEEECCCCCHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHEEEEEEEC
GVFSMDGDIAKLPEIVKLAEKYSAITYVDDAHASGVLGESGRGSADHFNLHGRIDIQIGT
CEECCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCEEEECEEEEEEECH
LSKAIGVVGGYVAGKRELIEWLNHRGRPFLFSTALPPAAVAASIEAINILSESDALTRKL
HHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHH
WDNAKYFKEKLKSLGFDTGKSETPITPVIIGEETKALEFSRKLFEEGVFAQGIVYPTVPK
HCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCEECCCCC
NKARVRTIVTAAHTKEDLDAALKAFEKVGKQLNII
CCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA