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The map label for this gene is tdh [H]

Identifier: 167039435

GI number: 167039435

Start: 810178

End: 811224

Strand: Reverse

Name: tdh [H]

Synonym: Teth514_0780

Alternate gene names: 167039435

Gene position: 811224-810178 (Counterclockwise)

Preceding gene: 167039437

Following gene: 167039434

Centisome position: 33.01

GC content: 39.64

Gene sequence:

>1047_bases
ATGGTGGAAGGATATATGACCGCTGTTGTTAAACAACATACCACAGAGGGTGCAGATATAATAAAAAAAGAAATACCAAT
AATAGGACCGGATGAAGTCTTAATAAAAGTCAAAGCTACATCTATTTGCGGCACAGACGTTCACATTTACGTTTGGAATG
AATGGGCAAAAAGCCGCATAAAACCTCCAAAGACAATGGGACATGAATTTGTAGGAGAAGTTGTAGAAATAGGTAAAAAT
GTAACATCTGTAAAGGTTGGAGATTTAGTAAGTGCGGAAACTCACATAGTATGTGGAAAATGCAAAGCTTGCAGAACAGG
TAATGCCCACATCTGCGAAAACACCCTCATACTCGGTGTTGATACAGACGGTGCTTTTGCAGAATACATTAAAGTCCCGG
AAAGCAATGTATGGCTAAACGATAAAGACATACCTTTAGAACTTCTCTCCATACAAGAACCCCTTGGAAACGCCGTTCAC
ACAGTATTTTCTGGAGAGGTAGTAGGAAAAACTGTCGCTGTAGTAGGTTGCGGTCCTATAGGTATGATGGCGATACCACT
TCTTAAAACAACAGGAGCTTCAGCTGTATTTGCAATAGAACCTGTCGAATACAGAAGGGAACTTGCTCATAAATTAGGTG
CAACACGAGTTATAAACCCTCTTAAAGAAGACGTTGTCAGTATAATAAAAAGCGAAACAGAAGGCTACGGCGCGGATGTA
GTATTGGACTTCTCTGGAAGCTCGATTGCAATAAGGCAAGGTCTTAAATATATCGCAAAAGGCGGAAGAATGTCTATTTT
AGGTCTTCCTGACAATGAAGTCCCTATAGACATAACCAATGATGTCATTTTTAAAGGCATAACTATACACGGCATCACAG
GAAGGCGAATGTACGATACTTGGTACCAAGTAAAAGGTTTATTGCGCTCAGGATTAAAAGATGCATTAAAGCCAATAATC
ACCCATACCTTCCCTCTCACTGAATACCAAAAAGGGATGGAACTAATGATAAAAGGCCAATGTGGCAAAGTTGTATTATA
TCCATAA

Upstream 100 bases:

>100_bases
ATGTAGTTCTTCAAATTTTTTTGTAATGTAAGAAGGAATTCTTCTAAAAATATAGAATATATTATGTATTAAGTTGAGTG
TACAAGAAAAGGAGTTGTCC

Downstream 100 bases:

>100_bases
ACAAAAGGAGGTTTTTAATATGTCAAGCATTCATGACCTTGACTTTATAAAAGAAAAGCTGGAAGAACTCAAAAAAGCAG
GTGTGTATAGAAAATTAACT

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MVEGYMTAVVKQHTTEGADIIKKEIPIIGPDEVLIKVKATSICGTDVHIYVWNEWAKSRIKPPKTMGHEFVGEVVEIGKN
VTSVKVGDLVSAETHIVCGKCKACRTGNAHICENTLILGVDTDGAFAEYIKVPESNVWLNDKDIPLELLSIQEPLGNAVH
TVFSGEVVGKTVAVVGCGPIGMMAIPLLKTTGASAVFAIEPVEYRRELAHKLGATRVINPLKEDVVSIIKSETEGYGADV
VLDFSGSSIAIRQGLKYIAKGGRMSILGLPDNEVPIDITNDVIFKGITIHGITGRRMYDTWYQVKGLLRSGLKDALKPII
THTFPLTEYQKGMELMIKGQCGKVVLYP

Sequences:

>Translated_348_residues
MVEGYMTAVVKQHTTEGADIIKKEIPIIGPDEVLIKVKATSICGTDVHIYVWNEWAKSRIKPPKTMGHEFVGEVVEIGKN
VTSVKVGDLVSAETHIVCGKCKACRTGNAHICENTLILGVDTDGAFAEYIKVPESNVWLNDKDIPLELLSIQEPLGNAVH
TVFSGEVVGKTVAVVGCGPIGMMAIPLLKTTGASAVFAIEPVEYRRELAHKLGATRVINPLKEDVVSIIKSETEGYGADV
VLDFSGSSIAIRQGLKYIAKGGRMSILGLPDNEVPIDITNDVIFKGITIHGITGRRMYDTWYQVKGLLRSGLKDALKPII
THTFPLTEYQKGMELMIKGQCGKVVLYP
>Mature_348_residues
MVEGYMTAVVKQHTTEGADIIKKEIPIIGPDEVLIKVKATSICGTDVHIYVWNEWAKSRIKPPKTMGHEFVGEVVEIGKN
VTSVKVGDLVSAETHIVCGKCKACRTGNAHICENTLILGVDTDGAFAEYIKVPESNVWLNDKDIPLELLSIQEPLGNAVH
TVFSGEVVGKTVAVVGCGPIGMMAIPLLKTTGASAVFAIEPVEYRRELAHKLGATRVINPLKEDVVSIIKSETEGYGADV
VLDFSGSSIAIRQGLKYIAKGGRMSILGLPDNEVPIDITNDVIFKGITIHGITGRRMYDTWYQVKGLLRSGLKDALKPII
THTFPLTEYQKGMELMIKGQCGKVVLYP

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=326, Percent_Identity=27.3006134969325, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4501929, Length=352, Percent_Identity=28.125, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI34577061, Length=354, Percent_Identity=27.683615819209, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI156523966, Length=365, Percent_Identity=26.027397260274, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI71565152, Length=357, Percent_Identity=26.6106442577031, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI71743840, Length=358, Percent_Identity=29.8882681564246, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI262073058, Length=358, Percent_Identity=29.8882681564246, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4501933, Length=352, Percent_Identity=27.5568181818182, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4501939, Length=359, Percent_Identity=25.9052924791086, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI71565154, Length=357, Percent_Identity=25.2100840336134, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=45.4545454545455, Blast_Score=302, Evalue=2e-83,
Organism=Escherichia coli, GI1788073, Length=324, Percent_Identity=30.8641975308642, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI226510992, Length=314, Percent_Identity=30.8917197452229, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1788075, Length=349, Percent_Identity=29.2263610315186, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1787863, Length=337, Percent_Identity=29.3768545994065, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI87082125, Length=345, Percent_Identity=30.7246376811594, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786825, Length=375, Percent_Identity=28.5333333333333, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1790718, Length=320, Percent_Identity=26.25, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788407, Length=326, Percent_Identity=24.2331288343558, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1786552, Length=350, Percent_Identity=28, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87081918, Length=335, Percent_Identity=26.2686567164179, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787572, Length=205, Percent_Identity=28.780487804878, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786518, Length=276, Percent_Identity=26.4492753623188, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=343, Percent_Identity=29.1545189504373, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17562878, Length=205, Percent_Identity=31.219512195122, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17562582, Length=283, Percent_Identity=29.6819787985866, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71988145, Length=288, Percent_Identity=29.1666666666667, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17562584, Length=293, Percent_Identity=27.3037542662116, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=359, Percent_Identity=25.6267409470752, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=328, Percent_Identity=25.9146341463415, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323099, Length=318, Percent_Identity=31.4465408805031, Blast_Score=133, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6319955, Length=339, Percent_Identity=28.6135693215339, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6322619, Length=339, Percent_Identity=28.6135693215339, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320033, Length=368, Percent_Identity=30.4347826086957, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319257, Length=290, Percent_Identity=30.3448275862069, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319258, Length=293, Percent_Identity=32.7645051194539, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324486, Length=330, Percent_Identity=30, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=309, Percent_Identity=29.4498381877023, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=328, Percent_Identity=28.6585365853659, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=330, Percent_Identity=30, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6319949, Length=290, Percent_Identity=26.551724137931, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323980, Length=212, Percent_Identity=30.188679245283, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17137530, Length=350, Percent_Identity=28.8571428571429, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI17737897, Length=350, Percent_Identity=27.7142857142857, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI17737895, Length=346, Percent_Identity=27.1676300578035, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221457811, Length=315, Percent_Identity=23.4920634920635, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI45550770, Length=315, Percent_Identity=23.4920634920635, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI45551930, Length=315, Percent_Identity=23.4920634920635, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 37797; Mature: 37797

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEGYMTAVVKQHTTEGADIIKKEIPIIGPDEVLIKVKATSICGTDVHIYVWNEWAKSRI
CCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCEEEEEEEEEEECCEEEEEEECHHHHCCC
KPPKTMGHEFVGEVVEIGKNVTSVKVGDLVSAETHIVCGKCKACRTGNAHICENTLILGV
CCCHHHHHHHHHHHHHHCCCCCEEEECCEECCCCEEEECCCCCCCCCCCEEECCEEEEEE
DTDGAFAEYIKVPESNVWLNDKDIPLELLSIQEPLGNAVHTVFSGEVVGKTVAVVGCGPI
CCCCCHHHHHCCCCCCEEECCCCCCEEEEEHHHHCCHHHHHHHCCCCCCCEEEEEECCCH
GMMAIPLLKTTGASAVFAIEPVEYRRELAHKLGATRVINPLKEDVVSIIKSETEGYGADV
HHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEE
VLDFSGSSIAIRQGLKYIAKGGRMSILGLPDNEVPIDITNDVIFKGITIHGITGRRMYDT
EEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCEEECCCEEEECEEEEECCCCCHHHH
WYQVKGLLRSGLKDALKPIITHTFPLTEYQKGMELMIKGQCGKVVLYP
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEEECCCCEEEEEC
>Mature Secondary Structure
MVEGYMTAVVKQHTTEGADIIKKEIPIIGPDEVLIKVKATSICGTDVHIYVWNEWAKSRI
CCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCEEEEEEEEEEECCEEEEEEECHHHHCCC
KPPKTMGHEFVGEVVEIGKNVTSVKVGDLVSAETHIVCGKCKACRTGNAHICENTLILGV
CCCHHHHHHHHHHHHHHCCCCCEEEECCEECCCCEEEECCCCCCCCCCCEEECCEEEEEE
DTDGAFAEYIKVPESNVWLNDKDIPLELLSIQEPLGNAVHTVFSGEVVGKTVAVVGCGPI
CCCCCHHHHHCCCCCCEEECCCCCCEEEEEHHHHCCHHHHHHHCCCCCCCEEEEEECCCH
GMMAIPLLKTTGASAVFAIEPVEYRRELAHKLGATRVINPLKEDVVSIIKSETEGYGADV
HHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEE
VLDFSGSSIAIRQGLKYIAKGGRMSILGLPDNEVPIDITNDVIFKGITIHGITGRRMYDT
EEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCEEECCCEEEECEEEEECCCCCHHHH
WYQVKGLLRSGLKDALKPIITHTFPLTEYQKGMELMIKGQCGKVVLYP
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEEECCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]