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The map label for this gene is cysK [H]

Identifier: 167039426

GI number: 167039426

Start: 798634

End: 799572

Strand: Direct

Name: cysK [H]

Synonym: Teth514_0771

Alternate gene names: 167039426

Gene position: 798634-799572 (Clockwise)

Preceding gene: 167039425

Following gene: 167039427

Centisome position: 32.5

GC content: 36.85

Gene sequence:

>939_bases
ATGTCTGAAAGAGAAGACAAAATTTATGAGGATATAACCCAGCTTATAGGCAATACACCTATGATTAGGTTAAATAAAAT
TGTTCCTGAAAATGCAGCGGAGGTCATAGTAAAATTAGAGTCTTTTAACCCAGGTGGGAGCGTTAAGGACAGAATTGCAT
TAAATATGATAAAAAGGGCTGAGGAAGAAGGAAGATTAAAACCTGGTGGGACAATTGTTGAAGCTACCAGTGGAAATACA
GGCATTGGTCTTGCAATGGTCAGTGCTGTAAAAGGGTATAAATTGATTCTTGTCATGCCTGATACGATGAGTATAGAACG
ACGAAATTTACTTTTGTCATATGGAGCAGAGCTTGTTTTAACACCCGGTGCAGAGGGCATGAAAGGAGCCATAAAAAAGG
CACAAGAAATTTTGGAATTGAATCCTGATTATATAATTTTAGATCAGTTTAAAAATTCTGCGAATCCAGAAATACATGAG
CTTACAACGGCAAAAGAAATATTAAAAGATACAAATGGAATAGTAGATGCATTTGTAGCAGGTGTAGGCACAGGGGGAAC
AATATCCGGAGTAGGGAAAGTTTTAAAGCAATATAACAAAGATATAAAGATTTTTGCAGTAGAACCAGAGGAATCTCCTG
TATTGTCAGGCGGCAAACCTGGACCTCATAAGATACAAGGAATAGGAGCTGGATTTATTCCCGACACATTAAATCTTGAC
GTTATCGATGAAATTATAAAGGTAAAAGAGAGAGATGCTTTTGAGATGTCAATGAAACTTGCAAAACAAGAAGGAATTCT
TTGTGGTATTTCTTCAGGCGCAAATGTTTTTGCGGCAATTGAAGTTGCAAATCGCATCGGGAAAGGAAAACGAGTTGTAA
CTGTGTTGCCTGATACTGGGGAAAGATATTTAAGTATGCACAAATTTTTTGAATATTGA

Upstream 100 bases:

>100_bases
GAAAGTATCTATTGACATTGATATAAGATTGTGATACTTTAAGAAGAGAAAATTTATAATTCTTATCGGAATACTCGGAA
TTAAAAGGAGGCAAAAAATT

Downstream 100 bases:

>100_bases
ACTCCATAATGAATAAAAAATGCAGAATATGAACAGATACTAAGAAGTAGAAGATAAATAGAGAGAGGCGATTTTTGTGA
GCACAATTTATTTAGACAAT

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MSEREDKIYEDITQLIGNTPMIRLNKIVPENAAEVIVKLESFNPGGSVKDRIALNMIKRAEEEGRLKPGGTIVEATSGNT
GIGLAMVSAVKGYKLILVMPDTMSIERRNLLLSYGAELVLTPGAEGMKGAIKKAQEILELNPDYIILDQFKNSANPEIHE
LTTAKEILKDTNGIVDAFVAGVGTGGTISGVGKVLKQYNKDIKIFAVEPEESPVLSGGKPGPHKIQGIGAGFIPDTLNLD
VIDEIIKVKERDAFEMSMKLAKQEGILCGISSGANVFAAIEVANRIGKGKRVVTVLPDTGERYLSMHKFFEY

Sequences:

>Translated_312_residues
MSEREDKIYEDITQLIGNTPMIRLNKIVPENAAEVIVKLESFNPGGSVKDRIALNMIKRAEEEGRLKPGGTIVEATSGNT
GIGLAMVSAVKGYKLILVMPDTMSIERRNLLLSYGAELVLTPGAEGMKGAIKKAQEILELNPDYIILDQFKNSANPEIHE
LTTAKEILKDTNGIVDAFVAGVGTGGTISGVGKVLKQYNKDIKIFAVEPEESPVLSGGKPGPHKIQGIGAGFIPDTLNLD
VIDEIIKVKERDAFEMSMKLAKQEGILCGISSGANVFAAIEVANRIGKGKRVVTVLPDTGERYLSMHKFFEY
>Mature_311_residues
SEREDKIYEDITQLIGNTPMIRLNKIVPENAAEVIVKLESFNPGGSVKDRIALNMIKRAEEEGRLKPGGTIVEATSGNTG
IGLAMVSAVKGYKLILVMPDTMSIERRNLLLSYGAELVLTPGAEGMKGAIKKAQEILELNPDYIILDQFKNSANPEIHEL
TTAKEILKDTNGIVDAFVAGVGTGGTISGVGKVLKQYNKDIKIFAVEPEESPVLSGGKPGPHKIQGIGAGFIPDTLNLDV
IDEIIKVKERDAFEMSMKLAKQEGILCGISSGANVFAAIEVANRIGKGKRVVTVLPDTGERYLSMHKFFEY

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=314, Percent_Identity=43.6305732484076, Blast_Score=248, Evalue=4e-66,
Organism=Homo sapiens, GI295821200, Length=314, Percent_Identity=43.6305732484076, Blast_Score=248, Evalue=4e-66,
Organism=Homo sapiens, GI4557415, Length=314, Percent_Identity=43.6305732484076, Blast_Score=248, Evalue=4e-66,
Organism=Escherichia coli, GI1788754, Length=314, Percent_Identity=53.5031847133758, Blast_Score=287, Evalue=6e-79,
Organism=Escherichia coli, GI2367138, Length=300, Percent_Identity=43.3333333333333, Blast_Score=247, Evalue=8e-67,
Organism=Caenorhabditis elegans, GI17535051, Length=300, Percent_Identity=51.6666666666667, Blast_Score=295, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17562970, Length=302, Percent_Identity=49.0066225165563, Blast_Score=281, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI32566674, Length=299, Percent_Identity=49.8327759197324, Blast_Score=280, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI115535073, Length=307, Percent_Identity=52.1172638436482, Blast_Score=275, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17561720, Length=302, Percent_Identity=48.0132450331126, Blast_Score=246, Evalue=9e-66,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=49.0566037735849, Blast_Score=204, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17534315, Length=320, Percent_Identity=37.1875, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI25147552, Length=318, Percent_Identity=36.4779874213836, Blast_Score=164, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17561716, Length=118, Percent_Identity=45.7627118644068, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71996324, Length=328, Percent_Identity=28.6585365853659, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17539800, Length=336, Percent_Identity=26.1904761904762, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321594, Length=324, Percent_Identity=37.6543209876543, Blast_Score=200, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6321449, Length=334, Percent_Identity=35.9281437125749, Blast_Score=157, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24643623, Length=315, Percent_Identity=41.9047619047619, Blast_Score=217, Evalue=8e-57,
Organism=Drosophila melanogaster, GI20129101, Length=315, Percent_Identity=41.9047619047619, Blast_Score=217, Evalue=8e-57,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33741; Mature: 33609

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEREDKIYEDITQLIGNTPMIRLNKIVPENAAEVIVKLESFNPGGSVKDRIALNMIKRA
CCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHH
EEEGRLKPGGTIVEATSGNTGIGLAMVSAVKGYKLILVMPDTMSIERRNLLLSYGAELVL
HHHCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHEECCCEEEE
TPGAEGMKGAIKKAQEILELNPDYIILDQFKNSANPEIHELTTAKEILKDTNGIVDAFVA
CCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHH
GVGTGGTISGVGKVLKQYNKDIKIFAVEPEESPVLSGGKPGPHKIQGIGAGFIPDTLNLD
CCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHH
VIDEIIKVKERDAFEMSMKLAKQEGILCGISSGANVFAAIEVANRIGKGKRVVTVLPDTG
HHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCEEHHHHHHHHCCCCCEEEEECCCCC
ERYLSMHKFFEY
HHHHHHHHHHCC
>Mature Secondary Structure 
SEREDKIYEDITQLIGNTPMIRLNKIVPENAAEVIVKLESFNPGGSVKDRIALNMIKRA
CCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHH
EEEGRLKPGGTIVEATSGNTGIGLAMVSAVKGYKLILVMPDTMSIERRNLLLSYGAELVL
HHHCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHEECCCEEEE
TPGAEGMKGAIKKAQEILELNPDYIILDQFKNSANPEIHELTTAKEILKDTNGIVDAFVA
CCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHH
GVGTGGTISGVGKVLKQYNKDIKIFAVEPEESPVLSGGKPGPHKIQGIGAGFIPDTLNLD
CCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHH
VIDEIIKVKERDAFEMSMKLAKQEGILCGISSGANVFAAIEVANRIGKGKRVVTVLPDTG
HHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCEEHHHHHHHHCCCCCEEEEECCCCC
ERYLSMHKFFEY
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA