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The map label for this gene is cadA [H]

Identifier: 167039425

GI number: 167039425

Start: 796364

End: 798463

Strand: Direct

Name: cadA [H]

Synonym: Teth514_0770

Alternate gene names: 167039425

Gene position: 796364-798463 (Clockwise)

Preceding gene: 167039424

Following gene: 167039426

Centisome position: 32.41

GC content: 35.95

Gene sequence:

>2100_bases
GTGCAAAATAATAACAAGTCATTTATTTTAAAAGGGCTTGATTGCGCAAGCTGTGCTGCCAAAATAGAAGAGGGTGTGAA
AAGGATAGAGGGTGTGACTTATGCTAATTGTGATTTTGTCAACAGCAAGCTTTCCGTTGAAATAGATGATTCATATGAGC
TGGAAAAAACGATAAAAGAATTGAAAAAACTCGTAAAAAATATAGAACCAAATGTTGAAATTATTGAATATGAAAATGAA
AAGATTAAAGATGATAATGAGCTATTGAGAAGGGGCATTCGATATGGAATTTCTGCTATTTTGTTTGCTGTTGCATTGAT
ATTTAATTTATCTGTTTATGTTAAATTTACCTTATTTTTTATAAGTTATATAATCGTAGGTGGAGAAGTCATCTTAACAG
CTGCTAAAAAGATTTTAAAAGGGCAGGTTTTCGATGAACATTTTCTTATGAGCATAGCGACAATCGGTGCTTTTGCGATT
GGAGAGTATCCTGAAGGTGTAGCTGTAATGCTTTTTTATCAGATTGGTGACCTTCTGCAGGATGCTGCTGTTGACCGTTC
GAAAAGGTCTATTAAAGAGTTAATGGACATTCGTCCCGATTACGCTAACTTAAAAATTGGAGATGAAATAAAAAGGGTTT
CACCAGAAGAAGTAAAAACTGGAGATATCATCATAGTGAAACCTGGCGAAAGAATACCGCTTGACGGAAAAGTAATTGAT
GGAAAGTCAATGGTTGATACTTCTGCATTAACTGGGGAGTCTGTTTTGAGAGAAGTTTATGAAGGCTCAGAGGTTTTAAG
CGGCTTTATAAACAAAAATGGCCTTCTCACAATAGAAGTAACGCAAGAATTTGGCGAATCGACCGTTTCAAAAATACTGG
ATCTAGTTGAGAAGGCGAGCAGTAGAAAAGCTTCTACAGAGAATTTTATAACAAAATTCGCGAAATATTACACTCCTATT
GTTGTTTTTTTGGCACTAATTATTGCAGTAATTCCTCTTTTAATTATACCAGGAGCAACTTTTAAGCAATTTATGTATAG
AGCACTTATTTTTCTTGTAATATCATGCCCCTGTGCACTGGTGTTATCAATTCCCTTAAGCTTTTTTGCTGGTATAGGTG
CTGCGTCAAAAAATGGCATCATTGTAAAAGGAAGCAACTATTTGGAAGCTTTGAGCAATGTAGAAACTGTTGTATTTGAT
AAAACAGGTACCCTTACAAAAGGGGTATTTAAGTTAACGGAAATTAAACCTGTAAATGGTATAAGTAGGGATGCGCTTTT
AGAATATACGGCATATGCCGAAAGTTTTTCAAACCATCCTATAGCAGAATCCATTTTAAAAGCCTATGGAAAAGAAGTAG
ACAGATCTAAAATAAAAAAGTATGAAGAAATTTCAGGAAATGGCGTAAGAGCAAATATAGATGGAAAAAAAGTCCTTGTA
GGTAATGCTAAATTAATGAAGGCCGAAAATATTGATTGTGTTACCAGTGACTCAATAGGTACTATCATTCATGTAGCTAT
AGATAACAAATATTCTGGTTATATCGTCATATCCGATGAAGTAAAAGAAGATTCCTCAAGAGCCATAGAAGGCCTAAGAG
AAATGGGCATTAAGAGGATTGTCATGCTTACGGGGGATAACAAAGCTATCAGCGATAAAATCGCTGCTTCATTAAGGATT
GATGAAGTGTATTCAGAACTTTTTCCAAATGAGAAAGTTGGTATACTTGAGAAGTTATATGCTAACAATAAAAAGGGCAA
ACTCATATTTGTCGGTGATGGCATAAATGATGCACCGGTTTTAGCGAGAGCTGATGTTGGTGTTGCAATGGGTGGAATCG
GGTCAGATGTTGCTATAGAAGCAGCCGATGTAGTTTTAATGACAGATGAACCTTCAAAACTGGTAACAGCGATAAAGATA
TCCAAAAAAACAAAATTAATAGTATGGGAAAATATCCTTCTTGCGCTGGGAGTAAAAATAGTAGTTTTAGCACTTGGTGC
TTTAGGGGTTCCTACAATGTGGGAAGCTGTATTCGCCGACGTTGGTGTTGCTCTCCTTGCAGTCCTTAATGCATTGCGTG
TGCTAACTGGGGCGGTTTAA

Upstream 100 bases:

>100_bases
GAAAAGTAGTGTATTATTCTTTAGCGGATGACCATGTAAAGAAAATATTTGAGCAGGGATTTAATCATATTAATGAGTGA
ATGAATAGAGGGTGAGTAAT

Downstream 100 bases:

>100_bases
AACCGCCCCTTAAGTTTATGGAAACACAGAAATCTTCGTGACTTTTTTGCCTATAAATAAACTGAATTTTGAAAGTATCT
ATTGACATTGATATAAGATT

Product: heavy metal translocating P-type ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 699; Mature: 699

Protein sequence:

>699_residues
MQNNNKSFILKGLDCASCAAKIEEGVKRIEGVTYANCDFVNSKLSVEIDDSYELEKTIKELKKLVKNIEPNVEIIEYENE
KIKDDNELLRRGIRYGISAILFAVALIFNLSVYVKFTLFFISYIIVGGEVILTAAKKILKGQVFDEHFLMSIATIGAFAI
GEYPEGVAVMLFYQIGDLLQDAAVDRSKRSIKELMDIRPDYANLKIGDEIKRVSPEEVKTGDIIIVKPGERIPLDGKVID
GKSMVDTSALTGESVLREVYEGSEVLSGFINKNGLLTIEVTQEFGESTVSKILDLVEKASSRKASTENFITKFAKYYTPI
VVFLALIIAVIPLLIIPGATFKQFMYRALIFLVISCPCALVLSIPLSFFAGIGAASKNGIIVKGSNYLEALSNVETVVFD
KTGTLTKGVFKLTEIKPVNGISRDALLEYTAYAESFSNHPIAESILKAYGKEVDRSKIKKYEEISGNGVRANIDGKKVLV
GNAKLMKAENIDCVTSDSIGTIIHVAIDNKYSGYIVISDEVKEDSSRAIEGLREMGIKRIVMLTGDNKAISDKIAASLRI
DEVYSELFPNEKVGILEKLYANNKKGKLIFVGDGINDAPVLARADVGVAMGGIGSDVAIEAADVVLMTDEPSKLVTAIKI
SKKTKLIVWENILLALGVKIVVLALGALGVPTMWEAVFADVGVALLAVLNALRVLTGAV

Sequences:

>Translated_699_residues
MQNNNKSFILKGLDCASCAAKIEEGVKRIEGVTYANCDFVNSKLSVEIDDSYELEKTIKELKKLVKNIEPNVEIIEYENE
KIKDDNELLRRGIRYGISAILFAVALIFNLSVYVKFTLFFISYIIVGGEVILTAAKKILKGQVFDEHFLMSIATIGAFAI
GEYPEGVAVMLFYQIGDLLQDAAVDRSKRSIKELMDIRPDYANLKIGDEIKRVSPEEVKTGDIIIVKPGERIPLDGKVID
GKSMVDTSALTGESVLREVYEGSEVLSGFINKNGLLTIEVTQEFGESTVSKILDLVEKASSRKASTENFITKFAKYYTPI
VVFLALIIAVIPLLIIPGATFKQFMYRALIFLVISCPCALVLSIPLSFFAGIGAASKNGIIVKGSNYLEALSNVETVVFD
KTGTLTKGVFKLTEIKPVNGISRDALLEYTAYAESFSNHPIAESILKAYGKEVDRSKIKKYEEISGNGVRANIDGKKVLV
GNAKLMKAENIDCVTSDSIGTIIHVAIDNKYSGYIVISDEVKEDSSRAIEGLREMGIKRIVMLTGDNKAISDKIAASLRI
DEVYSELFPNEKVGILEKLYANNKKGKLIFVGDGINDAPVLARADVGVAMGGIGSDVAIEAADVVLMTDEPSKLVTAIKI
SKKTKLIVWENILLALGVKIVVLALGALGVPTMWEAVFADVGVALLAVLNALRVLTGAV
>Mature_699_residues
MQNNNKSFILKGLDCASCAAKIEEGVKRIEGVTYANCDFVNSKLSVEIDDSYELEKTIKELKKLVKNIEPNVEIIEYENE
KIKDDNELLRRGIRYGISAILFAVALIFNLSVYVKFTLFFISYIIVGGEVILTAAKKILKGQVFDEHFLMSIATIGAFAI
GEYPEGVAVMLFYQIGDLLQDAAVDRSKRSIKELMDIRPDYANLKIGDEIKRVSPEEVKTGDIIIVKPGERIPLDGKVID
GKSMVDTSALTGESVLREVYEGSEVLSGFINKNGLLTIEVTQEFGESTVSKILDLVEKASSRKASTENFITKFAKYYTPI
VVFLALIIAVIPLLIIPGATFKQFMYRALIFLVISCPCALVLSIPLSFFAGIGAASKNGIIVKGSNYLEALSNVETVVFD
KTGTLTKGVFKLTEIKPVNGISRDALLEYTAYAESFSNHPIAESILKAYGKEVDRSKIKKYEEISGNGVRANIDGKKVLV
GNAKLMKAENIDCVTSDSIGTIIHVAIDNKYSGYIVISDEVKEDSSRAIEGLREMGIKRIVMLTGDNKAISDKIAASLRI
DEVYSELFPNEKVGILEKLYANNKKGKLIFVGDGINDAPVLARADVGVAMGGIGSDVAIEAADVVLMTDEPSKLVTAIKI
SKKTKLIVWENILLALGVKIVVLALGALGVPTMWEAVFADVGVALLAVLNALRVLTGAV

Specific function: Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=803, Percent_Identity=27.7708592777086, Blast_Score=278, Evalue=2e-74,
Organism=Homo sapiens, GI115529486, Length=843, Percent_Identity=27.5207591933571, Blast_Score=268, Evalue=2e-71,
Organism=Homo sapiens, GI55743073, Length=533, Percent_Identity=31.3320825515947, Blast_Score=231, Evalue=2e-60,
Organism=Escherichia coli, GI1789879, Length=694, Percent_Identity=34.4380403458213, Blast_Score=354, Evalue=8e-99,
Organism=Escherichia coli, GI1786691, Length=687, Percent_Identity=28.0931586608443, Blast_Score=278, Evalue=8e-76,
Organism=Escherichia coli, GI1786914, Length=475, Percent_Identity=29.0526315789474, Blast_Score=143, Evalue=4e-35,
Organism=Escherichia coli, GI2367363, Length=516, Percent_Identity=22.2868217054264, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17556548, Length=605, Percent_Identity=30.4132231404959, Blast_Score=222, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI32566766, Length=181, Percent_Identity=33.7016574585635, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17557770, Length=181, Percent_Identity=33.7016574585635, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17557486, Length=180, Percent_Identity=30.5555555555556, Blast_Score=76, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6320475, Length=543, Percent_Identity=29.2817679558011, Blast_Score=217, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6319772, Length=556, Percent_Identity=27.8776978417266, Blast_Score=173, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6325221, Length=641, Percent_Identity=24.6489859594384, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6321430, Length=640, Percent_Identity=23.28125, Blast_Score=113, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6321271, Length=259, Percent_Identity=28.1853281853282, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321432, Length=183, Percent_Identity=31.1475409836066, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI221329854, Length=346, Percent_Identity=31.2138728323699, Blast_Score=141, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24668708, Length=160, Percent_Identity=28.75, Blast_Score=66, Evalue=8e-11,
Organism=Drosophila melanogaster, GI281366617, Length=160, Percent_Identity=28.75, Blast_Score=66, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24668704, Length=160, Percent_Identity=28.75, Blast_Score=66, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24668696, Length=160, Percent_Identity=28.75, Blast_Score=66, Evalue=9e-11,
Organism=Drosophila melanogaster, GI161085803, Length=160, Percent_Identity=28.75, Blast_Score=66, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 76121; Mature: 76121

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00154 ATPASE_E1_E2 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNNNKSFILKGLDCASCAAKIEEGVKRIEGVTYANCDFVNSKLSVEIDDSYELEKTIKE
CCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCEEECCEEECCEEEEEECCCCHHHHHHHH
LKKLVKNIEPNVEIIEYENEKIKDDNELLRRGIRYGISAILFAVALIFNLSVYVKFTLFF
HHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISYIIVGGEVILTAAKKILKGQVFDEHFLMSIATIGAFAIGEYPEGVAVMLFYQIGDLLQ
HHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
DAAVDRSKRSIKELMDIRPDYANLKIGDEIKRVSPEEVKTGDIIIVKPGERIPLDGKVID
HHHHHHHHHHHHHHHHCCCCCCCCEECCHHHCCCCCCCCCCCEEEECCCCCCCCCCEEEC
GKSMVDTSALTGESVLREVYEGSEVLSGFINKNGLLTIEVTQEFGESTVSKILDLVEKAS
CCCHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCCEEEEEEHHHHCHHHHHHHHHHHHHHH
SRKASTENFITKFAKYYTPIVVFLALIIAVIPLLIIPGATFKQFMYRALIFLVISCPCAL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
VLSIPLSFFAGIGAASKNGIIVKGSNYLEALSNVETVVFDKTGTLTKGVFKLTEIKPVNG
HHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHCCCEEEEECCCCHHHHHHHHEEECCCCC
ISRDALLEYTAYAESFSNHPIAESILKAYGKEVDRSKIKKYEEISGNGVRANIDGKKVLV
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCCCEEEE
GNAKLMKAENIDCVTSDSIGTIIHVAIDNKYSGYIVISDEVKEDSSRAIEGLREMGIKRI
CCCEEEEECCCCEEECCCCCEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEE
VMLTGDNKAISDKIAASLRIDEVYSELFPNEKVGILEKLYANNKKGKLIFVGDGINDAPV
EEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCE
LARADVGVAMGGIGSDVAIEAADVVLMTDEPSKLVTAIKISKKTKLIVWENILLALGVKI
EEECCCCEEECCCCCCCEEEEEEEEEECCCCHHHEEEEEECCCEEEEEHHHHHHHHHHHH
VVLALGALGVPTMWEAVFADVGVALLAVLNALRVLTGAV
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQNNNKSFILKGLDCASCAAKIEEGVKRIEGVTYANCDFVNSKLSVEIDDSYELEKTIKE
CCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCEEECCEEECCEEEEEECCCCHHHHHHHH
LKKLVKNIEPNVEIIEYENEKIKDDNELLRRGIRYGISAILFAVALIFNLSVYVKFTLFF
HHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISYIIVGGEVILTAAKKILKGQVFDEHFLMSIATIGAFAIGEYPEGVAVMLFYQIGDLLQ
HHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
DAAVDRSKRSIKELMDIRPDYANLKIGDEIKRVSPEEVKTGDIIIVKPGERIPLDGKVID
HHHHHHHHHHHHHHHHCCCCCCCCEECCHHHCCCCCCCCCCCEEEECCCCCCCCCCEEEC
GKSMVDTSALTGESVLREVYEGSEVLSGFINKNGLLTIEVTQEFGESTVSKILDLVEKAS
CCCHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCCEEEEEEHHHHCHHHHHHHHHHHHHHH
SRKASTENFITKFAKYYTPIVVFLALIIAVIPLLIIPGATFKQFMYRALIFLVISCPCAL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
VLSIPLSFFAGIGAASKNGIIVKGSNYLEALSNVETVVFDKTGTLTKGVFKLTEIKPVNG
HHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHCCCEEEEECCCCHHHHHHHHEEECCCCC
ISRDALLEYTAYAESFSNHPIAESILKAYGKEVDRSKIKKYEEISGNGVRANIDGKKVLV
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCCCEEEE
GNAKLMKAENIDCVTSDSIGTIIHVAIDNKYSGYIVISDEVKEDSSRAIEGLREMGIKRI
CCCEEEEECCCCEEECCCCCEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEE
VMLTGDNKAISDKIAASLRIDEVYSELFPNEKVGILEKLYANNKKGKLIFVGDGINDAPV
EEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCE
LARADVGVAMGGIGSDVAIEAADVVLMTDEPSKLVTAIKISKKTKLIVWENILLALGVKI
EEECCCCEEECCCCCCCEEEEEEEEEECCCCHHHEEEEEECCCEEEEEHHHHHHHHHHHH
VVLALGALGVPTMWEAVFADVGVALLAVLNALRVLTGAV
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]