Click here to switch to the map view.

The map label for this gene is iscS [H]

Identifier: 167039427

GI number: 167039427

Start: 799649

End: 800803

Strand: Direct

Name: iscS [H]

Synonym: Teth514_0772

Alternate gene names: 167039427

Gene position: 799649-800803 (Clockwise)

Preceding gene: 167039426

Following gene: 167039428

Centisome position: 32.54

GC content: 35.41

Gene sequence:

>1155_bases
GTGAGCACAATTTATTTAGACAATGCGGCGACTACTCCAGTTGATAAAAGGGTATTAGAGGCGATGTTACCATATTATAG
TGATGTTTTTGGTAATCCCTCTTCTTTACATTCACATGGTCAAGAGGCGAAAAAAGCTATTGAAGAAGCGAGGGAAAAAG
TAGCAAAAGCACTAGGTGCAGATTCTGAGGAAATATATTTTACCAGTGGAGGGTCTGAGTCAGATAATTGGGCATTAAAA
GGTGTAGCATATGCGTTGAAAGAAAAAGGAAATCATATTATTACAACAGAAATTGAACATCATGCAGTGCTCCATACTTG
CCGATATCTTGAAAAAGAAGGATTCAAAGTAACATATCTTCCAGTTGACGAATATGGACTTGTAAAACCTGAAGATTTAA
AAAAGGCGATTACAGATAAAACAATCCTTGTTTCTATAATGTTTGCTAATAATGAGATAGGTACGATAGAGCCAATTGAG
GAGCTTGTCAAAATAGCTCATGAAAAAAACATATATTTTCATACTGATGCTGTGCAAGCAGTTGGAAATGTACCGATAGA
TGTAAAAAAATTAGATGTTGATTTGTTATCTCTATCTGCCCATAAAATATATGGACCTAAAGGCGTGGGAGCATTATATA
TAAAGAAGGGGGTAAAGATTCATTCGCTTATACAGGGAGGAACACAGGAAAAAAATAGAAGAGCAGGTACTGAAAATGTT
CCAGGAATAGTAGGACTGGGGGAAGCGATAGAGCTTATCACGAAAAATTTGGATTCTCATATAAATAAACTTACATTTTT
AAGAGATAAACTTATAAATGGAATATTAGAAAAAATACCTTATACGAGGTTAAACGGGCATCCAACAAAAAGGCTTCCAG
GCAATGTTAATGTATCATTTGAATTTATAGATGGCGAATCCCTTATTTTAAACTTAGATATGGCAGGAATATGTGCTTCA
AGTGGTTCAGCATGCACTTCTGGTTCACTTGAGCCATCTCATGTGCTTCTGGCAATTGGGCTCTCAAAAGAATTAGCTCG
AGGGTCTTTGAGACTTACAATAGGTAAAGATAACACTGAAGAAGATATAGATAAGGTTTTAGAAGCACTTCCACAAATTG
TTAAAAGATTAAGGTCAATATCACAGATTGTATGA

Upstream 100 bases:

>100_bases
ATGCACAAATTTTTTGAATATTGAACTCCATAATGAATAAAAAATGCAGAATATGAACAGATACTAAGAAGTAGAAGATA
AATAGAGAGAGGCGATTTTT

Downstream 100 bases:

>100_bases
GAGAATCTACAAGGAGGTTAGAAAATTTTTTTATGAAAAAGAATAACAGAGTAGTTGTGGGAATGAGCGGAGGTGTTGAT
AGCTCTGTTTCAGCGTATCT

Product: cysteine desulfurase

Products: NA

Alternate protein names: NifS protein homolog [H]

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MSTIYLDNAATTPVDKRVLEAMLPYYSDVFGNPSSLHSHGQEAKKAIEEAREKVAKALGADSEEIYFTSGGSESDNWALK
GVAYALKEKGNHIITTEIEHHAVLHTCRYLEKEGFKVTYLPVDEYGLVKPEDLKKAITDKTILVSIMFANNEIGTIEPIE
ELVKIAHEKNIYFHTDAVQAVGNVPIDVKKLDVDLLSLSAHKIYGPKGVGALYIKKGVKIHSLIQGGTQEKNRRAGTENV
PGIVGLGEAIELITKNLDSHINKLTFLRDKLINGILEKIPYTRLNGHPTKRLPGNVNVSFEFIDGESLILNLDMAGICAS
SGSACTSGSLEPSHVLLAIGLSKELARGSLRLTIGKDNTEEDIDKVLEALPQIVKRLRSISQIV

Sequences:

>Translated_384_residues
MSTIYLDNAATTPVDKRVLEAMLPYYSDVFGNPSSLHSHGQEAKKAIEEAREKVAKALGADSEEIYFTSGGSESDNWALK
GVAYALKEKGNHIITTEIEHHAVLHTCRYLEKEGFKVTYLPVDEYGLVKPEDLKKAITDKTILVSIMFANNEIGTIEPIE
ELVKIAHEKNIYFHTDAVQAVGNVPIDVKKLDVDLLSLSAHKIYGPKGVGALYIKKGVKIHSLIQGGTQEKNRRAGTENV
PGIVGLGEAIELITKNLDSHINKLTFLRDKLINGILEKIPYTRLNGHPTKRLPGNVNVSFEFIDGESLILNLDMAGICAS
SGSACTSGSLEPSHVLLAIGLSKELARGSLRLTIGKDNTEEDIDKVLEALPQIVKRLRSISQIV
>Mature_383_residues
STIYLDNAATTPVDKRVLEAMLPYYSDVFGNPSSLHSHGQEAKKAIEEAREKVAKALGADSEEIYFTSGGSESDNWALKG
VAYALKEKGNHIITTEIEHHAVLHTCRYLEKEGFKVTYLPVDEYGLVKPEDLKKAITDKTILVSIMFANNEIGTIEPIEE
LVKIAHEKNIYFHTDAVQAVGNVPIDVKKLDVDLLSLSAHKIYGPKGVGALYIKKGVKIHSLIQGGTQEKNRRAGTENVP
GIVGLGEAIELITKNLDSHINKLTFLRDKLINGILEKIPYTRLNGHPTKRLPGNVNVSFEFIDGESLILNLDMAGICASS
GSACTSGSLEPSHVLLAIGLSKELARGSLRLTIGKDNTEEDIDKVLEALPQIVKRLRSISQIV

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=386, Percent_Identity=47.6683937823834, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI156713448, Length=411, Percent_Identity=34.5498783454988, Blast_Score=223, Evalue=2e-58,
Organism=Escherichia coli, GI48994898, Length=385, Percent_Identity=47.2727272727273, Blast_Score=347, Evalue=1e-96,
Organism=Escherichia coli, GI1789175, Length=393, Percent_Identity=28.7531806615776, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1787970, Length=396, Percent_Identity=27.7777777777778, Blast_Score=131, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI25143064, Length=387, Percent_Identity=49.6124031007752, Blast_Score=372, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17533177, Length=331, Percent_Identity=33.2326283987915, Blast_Score=172, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6319831, Length=383, Percent_Identity=49.6083550913838, Blast_Score=362, Evalue=1e-101,
Organism=Drosophila melanogaster, GI20129463, Length=383, Percent_Identity=48.0417754569191, Blast_Score=363, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 41999; Mature: 41868

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTIYLDNAATTPVDKRVLEAMLPYYSDVFGNPSSLHSHGQEAKKAIEEAREKVAKALGA
CCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DSEEIYFTSGGSESDNWALKGVAYALKEKGNHIITTEIEHHAVLHTCRYLEKEGFKVTYL
CCCEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHCCCEEEEE
PVDEYGLVKPEDLKKAITDKTILVSIMFANNEIGTIEPIEELVKIAHEKNIYFHTDAVQA
ECCCCCCCCHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCEEEECHHHHH
VGNVPIDVKKLDVDLLSLSAHKIYGPKGVGALYIKKGVKIHSLIQGGTQEKNRRAGTENV
HCCCCCEEEEECHHHEEHHHHHCCCCCCCCEEEEECCCCHHHHHCCCCCHHHHCCCCCCC
PGIVGLGEAIELITKNLDSHINKLTFLRDKLINGILEKIPYTRLNGHPTKRLPGNVNVSF
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEE
EFIDGESLILNLDMAGICASSGSACTSGSLEPSHVLLAIGLSKELARGSLRLTIGKDNTE
EEECCCEEEEEECHHHEECCCCCCCCCCCCCCCEEEEEECCCHHHCCCCEEEEECCCCCH
EDIDKVLEALPQIVKRLRSISQIV
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STIYLDNAATTPVDKRVLEAMLPYYSDVFGNPSSLHSHGQEAKKAIEEAREKVAKALGA
CEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DSEEIYFTSGGSESDNWALKGVAYALKEKGNHIITTEIEHHAVLHTCRYLEKEGFKVTYL
CCCEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHCCCEEEEE
PVDEYGLVKPEDLKKAITDKTILVSIMFANNEIGTIEPIEELVKIAHEKNIYFHTDAVQA
ECCCCCCCCHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCEEEECHHHHH
VGNVPIDVKKLDVDLLSLSAHKIYGPKGVGALYIKKGVKIHSLIQGGTQEKNRRAGTENV
HCCCCCEEEEECHHHEEHHHHHCCCCCCCCEEEEECCCCHHHHHCCCCCHHHHCCCCCCC
PGIVGLGEAIELITKNLDSHINKLTFLRDKLINGILEKIPYTRLNGHPTKRLPGNVNVSF
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEE
EFIDGESLILNLDMAGICASSGSACTSGSLEPSHVLLAIGLSKELARGSLRLTIGKDNTE
EEECCCEEEEEECHHHEECCCCCCCCCCCCCCCEEEEEECCCHHHCCCCEEEEECCCCCH
EDIDKVLEALPQIVKRLRSISQIV
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10930739 [H]