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The map label for this gene is purE [H]

Identifier: 167039176

GI number: 167039176

Start: 533361

End: 533822

Strand: Direct

Name: purE [H]

Synonym: Teth514_0517

Alternate gene names: 167039176

Gene position: 533361-533822 (Clockwise)

Preceding gene: 167039175

Following gene: 167039177

Centisome position: 21.71

GC content: 36.58

Gene sequence:

>462_bases
ATGCCTAAGGTGGCTATAGTTGTTGGAAGTAAATCTGATTTGCCTGTAGTTGAAAGATGTACAAAAATTCTTGAAGAACT
TGAAATTCCCTATGATGTTAAAGTGCTGTCTGCCCATAGAACTCCCTTTGAGACACAAGAGTTTGCTGTGAATGCAGATA
AATATTATGATATAATCATTGCAGGTGCTGGAAAAGCTGCTCATCTGCCTGGTGTTATTGCTTCTTATACACTCTTGCCT
GTTATTGGCCTTCCTATAAAATCTTCTACTTTAGATGGACTTGATTCCCTTTTGTCAATAGTCCAAATGCCTAAAGGTAT
TCCTGTTGCAACAGTGGCTATAGATGGAGCAGAAAATGCAGCACTTTTAGCTTGTCATATTCTCTCTTTGAAATATACTT
ATTTAAAGAAGACCTTAGCTGATTATAGGGAGAAAATGGCTGAAGAAGTGTTAAACAATTAA

Upstream 100 bases:

>100_bases
AATTTTATTCATATTGAGATTTATAACTTTATCAGAGTGAAAATAAGACCCCAATTAGTACTTATCTAATTGGGGTCTTA
AAAGAAAAGGGGGTATAAAA

Downstream 100 bases:

>100_bases
GAGATTGGAGGAGATAAATATGGAAAAAAGAGAATTGCTTTATGAAGGAAAAGCCAAAAAAGTTTATAAGACAGATGAAG
AGAATTTGTATATCATCGAA

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 153; Mature: 152

Protein sequence:

>153_residues
MPKVAIVVGSKSDLPVVERCTKILEELEIPYDVKVLSAHRTPFETQEFAVNADKYYDIIIAGAGKAAHLPGVIASYTLLP
VIGLPIKSSTLDGLDSLLSIVQMPKGIPVATVAIDGAENAALLACHILSLKYTYLKKTLADYREKMAEEVLNN

Sequences:

>Translated_153_residues
MPKVAIVVGSKSDLPVVERCTKILEELEIPYDVKVLSAHRTPFETQEFAVNADKYYDIIIAGAGKAAHLPGVIASYTLLP
VIGLPIKSSTLDGLDSLLSIVQMPKGIPVATVAIDGAENAALLACHILSLKYTYLKKTLADYREKMAEEVLNN
>Mature_152_residues
PKVAIVVGSKSDLPVVERCTKILEELEIPYDVKVLSAHRTPFETQEFAVNADKYYDIIIAGAGKAAHLPGVIASYTLLPV
IGLPIKSSTLDGLDSLLSIVQMPKGIPVATVAIDGAENAALLACHILSLKYTYLKKTLADYREKMAEEVLNN

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=154, Percent_Identity=48.7012987012987, Blast_Score=130, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6324702, Length=151, Percent_Identity=50.3311258278146, Blast_Score=148, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16538; Mature: 16406

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKVAIVVGSKSDLPVVERCTKILEELEIPYDVKVLSAHRTPFETQEFAVNADKYYDIII
CCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHEECCCCEEEEEE
AGAGKAAHLPGVIASYTLLPVIGLPIKSSTLDGLDSLLSIVQMPKGIPVATVAIDGAENA
ECCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCH
ALLACHILSLKYTYLKKTLADYREKMAEEVLNN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PKVAIVVGSKSDLPVVERCTKILEELEIPYDVKVLSAHRTPFETQEFAVNADKYYDIII
CEEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHEECCCCEEEEEE
AGAGKAAHLPGVIASYTLLPVIGLPIKSSTLDGLDSLLSIVQMPKGIPVATVAIDGAENA
ECCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCH
ALLACHILSLKYTYLKKTLADYREKMAEEVLNN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]