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The map label for this gene is purC

Identifier: 167039177

GI number: 167039177

Start: 533842

End: 534549

Strand: Direct

Name: purC

Synonym: Teth514_0518

Alternate gene names: 167039177

Gene position: 533842-534549 (Clockwise)

Preceding gene: 167039176

Following gene: 167039178

Centisome position: 21.73

GC content: 29.8

Gene sequence:

>708_bases
ATGGAAAAAAGAGAATTGCTTTATGAAGGAAAAGCCAAAAAAGTTTATAAGACAGATGAAGAGAATTTGTATATCATCGA
ATACAAAGATGATGCAACTGCTTTTAATGGCTTAAAGAAAGGCACAATTGCCGAAAAAGGTATAGTAAATAACAAAGTTT
CTGCAATTTTATTTGCATTATTAGATAAAAATAATGTACCCACTCATTATGTGAAAAGACTTAGTGATAGAGAAATGTTG
GTTAAAAAAGTTGAGATTTTTCCTTTAGAAGTTATCGTGAGAAATTACGCAGCAGGAAGTATTTGTAAAAGATTAGGCCT
TGAAGAAGGACTAAAGTTTAAAACGCCTGTGTTAGAATTCTCCTATAAAAATGACGAATTGAAAGACCCAATGATTAATG
AATATCACATACAAGCTCTCGAATTAGCCACCAAAGAAGAGATTGAAATTATGACAGGAATGACGTTTAAAGTCAACGAA
ATTTTGTCAGAATATTTTTTATCTAAAGACATTATTTTGGTAGATTTTAAATTAGAATTTGGGAAAAGTAGTGAAGGAAT
ATTATTAGCTGATGAAATTTCTCCTGATACTTGCAGATTTTGGGACAAAAACACTATGGAAAAACTTGATAAAGATAGAT
TTAGAAAAGATTTGGGCAAAGTAGAAGAAGCATATTTAGAAATTTTAAAAAGACTTGGAGGTATGTAA

Upstream 100 bases:

>100_bases
CTCTCTTTGAAATATACTTATTTAAAGAAGACCTTAGCTGATTATAGGGAGAAAATGGCTGAAGAAGTGTTAAACAATTA
AGAGATTGGAGGAGATAAAT

Downstream 100 bases:

>100_bases
AGTGCTAATTGCAAAAGTCTATATAACTTTAAAAAAAGGAATACTTGACCCACAAGGAAAAGCAGTAAAGGGAGCTTTGT
ACTCATTAGGATACGAAGAA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MEKRELLYEGKAKKVYKTDEENLYIIEYKDDATAFNGLKKGTIAEKGIVNNKVSAILFALLDKNNVPTHYVKRLSDREML
VKKVEIFPLEVIVRNYAAGSICKRLGLEEGLKFKTPVLEFSYKNDELKDPMINEYHIQALELATKEEIEIMTGMTFKVNE
ILSEYFLSKDIILVDFKLEFGKSSEGILLADEISPDTCRFWDKNTMEKLDKDRFRKDLGKVEEAYLEILKRLGGM

Sequences:

>Translated_235_residues
MEKRELLYEGKAKKVYKTDEENLYIIEYKDDATAFNGLKKGTIAEKGIVNNKVSAILFALLDKNNVPTHYVKRLSDREML
VKKVEIFPLEVIVRNYAAGSICKRLGLEEGLKFKTPVLEFSYKNDELKDPMINEYHIQALELATKEEIEIMTGMTFKVNE
ILSEYFLSKDIILVDFKLEFGKSSEGILLADEISPDTCRFWDKNTMEKLDKDRFRKDLGKVEEAYLEILKRLGGM
>Mature_235_residues
MEKRELLYEGKAKKVYKTDEENLYIIEYKDDATAFNGLKKGTIAEKGIVNNKVSAILFALLDKNNVPTHYVKRLSDREML
VKKVEIFPLEVIVRNYAAGSICKRLGLEEGLKFKTPVLEFSYKNDELKDPMINEYHIQALELATKEEIEIMTGMTFKVNE
ILSEYFLSKDIILVDFKLEFGKSSEGILLADEISPDTCRFWDKNTMEKLDKDRFRKDLGKVEEAYLEILKRLGGM

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=236, Percent_Identity=32.2033898305085, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI5453539, Length=236, Percent_Identity=32.2033898305085, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI119220559, Length=243, Percent_Identity=31.6872427983539, Blast_Score=118, Evalue=5e-27,
Organism=Escherichia coli, GI1788820, Length=233, Percent_Identity=44.206008583691, Blast_Score=213, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI17531275, Length=238, Percent_Identity=34.8739495798319, Blast_Score=116, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6319326, Length=240, Percent_Identity=29.5833333333333, Blast_Score=83, Evalue=3e-17,
Organism=Drosophila melanogaster, GI18860083, Length=239, Percent_Identity=33.4728033472803, Blast_Score=120, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24583917, Length=250, Percent_Identity=31.2, Blast_Score=109, Evalue=1e-24,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_THEP3 (B0KBQ8)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001665689.1
- ProteinModelPortal:   B0KBQ8
- SMR:   B0KBQ8
- GeneID:   5874579
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_1716
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- ProtClustDB:   PRK09362
- BioCyc:   TPSE340099:TETH39_1716-MONOMER
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 27199; Mature: 27199

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKRELLYEGKAKKVYKTDEENLYIIEYKDDATAFNGLKKGTIAEKGIVNNKVSAILFAL
CCCHHHHHCCCCCCEEECCCCCEEEEEECCCCHHHCCCCCCCCHHCCCCCHHHHHHHHHH
LDKNNVPTHYVKRLSDREMLVKKVEIFPLEVIVRNYAAGSICKRLGLEEGLKFKTPVLEF
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCEEEE
SYKNDELKDPMINEYHIQALELATKEEIEIMTGMTFKVNEILSEYFLSKDIILVDFKLEF
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHCCCEEEEEEEEEC
GKSSEGILLADEISPDTCRFWDKNTMEKLDKDRFRKDLGKVEEAYLEILKRLGGM
CCCCCCEEEEECCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEKRELLYEGKAKKVYKTDEENLYIIEYKDDATAFNGLKKGTIAEKGIVNNKVSAILFAL
CCCHHHHHCCCCCCEEECCCCCEEEEEECCCCHHHCCCCCCCCHHCCCCCHHHHHHHHHH
LDKNNVPTHYVKRLSDREMLVKKVEIFPLEVIVRNYAAGSICKRLGLEEGLKFKTPVLEF
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCEEEE
SYKNDELKDPMINEYHIQALELATKEEIEIMTGMTFKVNEILSEYFLSKDIILVDFKLEF
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHCCCEEEEEEEEEC
GKSSEGILLADEISPDTCRFWDKNTMEKLDKDRFRKDLGKVEEAYLEILKRLGGM
CCCCCCEEEEECCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA