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The map label for this gene is pdp [H]

Identifier: 167039070

GI number: 167039070

Start: 418684

End: 419979

Strand: Direct

Name: pdp [H]

Synonym: Teth514_0409

Alternate gene names: 167039070

Gene position: 418684-419979 (Clockwise)

Preceding gene: 167039069

Following gene: 167039071

Centisome position: 17.04

GC content: 38.5

Gene sequence:

>1296_bases
ATGCGGATGTATGACCTTATAATGAAAAAGAGAGACGGTGGAGTTCTTACAAAAGAAGAGATTGATTTTATAATCTCTTC
TTATACCAAAGATTATCTTCCTGATTATCAGATGAGCGCTTTGGCAATGGCTATATATTTTAGAGGAATGACGCCAGAAG
AGACTGCACATCTTACTATGGCTATGGCTTACTCTGGCGATGTGATGGATTTATCAGCCATTAAAGGAATCAAAGTGGAT
AAACACTCAACTGGTGGTGTAGCTGACACTACTACACTAGTGCTTGCTCCGATGGTAGCAGCCTGTGGAGCGCCTGTTGC
AAAAATGTCAGGAAGAGGTTTAGGACATACCGGTGGAACGATAGATAAACTTGAGTCAATACCAGGAATGAGAATAGAAC
TCAGCGAAGAGGAGTTTACTGACAACGTAAATAAATACGGCATTGCTATTATTGGGCAGACAAAAAATCTTACACCTGCT
GATAAAAAGTTATATGCGTTAAGGGATGTTACTGCAACAGTAGATTCTATTCCACTTATTGCAAGCTCTGTTATGAGCAA
AAAGATTGCAGCAGGTGCAGATGCCATAGTATTAGATGTGAAAGTGGGTAGAGGAGCTTTTATGAAAGATTTAGAAAGCG
CCAAAGCCCTTGCTAAATTGATGGTAGATATCGGTAATTCTGTTGGTAGAAAAACTGTGGCGCATGTTACAAATATGGAT
TACCCACTTGGGCTTGCGATAGGAAATGCTCTCGAGATAATAGAAGCTGTTCAAGTTTTAAAAGGTCATGGTTCTAAAGA
TTTATTGGAAGTATGTATGCTTTTGGGTTCTGATATGCTTCAAATTGCAGGTGTTGCAAAAGACGATACAGAGGCGAGGG
CAAAACTAAAAGAAGTGCTTGATAGCGGAAAAGCCCTACAAAAATTTAAAGAATTTATAAAAGCACAAGATGGAGATGAA
AGAGTAGTTGACGATTTTTCACTTTTACCACAGGCTAAGTATGTAAGACCTTGGATTGCCGACAGGGATGTATATATAAA
AGACCTGATGGCTTTAGATTTAGGCCTTGTAGCGATGAAGTTAGGAGCGGGAAGAGAAAGAAAAGAAGACAAAATAGATT
TAGCAGTTGGTATAATGTTAGGGGGAAAAGTTGGAGATATAGTTAGAAAAGGTGAGCCTATTGCTACAATATATGCTAAT
GATGAGGGTAAAGCTGAATGGGCTTTAAATGAAATTAAAAAGTATATTCTTCTCTCTGATGAGCCTGTGGAAAGGCCAAC
ATTAATATTTGAGTAA

Upstream 100 bases:

>100_bases
AGATATTGCTGCCACAATAGCTGAAACATTCAGGGTTGGTCCTACAAAGCATGGCACATCTTTCTTGAAGGAATTACCTT
TATGAGTGGGGGTATGATTT

Downstream 100 bases:

>100_bases
CAAAAAGCGGTTCTTTTTAGTGTTTTGTAAGAAGAACCGCTTATTTCTATTAAATTTTTGCCGATTTAAACCGATAAATA
AATACGGAATTTTTATTTTT

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MRMYDLIMKKRDGGVLTKEEIDFIISSYTKDYLPDYQMSALAMAIYFRGMTPEETAHLTMAMAYSGDVMDLSAIKGIKVD
KHSTGGVADTTTLVLAPMVAACGAPVAKMSGRGLGHTGGTIDKLESIPGMRIELSEEEFTDNVNKYGIAIIGQTKNLTPA
DKKLYALRDVTATVDSIPLIASSVMSKKIAAGADAIVLDVKVGRGAFMKDLESAKALAKLMVDIGNSVGRKTVAHVTNMD
YPLGLAIGNALEIIEAVQVLKGHGSKDLLEVCMLLGSDMLQIAGVAKDDTEARAKLKEVLDSGKALQKFKEFIKAQDGDE
RVVDDFSLLPQAKYVRPWIADRDVYIKDLMALDLGLVAMKLGAGRERKEDKIDLAVGIMLGGKVGDIVRKGEPIATIYAN
DEGKAEWALNEIKKYILLSDEPVERPTLIFE

Sequences:

>Translated_431_residues
MRMYDLIMKKRDGGVLTKEEIDFIISSYTKDYLPDYQMSALAMAIYFRGMTPEETAHLTMAMAYSGDVMDLSAIKGIKVD
KHSTGGVADTTTLVLAPMVAACGAPVAKMSGRGLGHTGGTIDKLESIPGMRIELSEEEFTDNVNKYGIAIIGQTKNLTPA
DKKLYALRDVTATVDSIPLIASSVMSKKIAAGADAIVLDVKVGRGAFMKDLESAKALAKLMVDIGNSVGRKTVAHVTNMD
YPLGLAIGNALEIIEAVQVLKGHGSKDLLEVCMLLGSDMLQIAGVAKDDTEARAKLKEVLDSGKALQKFKEFIKAQDGDE
RVVDDFSLLPQAKYVRPWIADRDVYIKDLMALDLGLVAMKLGAGRERKEDKIDLAVGIMLGGKVGDIVRKGEPIATIYAN
DEGKAEWALNEIKKYILLSDEPVERPTLIFE
>Mature_431_residues
MRMYDLIMKKRDGGVLTKEEIDFIISSYTKDYLPDYQMSALAMAIYFRGMTPEETAHLTMAMAYSGDVMDLSAIKGIKVD
KHSTGGVADTTTLVLAPMVAACGAPVAKMSGRGLGHTGGTIDKLESIPGMRIELSEEEFTDNVNKYGIAIIGQTKNLTPA
DKKLYALRDVTATVDSIPLIASSVMSKKIAAGADAIVLDVKVGRGAFMKDLESAKALAKLMVDIGNSVGRKTVAHVTNMD
YPLGLAIGNALEIIEAVQVLKGHGSKDLLEVCMLLGSDMLQIAGVAKDDTEARAKLKEVLDSGKALQKFKEFIKAQDGDE
RVVDDFSLLPQAKYVRPWIADRDVYIKDLMALDLGLVAMKLGAGRERKEDKIDLAVGIMLGGKVGDIVRKGEPIATIYAN
DEGKAEWALNEIKKYILLSDEPVERPTLIFE

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=441, Percent_Identity=39.9092970521542, Blast_Score=293, Evalue=3e-79,
Organism=Homo sapiens, GI4503445, Length=441, Percent_Identity=39.9092970521542, Blast_Score=293, Evalue=3e-79,
Organism=Homo sapiens, GI166158922, Length=441, Percent_Identity=39.9092970521542, Blast_Score=293, Evalue=3e-79,
Organism=Escherichia coli, GI1790842, Length=407, Percent_Identity=46.6830466830467, Blast_Score=345, Evalue=4e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 46710; Mature: 46710

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMYDLIMKKRDGGVLTKEEIDFIISSYTKDYLPDYQMSALAMAIYFRGMTPEETAHLTM
CCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHEEEE
AMAYSGDVMDLSAIKGIKVDKHSTGGVADTTTLVLAPMVAACGAPVAKMSGRGLGHTGGT
EEEECCCCEEHHHHCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCC
IDKLESIPGMRIELSEEEFTDNVNKYGIAIIGQTKNLTPADKKLYALRDVTATVDSIPLI
HHHHHCCCCCEEEECHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
ASSVMSKKIAAGADAIVLDVKVGRGAFMKDLESAKALAKLMVDIGNSVGRKTVAHVTNMD
HHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCC
YPLGLAIGNALEIIEAVQVLKGHGSKDLLEVCMLLGSDMLQIAGVAKDDTEARAKLKEVL
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHH
DSGKALQKFKEFIKAQDGDERVVDDFSLLPQAKYVRPWIADRDVYIKDLMALDLGLVAMK
HCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHH
LGAGRERKEDKIDLAVGIMLGGKVGDIVRKGEPIATIYANDEGKAEWALNEIKKYILLSD
HCCCCCCCCCCCEEEEEEEECCCHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHEEECC
EPVERPTLIFE
CCCCCCCCEEC
>Mature Secondary Structure
MRMYDLIMKKRDGGVLTKEEIDFIISSYTKDYLPDYQMSALAMAIYFRGMTPEETAHLTM
CCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHEEEE
AMAYSGDVMDLSAIKGIKVDKHSTGGVADTTTLVLAPMVAACGAPVAKMSGRGLGHTGGT
EEEECCCCEEHHHHCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCC
IDKLESIPGMRIELSEEEFTDNVNKYGIAIIGQTKNLTPADKKLYALRDVTATVDSIPLI
HHHHHCCCCCEEEECHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
ASSVMSKKIAAGADAIVLDVKVGRGAFMKDLESAKALAKLMVDIGNSVGRKTVAHVTNMD
HHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCC
YPLGLAIGNALEIIEAVQVLKGHGSKDLLEVCMLLGSDMLQIAGVAKDDTEARAKLKEVL
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHH
DSGKALQKFKEFIKAQDGDERVVDDFSLLPQAKYVRPWIADRDVYIKDLMALDLGLVAMK
HCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHH
LGAGRERKEDKIDLAVGIMLGGKVGDIVRKGEPIATIYANDEGKAEWALNEIKKYILLSD
HCCCCCCCCCCCEEEEEEEECCCHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHEEECC
EPVERPTLIFE
CCCCCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8987664; 9817849 [H]