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The map label for this gene is gyrA [H]

Identifier: 167038685

GI number: 167038685

Start: 11111

End: 13534

Strand: Direct

Name: gyrA [H]

Synonym: Teth514_0010

Alternate gene names: 167038685

Gene position: 11111-13534 (Clockwise)

Preceding gene: 167038684

Following gene: 167038687

Centisome position: 0.45

GC content: 35.23

Gene sequence:

>2424_bases
ATGAGTGAAGAAAAAGAGAAGGTAATCCCAGTAGGCATTGAAGATGAAATGAAAAAATCTTATATAGATTATGCAATGAG
TGTAATTGTTGGAAGGGCATTGCCAGATGTAAGAGATGGTTTAAAACCAGTTCATAGAAGAATTCTTTATGCGATGAATG
AGTTAGGATTAACTCCTGATAAGCCATATAAAAAAAGTGTTGCAGTTGTTGGTGAAGTTTTAGGGAAATATCATCCTCAT
GGTGATGCGGCTGTTTATGATACTTTAGTGAGACTAGCACAGGATTTTTCAATGAGAGAAACTTTGATAGATGGGCATGG
AAACTTTGGAAGCATAGATGGAGACCCCCCAGCTGCCATGAGGTATACAGAAGCGAGGCTTTCAAAAATTGCCCTTGAAA
TGCTTACGGATATAAATAAAGAAACAGTAGATTTTGTGCCAAACTTTGACGAAACATTAAAAGAACCGGTAGTGCTTCCT
TCAAGATTTCCTAATCTTTTAGTTAACGGGTCTCAAGGAATTGCCGTAGGTATGGCTACCAATATTCCTCCTCACAATTT
AGGAGAAGTCATAGACGGAATTATCGCTTATATAGACAATCCTTATATTTCAGTAGATGAACTAATGAAATATATAAAAG
GGCCTGACTTTCCTACAGGAGGAGTAATTTTAGGAAGAGACGGTATAAAAGAGACTTATGAGACAGGAAGAGGCAAAATT
GTCGTTAGAGCAAAGGCAGAAATTGAAGAACACCACGGTAAGACGAGAATTGTAATTACTGAAATTCCTTATATGGTGCT
TAAAGCTAAGTTAATTGAAAAAATTGCTGAGCTAGTTCGCGAAAAGCACATAGAAGGAATTTCTGATTTGAGAGATGAAT
CTGATAGAAATGGAATGAAAGTTGTAATAGAACTAAAAAAAGATGTCAATCCAAAGGTGATACTTAATAAACTTTACATG
CACACGCAAATGCAGCAGACCTTTGGAGCTATAATGTTGGCTCTTGTAGACGGGGAGCCTAAGATATTAAACCTCAAGCA
AATTATAGAAAAGTATGTAGATCATCAAGCGGATGTTGTAACGAGAAGGACTAAGTTTGACTTAAGAAAAGCGGAAGAAA
GAGCACATATTTTAGAAGGGCTAAAAATTGCTCTTGACCACATTGATGAAGTTATAAACATAATAAGAAGTTCAAAGACA
GAAGCAATTGCTAAGCAAAATTTAATGGACAAGTTTGGATTGAGCGAAAAACAAGCACAAGCGATAGTTGATATGAGATT
AGGAAGACTGACGGGGCTTGAAAGGCAAAAAGTAGAAGATGAGCTTGAAGAGTTAATGGAAAAGATAAAAGAATTAAAAG
GAATTTTGGCAGATGAAAGAAAAGTACTGGAAATAATTAAAAAAGAGCTTTTAGAAATAAAAGATAAATACGCTACTCCG
AGAAAGACAAACATTGTGGCAAAAGAAGAAGAGCTAGATTTAGAGGATTTGGTTCAATTGGAAGATGTAGTTGTGACAAT
GACTCATTATGGATATATAAAGAGAATGCCTCTTGATACTTATAAGGCGCAAAAACGTGGGGGAAAGGGCATATTAGGTA
TATCAACAAGAGAAGATGACTTTGTACGGGATATTTTTATTACTACAACTCATGACAGATTGTTGTTCTTTACAAACAAA
GGGAAGGTATATAGTTTAAGAACTATAGATATTCCTGAAACAGGAAGGCAGGCAAAAGGCACAGCTATTGTCAATCTCAT
ACAGATAGGTCAAGGAGAAAAAGTCACAGCGGTTATTCCTCTTAAAAAGTCTCAAGATATTAAATATGTTGTTATGTGTA
CTAAAAAAGGCATAATTAAAAAGACTTCTATAGAAGAGTTTAGGTCAATTAAGAGAAATGGTATAATAGCTATCACGTTG
GAAGAAAGTGATGAGCTTATAAATGTAAAATTAACAAATGGAGAAAGAGAAATAATAATAGGGACTGCCAGAGGCTATGC
TATAAGATTTAATGAAAAAGACATAAGGCCTATGGGAAGGGTGGCAAAGGGTGTAATAGCTATTTCCTTGAGAGAAGATG
ATGAAGTGGTAGAAATGGACCTTGTTCACCCGGGTAGCGAAATTTTGGTAGTTACAGAAAAAGGATTTGGAAAAAGAACT
GATTTAGAGGAATACAGGCTTCAAACAAGAGCGGGAAAAGGAATAATTGCAATAAGACTTAGTGAAAAAACTGGTAAATT
AGTATCTATAAGGTCGGTAAATCCGGAAGATGAATTTATGATAATTTCTGCAAATGGAATTCTTATAAGAATGAAAGTGT
CCGATATTTCTAAGATGCACAGAGATACAAGAGGAGTAACTCTTATGAAACTTGATGATGGGGACAGGGTTGTTTCTACT
GCAAGAATAGAAAATGAAGAATAA

Upstream 100 bases:

>100_bases
TCACCATTTTAATGGGGGACAAAGTCGAACCAAGAAGGGAATTTATAGAAAAGCACGCAAAAACAGTTAGAAATTTAGAC
ATATAAAAGAGGTGAAATAG

Downstream 100 bases:

>100_bases
AATAAGCCCTCAAATTTGTGGGGGCTTATTTTTTAAAAGCTCTTTCATATTGTTTTGGCCAGTCTTCCTTAGAAGTGTAC
GTATGTAAAACCCAATAGGG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 807; Mature: 806

Protein sequence:

>807_residues
MSEEKEKVIPVGIEDEMKKSYIDYAMSVIVGRALPDVRDGLKPVHRRILYAMNELGLTPDKPYKKSVAVVGEVLGKYHPH
GDAAVYDTLVRLAQDFSMRETLIDGHGNFGSIDGDPPAAMRYTEARLSKIALEMLTDINKETVDFVPNFDETLKEPVVLP
SRFPNLLVNGSQGIAVGMATNIPPHNLGEVIDGIIAYIDNPYISVDELMKYIKGPDFPTGGVILGRDGIKETYETGRGKI
VVRAKAEIEEHHGKTRIVITEIPYMVLKAKLIEKIAELVREKHIEGISDLRDESDRNGMKVVIELKKDVNPKVILNKLYM
HTQMQQTFGAIMLALVDGEPKILNLKQIIEKYVDHQADVVTRRTKFDLRKAEERAHILEGLKIALDHIDEVINIIRSSKT
EAIAKQNLMDKFGLSEKQAQAIVDMRLGRLTGLERQKVEDELEELMEKIKELKGILADERKVLEIIKKELLEIKDKYATP
RKTNIVAKEEELDLEDLVQLEDVVVTMTHYGYIKRMPLDTYKAQKRGGKGILGISTREDDFVRDIFITTTHDRLLFFTNK
GKVYSLRTIDIPETGRQAKGTAIVNLIQIGQGEKVTAVIPLKKSQDIKYVVMCTKKGIIKKTSIEEFRSIKRNGIIAITL
EESDELINVKLTNGEREIIIGTARGYAIRFNEKDIRPMGRVAKGVIAISLREDDEVVEMDLVHPGSEILVVTEKGFGKRT
DLEEYRLQTRAGKGIIAIRLSEKTGKLVSIRSVNPEDEFMIISANGILIRMKVSDISKMHRDTRGVTLMKLDDGDRVVST
ARIENEE

Sequences:

>Translated_807_residues
MSEEKEKVIPVGIEDEMKKSYIDYAMSVIVGRALPDVRDGLKPVHRRILYAMNELGLTPDKPYKKSVAVVGEVLGKYHPH
GDAAVYDTLVRLAQDFSMRETLIDGHGNFGSIDGDPPAAMRYTEARLSKIALEMLTDINKETVDFVPNFDETLKEPVVLP
SRFPNLLVNGSQGIAVGMATNIPPHNLGEVIDGIIAYIDNPYISVDELMKYIKGPDFPTGGVILGRDGIKETYETGRGKI
VVRAKAEIEEHHGKTRIVITEIPYMVLKAKLIEKIAELVREKHIEGISDLRDESDRNGMKVVIELKKDVNPKVILNKLYM
HTQMQQTFGAIMLALVDGEPKILNLKQIIEKYVDHQADVVTRRTKFDLRKAEERAHILEGLKIALDHIDEVINIIRSSKT
EAIAKQNLMDKFGLSEKQAQAIVDMRLGRLTGLERQKVEDELEELMEKIKELKGILADERKVLEIIKKELLEIKDKYATP
RKTNIVAKEEELDLEDLVQLEDVVVTMTHYGYIKRMPLDTYKAQKRGGKGILGISTREDDFVRDIFITTTHDRLLFFTNK
GKVYSLRTIDIPETGRQAKGTAIVNLIQIGQGEKVTAVIPLKKSQDIKYVVMCTKKGIIKKTSIEEFRSIKRNGIIAITL
EESDELINVKLTNGEREIIIGTARGYAIRFNEKDIRPMGRVAKGVIAISLREDDEVVEMDLVHPGSEILVVTEKGFGKRT
DLEEYRLQTRAGKGIIAIRLSEKTGKLVSIRSVNPEDEFMIISANGILIRMKVSDISKMHRDTRGVTLMKLDDGDRVVST
ARIENEE
>Mature_806_residues
SEEKEKVIPVGIEDEMKKSYIDYAMSVIVGRALPDVRDGLKPVHRRILYAMNELGLTPDKPYKKSVAVVGEVLGKYHPHG
DAAVYDTLVRLAQDFSMRETLIDGHGNFGSIDGDPPAAMRYTEARLSKIALEMLTDINKETVDFVPNFDETLKEPVVLPS
RFPNLLVNGSQGIAVGMATNIPPHNLGEVIDGIIAYIDNPYISVDELMKYIKGPDFPTGGVILGRDGIKETYETGRGKIV
VRAKAEIEEHHGKTRIVITEIPYMVLKAKLIEKIAELVREKHIEGISDLRDESDRNGMKVVIELKKDVNPKVILNKLYMH
TQMQQTFGAIMLALVDGEPKILNLKQIIEKYVDHQADVVTRRTKFDLRKAEERAHILEGLKIALDHIDEVINIIRSSKTE
AIAKQNLMDKFGLSEKQAQAIVDMRLGRLTGLERQKVEDELEELMEKIKELKGILADERKVLEIIKKELLEIKDKYATPR
KTNIVAKEEELDLEDLVQLEDVVVTMTHYGYIKRMPLDTYKAQKRGGKGILGISTREDDFVRDIFITTTHDRLLFFTNKG
KVYSLRTIDIPETGRQAKGTAIVNLIQIGQGEKVTAVIPLKKSQDIKYVVMCTKKGIIKKTSIEEFRSIKRNGIIAITLE
ESDELINVKLTNGEREIIIGTARGYAIRFNEKDIRPMGRVAKGVIAISLREDDEVVEMDLVHPGSEILVVTEKGFGKRTD
LEEYRLQTRAGKGIIAIRLSEKTGKLVSIRSVNPEDEFMIISANGILIRMKVSDISKMHRDTRGVTLMKLDDGDRVVSTA
RIENEE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=175, Percent_Identity=29.7142857142857, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI19913408, Length=175, Percent_Identity=29.1428571428571, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1788562, Length=839, Percent_Identity=50.4171632896305, Blast_Score=831, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=730, Percent_Identity=35.8904109589041, Blast_Score=416, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17535065, Length=170, Percent_Identity=32.3529411764706, Blast_Score=75, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=188, Percent_Identity=30.3191489361702, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 90961; Mature: 90830

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEEKEKVIPVGIEDEMKKSYIDYAMSVIVGRALPDVRDGLKPVHRRILYAMNELGLTPD
CCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
KPYKKSVAVVGEVLGKYHPHGDAAVYDTLVRLAQDFSMRETLIDGHGNFGSIDGDPPAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCHHH
RYTEARLSKIALEMLTDINKETVDFVPNFDETLKEPVVLPSRFPNLLVNGSQGIAVGMAT
HHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHCCEECCCCCCCEEEECCCCEEEEEEC
NIPPHNLGEVIDGIIAYIDNPYISVDELMKYIKGPDFPTGGVILGRDGIKETYETGRGKI
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCCCCHHHHHCCCCEE
VVRAKAEIEEHHGKTRIVITEIPYMVLKAKLIEKIAELVREKHIEGISDLRDESDRNGMK
EEEEEHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCE
VVIELKKDVNPKVILNKLYMHTQMQQTFGAIMLALVDGEPKILNLKQIIEKYVDHQADVV
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEECHHHHHHHHHCCHHHHH
TRRTKFDLRKAEERAHILEGLKIALDHIDEVINIIRSSKTEAIAKQNLMDKFGLSEKQAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHH
AIVDMRLGRLTGLERQKVEDELEELMEKIKELKGILADERKVLEIIKKELLEIKDKYATP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCC
RKTNIVAKEEELDLEDLVQLEDVVVTMTHYGYIKRMPLDTYKAQKRGGKGILGISTREDD
CCCCEEECHHCCCHHHHHHHHHHHEEEECCCEEEECCCHHHHHHHCCCCEEEEECCCCCC
FVRDIFITTTHDRLLFFTNKGKVYSLRTIDIPETGRQAKGTAIVNLIQIGQGEKVTAVIP
CEEEEEEEEECCEEEEEECCCCEEEEEEECCCCCCCCCCCHHEEEEEECCCCCEEEEEEE
LKKSQDIKYVVMCTKKGIIKKTSIEEFRSIKRNGIIAITLEESDELINVKLTNGEREIII
CCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCEEEEEECCCCCEEEEEEECCCEEEEE
GTARGYAIRFNEKDIRPMGRVAKGVIAISLREDDEVVEMDLVHPGSEILVVTEKGFGKRT
EECCCEEEEECCCCCCHHHHHHCCEEEEEECCCCCEEEEEEECCCCCEEEEEECCCCCCC
DLEEYRLQTRAGKGIIAIRLSEKTGKLVSIRSVNPEDEFMIISANGILIRMKVSDISKMH
CHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCCCEEEEEECCEEEEEEHHHHHHHH
RDTRGVTLMKLDDGDRVVSTARIENEE
HHHCCEEEEEECCCCCEEEEEECCCCC
>Mature Secondary Structure 
SEEKEKVIPVGIEDEMKKSYIDYAMSVIVGRALPDVRDGLKPVHRRILYAMNELGLTPD
CCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
KPYKKSVAVVGEVLGKYHPHGDAAVYDTLVRLAQDFSMRETLIDGHGNFGSIDGDPPAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCHHH
RYTEARLSKIALEMLTDINKETVDFVPNFDETLKEPVVLPSRFPNLLVNGSQGIAVGMAT
HHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHCCEECCCCCCCEEEECCCCEEEEEEC
NIPPHNLGEVIDGIIAYIDNPYISVDELMKYIKGPDFPTGGVILGRDGIKETYETGRGKI
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCCCCHHHHHCCCCEE
VVRAKAEIEEHHGKTRIVITEIPYMVLKAKLIEKIAELVREKHIEGISDLRDESDRNGMK
EEEEEHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCE
VVIELKKDVNPKVILNKLYMHTQMQQTFGAIMLALVDGEPKILNLKQIIEKYVDHQADVV
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEECHHHHHHHHHCCHHHHH
TRRTKFDLRKAEERAHILEGLKIALDHIDEVINIIRSSKTEAIAKQNLMDKFGLSEKQAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHH
AIVDMRLGRLTGLERQKVEDELEELMEKIKELKGILADERKVLEIIKKELLEIKDKYATP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCC
RKTNIVAKEEELDLEDLVQLEDVVVTMTHYGYIKRMPLDTYKAQKRGGKGILGISTREDD
CCCCEEECHHCCCHHHHHHHHHHHEEEECCCEEEECCCHHHHHHHCCCCEEEEECCCCCC
FVRDIFITTTHDRLLFFTNKGKVYSLRTIDIPETGRQAKGTAIVNLIQIGQGEKVTAVIP
CEEEEEEEEECCEEEEEECCCCEEEEEEECCCCCCCCCCCHHEEEEEECCCCCEEEEEEE
LKKSQDIKYVVMCTKKGIIKKTSIEEFRSIKRNGIIAITLEESDELINVKLTNGEREIII
CCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCEEEEEECCCCCEEEEEEECCCEEEEE
GTARGYAIRFNEKDIRPMGRVAKGVIAISLREDDEVVEMDLVHPGSEILVVTEKGFGKRT
EECCCEEEEECCCCCCHHHHHHCCEEEEEECCCCCEEEEEEECCCCCEEEEEECCCCCCC
DLEEYRLQTRAGKGIIAIRLSEKTGKLVSIRSVNPEDEFMIISANGILIRMKVSDISKMH
CHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCCCEEEEEECCEEEEEEHHHHHHHH
RDTRGVTLMKLDDGDRVVSTARIENEE
HHHCCEEEEEECCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]