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The map label for this gene is gyrB [H]

Identifier: 167038684

GI number: 167038684

Start: 9195

End: 11096

Strand: Direct

Name: gyrB [H]

Synonym: Teth514_0009

Alternate gene names: 167038684

Gene position: 9195-11096 (Clockwise)

Preceding gene: 167038681

Following gene: 167038685

Centisome position: 0.37

GC content: 35.33

Gene sequence:

>1902_bases
ATGGCAAAGGATGAAACTTATACTGCGAGTCAAATTCAAATATTAGAGGGTTTAGAAGCCGTAAGAAAGAGGCCAGGAAT
GTATATAGGTTCTACTGGCAGCAGGGGATTGCATCACCTTGTATACGAGGTAGTAGATAATAGTATAGATGAAGCATTGG
CAGGGTATTGCAAAAATATAGTAGTTACTATACACAAAGATAATTCCATAACGGTTGAAGACGACGGGAGAGGTATACCT
ACAGATATACACCCAAAAGTTGGAAAACCGGCTGTAGAAGTAGCTTTAACGATGTTACACGCAGGTGGAAAATTTAATAA
TGATGCTTACAAAGTATCTGGAGGATTACACGGAGTAGGTGTTTCTGTTGTAAATGCATTATCTGAAAAATTGGAAGTTG
TTGTAAAACAGCGTGGGAAAATTTTCAGGCAAACATATGAAAGAGGAGTACCAAAAACTGATTTAGAGATTATTGGGGAA
ACAGAAGAGACGGGTACGACTATTACTTTTAAGCCAGATAAAGAAATTTTTGAGGAAACTGTATTCAATTATGATGTATT
AGCTCAAAGATTAAGAGAATTAGCTTTTTTAAATAAAGGTATAAATATCAGGCTTATAGATGAAAGAGACGGAAAGGAAG
AGGTCTTTAACTACGAAGGTGGAATTATATCTTTTGTGAAATATCTCAATAGAAATAAAGAAGTTTTACATGAGGAACCT
ATATACATGGAAGCAAAAAACACTGATTATGAAGTAGAGGTTTGCATGCAGTATAATGATACGTATACTGAAAATATTTT
TAGTTTTGCCAATAATATTGATACTAGAGAAGGTGGTACTCATCTTGTTGGATTTAAAAGTGCTCTTACTAAAGTTATCA
ATGACTATGCTAGAAAATACGGAATTATAAAAGATAACGAGAAAAATTTGCAGGGTGAAGATGTAAGAGAGGGCTTGACT
GCTATTGTAAGTGTAAAGTTAAAAAACCCACAGTTTGAAGGCCAGACTAAAACAAAATTAGGAAATTCTGAAATGAGGTC
TATTGTAGAAAATGTAGTGATAGAGAAACTATCGGCTTTTTTAGAAGAAAATCCCTCGGTTGCAAAAGTAATAGTAGAAA
AGGCTACACAAGCTGCAAGGGCGAGAGAAGCAGCGAGAAAAGCCAGAGAACTCACTAGAAGAAAATCTGCACTTGAAAAT
ACTACTTTACCGGGAAAACTTGCTGACTGTTCGGAAAAAGACCCTTCTAAGTGTGAGCTTTTCTTGGTAGAAGGTGATTC
TGCTGGAGGTTCTGCTAAAACAGGTAGAAATAGTAGATTTCAAGCGATACTTCCACTACGAGGGAAAATTTTAAATGTGG
AAAAGGCGAGACTTGACAAGATACTCTCTAATGAAGAGATAAGAGCAATGATAACTGCTTTAGGTACTGGAATAGGAGAT
GAATTTGATATAAGTAAGTTAAGGTACCACAAAGTAGTCATAATGACAGATGCGGACGTAGATGGAAGTCATATTAGGAC
ACTGCTTTTAACATTTTTCTATAGGTTTATGAGACCTTTAATTGAAAATGGAAATGTGTACATTGCTCAACCGCCTTTAT
ATAAAATTACAAAAGGCAAAAAGGTGTATTATGCTTACTCGGATAGAGAATTAGACAGGATTTTAAATGAAATTGGAAGG
GAAAATTATACTGTTCAAAGGTATAAAGGTCTTGGAGAAATGAATGCTGACCAGTTATGGGATACAACTATGGATCCAGA
GAAGAGGACGATGCTTAAAGTTACATTAGAGGATGCGATAGCTGCAGATGAAATTTTCACCATTTTAATGGGGGACAAAG
TCGAACCAAGAAGGGAATTTATAGAAAAGCACGCAAAAACAGTTAGAAATTTAGACATATAA

Upstream 100 bases:

>100_bases
TCATTTCCCGGGAAAATTTTTCGGGAAATATTTTGAATTGAGCAATTTTTAAAATAATGATAAAATAAAACTGTTGGATA
AATTTGCGGAGGTTGTGAAT

Downstream 100 bases:

>100_bases
AAGAGGTGAAATAGATGAGTGAAGAAAAAGAGAAGGTAATCCCAGTAGGCATTGAAGATGAAATGAAAAAATCTTATATA
GATTATGCAATGAGTGTAAT

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 633; Mature: 632

Protein sequence:

>633_residues
MAKDETYTASQIQILEGLEAVRKRPGMYIGSTGSRGLHHLVYEVVDNSIDEALAGYCKNIVVTIHKDNSITVEDDGRGIP
TDIHPKVGKPAVEVALTMLHAGGKFNNDAYKVSGGLHGVGVSVVNALSEKLEVVVKQRGKIFRQTYERGVPKTDLEIIGE
TEETGTTITFKPDKEIFEETVFNYDVLAQRLRELAFLNKGINIRLIDERDGKEEVFNYEGGIISFVKYLNRNKEVLHEEP
IYMEAKNTDYEVEVCMQYNDTYTENIFSFANNIDTREGGTHLVGFKSALTKVINDYARKYGIIKDNEKNLQGEDVREGLT
AIVSVKLKNPQFEGQTKTKLGNSEMRSIVENVVIEKLSAFLEENPSVAKVIVEKATQAARAREAARKARELTRRKSALEN
TTLPGKLADCSEKDPSKCELFLVEGDSAGGSAKTGRNSRFQAILPLRGKILNVEKARLDKILSNEEIRAMITALGTGIGD
EFDISKLRYHKVVIMTDADVDGSHIRTLLLTFFYRFMRPLIENGNVYIAQPPLYKITKGKKVYYAYSDRELDRILNEIGR
ENYTVQRYKGLGEMNADQLWDTTMDPEKRTMLKVTLEDAIAADEIFTILMGDKVEPRREFIEKHAKTVRNLDI

Sequences:

>Translated_633_residues
MAKDETYTASQIQILEGLEAVRKRPGMYIGSTGSRGLHHLVYEVVDNSIDEALAGYCKNIVVTIHKDNSITVEDDGRGIP
TDIHPKVGKPAVEVALTMLHAGGKFNNDAYKVSGGLHGVGVSVVNALSEKLEVVVKQRGKIFRQTYERGVPKTDLEIIGE
TEETGTTITFKPDKEIFEETVFNYDVLAQRLRELAFLNKGINIRLIDERDGKEEVFNYEGGIISFVKYLNRNKEVLHEEP
IYMEAKNTDYEVEVCMQYNDTYTENIFSFANNIDTREGGTHLVGFKSALTKVINDYARKYGIIKDNEKNLQGEDVREGLT
AIVSVKLKNPQFEGQTKTKLGNSEMRSIVENVVIEKLSAFLEENPSVAKVIVEKATQAARAREAARKARELTRRKSALEN
TTLPGKLADCSEKDPSKCELFLVEGDSAGGSAKTGRNSRFQAILPLRGKILNVEKARLDKILSNEEIRAMITALGTGIGD
EFDISKLRYHKVVIMTDADVDGSHIRTLLLTFFYRFMRPLIENGNVYIAQPPLYKITKGKKVYYAYSDRELDRILNEIGR
ENYTVQRYKGLGEMNADQLWDTTMDPEKRTMLKVTLEDAIAADEIFTILMGDKVEPRREFIEKHAKTVRNLDI
>Mature_632_residues
AKDETYTASQIQILEGLEAVRKRPGMYIGSTGSRGLHHLVYEVVDNSIDEALAGYCKNIVVTIHKDNSITVEDDGRGIPT
DIHPKVGKPAVEVALTMLHAGGKFNNDAYKVSGGLHGVGVSVVNALSEKLEVVVKQRGKIFRQTYERGVPKTDLEIIGET
EETGTTITFKPDKEIFEETVFNYDVLAQRLRELAFLNKGINIRLIDERDGKEEVFNYEGGIISFVKYLNRNKEVLHEEPI
YMEAKNTDYEVEVCMQYNDTYTENIFSFANNIDTREGGTHLVGFKSALTKVINDYARKYGIIKDNEKNLQGEDVREGLTA
IVSVKLKNPQFEGQTKTKLGNSEMRSIVENVVIEKLSAFLEENPSVAKVIVEKATQAARAREAARKARELTRRKSALENT
TLPGKLADCSEKDPSKCELFLVEGDSAGGSAKTGRNSRFQAILPLRGKILNVEKARLDKILSNEEIRAMITALGTGIGDE
FDISKLRYHKVVIMTDADVDGSHIRTLLLTFFYRFMRPLIENGNVYIAQPPLYKITKGKKVYYAYSDRELDRILNEIGRE
NYTVQRYKGLGEMNADQLWDTTMDPEKRTMLKVTLEDAIAADEIFTILMGDKVEPRREFIEKHAKTVRNLDI

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=631, Percent_Identity=26.9413629160063, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI19913406, Length=613, Percent_Identity=26.7536704730832, Blast_Score=152, Evalue=1e-36,
Organism=Escherichia coli, GI48994957, Length=564, Percent_Identity=59.9290780141844, Blast_Score=668, Evalue=0.0,
Organism=Escherichia coli, GI1789408, Length=630, Percent_Identity=40.3174603174603, Blast_Score=465, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17535065, Length=622, Percent_Identity=28.4565916398714, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI212645845, Length=592, Percent_Identity=26.5202702702703, Blast_Score=153, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI212645657, Length=180, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324241, Length=639, Percent_Identity=27.0735524256651, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI17136538, Length=613, Percent_Identity=26.9168026101142, Blast_Score=160, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 71305; Mature: 71174

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKDETYTASQIQILEGLEAVRKRPGMYIGSTGSRGLHHLVYEVVDNSIDEALAGYCKNI
CCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCHHHHHHHHHHCCE
VVTIHKDNSITVEDDGRGIPTDIHPKVGKPAVEVALTMLHAGGKFNNDAYKVSGGLHGVG
EEEEECCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCHHH
VSVVNALSEKLEVVVKQRGKIFRQTYERGVPKTDLEIIGETEETGTTITFKPDKEIFEET
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEECCCCCCCCEEEECCCHHHHHHH
VFNYDVLAQRLRELAFLNKGINIRLIDERDGKEEVFNYEGGIISFVKYLNRNKEVLHEEP
HCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCCCHHHHHHHHCCCHHHHCCCC
IYMEAKNTDYEVEVCMQYNDTYTENIFSFANNIDTREGGTHLVGFKSALTKVINDYARKY
CEEEECCCCEEEEEEEECCCHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHC
GIIKDNEKNLQGEDVREGLTAIVSVKLKNPQFEGQTKTKLGNSEMRSIVENVVIEKLSAF
CCCCCCCCCCCCHHHHHHHHEEEEEEECCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHH
LEENPSVAKVIVEKATQAARAREAARKARELTRRKSALENTTLPGKLADCSEKDPSKCEL
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEE
FLVEGDSAGGSAKTGRNSRFQAILPLRGKILNVEKARLDKILSNEEIRAMITALGTGIGD
EEEECCCCCCCCCCCCCCCEEEEECCCCEEECHHHHHHHHHHCCHHHHHHHHHHHCCCCC
EFDISKLRYHKVVIMTDADVDGSHIRTLLLTFFYRFMRPLIENGNVYIAQPPLYKITKGK
CCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEECCCC
KVYYAYSDRELDRILNEIGRENYTVQRYKGLGEMNADQLWDTTMDPEKRTMLKVTLEDAI
EEEEEECCHHHHHHHHHHCCCCCEEHHHCCCCCCCHHHHCCCCCCCCHHEEEEEEHHHHH
AADEIFTILMGDKVEPRREFIEKHAKTVRNLDI
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AKDETYTASQIQILEGLEAVRKRPGMYIGSTGSRGLHHLVYEVVDNSIDEALAGYCKNI
CCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCHHHHHHHHHHCCE
VVTIHKDNSITVEDDGRGIPTDIHPKVGKPAVEVALTMLHAGGKFNNDAYKVSGGLHGVG
EEEEECCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCHHH
VSVVNALSEKLEVVVKQRGKIFRQTYERGVPKTDLEIIGETEETGTTITFKPDKEIFEET
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEECCCCCCCCEEEECCCHHHHHHH
VFNYDVLAQRLRELAFLNKGINIRLIDERDGKEEVFNYEGGIISFVKYLNRNKEVLHEEP
HCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCCCHHHHHHHHCCCHHHHCCCC
IYMEAKNTDYEVEVCMQYNDTYTENIFSFANNIDTREGGTHLVGFKSALTKVINDYARKY
CEEEECCCCEEEEEEEECCCHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHC
GIIKDNEKNLQGEDVREGLTAIVSVKLKNPQFEGQTKTKLGNSEMRSIVENVVIEKLSAF
CCCCCCCCCCCCHHHHHHHHEEEEEEECCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHH
LEENPSVAKVIVEKATQAARAREAARKARELTRRKSALENTTLPGKLADCSEKDPSKCEL
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEE
FLVEGDSAGGSAKTGRNSRFQAILPLRGKILNVEKARLDKILSNEEIRAMITALGTGIGD
EEEECCCCCCCCCCCCCCCEEEEECCCCEEECHHHHHHHHHHCCHHHHHHHHHHHCCCCC
EFDISKLRYHKVVIMTDADVDGSHIRTLLLTFFYRFMRPLIENGNVYIAQPPLYKITKGK
CCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEECCCC
KVYYAYSDRELDRILNEIGRENYTVQRYKGLGEMNADQLWDTTMDPEKRTMLKVTLEDAI
EEEEEECCHHHHHHHHHHCCCCCEEHHHCCCCCCCHHHHCCCCCCCCHHEEEEEEHHHHH
AADEIFTILMGDKVEPRREFIEKHAKTVRNLDI
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]