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The map label for this gene is coaBC [H]

Identifier: 163845175

GI number: 163845175

Start: 1037145

End: 1038365

Strand: Reverse

Name: coaBC [H]

Synonym: BSUIS_B1059

Alternate gene names: 163845175

Gene position: 1038365-1037145 (Counterclockwise)

Preceding gene: 163845176

Following gene: 163845173

Centisome position: 74.12

GC content: 60.85

Gene sequence:

>1221_bases
ATGGCATTGCTGGACGGTAAGCGCATCCTCCTCATCATTGGCGGTGGCATTGCCGCCTATAAGACGCCGGATCTCATTCG
CCGCCTGCGTGAGCGCGGTGCGCATGTGCGCCCATTGATGACGGCTGCGGCACAGCAATTCGTAACGCCGCTGACCATTG
GCGCGGTTTCCGCCGATCATGTCTTCACCGATCTGTTCTCGCGTGAGGATGAGCAGGATGTGGGCCATATCCGGCTTGCC
CGCGAGGCTGATCTGATTGTGGTCGCACCCGCAACGGCTGACCTGATGGCGAAGATGGCCAACGGGCTTGCGGATGATCT
GGCGAGTGCGGTGCTGTTGGCCCGCAAGGTTCCGCTGCTGATCGCGCCCGCCATGAACCCGGCCATGTGGGACAATCCCG
CGACAAGGCGCAACCGTTTGACGCTTGAAAAGGATGGCGTGCGCTTCATCGGGCCGGAAAAGGGCGAGATGGCCGAAAGC
GGGGAGGCTGGAACTGGCCGCATGAGCGAGCCGCTGGCAATTGTCGCGGCCATTGAAAATCTGCTCTCACCGCAGGCAAA
ACCGCTTGCCGGCAAAACAATCGTCATGACTTCCGGCCCCACATATGAGCCGATCGATCCGGTGCGTTATATCGCCAATC
GTTCGTCGGGCAAGCAGGGGCATGCCATTGCGGCAGCACTCGCGCGGCTTGGTGCGACGGTGCATCTCGTCTCCGGCCCG
GTCAATATTCCCGATCCCGAAGGTGTTGACGTTATCCATGTCGAGACGGCGCGTGAAATGCAGGCGGCTGTGGAACGGCA
TCTTCCCGCCGATGCGGCAGTAATGGTGGCCGCGGTTGCCGACTGGCGCAGCGCCAATGAGGCCGGGCAGAAGATCAAGA
AGAAGCCCGGCGAAGGTGCGCCCGTGCTTGCCATGGTCGAGAACCCGGACATTCTGGCAGGCATCGGCCATAGCAAAAAG
CGGCCCGGACTGGTTGTCGGCTTTGCAGCGGAAACGCAGGACGTGGCCGAAAATGCGAGAGCCAAGCTTGAGAAAAAAGG
TGCGGACTGGATCGTCGCCAATGATGTTTCGCATGGGCCGGGTAAGGACGGCGTGATGGGCGGCGACCGCAACCGGGTGC
GTATCTTGAGCCATTCCGGCATTGAGGAATGGCCGGAAATGAGCAAGGAAGACGTCGCTGAAAGACTGGCGGAAAAAATC
GCTGCCAGCCTTCTTGGTTAA

Upstream 100 bases:

>100_bases
CCGCATCGCGCAGGTGGTGATTGCGGTTTCCATGGCCGGGATAGCAATAAAGCTCTATATCTGGCTGTAAAACTATTCTC
TTTTGAGAGGTCGGCAACAC

Downstream 100 bases:

>100_bases
ACCCAGCCTTCTTGGTTAAACCTTGTCACGCACCTGATAGTCCTTGATGGTGGCGAAGCGGATATCCTTCCAGCGTTCGG
CCTCGTAATTGAGCGAGAAA

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MALLDGKRILLIIGGGIAAYKTPDLIRRLRERGAHVRPLMTAAAQQFVTPLTIGAVSADHVFTDLFSREDEQDVGHIRLA
READLIVVAPATADLMAKMANGLADDLASAVLLARKVPLLIAPAMNPAMWDNPATRRNRLTLEKDGVRFIGPEKGEMAES
GEAGTGRMSEPLAIVAAIENLLSPQAKPLAGKTIVMTSGPTYEPIDPVRYIANRSSGKQGHAIAAALARLGATVHLVSGP
VNIPDPEGVDVIHVETAREMQAAVERHLPADAAVMVAAVADWRSANEAGQKIKKKPGEGAPVLAMVENPDILAGIGHSKK
RPGLVVGFAAETQDVAENARAKLEKKGADWIVANDVSHGPGKDGVMGGDRNRVRILSHSGIEEWPEMSKEDVAERLAEKI
AASLLG

Sequences:

>Translated_406_residues
MALLDGKRILLIIGGGIAAYKTPDLIRRLRERGAHVRPLMTAAAQQFVTPLTIGAVSADHVFTDLFSREDEQDVGHIRLA
READLIVVAPATADLMAKMANGLADDLASAVLLARKVPLLIAPAMNPAMWDNPATRRNRLTLEKDGVRFIGPEKGEMAES
GEAGTGRMSEPLAIVAAIENLLSPQAKPLAGKTIVMTSGPTYEPIDPVRYIANRSSGKQGHAIAAALARLGATVHLVSGP
VNIPDPEGVDVIHVETAREMQAAVERHLPADAAVMVAAVADWRSANEAGQKIKKKPGEGAPVLAMVENPDILAGIGHSKK
RPGLVVGFAAETQDVAENARAKLEKKGADWIVANDVSHGPGKDGVMGGDRNRVRILSHSGIEEWPEMSKEDVAERLAEKI
AASLLG
>Mature_405_residues
ALLDGKRILLIIGGGIAAYKTPDLIRRLRERGAHVRPLMTAAAQQFVTPLTIGAVSADHVFTDLFSREDEQDVGHIRLAR
EADLIVVAPATADLMAKMANGLADDLASAVLLARKVPLLIAPAMNPAMWDNPATRRNRLTLEKDGVRFIGPEKGEMAESG
EAGTGRMSEPLAIVAAIENLLSPQAKPLAGKTIVMTSGPTYEPIDPVRYIANRSSGKQGHAIAAALARLGATVHLVSGPV
NIPDPEGVDVIHVETAREMQAAVERHLPADAAVMVAAVADWRSANEAGQKIKKKPGEGAPVLAMVENPDILAGIGHSKKR
PGLVVGFAAETQDVAENARAKLEKKGADWIVANDVSHGPGKDGVMGGDRNRVRILSHSGIEEWPEMSKEDVAERLAEKIA
ASLLG

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=186, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI87082301, Length=399, Percent_Identity=46.6165413533835, Blast_Score=286, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17560194, Length=187, Percent_Identity=35.8288770053476, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322762, Length=193, Percent_Identity=27.4611398963731, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24657262, Length=186, Percent_Identity=32.7956989247312, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43008; Mature: 42877

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLDGKRILLIIGGGIAAYKTPDLIRRLRERGAHVRPLMTAAAQQFVTPLTIGAVSADH
CCCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHCCCCCHHH
VFTDLFSREDEQDVGHIRLAREADLIVVAPATADLMAKMANGLADDLASAVLLARKVPLL
HHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
IAPAMNPAMWDNPATRRNRLTLEKDGVRFIGPEKGEMAESGEAGTGRMSEPLAIVAAIEN
EECCCCCCCCCCCCCCCCCEEEECCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
LLSPQAKPLAGKTIVMTSGPTYEPIDPVRYIANRSSGKQGHAIAAALARLGATVHLVSGP
HHCCCCCCCCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCEEEEEECC
VNIPDPEGVDVIHVETAREMQAAVERHLPADAAVMVAAVADWRSANEAGQKIKKKPGEGA
CCCCCCCCCEEEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCCCC
PVLAMVENPDILAGIGHSKKRPGLVVGFAAETQDVAENARAKLEKKGADWIVANDVSHGP
CEEEEECCCCEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCCCCC
GKDGVMGGDRNRVRILSHSGIEEWPEMSKEDVAERLAEKIAASLLG
CCCCCCCCCCCEEEEEECCCCHHHHCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALLDGKRILLIIGGGIAAYKTPDLIRRLRERGAHVRPLMTAAAQQFVTPLTIGAVSADH
CCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHCCCCCHHH
VFTDLFSREDEQDVGHIRLAREADLIVVAPATADLMAKMANGLADDLASAVLLARKVPLL
HHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
IAPAMNPAMWDNPATRRNRLTLEKDGVRFIGPEKGEMAESGEAGTGRMSEPLAIVAAIEN
EECCCCCCCCCCCCCCCCCEEEECCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
LLSPQAKPLAGKTIVMTSGPTYEPIDPVRYIANRSSGKQGHAIAAALARLGATVHLVSGP
HHCCCCCCCCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCEEEEEECC
VNIPDPEGVDVIHVETAREMQAAVERHLPADAAVMVAAVADWRSANEAGQKIKKKPGEGA
CCCCCCCCCEEEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCCCC
PVLAMVENPDILAGIGHSKKRPGLVVGFAAETQDVAENARAKLEKKGADWIVANDVSHGP
CEEEEECCCCEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCCCCC
GKDGVMGGDRNRVRILSHSGIEEWPEMSKEDVAERLAEKIAASLLG
CCCCCCCCCCCEEEEEECCCCHHHHCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA