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The map label for this gene is ubiB [H]

Identifier: 163845176

GI number: 163845176

Start: 1038396

End: 1039979

Strand: Reverse

Name: ubiB [H]

Synonym: BSUIS_B1060

Alternate gene names: 163845176

Gene position: 1039979-1038396 (Counterclockwise)

Preceding gene: 163845177

Following gene: 163845175

Centisome position: 74.24

GC content: 58.9

Gene sequence:

>1584_bases
ATGAGTAACCTTTCCGCCGTTTTCCGGCTGATGCGGGCCGGATGGATATTGACGCGCGAGGGCGTGATCAGCGCGCTTCC
CGTAGAAGGACTTTCCGGCCTCCCGGCGCTCGGACACAGGATTGCCGGTTTTCTGGCCCGTCCACGCGCGCGTCAGATGG
AGCGTTCCGAACGCATGTCACGGGCCATGAACAAGCTTGGCCCTTCCTATGTGAAGCTTGGCCAGTTTCTGGCGACGCGC
CCCGATATTGTCGGGCATGACGTTGCCGCTGATCTGGAATTGTTGCAAGATCGGCTCGACTTCTTTCCGCAGGCTGGAGC
GGTTGCGGCCATTGAAGGTTCGCTTGGCCGCAAGATCGATGATCTTTATGTGCGTTTCGATGCGCCGATCGCGGCGGCGT
CGATGGCGCAGGTGCATCCGGCCGAGGTGATGAAGGATGGTGCGCCGCAAAAGGTTGCGGTGAAGGTCATCCGCCCCGGC
GTGCGCCAGCGTTTTGCGCGCGATCTGGAAAGTTTCTTTATGGTCGCCCGTATGCAGGAGCGCCATATGCCTTTCACGCG
CCGCCTGCGCCCGGTGCAGGTGGTCGAAACCCTGTCGCAGACCACGCGCATCGAAATGGATTTGCGGCTTGAAGCGGCTG
CCCTTTCTGAAATTGCCGAGAATATCAAGGGAGATGAGGGGTTCCGGGTTCCCAAGGTGGACTGGGAGCGCACGGGCCGC
GATGTGCTGACGCTCGAATGGATCGACGGTATCAAGATGTCGGACATTCCCGCACTTGAAGCTGCCGGTTTCGACCTCAA
GAAGCTTGCCGAAACGCTGATCCAGTCGTTTTTGCGCCATACGCTGCGTGATGGTTTCTTCCATGCCGACATGCATCCGG
GCAATCTGTTCGTGGATCATCAGGGACTGGTGGTGGCGGTCGATTTCGGCATCACGGGCCGGCTCGACAAGCAGCAGCGG
CGGTTCCTTGCCGAAATTCTCTATGGCTTCATCACACGCGATTATATGCGCGTGGCAGAGGTCCATTTCGAGGCAGGTTA
TGTGCCTTACACGCATGATGTGGCAAGTTTTGCGCAGGCCATCCGCGCAATTGGCGAGCCGATCCATGGTCAGCCCGCCG
AAACCATTTCCATGGCCAAGCTTCTGACGCTCCTGTTTGAAGTGACCGAGCTTTTTGACATGGAAACGCGGCCCGAGCTT
TTGATGCTCCAGAAGACCATGGTGGTGGTGGAGGGCGTGTCGCGCACGCTTGATCCGCATTTCAACATGTGGAAGGCGGC
GGAACCTGTCGTGGGCGACTGGATCCGGAAGAATCTTGGTCCGCAGGGCATGGTGCTGGATGCGAAGGAGAGTGCTTACG
CATTGCTGCATTTCACGCGCAAGACGCCGGAATTGTTGCAGCGCATCGATCGCATCTCGGTCGCTCTGGACACTATGGCG
GCCAATGGATTGCGCTTTGACGATGCGACGGCAGAGGCCATTGGCCGCGCTGAAGCGCAGCATTCTCGCTGGGGCCGCAT
CGCGCAGGTGGTGATTGCGGTTTCCATGGCCGGGATAGCAATAAAGCTCTATATCTGGCTGTAA

Upstream 100 bases:

>100_bases
TCGCAATTTCACCGGCGGCATTGCCGCGCTCCATTCCGGCTGGAAGCTTTGATCGTGCCTGTGATGAGTTCGGGTCGCAA
CCAGCGTGAGGCATCGGCGC

Downstream 100 bases:

>100_bases
AACTATTCTCTTTTGAGAGGTCGGCAACACATGGCATTGCTGGACGGTAAGCGCATCCTCCTCATCATTGGCGGTGGCAT
TGCCGCCTATAAGACGCCGG

Product: 2-polyprenylphenol 6-hydroxylase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MSNLSAVFRLMRAGWILTREGVISALPVEGLSGLPALGHRIAGFLARPRARQMERSERMSRAMNKLGPSYVKLGQFLATR
PDIVGHDVAADLELLQDRLDFFPQAGAVAAIEGSLGRKIDDLYVRFDAPIAAASMAQVHPAEVMKDGAPQKVAVKVIRPG
VRQRFARDLESFFMVARMQERHMPFTRRLRPVQVVETLSQTTRIEMDLRLEAAALSEIAENIKGDEGFRVPKVDWERTGR
DVLTLEWIDGIKMSDIPALEAAGFDLKKLAETLIQSFLRHTLRDGFFHADMHPGNLFVDHQGLVVAVDFGITGRLDKQQR
RFLAEILYGFITRDYMRVAEVHFEAGYVPYTHDVASFAQAIRAIGEPIHGQPAETISMAKLLTLLFEVTELFDMETRPEL
LMLQKTMVVVEGVSRTLDPHFNMWKAAEPVVGDWIRKNLGPQGMVLDAKESAYALLHFTRKTPELLQRIDRISVALDTMA
ANGLRFDDATAEAIGRAEAQHSRWGRIAQVVIAVSMAGIAIKLYIWL

Sequences:

>Translated_527_residues
MSNLSAVFRLMRAGWILTREGVISALPVEGLSGLPALGHRIAGFLARPRARQMERSERMSRAMNKLGPSYVKLGQFLATR
PDIVGHDVAADLELLQDRLDFFPQAGAVAAIEGSLGRKIDDLYVRFDAPIAAASMAQVHPAEVMKDGAPQKVAVKVIRPG
VRQRFARDLESFFMVARMQERHMPFTRRLRPVQVVETLSQTTRIEMDLRLEAAALSEIAENIKGDEGFRVPKVDWERTGR
DVLTLEWIDGIKMSDIPALEAAGFDLKKLAETLIQSFLRHTLRDGFFHADMHPGNLFVDHQGLVVAVDFGITGRLDKQQR
RFLAEILYGFITRDYMRVAEVHFEAGYVPYTHDVASFAQAIRAIGEPIHGQPAETISMAKLLTLLFEVTELFDMETRPEL
LMLQKTMVVVEGVSRTLDPHFNMWKAAEPVVGDWIRKNLGPQGMVLDAKESAYALLHFTRKTPELLQRIDRISVALDTMA
ANGLRFDDATAEAIGRAEAQHSRWGRIAQVVIAVSMAGIAIKLYIWL
>Mature_526_residues
SNLSAVFRLMRAGWILTREGVISALPVEGLSGLPALGHRIAGFLARPRARQMERSERMSRAMNKLGPSYVKLGQFLATRP
DIVGHDVAADLELLQDRLDFFPQAGAVAAIEGSLGRKIDDLYVRFDAPIAAASMAQVHPAEVMKDGAPQKVAVKVIRPGV
RQRFARDLESFFMVARMQERHMPFTRRLRPVQVVETLSQTTRIEMDLRLEAAALSEIAENIKGDEGFRVPKVDWERTGRD
VLTLEWIDGIKMSDIPALEAAGFDLKKLAETLIQSFLRHTLRDGFFHADMHPGNLFVDHQGLVVAVDFGITGRLDKQQRR
FLAEILYGFITRDYMRVAEVHFEAGYVPYTHDVASFAQAIRAIGEPIHGQPAETISMAKLLTLLFEVTELFDMETRPELL
MLQKTMVVVEGVSRTLDPHFNMWKAAEPVVGDWIRKNLGPQGMVLDAKESAYALLHFTRKTPELLQRIDRISVALDTMAA
NGLRFDDATAEAIGRAEAQHSRWGRIAQVVIAVSMAGIAIKLYIWL

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=288, Percent_Identity=29.8611111111111, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI40254938, Length=339, Percent_Identity=24.188790560472, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI217035081, Length=232, Percent_Identity=28.0172413793103, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI34147522, Length=303, Percent_Identity=28.3828382838284, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI27363457, Length=293, Percent_Identity=27.3037542662116, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI32261307, Length=314, Percent_Identity=24.5222929936306, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI217416386, Length=226, Percent_Identity=28.7610619469027, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI2367309, Length=442, Percent_Identity=36.8778280542986, Blast_Score=281, Evalue=6e-77,
Organism=Caenorhabditis elegans, GI17559152, Length=342, Percent_Identity=22.8070175438596, Blast_Score=99, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6325148, Length=440, Percent_Identity=23.1818181818182, Blast_Score=107, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6321319, Length=322, Percent_Identity=22.9813664596273, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24662575, Length=310, Percent_Identity=30.3225806451613, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI22024280, Length=256, Percent_Identity=25.390625, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 59016; Mature: 58885

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLSAVFRLMRAGWILTREGVISALPVEGLSGLPALGHRIAGFLARPRARQMERSERMS
CCCHHHHHHHHHHCCEEECCCCHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
RAMNKLGPSYVKLGQFLATRPDIVGHDVAADLELLQDRLDFFPQAGAVAAIEGSLGRKID
HHHHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCHHCCCHH
DLYVRFDAPIAAASMAQVHPAEVMKDGAPQKVAVKVIRPGVRQRFARDLESFFMVARMQE
HEEEEECCCHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHMPFTRRLRPVQVVETLSQTTRIEMDLRLEAAALSEIAENIKGDEGFRVPKVDWERTGR
HCCCHHHCCCHHHHHHHHHHHHEEEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCC
DVLTLEWIDGIKMSDIPALEAAGFDLKKLAETLIQSFLRHTLRDGFFHADMHPGNLFVDH
CEEEEEECCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEC
QGLVVAVDFGITGRLDKQQRRFLAEILYGFITRDYMRVAEVHFEAGYVPYTHDVASFAQA
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IRAIGEPIHGQPAETISMAKLLTLLFEVTELFDMETRPELLMLQKTMVVVEGVSRTLDPH
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
FNMWKAAEPVVGDWIRKNLGPQGMVLDAKESAYALLHFTRKTPELLQRIDRISVALDTMA
CCHHHHCCCHHHHHHHHCCCCCCEEEECCCCCEEHHHHHCCCHHHHHHHHHHHHHHHHHH
ANGLRFDDATAEAIGRAEAQHSRWGRIAQVVIAVSMAGIAIKLYIWL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEC
>Mature Secondary Structure 
SNLSAVFRLMRAGWILTREGVISALPVEGLSGLPALGHRIAGFLARPRARQMERSERMS
CCHHHHHHHHHHCCEEECCCCHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
RAMNKLGPSYVKLGQFLATRPDIVGHDVAADLELLQDRLDFFPQAGAVAAIEGSLGRKID
HHHHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCHHCCCHH
DLYVRFDAPIAAASMAQVHPAEVMKDGAPQKVAVKVIRPGVRQRFARDLESFFMVARMQE
HEEEEECCCHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHMPFTRRLRPVQVVETLSQTTRIEMDLRLEAAALSEIAENIKGDEGFRVPKVDWERTGR
HCCCHHHCCCHHHHHHHHHHHHEEEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCC
DVLTLEWIDGIKMSDIPALEAAGFDLKKLAETLIQSFLRHTLRDGFFHADMHPGNLFVDH
CEEEEEECCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEC
QGLVVAVDFGITGRLDKQQRRFLAEILYGFITRDYMRVAEVHFEAGYVPYTHDVASFAQA
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IRAIGEPIHGQPAETISMAKLLTLLFEVTELFDMETRPELLMLQKTMVVVEGVSRTLDPH
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
FNMWKAAEPVVGDWIRKNLGPQGMVLDAKESAYALLHFTRKTPELLQRIDRISVALDTMA
CCHHHHCCCHHHHHHHHCCCCCCEEEECCCCCEEHHHHHCCCHHHHHHHHHHHHHHHHHH
ANGLRFDDATAEAIGRAEAQHSRWGRIAQVVIAVSMAGIAIKLYIWL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA