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The map label for this gene is aspC

Identifier: 16273507

GI number: 16273507

Start: 1684756

End: 1685946

Strand: Direct

Name: aspC

Synonym: HI1617

Alternate gene names: 16273507

Gene position: 1684756-1685946 (Clockwise)

Preceding gene: 16273506

Following gene: 16273513

Centisome position: 92.06

GC content: 39.55

Gene sequence:

>1191_bases
ATGTTTGAACATATCAAAGCGGCACCAGCCGATCCAATCTTAGGCTTAGGCGAAGCATTTAAATCCGAAACTCGCGAAAA
TAAAATCAATTTGGGTATTGGCGTTTATAAAGATGCGCAAGGCACAACCCCAATTATGCACGCGGTAAAAGAAGCCGAAA
AACGATTATTTGATAAGGAAAAAACCAAGAATTATCTGACTATCGATGGTATTGCGGATTATAACGAACAAACAAAAGCA
CTCCTTTTCGGTAAAGATTCTGAAGTCATCCAATCTAATCGAGCAAGAACAGTACAAAGTTTAGGCGGAACAGGTGCATT
ACGCATTGCGGCAGAATTTATTAAACGCCAAACTAAAGCACAAAATGTTTGGATCAGCACACCAACTTGGCCAAACCACA
ATGCGATTTTCAATGCTGTCGGTATGACCATTCGTGAATATCGTTATTATGATGCTGAACGCAAAGCCCTTGATTGGGAA
CACTTATTAGAAGATTTAAGCCAAGCAAGCGAAGGCGATGTGGTGCTTTTACACGGTTGTTGCCATAATCCGACTGGTAT
TGACCCTACTCCAGAACAATGGCAAGAATTAGCCGCACTTTCAGCTAAAAATGGTTGGTTGCCACTCTTTGACTTTGCTT
ATCAAGGTTTAGCCAACGGATTAGATGAAGATGCTTATGGTTTACGTGCTTTTGCAGCAAACCACAAAGAATTATTAGTG
GCGAGTTCATTCTCGAAAAACTTTGGTTTATATAATGAACGTGTTGGTGCATTTACCCTTGTGGCAGAAAATGCAGAAAT
TGCATCAACCTCATTAACCCAAGTAAAATCAATTATTCGCACCCTATACTCTAACCCAGCTTCTCACGGCGGGGCGACCG
TAGCAACAGTATTAAATGATGCTCAACTTCGCCAAGAATGGGAAAATGAATTAACTGAAATGCGTGAACGCATCAAAAAA
ATGCGTCACTTATTCGTTCAGTTATTAAAAGAATATGGTGCAGAACAAGATTTCAGCTTTATCATTGAACAAAACGGTAT
GTTTTCTTTCAGTGGATTAACAGGGGAACAAGTGGATCGTTTAAAAAATGAATTTGCCATTTACGCTGTTCGTTCTGGTC
GTATCAACGTAGCTGGAATCACAGAAGATAATATTCGCTATCTATGTGAAAGTATCGTGAAAGTACTTTAA

Upstream 100 bases:

>100_bases
ATATCAAAGCGTGGTTAATTTTTATAAAATCTTTCTTGATAAAATAAAATGACTGAAGTATAAAACTATTCATCACACAA
CACATACATAAGGAAAAGCT

Downstream 100 bases:

>100_bases
TTAGAGTTAGAAATCATCTCTAACCTAAAATAGAGCAAATATAAATAGTTAAAGCCTTGATTATCAAGGCTTTAATTTTA
TCTAATCATTAACAAATTCT

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: AspAT; Transaminase A

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MFEHIKAAPADPILGLGEAFKSETRENKINLGIGVYKDAQGTTPIMHAVKEAEKRLFDKEKTKNYLTIDGIADYNEQTKA
LLFGKDSEVIQSNRARTVQSLGGTGALRIAAEFIKRQTKAQNVWISTPTWPNHNAIFNAVGMTIREYRYYDAERKALDWE
HLLEDLSQASEGDVVLLHGCCHNPTGIDPTPEQWQELAALSAKNGWLPLFDFAYQGLANGLDEDAYGLRAFAANHKELLV
ASSFSKNFGLYNERVGAFTLVAENAEIASTSLTQVKSIIRTLYSNPASHGGATVATVLNDAQLRQEWENELTEMRERIKK
MRHLFVQLLKEYGAEQDFSFIIEQNGMFSFSGLTGEQVDRLKNEFAIYAVRSGRINVAGITEDNIRYLCESIVKVL

Sequences:

>Translated_396_residues
MFEHIKAAPADPILGLGEAFKSETRENKINLGIGVYKDAQGTTPIMHAVKEAEKRLFDKEKTKNYLTIDGIADYNEQTKA
LLFGKDSEVIQSNRARTVQSLGGTGALRIAAEFIKRQTKAQNVWISTPTWPNHNAIFNAVGMTIREYRYYDAERKALDWE
HLLEDLSQASEGDVVLLHGCCHNPTGIDPTPEQWQELAALSAKNGWLPLFDFAYQGLANGLDEDAYGLRAFAANHKELLV
ASSFSKNFGLYNERVGAFTLVAENAEIASTSLTQVKSIIRTLYSNPASHGGATVATVLNDAQLRQEWENELTEMRERIKK
MRHLFVQLLKEYGAEQDFSFIIEQNGMFSFSGLTGEQVDRLKNEFAIYAVRSGRINVAGITEDNIRYLCESIVKVL
>Mature_396_residues
MFEHIKAAPADPILGLGEAFKSETRENKINLGIGVYKDAQGTTPIMHAVKEAEKRLFDKEKTKNYLTIDGIADYNEQTKA
LLFGKDSEVIQSNRARTVQSLGGTGALRIAAEFIKRQTKAQNVWISTPTWPNHNAIFNAVGMTIREYRYYDAERKALDWE
HLLEDLSQASEGDVVLLHGCCHNPTGIDPTPEQWQELAALSAKNGWLPLFDFAYQGLANGLDEDAYGLRAFAANHKELLV
ASSFSKNFGLYNERVGAFTLVAENAEIASTSLTQVKSIIRTLYSNPASHGGATVATVLNDAQLRQEWENELTEMRERIKK
MRHLFVQLLKEYGAEQDFSFIIEQNGMFSFSGLTGEQVDRLKNEFAIYAVRSGRINVAGITEDNIRYLCESIVKVL

Specific function: Unknown

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI73486658, Length=396, Percent_Identity=43.6868686868687, Blast_Score=356, Evalue=2e-98,
Organism=Homo sapiens, GI4504067, Length=400, Percent_Identity=41.5, Blast_Score=318, Evalue=4e-87,
Organism=Homo sapiens, GI117414139, Length=381, Percent_Identity=29.3963254593176, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1787159, Length=396, Percent_Identity=62.6262626262626, Blast_Score=536, Evalue=1e-154,
Organism=Escherichia coli, GI1790488, Length=397, Percent_Identity=41.5617128463476, Blast_Score=338, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI71981858, Length=395, Percent_Identity=43.2911392405063, Blast_Score=358, Evalue=3e-99,
Organism=Caenorhabditis elegans, GI25147133, Length=395, Percent_Identity=40, Blast_Score=340, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI17569539, Length=395, Percent_Identity=37.2151898734177, Blast_Score=288, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17569537, Length=388, Percent_Identity=31.4432989690722, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI25147136, Length=220, Percent_Identity=38.6363636363636, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI17550384, Length=263, Percent_Identity=34.2205323193916, Blast_Score=174, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6323055, Length=405, Percent_Identity=38.2716049382716, Blast_Score=300, Evalue=3e-82,
Organism=Saccharomyces cerevisiae, GI6322743, Length=427, Percent_Identity=33.0210772833724, Blast_Score=235, Evalue=8e-63,
Organism=Drosophila melanogaster, GI24580970, Length=396, Percent_Identity=42.9292929292929, Blast_Score=343, Evalue=1e-94,
Organism=Drosophila melanogaster, GI24580972, Length=396, Percent_Identity=42.9292929292929, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI19920542, Length=390, Percent_Identity=43.3333333333333, Blast_Score=339, Evalue=2e-93,
Organism=Drosophila melanogaster, GI19922362, Length=395, Percent_Identity=38.9873417721519, Blast_Score=312, Evalue=2e-85,
Organism=Drosophila melanogaster, GI24654046, Length=395, Percent_Identity=38.9873417721519, Blast_Score=312, Evalue=2e-85,

Paralogues:

None

Copy number: 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): AAT_HAEIN (P44425)

Other databases:

- EMBL:   L42023
- PIR:   I64132
- RefSeq:   NP_439759.1
- ProteinModelPortal:   P44425
- SMR:   P44425
- GeneID:   950841
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1617
- NMPDR:   fig|71421.1.peg.1533
- TIGR:   HI_1617
- HOGENOM:   HBG446828
- OMA:   IASSYSK
- ProtClustDB:   PRK09257
- BioCyc:   HINF71421:HI_1617-MONOMER
- BRENDA:   2.6.1.1
- GO:   GO:0005737
- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11879
- PRINTS:   PR00799

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.1

Molecular weight: Translated: 44322; Mature: 44322

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: BINDING 34-34 BINDING 130-130 BINDING 183-183 BINDING 374-374

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEHIKAAPADPILGLGEAFKSETRENKINLGIGVYKDAQGTTPIMHAVKEAEKRLFDKE
CCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECEEEEECCCCCHHHHHHHHHHHHHHHHHH
KTKNYLTIDGIADYNEQTKALLFGKDSEVIQSNRARTVQSLGGTGALRIAAEFIKRQTKA
HCCCEEEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
QNVWISTPTWPNHNAIFNAVGMTIREYRYYDAERKALDWEHLLEDLSQASEGDVVLLHGC
CEEEEECCCCCCCCHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHCCCCCCEEEEECC
CHNPTGIDPTPEQWQELAALSAKNGWLPLFDFAYQGLANGLDEDAYGLRAFAANHKELLV
CCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHEEE
ASSFSKNFGLYNERVGAFTLVAENAEIASTSLTQVKSIIRTLYSNPASHGGATVATVLND
EECCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
AQLRQEWENELTEMRERIKKMRHLFVQLLKEYGAEQDFSFIIEQNGMFSFSGLTGEQVDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCCHHHHHH
LKNEFAIYAVRSGRINVAGITEDNIRYLCESIVKVL
HHCCEEEEEEECCEEEEEECCHHHHHHHHHHHHHHC
>Mature Secondary Structure
MFEHIKAAPADPILGLGEAFKSETRENKINLGIGVYKDAQGTTPIMHAVKEAEKRLFDKE
CCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECEEEEECCCCCHHHHHHHHHHHHHHHHHH
KTKNYLTIDGIADYNEQTKALLFGKDSEVIQSNRARTVQSLGGTGALRIAAEFIKRQTKA
HCCCEEEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
QNVWISTPTWPNHNAIFNAVGMTIREYRYYDAERKALDWEHLLEDLSQASEGDVVLLHGC
CEEEEECCCCCCCCHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHCCCCCCEEEEECC
CHNPTGIDPTPEQWQELAALSAKNGWLPLFDFAYQGLANGLDEDAYGLRAFAANHKELLV
CCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHEEE
ASSFSKNFGLYNERVGAFTLVAENAEIASTSLTQVKSIIRTLYSNPASHGGATVATVLND
EECCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
AQLRQEWENELTEMRERIKKMRHLFVQLLKEYGAEQDFSFIIEQNGMFSFSGLTGEQVDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCCHHHHHH
LKNEFAIYAVRSGRINVAGITEDNIRYLCESIVKVL
HHCCEEEEEEECCEEEEEECCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800